Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
Biotin-PEG11-amine is a biotinylated polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the selective degradation of target proteins by connecting an E3 ligase to a protein of interest, thereby enhancing cellular degradation pathways. Its application in PROTAC development makes it a valuable tool for investigating protein regulation and therapeutic interventions in various biological processes. -
PROTAC Linker
Mal-PEG4-OH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the connection between the target protein and an E3 ligase, thereby promoting ubiquitination and subsequent degradation of the target protein. Mal-PEG4-OH is essential for researchers developing targeted protein degradation strategies in various therapeutic applications, enabling enhanced specificity and efficacy in protein modulation studies. -
PROTAC Linkers
Heptaethylene glycol is a PEG-based linker utilized in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the assembly of target protein degraders, enabling selective and efficient modulation of protein levels within cells. This compound is essential for researchers exploring targeted protein degradation mechanisms and therapeutic applications in cancer and other diseases. -
PROTAC Linkers
NH2-PEG2-CH2-Boc is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the connection between a target protein and an E3 ligase, enhancing the selective degradation of specific proteins within cellular contexts. It serves as a valuable tool in drug discovery and development, specifically in the study of protein regulation and degradation pathways. -
PROTAC Linker
Pentaethylene glycol monomethyl ether is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimera) molecules. This compound plays a crucial role in the formation of PROTACs, facilitating targeted degradation of specific proteins through the ubiquitin-proteasome system. Its application in chemical biology enables researchers to explore new avenues for therapeutic interventions by harnessing the power of protein modulation. -
PROTAC Linkers
DNP-PEG4-NHS ester is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of targeted protein degradation agents. This compound facilitates the conjugation of ligands to E3 ligases, enhancing the efficiency and selectivity of PROTAC molecules. Its utility in drug discovery and research applications includes the development of novel therapeutic strategies aimed at degrading specific proteins in cellular studies. -
PROTAC Linker
Triethylene glycol serves as a PEG-based linker in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the formation of bifunctional molecules that can selectively target and degrade specific proteins within cells. Its unique properties enhance the efficacy of PROTAC technology for various applications in chemical biology and therapeutic development, allowing for precise modulation of protein levels. -
PROTAC Linker
Boc-NH-PEG4 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ubiquitin ligases, enhancing protein degradation pathways. Its application in drug discovery and development is essential for the creation of novel therapeutic agents targeting various diseases through targeted protein degradation. -
PROTAC Linker
Boc-C2-NH2 is an ether-based PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). This compound serves as a crucial component in the synthesis of PROTACs, enabling targeted degradation of specific proteins. Its application is integral in chemical biology and drug discovery, providing a tool for the selective modulation of protein levels in various cellular contexts. -
PROTAC Linkers
Azido-PEG5-azide is a PEG-based linker specifically designed for PROTAC synthesis, targeting the interaction of protein degradation pathways. This compound features an azide functional group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions, facilitating the conjugation to alkyne-modified molecules or those containing DBCO or BCN groups. Its versatility in click chemistry applications makes it a valuable tool in the development of bifunctional PROTACs for targeted protein degradation studies. -
PROTAC Linker
trans-3-((tert-Butoxycarbonyl)amino)cyclobutanecarboxylic acid serves as a versatile PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound effectively bridges E3 ligases and target proteins, enabling targeted degradation of specific proteins within cellular systems. Its structural properties make it suitable for various research applications in targeted protein degradation and drug discovery. -
PROTAC Linker
tert-Butyl (9-aminononyl)carbamate is a PROTAC linker characterized by its alkane chain with a terminal amine and Boc-protected amino groups. This compound facilitates the synthesis of PROTACs and serves various conjugation applications. Its reactive amine group interacts with carboxylic acids, activated NHS esters, and carbonyl compounds, while the Boc group can be easily deprotected under mild acidic conditions to yield the free amine for further modifications. -
PROTAC Linker
8-Bromooctan-1-ol is a PROTAC linker used in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the ubiquitination and degradation of target proteins by linking E3 ligases with the proteins of interest. Its primary applications include the development of targeted protein degradation strategies in chemical biology and drug discovery. -
