Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
2-(Aminooxy)ethanol serves as a versatile PROTAC linker, facilitating the construction of PROTAC molecules designed for targeted protein degradation. It features a significant role in connecting ligands to E3 ubiquitin ligases, thereby enhancing the selective degradation of specific proteins within cellular contexts. This compound is pivotal in drug discovery and development, particularly for the targeted modulation of disease-related proteins. -
PROTAC Linker
3-Oxocyclobutane-1-carbonitrile is a versatile PROTAC linker that plays a critical role in the design and synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates targeted protein degradation by linking an E3 ligase ligand to a protein of interest, thereby enhancing the specificity and efficacy of therapeutic interventions. Its application in drug discovery makes it an essential reagent for researchers exploring novel therapeutic strategies in cellular regulation and targeted degradation. -
PROTAC Linker
Methyl 3-aminobicyclo[1.1.1]pentane-1-carboxylate hydrochloride serves as a PROTAC linker, facilitating the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound enhances the targeted degradation of specific proteins through the recruitment of E3 ligases, making it a valuable tool for drug discovery and development. Its robust linkage properties support the design and optimization of innovative therapeutic strategies in chemical biology and pharmacology research. -
PROTAC Linker
Boc-C9-Br is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). It facilitates the recruitment of E3 ligases to target proteins for ubiquitination and subsequent degradation. This compound enhances the development of targeted protein degradation strategies in chemical biology and therapeutic research applications. -
PROTAC Linker
Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the recruitment of E3 ubiquitin ligases to target proteins, enhancing their ubiquitination and subsequent degradation. Its application in PROTAC development supports targeted protein degradation studies and therapeutic exploration in various diseases, including cancer. -
PROTAC Linker
3-Chlorobicyclo[1.1.1]pentan-1-amine hydrochloride functions as a linker in the development of PROTAC (Proteolysis Targeting Chimeras) molecules. This compound facilitates the covalent attachment of targeted proteins, enhancing the specificity and efficacy of protein degradation strategies. It is valuable in biochemical research aimed at elucidating protein function and exploring novel therapeutic approaches in drug discovery. -
PROTAC Linker
4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid serves as a versatile linker for the design and synthesis of PROTACs (proteolysis-targeting chimeras). Its structural properties facilitate the assembly of target protein degradation complexes, enhancing cellular specificity and efficacy. This compound is instrumental in furthering research in targeted protein degradation strategies, aiding the development of therapeutics for various diseases. -
PROTAC Linker
tert-Butyl (8-bromooctyl)carbamate functions as a PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs). Its structural properties enhance the stability and efficacy of the resulting conjugates, promoting selective protein degradation. This compound is essential for researchers exploring targeted protein degradation pathways and advancing therapeutic strategies. -
PROTAC Linker
tert-Butyl (3-(methylamino)propyl)carbamate serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is crucial for connecting the Warhead and E3 ligase, enhancing the specificity and efficacy of targeted protein degradation. Its application in research allows for the investigation of cellular processes and therapeutic strategies through the selective modulation of protein levels. -
PROTAC Linker
cis-3-((tert-Butoxycarbonyl)amino)cyclobutanecarboxylic acid serves as a versatile PROTAC linker involved in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins, thereby enabling targeted therapeutic strategies. Its structural properties make it suitable for various applications in drug discovery and development, particularly in the context of targeted protein modulation and degradation studies. -
PROTAC Linker
Methyl 3-(hydroxymethyl)bicyclo[1.1.1]pentane-1-carboxylate is a specialized linker for proteolysis-targeting chimeras (PROTACs). It facilitates the development of targeted protein degradation strategies by connecting ligand components. This compound is essential for researchers investigating targeted therapies and protein regulation through PROTAC technology. -
PROTAC Linkers
BM-PEG3 is a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the formation of bifunctional molecules that promote targeted degradation of proteins via the ubiquitin-proteasome system. This linker is essential for researchers focusing on the development of novel therapeutics that harness the power of targeted protein degradation for disease intervention. -
PROTAC Linker
(9H-Fluoren-9-yl)methyl (2-hydroxyethyl)carbamate serves as a PROTAC linker, facilitating the construction of PROTAC molecules for targeted protein degradation. This compound plays a crucial role in bridging target proteins with E3 ligases, enabling the development of novel therapeutics. Its structural properties support applications in drug discovery, particularly in studying selective protein modulation and degradation pathways. -
