Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
Boc-NH-PEG3 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the assembly of PROTACs by providing a flexible and hydrophilic spacer that connects the target ligand and E3 ligase components. Its primary application lies in advancing research in targeted protein degradation, enabling the selective modulation of protein levels within cells. -
PROTAC Linkers
Biotin-PEG12-NHS ester is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the covalent attachment of proteins through biotinylation, enhancing the pharmacokinetic properties of PROTACs. Its unique structure allows for improved solubility and stability, making it a valuable tool in targeted protein degradation research and drug discovery applications. -
PROTACT linker
2-(2-((6-Chlorohexyl)oxy)ethoxy)acetic acid serves as a PROTACT linker, facilitating the targeted protein degradation of SMARCA2 and SMARCA4. This compound enhances the specificity and efficacy of proteolysis-targeting chimeras (PROTACs) by promoting the interaction between ligands and E3 ubiquitin ligases. It is an essential tool for researchers investigating protein homeostasis and therapeutic strategies in various biological contexts. -
PROTAC Linker
Boc-NH-PEG12-NH2 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target protein ligands to E3 ligase recruiters, enhancing the effectiveness of PROTACs in promoting targeted protein degradation. It is a valuable tool for researchers investigating novel therapeutic strategies through the modulation of protein homeostasis. -
PROTAC Linker
2-(4-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperazin-1-yl)acetic acid serves as a versatile PROTAC linker, facilitating the assembly of proteolysis-targeting chimeras. This compound effectively engages with E3 ligases, promoting targeted protein degradation. Its application is pivotal in the design and synthesis of hybrid molecules for research in drug discovery and therapeutic development. -
PROTAC Linker
2-(Bromomethyl)-1,3-dioxolane is a chemical linker specifically designed for use in synthesizing PROTACs (proteolysis-targeting chimeras). This compound facilitates the construction of bifunctional molecules that can selectively induce the degradation of target proteins through the ubiquitin-proteasome system. Its utility in the development of targeted protein degradation strategies makes it valuable for research in drug discovery and therapeutic applications. -
PROTAC Linker
tert-Butyl 8-aminooctanoate is a versatile PROTAC linker designed to facilitate the synthesis of PROTAC molecules. Its structure enables optimal interaction with target proteins, enhancing the overall efficacy of targeted protein degradation assays. This reagent is essential for researchers focused on investigating novel therapeutic strategies involving proteolysis-targeting chimeras. -
PROTAC Linkers
mPEG45-Epoxide is a polyethylene glycol (PEG) derivative featuring polyether units, designed for use as a linker in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the conjugation of ligands to E3 ubiquitin ligases, enabling targeted protein degradation. mPEG45-Epoxide is instrumental in the development of novel therapeutic agents and in studying protein regulation mechanisms within cellular environments. -
PROTAC Linker
4-Boc-aminomethyl-piperidine is a versatile PROTAC linker that facilitates the development of targeted protein degradation therapies. This compound is essential for synthesizing various PROTACs, enabling the selective degradation of specific proteins within cellular pathways. Its application in research helps to advance therapeutic strategies for diseases driven by protein misregulation. -
PROTAC Linker
trans-4-[[(1,1-Dimethylethoxy)carbonyl]amino]cyclohexaneacetic acid acts as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras. This compound is instrumental in the synthesis of PROTACs, which harness the cell's ubiquitin-proteasome system for targeted protein degradation. Its unique structure enhances the activity and specificity of PROTACs in various research applications, making it a critical reagent for studies in targeted therapy and protein modulation. -
PROTAC Linker
(E)-tert-Butyldimethyl((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)but-3-en-1-yl)oxy)silane serves as a versatile PROTAC linker, facilitating the assembly of proteolysis-targeting chimeras (PROTACs). This compound enables the selective degradation of target proteins via the ubiquitin-proteasome system and is instrumental in drug discovery and development. Its unique structure allows for effective conjugation, enhancing cellular permeability and targeting specificity in therapeutic applications. -