PROTAC Linker
3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)propanoic acid functions as a PROTAC linker, playing a critical role in the design and synthesis of PROTAC molecules. This compound facilitates the development of bifunctional degraders that enhance target protein degradation through the proteasome pathway. Its unique chemical structure enables efficient conjugation, making it valuable for research applications aimed at advancing targeted protein degradation techniques. -
PROTAC Linker
tert-Butyl 4-(2-hydroxyethoxy)piperidine-1-carboxylate serves as a PROTAC linker, facilitating the development of proteolysis targeting chimeras (PROTACs). This compound is critical for the construction of these bifunctional molecules, enabling targeted degradation of specific proteins within cellular pathways. Researchers utilize this linker in various applications, including drug discovery and the study of protein dynamics. -
PROTAC Linker
tert-Butyl (7-aminoheptyl)carbamate serves as a versatile PROTAC linker, facilitating the design and synthesis of targeted protein degradation compounds. This linker is instrumental in creating compounds like CPD-10, enabling research into targeted therapies and proteomics. Its structure allows for efficient conjugation with various ligands, supporting advancements in drug discovery and development in the field of molecular biology. -
PROTAC Linker
tert-Butyl 4-(3-hydroxypropyl)tetrahydropyridine-1(2H)-carboxylate is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of proteins by linking ligands that recruit E3 ligases to target proteins, enhancing the efficacy of targeted protein degradation strategies. It is essential for researchers focused on developing innovative therapeutic approaches in the field of targeted protein modulation. -
PROTAC Linker
(3-Bromopropoxy)(tert-butyl)dimethylsilane serves as a key PROTAC linker utilized in the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates the connection between target proteins and E3 ligases, promoting the targeted degradation of specific proteins within cellular environments. Its application in PROTAC synthesis supports advancements in targeted protein degradation research and therapeutic strategies. -
PROTAC Link
mPEG45-diol is a polyether-based PEG derivative designed as a linker for PROTAC (Proteolysis Targeting Chimera) synthesis. Its functional properties facilitate the conjugation of small molecules to E3 ligases, enabling targeted degradation of specific protein targets within cellular systems. This compound is vital for optimizing the design and efficacy of PROTAC molecules in cellular and molecular biology research applications. -
PROTAC Linker
2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptane-6-carboxylic acid serves as a crucial PROTAC linker in the development of proteolysis targeting chimeras. This compound facilitates the connection between target proteins and E3 ligases, enabling targeted degradation pathways. It is particularly valuable in research focused on protein regulation and therapeutic development for various diseases. -
PROTAC Linker
6-Heptyn-1-ol is a PROTAC linker characterized by its alkyne functional group, facilitating the construction of Proteolysis Targeting Chimeras (PROTACs). It serves as a vital component for the conjugation of different moieties, enhancing the targeted degradation of specific proteins of interest. This compound is instrumental in research applications focused on elucidating protein function and developing novel therapeutic strategies. -
PROTAC Linker
Boc-(7-Azaspiro[3.5]nonane)-NH2 is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the effective conjugation of target proteins and E3 ligases, enabling enhanced degradation of specific proteins within cells. Its unique structural properties make it suitable for a variety of research applications in targeted protein degradation, offering potential for therapeutic advancements in various disease models. -
PROTAC Linker
2-(4-(((tert-butoxycarbonyl)amino)methyl)phenyl)acetic acid serves as a PROTAC linker essential for the synthesis of PROTAC molecules. This compound plays a critical role in the development of targeted protein degradation strategies, facilitating the selective elimination of specific proteins within cellular environments. It is valuable for research applications in drug discovery and proteomics, enabling innovative approaches to modulating protein levels in various biological systems. -
PROTAC Linker
8-Bromooctanoic acid functions as a PROTAC linker, enabling targeted protein degradation through the formation of heterobifunctional molecules. This compound plays a crucial role in the synthesis of PROTAC CYP1B1 degrader-2, facilitating the selective degradation of the CYP1B1 protein for various research applications. Its unique chemical structure supports the development of innovative therapeutic strategies in the field of cancer research and beyond. -
PROTAC Linkers
Mal-PEG12-NHS ester is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an NHS ester group, facilitating the conjugation of target proteins or ligands. Mal-PEG12-NHS ester serves as an effective tool in chemical biology research, enabling the development of novel therapeutic strategies through targeted protein degradation. -