PROTAC Linker
tert-Butyl 6-amino-2-azaspiro[3.3]heptane-2-carboxylate serves as a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the development of innovative therapeutic strategies by promoting targeted protein degradation. Its structural attributes enhance the stability and efficacy of PROTAC constructs, making it a valuable tool in chemical biology and drug discovery research. -
PROTAC Linker
Fmoc-7-amino-heptanoic acid serves as a versatile PROTAC linker with a terminal Fmoc-protected amine and carboxylic acid functionalities. It facilitates the synthesis of PROTACs by allowing the deprotection of the Fmoc group under basic conditions, yielding a free amine suitable for additional conjugation reactions. The carboxylic acid is reactive towards primary amines in the presence of coupling agents, enabling the formation of stable amide bonds essential for constructing complex molecular architectures in chemical research. -
PROTAC Linker
N-Boc-8-amino-octanoic acid serves as a versatile linker in the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an alkane chain with a terminal carboxylic acid and a Boc-protected amino group, allowing for stable amide bond formation with primary amines in the presence of coupling agents such as EDC or HATU. The Boc group can be easily removed using mild acidic conditions, resulting in the release of the free amine and enabling further modifications in PROTAC development. -
PROTAC Linker
2-[(tert-Butoxy)carbonyl]-2-azaspiro[3.5]nonane-7-carboxylic acid serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enables the efficient targeting and degradation of specific proteins by linking ligands to E3 ligases. It is essential for research applications focused on targeted protein degradation and cellular regulation studies. -
PROTAC Linker
Amino-PEG12-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an amino group that enhances solubility and facilitates the conjugation of target ligands. It plays a crucial role in the development of PROTACs for targeted protein degradation studies, offering potential applications in drug development and cellular biology research. -
PROTAC Linker
Bromo-PEG1-acid is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the targeted degradation of specific proteins through the recruitment of E3 ligases, enhancing the development of novel therapeutic strategies. Its biocompatibility and versatile chemistry make it a valuable tool for researchers in the field of targeted protein modulation and drug discovery. -
PROTAC Linker
Propargyl-PEG4-acid functions as a versatile PROTAC linker, facilitating the development of targeted protein degradation strategies. This PEG-based compound enables the synthesis of BTK-IAP PROTACs, including Ibrutinib-based analogues, significantly enhancing BTK degradation with a DC50 of 200 nM in THP-1 cells. Additionally, it possesses an alkyne group, making it a valuable clickable reagent for copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions, thereby expanding its utility in chemical biology research. -
PROTAC Linker
Propargyl-PEG5-OH is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs through click chemistry. Featuring an alkyne group, this compound can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-labeled molecules. Its unique characteristics make it a valuable tool for researchers studying targeted protein degradation and related applications in chemical biology. -
PROTAC Linker
Biotin-PEG3-SH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimera) molecules. This compound features a biotin moiety, enhancing target protein recruitment and facilitating the ubiquitin-proteasome system's engagement for targeted degradation. It is ideal for studies in protein regulation and cellular pathways, making it a valuable tool in chemical biology research and drug development applications. -
PROTAC Linker
Thiol-PEG2-acid is a polyethylene glycol (PEG) linker designed for use in PROTAC (proteolysis targeting chimera) synthesis. It facilitates the conjugation of proteins and small molecules, enhancing the targeting and degradation of specific intracellular proteins. This compound is pivotal for researchers exploring targeted protein degradation and therapeutic applications in cancer and other diseases. -
PROTAC Linker
Acid-PEG2-C2-Boc is a PEG-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimera) molecules. This compound facilitates the development of targeted protein degradation strategies by connecting a target protein ligand to an E3 ligase ligand. Its adaptability and solubility properties make it suitable for diverse research applications in the field of targeted therapy and drug development. -
PROTAC Linker
Biotin-PEG6-NHS ester is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound allows for efficient conjugation to target proteins, facilitating the targeted degradation of specific intracellular proteins. Its biotin moiety enhances affinity for streptavidin or avidin, making it valuable in various biochemical assays and applications in drug discovery. This linker is essential for developing targeted therapeutics utilizing the PROTAC technology. -
PROTAC Linker