PROTAC Linker
tert-Butyl (7-azaspiro[3.5]nonan-2-yl)carbamate is a versatile PROTAC linker designed to facilitate the synthesis of PROTAC molecules. This compound enhances the targeted degradation of specific proteins through the ubiquitin-proteasome system, promoting effective protein removal. Its unique structural features support the development of novel therapeutic agents for research in targeted protein degradation. -
PROTAC Linker
tert-Butyl N-{2-azaspiro[3.4]octan-6-yl}carbamate serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enables the selective degradation of target proteins, enhancing cellular studies in target validation and therapeutic development. Its structural properties make it suitable for a variety of research applications in chemical biology and drug discovery. -
PROTAC Linker
tert-Butyl 9-amino-3-azaspiro[5.5]undecane-3-carboxylate serves as a link for PROTAC (proteolysis-targeting chimera) synthesis, facilitating the creation of bifunctional molecules that can selectively target specific proteins for degradation. This compound is instrumental in the field of targeted protein degradation research, enabling the development of novel therapeutics that can modulate protein levels in a controlled manner. -
PROTAC Linker
tert-Butyl (3-(hydroxymethyl)bicyclo[1.1.1]pentan-1-yl)carbamate is a specialized PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of covalent bonds between target proteins and E3 ligases, thus enhancing the ubiquitin-proteasome degradation pathway. Its effectiveness in linking various pharmacophores makes it a valuable tool for researchers exploring targeted protein degradation and related therapeutic applications. -
PROTAC Linkers
Di(N-succinimidyl)adipate is an alkyl chain-based PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). Its structure allows for effective conjugation with various target proteins and E3 ligases, enabling the selective degradation of specific intracellular proteins. This reagent is essential for researchers aiming to explore targeted protein degradation mechanisms and develop innovative therapeutic strategies. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-(1-(3-azetidinylmethyl)piperazine) is an E3 ligase ligand-linker conjugate designed for targeted protein degradation via the PROTAC (proteolysis-targeting chimera) platform. This compound features a CRBN-based ligand that facilitates the recruitment of E3 ubiquitin ligase, enabling selective degradation of target proteins. It is a valuable tool for researchers investigating protein regulation, cellular pathways, and therapeutic strategies in drug discovery and development. -
E3 Ligase Ligand-Linker Conjugate
Desamino lenalidomide-acetylene-C-piperazine hydrochloride is an E3 ligase ligand-linker conjugate that features a CRBN-based ligand and a versatile linker. This compound serves as a critical component in the synthesis of PROTACs (Proteolysis Targeting Chimeras), enabling targeted protein degradation. It is suitable for research applications focused on protein regulation and therapeutic development in oncology and other fields. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-piperidin-C-piperidin is an E3 ligase ligand-linker conjugate that includes a CRBN-based ligand. This compound is designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras), enabling targeted protein degradation. It serves as a versatile tool in drug discovery and basic research aimed at modulating protein levels within biological systems. -
E3 Ligase Ligand-Linker Conjugate
Lenalidomide-C6-Br is an E3 ligase ligand-linker conjugate designed to facilitate targeted protein degradation. This compound plays a crucial role in the synthesis of PROTAC EGFR degrader 9, enabling selective degradation of the epidermal growth factor receptor (EGFR). Its innovative design allows for precise modulation of protein levels, making it valuable in studies focused on therapeutic approaches for cancer and other diseases linked to EGFR dysregulation. -
E3 Ligase Ligand-linker Conjugate
Lenalidomide-acetylene-C3-MsO is an E3 ligase ligand-linker conjugate designed for the synthesis of specific drug conjugates, such as SIAIS039. This compound enables targeted protein degradation through the activation of the ubiquitin-proteasome system. Its utility in research encompasses the investigation of protein interactions and the development of novel therapeutic strategies in cellular models. -
E3 Ligase Ligand-Linker Conjugate