PROTAC Linker
Bromo-PEG5-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). This compound features a bromo group that facilitates the recruitment of E3 ligases, enabling targeted degradation of specific proteins within the cell. Bromo-PEG5-Boc is essential in developing innovative therapeutic strategies that leverage the ubiquitin-proteasome system for the selective removal of pathogenic proteins. Its application extends to various fields of research, including cancer biology and drug discovery. -
PROTAC Linker
1,7-Bis-Boc-1,4,7-triazaheptane is a versatile alkyl/ether-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its structure facilitates the creation of bifunctional molecules that engage target proteins for degradation via the ubiquitin-proteasome system. This compound is essential for researchers exploring targeted protein regulation and novel therapeutic strategies in the field of drug discovery. -
PROTAC Linkers
Biotin-PEG3-acid is a biotin-labeled linker featuring a polyethylene glycol (PEG) moiety, specifically designed for use in the synthesis of PROTACs (PROteolysis TArgeting Chimeras). This compound facilitates targeted degradation of proteins by linking E3 ligases to the proteins of interest, promoting ubiquitination and subsequent proteasomal degradation. With its application in drug discovery and development, Biotin-PEG3-acid supports the study of protein function and regulation in various biological contexts. -
PROTAC linker
Biotin-PEG4-acid is a PEG-based linker designed for use in proteolysis-targeting chimeras (PROTACs). This compound facilitates the efficient synthesis of PROTACs by providing a biotin moiety that enhances target protein degradation. Its application is critical in studies related to targeted protein degradation and drug discovery, enabling researchers to explore novel therapeutic strategies. -
PROTAC Linkers
Azido-PEG2-C6-Cl is a PEG-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing partners. Additionally, it readily engages in strain-promoted alkyne-azide cycloaddition (SPAAC) with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN)-bearing molecules. These properties make Azido-PEG2-C6-Cl a versatile tool for advancing targeted protein degradation research. -
PROTAC Linker
Azido-PEG3-C6-Cl is a PEG-based linker designed for use in the synthesis of proteolysis targeting chimeras (PROTACs). This compound features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) groups. It serves as a versatile tool in chemical biology, enabling the creation of targeted protein degraders for research applications in drug discovery and therapeutic intervention. -
PROTAC Linkers
Br-PEG3-C2-Boc is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the formation of linkers that connect a target protein to an E3 ligase, promoting targeted protein degradation. Its unique structure enables improved solubility and enhances the overall efficacy of PROTAC molecules in cellular applications and drug discovery research. -
PROTAC Linkers
Bromo-PEG5-alcohol is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a bromo group that enhances its reactivity, facilitating the conjugation of protein targets for targeted degradation. Its use in PROTAC development makes it valuable for research into protein regulation and therapeutic applications in various diseases. -
PROTAC Linkers
Hydroxy-PEG3-CH2-Boc is a polyethylene glycol (PEG)-based linker specifically designed for PROTAC (proteolysis-targeting chimera) applications. This compound facilitates the conjugation of target proteins to E3 ligases, enhancing target degradation through the ubiquitin-proteasome pathway. Its biocompatibility and tunable properties make it ideal for use in the development of novel therapeutic agents aimed at selective protein modulation in various biological research applications. -
PROTAC Linker
Boc-NH-PEG1-CH2COOH is a polyethylene glycol (PEG) based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its structure facilitates precise conjugation, enhancing the delivery and efficacy of target-specific degradation. This linker is particularly valuable in research applications aimed at studying protein degradation pathways and developing novel therapeutics. -
PROTAC Linkers
Biotin-PEG4-amino-t-Bu-DADPS-C3-alkyne is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne functional group and is suitable for click chemistry applications, specifically enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. It serves as a valuable tool for bioconjugation and the development of targeted protein degradation strategies in chemical biology research. -
PROTAC Linkers
Biotin-PEG2-OH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). This compound facilitates the targeted degradation of specific proteins through the recruitment of E3 ubiquitin ligases. It is valuable for researchers investigating protein turnover, cellular signaling pathways, and the development of novel therapeutic strategies in drug discovery. -
PROTAC Linker
Boc-piperazine-benzoic acid acts as a PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound can be utilized in the development of PROTACs that target specific proteins for degradation, including the androgen receptor (AR) degrader ARD-2128. Its implementation in research enables advanced studies in protein regulation and therapeutic applications in cancer treatment. -
