Catalog No.
Product Name
Application
Product Information
Citations
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Ligands for E3 Ligase
VH032 analogue-1 is an E3 ligase ligand that targets the von Hippel-Lindau (VHL) protein, facilitating its recruitment. This analogue serves as a key intermediate in the synthesis of PROTAC molecules by removing protective groups under acidic conditions. Its role in PROTAC synthesis makes it a valuable tool for researchers developing targeted protein degradation strategies. -
Ligands for E3 Ligase
VH032-NH-CO-CH2-NHBoc is a Boc-modified ligand that targets the von Hippel-Lindau (VHL) protein, functioning as a crucial component for developing Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the recruitment of VHL to specific target proteins, enabling targeted degradation of these proteins through the ubiquitin-proteasome pathway. Under acidic conditions, VH032-NH-CO-CH2-NHBoc removes the Boc protection, allowing for the formation of PROTAC molecules that capitalize on VHL's E3 ligase activity. Its application is significant in studies focusing on targeted protein degradation and therapeutic development. -
CRBN Ligand
CRBN Ligand-191 is an E3 ligase ligand that targets the cereblon (CRBN) protein, facilitating ubiquitination and subsequent degradation of tagged substrates. This compound is essential in the synthesis of PROTACs, such as the PROTAC ALK degrader-4, which enables selective degradation of specific oncoproteins. Researchers can utilize CRBN Ligand-191 to explore targeted protein degradation mechanisms and study protein homeostasis in various biological contexts. -
Ligands for E3 Ligase
VHL Ligand 36 is a selective ligand for the von Hippel-Lindau (VHL) E3 ligase, facilitating targeted ubiquitination of substrate proteins. This compound is instrumental in research applications focused on studying the VHL pathway and its implications in various cellular processes, including tumorigenesis and hypoxia response. Additionally, VHL Ligand 36 serves as a precursor for synthesizing SD-2301, expanding its utility in chemical biology investigations. -
Ligands for E3 Ligase
4-[(1E)-2-Nitroethenyl]benzoic acid is a specific ligand for E3 ligase, which plays a crucial role in ubiquitination and protein degradation. This compound facilitates the synthesis of PROTAC BRD4 Degrader-38, enabling targeted degradation of specific proteins within cellular pathways. Its application in protein targeting and degradation makes it a valuable tool for researchers investigating proteostasis and related therapeutic interventions. -
Ligands for E3 Ligase
Pomalidomide 5'-fluoro-6'-piperazine-4-methylpiperidine hydrochloride is a ligand that targets the E3 ubiquitin ligase cereblon (CRBN). This compound is designed to facilitate the recruitment of cereblon protein for targeted protein degradation. Pomalidomide 5'-fluoro-6'-piperazine-4-methylpiperidine hydrochloride can be utilized in the development of PROTACs by linking to other protein ligands, enabling innovative research in protein homeostasis and disease modulation. -
MDM2 E3 Ligase Inhibitor
MEL23 is an MDM2 E3 ligase inhibitor that specifically targets the E3 ligase activity of the MDM2-MDMX complex. This compound effectively inhibits the ubiquitination of MDM2 and p53, leading to decreased viability in cells expressing wild-type p53. Additionally, MEL23 stabilizes MDM2 through a mechanism that does not involve p53 transcription, making it a valuable tool for research into cancer biology and therapeutic strategies targeting the p53 pathway. -
Ligands for E3 Ligase
N-Boc-SBP-0636457-OH is a ligand specifically targeting E3 ubiquitin ligases, facilitating the recruitment of IAP E3 ligases. This compound can be conjugated with Bcl-xL ligands via a linker to create the PROTAC Bcl-xL degrader-1, advancing research in targeted protein degradation and therapeutic applications in cancer biology. Its utility in the development of bifunctional molecules positions it as a valuable tool for studying protein homeostasis and signaling pathways. -
Ligands for E3 Ligase
E3 Ligase Ligand 77 is a ligand targeting the CRBN type E3 ubiquitin ligase. This compound facilitates the synthesis of PROTACs, including PROTAC RET Degrader 1. Its primary application is in the development of targeted protein degradation strategies, enabling researchers to investigate and manipulate protein levels in various biological contexts. E3 Ligase Ligand 77 serves as a valuable tool in cellular and molecular biology studies. -