Dihydrouracil-Ph-piperazine-Boc is an E3 ligase ligand-linker conjugate designed for targeted protein degradation applications. This compound features a CRBN-based ligand that facilitates selective recruitment of E3 ligases, enabling the synthesis of PROTACs (proteolysis-targeting chimeras). It serves as a valuable tool for researchers exploring degradation-based therapies and the modulation of cellular protein levels. -
Ligands for E3 Ligase
Pomalidomide 4'-PEG5-azide is a Pomalidomide-derived ligand specifically targeting the cereblon (CRBN) protein. This compound facilitates the recruitment of CRBN, making it a valuable tool in the development of PROTACs by linking to proteins through a suitable linker. Its application in chemical biology research enhances understanding of protein degradation pathways and E3 ligase modulation. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-5-piperazine-azetidine is an E3 ligase ligand-linker conjugate that incorporates a CRBN-based ligand attached to a versatile linker. This compound is designed to facilitate the synthesis of PROTACs (proteolysis targeting chimeras), enabling targeted degradation of specific proteins within cellular systems. Key applications include the investigation of protein function and the development of novel therapeutic strategies for diseases associated with dysregulated protein levels. -
E3 Ligase Ligand-Linker Conjugate
3-(1-Oxo-5-(3,9-diazaspiro[5.5]undecan-3-yl)isoindolin-2-yl)piperidine-2,6-dione is an E3 ligase ligand-linker conjugate designed for targeted protein degradation applications. This compound incorporates a CRBN-based ligand, enabling the synthesis of PROTAC (Proteolysis Targeting Chimeras) for selective protein modulation. It serves as a critical tool in chemical biology for studying protein function and therapeutic interventions in various diseases. -
E3 Ligase Ligand-Linker Conjugate
(S)-Phthalimidinoglutarimide-6-piperazine is an E3 ligase ligand-linker conjugate designed for targeted protein degradation applications. This compound serves as a key component in the synthesis of PROTAC SMARCA2 degrader-35, facilitating the selective degradation of the SMARCA2 protein. Its role in research underscores its potential for advancing studies in targeted therapeutics and proteostasis modulation. -
E3 Ligase Ligand-Linker Conjugate
Desamino lenalidomide-Pip-azetidine hydrochloride is an E3 ligase ligand-linker conjugate that utilizes a cereblon (CRBN)-based ligand in conjunction with a linker moiety. This compound facilitates the synthesis of PROTACs (proteolysis-targeting chimeras), which can selectively target and degrade specific proteins within cellular systems. Its application in drug discovery and development enhances the understanding of protein regulation and degradation pathways. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-O-PEG2-NHS ester is an E3 ligase ligand-linker conjugate that incorporates thalidomide-derived cereblon ligands with a PEG linker, facilitating targeted protein degradation via PROTAC technology. This compound is designed for use in research applications involving ubiquitin-proteasome system studies, enabling the modulation of protein levels in a cellular context. Its unique properties make it suitable for exploring therapeutics that can selectively eliminate disease-associated proteins. -
E3 Ligase Ligand-Linker Conjugate
(S)-Deoxy-thalidomide-(R)-pyrrolidine-3-carbaldehyde is an E3 ligase ligand-linker conjugate featuring a CRBN-based ligand. This compound is instrumental in the synthesis of proteolysis-targeting chimeras (PROTACs), facilitating targeted degradation of specific proteins within cellular systems. Its unique structure enables efficient recruitment of E3 ligases, making it essential for studies in targeted protein degradation and drug development. -
E3 Ligase Ligand-Linker Conjugate
Desamino lenalidomide-Pip-Pip hydrochloride is an E3 ligase ligand-linker conjugate that incorporates a cereblon (CRBN) ligand and a linker moiety. This compound is designed for the synthesis of proteolysis-targeting chimeras (PROTACs), enabling targeted protein degradation. Its effective engagement with E3 ligases facilitates the selective modulation of protein levels, making it valuable for research in cancer and other diseases. -
E3 Ligase Ligand-Linker Conjugate