PROTAC Linker
H2N-PEG2-CH2COOtBu is a polyethylene glycol (PEG) linker specifically designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the formation of bifunctional molecules that promote targeted protein degradation, making it essential for research in drug development and cellular regulation studies. Its application in PROTAC technology allows for the selective modulation of protein levels, offering significant potential in the fields of cancer therapy and targeted therapeutics. -
PROTAC Linkers
Boc-NH-PEG6-amine is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the effective conjugation of target binding moieties to E3 ligase ligands, promoting targeted protein degradation. It is particularly valuable in drug discovery and development, enabling researchers to explore novel therapeutic strategies through targeted modulation of protein levels. -
PROTAC Linker
4-Maleimidobutyric acid is a versatile alkyl chain-based PROTAC linker designed for the synthesis of protein-targeting chimeras. This compound facilitates the effective conjugation of E3 ligase ligands and target proteins, enhancing the efficacy of PROTAC-mediated degradation. Its application is crucial in drug discovery and development, particularly in medicinal chemistry aimed at targeted protein degradation strategies. -
PROTAC Linkers
Thiol-PEG4-alcohol is a polyethylene glycol (PEG)-based linker specifically designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. Its terminal thiol group facilitates the conjugation of various ligands, enabling the effective formation of PROTACs that can induce targeted protein degradation. This linker is instrumental in research applications focusing on protein modulation and has potential implications in drug discovery and development. -
PROTAC Linkers
N-Mal-N-bis(PEG2-NHS ester) is a polyethylene glycol (PEG) based PROTAC linker designed to enable the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins by linking E3 ligases to the desired protein, improving cellular uptake and solubility. Its utility in research applications includes the development of tailored PROTACs for targeted protein degradation studies and therapeutic interventions. -
PROTAC Linker
tert-Butyl 6-formyl-2-azaspiro[3.3]heptane-2-carboxylate serves as a PROTAC linker, facilitating the development of PROTAC molecules aimed at targeted protein degradation. Its unique structure enables efficient conjugation to target proteins, enhancing the specificity and efficacy of the resulting bifunctional degraders. This compound is instrumental in advancing research in proteomics and drug discovery, providing valuable insights into the modulation of protein levels within cellular systems. -
PROTAC Linker
3-(Methylamino)propan-1-ol is a PROTAC linker that facilitates the creation of proteolysis-targeting chimeras (PROTACs). This compound is essential for binding to the target protein and recruiting an E3 ligase, thus promoting targeted protein degradation. Its application is pivotal in the development of novel therapeutic strategies for a range of diseases by enabling targeted modulation of protein levels. -
PROTAC Linker
tert-Butyl 2-azaspiro[3.3]heptan-6-ylcarbamate functions as a PROTAC linker, playing a crucial role in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the targeted degradation of specific proteins, thereby enhancing the potential for therapeutic interventions in various biological pathways. It serves as a valuable tool for researchers investigating targeted protein degradation mechanisms and the development of innovative treatments. -
PROTAC Linker
4-(1-Boc-4-piperidyl)phenylboronic acid pinacol ester serves as a versatile PROTAC linker. It enables the synthesis of Proteolysis Targeting Chimeras (PROTACs), facilitating the targeted degradation of specific proteins. Its unique structural features provide effective conjugation capabilities, making it a valuable tool in drug discovery and targeted protein degradation research. -
PROTAC Linker
Monomethyl octanoate serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is essential in the synthesis of bifunctional molecules that can selectively degrade target proteins, enhancing the study of protein function and dynamics. Its integral role in PROTAC design makes it a valuable tool for researchers investigating targeted protein degradation and therapeutic applications in drug discovery. -
PROTAC Linker
5-Iodopent-1-yne is a versatile PROTAC linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the effective recruitment of E3 ligases, enabling targeted degradation of specific proteins within cellular contexts. Its alkynyl functional group enhances click chemistry applications, making it a valuable tool for researchers investigating protein modulation and degradation pathways. -
PROTAC Linker
6-((tert-Butoxycarbonyl)amino)spiro[3.3]heptane-2-carboxylic acid serves as a versatile PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). This compound is crucial for the optimization of protein degradation strategies and the targeted modulation of biological pathways. Its structural attributes enhance selectivity and efficacy in protein targeting, making it instrumental for research in targeted protein degradation and related therapeutic applications.