Ligands for E3 Ligase
(S,S,S)-VH032-cyclopropane-F is a ligand that targets E3 ubiquitin ligases, facilitating the selective degradation of specific proteins through the ubiquitin-proteasome system. This compound can be conjugated to target protein ligands using a linker to generate PROTAC derivatives, such as cis-VZ185, which are valuable tools for studying protein dynamics and cellular functions. Its unique mechanism provides opportunities for innovative research in targeted protein degradation and therapeutic development. -
Ligands for E3 Ligase
E3 Ligase Ligand 33 (56-9B) acts as a ligand for E3 ubiquitin ligases, facilitating the ubiquitination process crucial for protein degradation and regulation. This compound is particularly valuable in anti-cancer research, where modulation of protein turnover can influence tumor progression and cell survival. Its application in target identification and pathway analysis makes it an essential tool for advancing understanding of ubiquitin-mediated signaling. -
CRBN ligand
Pomalidomide 7'OMe is a potent CRBN ligand that functions as an E3 ligase recruiter, facilitating the targeted degradation of proteins through the ubiquitin-proteasome pathway. Its unique structure allows for the potential linkage to BRD9 ligands, making it an essential component in the synthesis of PROTAC BRD9 degrader-9. This compound is valuable for research applications in targeted protein degradation and cellular signaling pathways. -
Ligands for E3 Ligase
CRBN ligand-190 is a ligand for the CRBN-type E3 ubiquitin ligase, facilitating the targeted ubiquitination and degradation of proteins. This compound is instrumental in the development of PROTACs (proteolysis-targeting chimeras), notably for synthesizing PROTAC HPK1 Degrader-7. Its utility in protein degradation strategies makes it a valuable tool for research in targeted therapy and protein homeostasis. -
Ligands for E3 Ligase
CRBN ligand-1 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound plays a critical role in mediating protein degradation through the ubiquitin-proteasome pathway, making it an important tool for studying protein homeostasis and cellular signaling mechanisms. It is utilized in research applications focused on targeted protein degradation and the development of novel therapeutics for diseases related to dysregulated protein dynamics. -
Ligands for E3 Ligase Chemical
cIAP1 ligand 4 is an E3 ligase ligand designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the targeted degradation of proteins by engaging the cellular ubiquitin-proteasome system. Its application in molecular biology research allows for advanced manipulation of protein levels, enhancing studies related to protein function and cellular signaling pathways. -
Ligands for E3 Ligase
E3 Ligase Ligand 29 serves as a ligand for E3 ligases, facilitating the ubiquitination process by targeting specific substrates for proteasomal degradation. This compound plays a crucial role in modulating cellular protein levels and has significant applications in research focused on protein homeostasis, cancer biology, and signal transduction pathways. The ability to selectively influence E3 ligase activity makes it a valuable tool for studying ubiquitin-mediated mechanisms. -
Ligands for E3 Ligase
Dihydrouracil-Ph-2-Me-piperidine serves as a ligand for E3 ligase, facilitating targeted protein degradation through the PROTAC technology. It is instrumental in synthesizing the PROTAC HPK1 Degrader-6, which can be employed in studies aimed at modulating cellular pathways by specifically degrading target proteins. This compound is valuable for researchers investigating the therapeutic potential of PROTACs and E3 ligase-mediated protein degradation in various biological contexts. -
Ligands for E3 Ligase
CRBN ligand-181 is an E3 ubiquitin ligase ligand designed to engage the cereblon (CRBN) target. This compound serves as a key building block for the development of proteolysis-targeting chimeras (PROTACs), enabling targeted degradation of specific proteins within cellular systems. Its application in research facilitates the study of targeted protein degradation and modulation of cellular pathways. -
Thalidomide Analog