DGY-02-126-O-C-COOH is an E3 ligase ligand-linker conjugate that features a CRBN-based ligand and a suitable linker. This compound facilitates the synthesis of PROTAC (Proteolysis Targeting Chimera) molecules, which are instrumental in targeted protein degradation research. Its unique structure supports the development of innovative therapeutic strategies by modulating protein interactions within cellular systems. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-piperazine-tert-butyl formate is an E3 ligase ligand-linker conjugate that incorporates a CRBN-based ligand, facilitating targeted protein degradation through the PROTAC (Proteolysis Targeting Chimera) approach. This compound acts by engaging E3 ligases, promoting ubiquitination and subsequent proteasomal degradation of target proteins. It is valuable for research applications involving protein regulation, cellular signaling, and the development of novel therapeutic strategies in various disease contexts. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-O-amido-C3-NH2 hydrochloride serves as an E3 ligase ligand-linker conjugate, featuring a cereblon (CRBN)-based ligand linked to a suitable chemical moiety. This compound is pivotal for the synthesis of Proteolysis Targeting Chimeras (PROTACs), facilitating selective protein degradation pathways. Its application in chemical biology research extends to targeted protein degradation and the investigation of novel therapeutic strategies. -
E3 Ligase Ligand-Linker Conjugate
2-(2,6-Dioxopiperidin-3-yl)phthalimidine-Piperazine-piperidine hydrochloride is a ligand-linker conjugate targeting E3 ligases, specifically designed for the synthesis of PROTAC (proteolysis-targeting chimera) compounds. This molecule features a CRBN-based ligand, facilitating targeted protein degradation for elucidating protein function and potential therapeutic applications. Its utility in drug discovery and development supports research in protein homeostasis and cellular regulation. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-piperazine-Pip dihydrochloride is an E3 ligase ligand-linker conjugate designed for targeted protein degradation applications. This compound features a CRBN-based ligand combined with a linker, facilitating the synthesis of PROTACs (Proteolysis Targeting Chimeras). It is suitable for research involving the modulation of protein levels in various biological pathways, providing valuable insights into cellular processes and therapeutic development. -
E3 Ligase Ligand-Linker Conjugate
2-(2,6-Dioxopiperidin-3-yl)phthalimidine-Piperazine-piperidine dihydrochloride is a conjugate designed to target E3 ligases, specifically featuring a CRBN-based ligand and linker. This compound is instrumental in the synthesis of PROTACs, facilitating the targeted degradation of proteins in various research applications. It serves as a valuable tool for studying protein homeostasis and elucidating cellular mechanisms related to protein turnover. -
E3 Ligase Ligand-Linker Conjugate
Amino-PEG4-(S,R,S)-AHPC-Me is a ligand-linker conjugate designed for E3 ligase targeting. This compound facilitates the development of PROTACs, specifically enabling the synthesis of NR-V04. It is utilized in research applications focused on targeted protein degradation and the modulation of protein homeostasis. -
E3 Ligase Ligand-Linker Conjugate
(S)-Thalidomide-azetidine-O-Pip is an E3 ligase ligand-linker conjugate designed for targeted protein degradation via the knockdown of specific proteins. This compound features a CRBN-based ligand that enables the selective recruitment of E3 ligases, facilitating the formation of PROTACs (PROteolysis TArgeting Chimeras). It is valuable in studies focused on therapeutic strategies, cancer research, and functional proteomics. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-NH-C10-Boc is a conjugate designed as an E3 ubiquitinase ligand-linker, facilitating the recruitment of the Cereblon ubiquitinase. This compound enables the synthesis of PROTAC molecules that induce targeted protein degradation, through its versatile PTOTAC linker. It has applications in developing therapeutics by coupling with specific ligands, such as EP300/CBP ligand 2, to create PROTACs that promote proteolytic activity against designated targets. -
E3 Ligase Ligand-Linker Conjugate
Lenalidomide-COCH-PEG2-azido is an E3 ligase ligand-linker conjugate designed to target cereblon, facilitating the development of targeted protein degradation strategies. This compound plays a crucial role in synthesizing PROTAC AKR1C3 degrader-1, aiding researchers in studying protein turnover and degradation pathways. It is particularly useful in the investigation of cellular responses to E3 ligase modulation and the development of novel biotherapeutic approaches. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-O-Triazole-C4-amino is an E3 ligase ligand-linker conjugate that facilitates the formation of proteolysis-targeting chimeras (PROTACs). This compound is essential for researchers investigating targeted protein degradation mechanisms, providing a robust approach to modulate specific protein levels within cells. It plays a significant role in drug development and environmental toxicity research applications by enabling the selective degradation of disease-related proteins. -
E3 Ligase Ligand-linker Conjugate
E3 Ligase Ligand-linker Conjugate 109 is an E3 ligase ligand-linker conjugate designed for the synthesis of PROTAC SOS1 degrader. This compound facilitates targeted protein degradation, enabling researchers to investigate the therapeutic potential of protein modulation in cellular systems. Its utility in developing targeted degradation strategies makes it an essential tool for drug discovery and development research. -
E3 Ligase Ligand-Linker Conjugate
Desamino lenalidomide-pent-4-yn-1-ol is an E3 ligase ligand-linker conjugate designed to facilitate the synthesis of PROTACs (proteolysis-targeting chimeras). This compound utilizes a CRBN-based ligand in conjunction with a pent-4-yn-1-ol linker, enabling targeted degradation of proteins through the ubiquitin-proteasome pathway. It serves as a valuable tool for studying protein regulation and therapeutic interventions in diseases related to protein misfolding and degradation. -
E3 ligase ligand-linker conjugate
(S,R,S)-AHPC-Me-8-bromooctanoic acid is an E3 ligase ligand-linker conjugate designed for the synthesis of PROTAC compounds. This reagent facilitates the targeted degradation of proteins, specifically functioning in the development of CYP1B1 degrader-2. It is a valuable tool for researchers investigating targeted protein degradation and related therapeutic applications in drug discovery. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-((3R)-3-pyrrolidinemethanol) is an E3 ligase ligand-linker conjugate that features a cereblon (CRBN)-based ligand and attached linker. This compound is essential for the design and synthesis of PROTACs (proteolysis targeting chimeras), which facilitate the degradation of specific proteins within cellular systems. Its ability to selectively target E3 ligases makes it a valuable tool in chemical biology research and therapeutic development. -
E3 Ligase Ligand-linker Conjugate
E3 Ligase Ligand-linker Conjugate 108 is an E3 ligase ligand-linker conjugate designed for the synthesis of targeted protein degradation compounds. This reagent facilitates the development of PROTACs, specifically enabling the degradation of the SOS1 protein. It serves as a crucial tool in research applications focused on targeted protein modulation and therapeutic intervention in cellular processes related to disease states. -
E3 Ligase Ligand-Linker Conjugate
tert-Butyl (S)-5-amino-4-(4-hydroxy-1-oxoisoindolin-2-yl)-5-oxopentanoate serves as an E3 ligase ligand-linker conjugate specifically designed for the development of PROTACs (proteolysis-targeting chimeras). This compound features a CRBN-based ligand essential for targeted protein degradation mechanisms. Its application in research facilitates the selective modulation of protein levels, contributing to studies in drug discovery and therapeutic development. -
E3 Ligase Ligand-Linker Conjugate
Lenalidomide 5'-piperazine-C1-piperidine is an E3 ligase ligand-linker conjugate that features a CRBN-based ligand coupled with a linker moiety. This compound is designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras), facilitating targeted protein degradation. Its primary application lies in the study and modulation of protein levels in various biological contexts, making it an essential tool for cancer research and drug discovery. -
E3 Ligase Ligand-Linker Conjugate
(S,R,S)-AHPC-Me-CO-C3-COOH is an E3 ligase ligand-linker conjugate featuring a VHL ligand combined with a linker structure derived from (S,R,S)-AHPC. This versatile compound facilitates the design and synthesis of PROTACs (proteolysis-targeting chimeras), enabling targeted protein degradation. Its unique structure supports research applications in targeted therapy and cellular protein regulation studies. -
Ligand For E3 Ligase
E3 ligase Ligand 79 serves as a ligand for the CRBN E3 ligase, facilitating the development of targeted protein degradation strategies. This compound is crucial for the synthesis of PROTAC CDK2/4 Degrader-1, which allows for selective degradation of protein targets in various biological contexts. Researchers can utilize this ligand to study the mechanisms of E3 ligase-mediated degradation and its potential therapeutic applications.