3-Azathalidomide is a Thalidomide analog that primarily targets the E3 ubiquitin ligase, making it a valuable tool in protein degradation studies. This compound exhibits biological activity that facilitates the development of PROTACs (proteolysis-targeting chimeras), enabling targeted protein degradation in various cellular contexts. Its application is particularly relevant in drug discovery and targeted therapeutics research, where modulation of protein levels is essential for understanding disease mechanisms and therapeutic interventions. -
Thalidomide Analog
Thalidomide-5-Cl is a thalidomide analog that serves as a useful tool in research targeting protein degradation via the PROTAC (proteolysis-targeting chimera) mechanism. It exhibits biological activity through its interaction with cereblon, leading to the recruitment of E3 ligases and subsequent ubiquitination of target proteins. This compound is valuable for studies aimed at understanding the modulation of cellular processes and the development of innovative therapeutic strategies. -
Ligands for E3 Ligase
LC3 ligand-2 is a ligand for E3 ligases that facilitates targeted protein degradation through the PROTAC system. This compound is utilized in the synthesis of PROTAC PDEδ autophagic degrader 1, providing a valuable tool for researchers studying autophagy and protein homeostasis. Its application extends to the development of novel therapeutic strategies for diseases associated with protein misfolding and aggregation. -
CRBN Ligand
CRBN ligand-186 is a potent ligand for the CRBN-type E3 ubiquitin ligase, facilitating the construction of PROTAC (proteolysis targeting chimeras). This compound is designed to promote targeted protein degradation by harnessing the ubiquitin-proteasome system. It is instrumental in research applications aimed at investigating protein interactions and elucidating cellular processes involved in metabolic regulation and disease pathogenesis. -
Ligands for E3 Ligase
CRBN ligand-111 acts as a ligand for the CRBN E3 ubiquitin ligase, facilitating targeted protein degradation through PROTAC (proteolysis-targeting chimeras) technology. This compound is vital for research focused on the modulation of ubiquitin-proteasome pathways, enabling the selective degradation of proteins involved in various cellular processes. Its application is particularly significant in studies aimed at therapeutic development, including cancer biology and neurodegenerative diseases. -
Thalidomide Analog
5-(2-Chloroacetamide) thalidomide is a Thalidomide analog that functions as an E3 ligase recruiter, facilitating the ubiquitination and targeted degradation of specific proteins. The inclusion of a chloroacetamide moiety enhances its reactivity towards thiol groups, potentially increasing its efficacy in modulating protein degradation pathways. This compound is of interest for research applications in targeted protein therapy and cancer biology, providing insights into the mechanisms of protein homeostasis. -
Ligands for E3 Ligase
CRBN ligand-76 is a ligand for the CRBN E3 ubiquitin ligase, facilitating the development of PROTAC (Proteolysis Targeting Chimeras). This compound engages specifically with the CRBN E3 ligase, promoting ubiquitination and degradation of target proteins. Its application in targeted protein degradation offers potential for therapeutic intervention in various diseases, including cancer and neurodegenerative disorders. -
Ligands for E3 Ligase
CRBN ligand-148 is an E3 ubiquitin ligase ligand specifically targeting cereblon (CRBN). This compound facilitates the development of proteolysis-targeting chimeras (PROTACs) by promoting the ubiquitination and subsequent degradation of target proteins. Its biological activity is leveraged in research focused on targeted protein degradation and the modulation of cellular pathways. -
Ligands for E3 Ligase
CRBN ligand-14 is a ligand targeting the CRBN E3 ubiquitin ligase, facilitating the formation of PROTACs (PROteolysis TArgeting Chimeras). This compound plays a crucial role in targeted protein degradation, enabling the selective elimination of proteins of interest within cellular systems. It is particularly valuable in drug discovery and development, providing insights into protein regulation and therapeutic interventions in various diseases. -
Thalidomide Analog
Thalidomide-4,5-F is a fluorinated analogue of Thalidomide, primarily acting through the promotion of protein ubiquitinylation. This modification can enhance the degradation of target proteins, making it a valuable tool for research in cellular regulation and signaling pathways. The compound's unique fluorinated structure allows for further derivatization at the fluorine sites, expanding its potential applications in medicinal chemistry and pharmaceutical development. -
Ligands for E3 Ligase
Thalidomide-C-amide-C5-amine functions as a ligand for E3 ligases, facilitating targeted protein degradation in cellular contexts. This compound is specifically utilized in the synthesis of PROTAC BET Degrader-10, enabling selective modulation of BET proteins. Its applications extend to studies in protein homeostasis, cancer research, and the development of novel therapeutic strategies. -
Pomalidomide Derivative
Pomalidomide-COCH2Cl is a derivative of Pomalidomide featuring a chloroacetamide group on the benzyl ring. This compound functions by inhibiting immunomodulatory effects and has shown promise in the treatment of various cancers and hematological disorders. It is particularly valuable for research into the modulation of immune responses and the exploration of novel therapeutic strategies. -
Ligands for E3 Ligase
CRBN ligand-183 is a ligand for the CRBN-type E3 ubiquitin ligase, facilitating the development of PROTACs (proteolysis-targeting chimeras). This compound enables targeted protein degradation by harnessing the cellular ubiquitin-proteasome system. It is a valuable tool for research applications in drug discovery and development, particularly in understanding protein function and regulation. -
Ligands for E3 Ligase
CRBN ligand-110 serves as a selective ligand for the CRBN E3 ubiquitin ligase, facilitating the development of PROTAC (Proteolysis Targeting Chimeras). Its integration into PROTAC designs allows for targeted degradation of specific proteins, making it a valuable tool in drug discovery and therapeutic research. This compound is instrumental in exploring novel approaches to modulate protein levels and activity in cellular systems. -
Ligands for E3 Ligase
CRBN ligand-63 is a ligand for the CRBN-type E3 ubiquitin ligase, functioning as a key component in the development of PROTAC (proteolysis-targeting chimeras). This compound facilitates targeted protein degradation by harnessing the cellular ubiquitin-proteasome system, offering valuable utility in research focused on protein regulation and therapeutic interventions. Its application extends to the study of cellular pathways and the modulation of protein levels in various biological contexts. -
Ligands for E3 Ligase
3-(5-Bromo-2-chlorophenyl)piperidine-2,6-dione is a ligand for the CRBN-type E3 ubiquitin ligase, enabling the development of PROTAC (proteolysis-targeting chimeras) for targeted protein degradation. This compound facilitates the recruitment of ubiquitin ligases to specific proteins, highlighting its utility in studies focused on protein regulation and degradation pathways. Its application in drug discovery aims to enhance therapeutic strategies by modulating the cellular levels of target proteins. -
Thalidomide Analogue
Thalidomide-5-(C6-amine) is a thalidomide analogue functioning as a PROTAC building block, featuring an E3 ligase ligand with a terminal amine group. This amine group facilitates conjugation reactions with NHS ester groups or carboxylic acids in the presence of coupling agents such as EDC or HATU. Thalidomide-5-(C6-amine) is valuable in the development of bifunctional degraders, supporting research in targeted protein degradation and therapeutic interventions. -
Ligand for E3 Ligase
CRBN ligand-426 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a proteolysis-targeting chimeric molecule (PROTAC). It is useful in studies related to targeted protein degradation and the modulation of cellular protein levels. -
Ligand for E3 Ligase
CRBN ligand-314 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN for targeted protein degradation. This compound can be combined with a target protein ligand through a linker to create a PROTAC (proteolysis-targeting chimera), a valuable tool in the study of protein function and turnover in cellular processes. Its applications include research on targeted therapy and novel drug development strategies in oncology and other disease areas. -
Ligand for E3 Ligase
CRBN ligand-429 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein for targeted protein degradation applications. This compound can be effectively conjugated to a target protein ligand using a linker, enabling the formation of PROTAC (proteolysis-targeting chimeras) molecules. It serves as a valuable tool in the study of targeted degradation pathways and has potential utility in therapeutic research focused on modulating protein levels within cellular systems. -
Ligands for E3 Ligase
CRBN ligand-164 is a selective ligand for the CRBN E3 ubiquitin ligase, facilitating the ubiquitination of target proteins. This compound is instrumental in the development of PROTACs (proteolysis-targeting chimeras), which harness the ubiquitin-proteasome system to selectively degrade proteins of interest. Its ability to induce targeted protein degradation makes CRBN ligand-164 valuable in drug discovery and therapeutic research. -
Ligand for E3 Ligase
CRBN ligand-221 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in protein degradation pathways. This compound can be conjugated to a target protein ligand through a linker, allowing for the development of proteolysis targeting chimeras (PROTACs). Its applications include targeted protein degradation studies and the exploration of novel therapeutic strategies in various diseases. -
Ligand for E3 Ligase
CRBN ligand-750 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound serves as a valuable tool for the development of PROTACs (Proteolysis Targeting Chimeras) by enabling the targeted degradation of specific proteins through ubiquitin-mediated pathways. Its application in chemical biology underscores its potential in elucidating protein function and developing innovative therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-207 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN in protein degradation pathways. This compound serves as a crucial element for developing PROTACs (Proteolysis Targeting Chimeras) by linking to target protein ligands through a suitable linker. Its ability to promote targeted protein degradation makes it a valuable tool in cellular and molecular biology research, particularly in studies focused on ubiquitin-mediated proteolysis and the modulation of protein homeostasis. -
Ligand for E3 Ligase
CRBN ligand-341 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC (proteolysis-targeting chimera), enabling targeted protein degradation. Its utilization aids in studying protein homeostasis and the modulation of cellular functions in various research applications. -
Ligand for E3 Ligase
CRBN ligand-885 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to target protein ligands through a linker to create proteolysis-targeting chimeras (PROTACs), enabling targeted protein degradation. Its application is crucial in the study of protein homeostasis and the modulation of various cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-230 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN in targeted protein degradation applications. This compound can be conjugated to target protein ligands via a linker, thereby enabling the formation of PROTACs (Proteolysis Targeting Chimeras). CRBN ligand-230 is instrumental in research focused on ubiquitination processes and therapeutic strategies for targeted protein modulation. -
Ligand for E3 Ligase
CRBN ligand-559 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). It is valuable for research applications focused on targeted protein degradation pathways and the exploration of E3 ligase-mediated ubiquitination processes. -
Ligand for E3 Ligase
CRBN ligand-203 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). It serves a critical role in targeted protein degradation studies and is useful for research into therapeutic applications involving the modulation of protein levels within cells. -
Ligand for E3 Ligase
CRBN ligand-355 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to specific target protein ligands through a linker to create PROTACs (Proteolysis Targeting Chimeras), enabling targeted protein degradation. It serves as a valuable tool for researchers investigating protein dynamics, ubiquitination pathways, and therapeutic strategies in cancer and other diseases. -
Ligand for E3 Ligase
CRBN ligand-335 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be utilized in the construction of PROTACs by linking it to other target protein ligands via a suitable linker. Its application supports the study of targeted protein degradation and the modulation of protein levels in various biological contexts. -
Ligand for E3 Ligase
CRBN ligand-561 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized to assemble a PROTAC (Proteolysis Targeting Chimera) by linking it to a target protein ligand through a suitable linker. Research applications include targeted protein degradation and investigations into proteostasis mechanisms, offering insights into therapeutic strategies for various diseases.