Propargyl-PEG1-NH2 is a PEG-based linker specifically designed for use in synthesizing PROTACs. Its alkyne functional group enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing compounds. This reagent is instrumental in the development of targeted protein degradation strategies, facilitating the formation of advanced protein-targeting therapeutics in chemical biology research. -
PROTAC Linkers
Amine-PEG3-Desthiobiotin is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of a target protein ligand to E3 ligases, promoting targeted degradation of unwanted proteins in cellular systems. Its unique structure enhances solubility and bioavailability, making it suitable for various applications in chemical biology and drug discovery. -
PROTAC Linker
Fmoc-PEG4-NHS ester is a PEG-derived linker designed for use in PROTAC synthesis. This compound facilitates the conjugation of target proteins to E3 ligases, enabling the targeted degradation of specific proteins within the cell. Its application in PROTAC development makes it a valuable tool for researchers investigating protein regulation and degradation pathways. -
PROTAC Linker
PEG3 is a polyethylene glycol (PEG) based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This linker facilitates the effective recruitment of E3 ligases, enabling targeted degradation of specific proteins. PEG3 can be applied in various research settings focused on elucidating protein function, developing novel therapeutics, and advancing chemical biology studies. -
PROTAC Linker
Mal-PEG6-acid is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (proteolysis targeting chimeras). Its primary mechanism involves the covalent attachment to target proteins, facilitating targeted degradation via the ubiquitin-proteasome pathway. This compound is crucial for the development of innovative therapeutic agents in chemical biology and drug discovery, allowing researchers to explore various protein interactions and post-translational modifications. -
PROTAC Linker
1,4-Diiodobutane is a versatile PROTAC linker that plays a crucial role in the synthesis of proteolysis-targeting chimeras (PROTACs). Its structure facilitates the recruitment of E3 ligases, enabling targeted protein degradation. This compound is essential for researchers working on novel therapeutic strategies involving targeted protein modulation and degradation in various biological contexts. -
PROTAC Linker
((3-Bromopropoxy)methyl)benzene is a PROTAC linker specifically designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in enhancing the stability and efficacy of PROTACs by providing a suitable spacer between the target protein ligand and E3 ligase ligand. Its unique structural properties make it valuable for applications in targeted protein degradation and drug discovery research. -
PROTAC Linker
4-Cyanobutanoic acid serves as a versatile PROTAC linker, integral to the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the development of novel therapeutic agents by promoting protein degradation, thereby enhancing targeted drug discovery and development. Its application in research aids in advancing studies related to cellular regulation and therapeutic intervention strategies. -
PROTAC Linker
7-(Tert-Butoxycarbonyl)-7-azaspiro[3.5]nonane-2-carboxylic acid serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in connecting target proteins to E3 ligases, enabling specific protein degradation. It is instrumental in drug discovery research, particularly in applications related to targeted protein modulation and therapeutic interventions. -
PROTAC Linker
3-(tert-Butyldimethylsilyloxy)propan-1-amine is a PROTAC linker that serves as a crucial component in the synthesis of proteolysis-targeting chimeras (PROTACs). Its incorporation into PROTAC design facilitates the selective degradation of target proteins, enhancing research in targeted protein modulation and therapeutic development. This compound is valuable for studies focused on protein homeostasis and the exploration of novel cellular pathways. -
PROTAC Linker
Bicyclo[2.2.2]octane-1,4-dicarboxylic acid serves as a essential PROTAC linker in the development of proteolysis-targeting chimeras. This compound facilitates the assembly of targeted protein degradation systems by connecting E3 ligase and protein of interest, promoting efficient ubiquitination and subsequent proteasomal degradation. Its application is particularly valuable in drug discovery and molecular biology research focused on targeted protein modulation. -
PROTAC Linker
tert-Butyl 4-(3-bromopropyl)piperazine-1-carboxylate serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins, making it valuable for targeted protein modulation studies. Its application in synthetic biology allows for innovative approaches in drug discovery and therapeutic interventions by leveraging the ubiquitin-proteasome system for protein degradation. -
PROTAC Linker
1-Chloro-3-(3-chloropropoxy)propane is a key PROTAC linker utilized in the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins with E3 ligases, promoting targeted degradation pathways. Its application is vital in chemical biology and drug development research, allowing for the selective modulation of protein levels within cells. -
PROTAC Linker
8-Amino-1-octanol is a versatile PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). By providing a functional handle for the connection of ligand and protein target, this compound enhances the development of targeted protein degradation strategies. 8-Amino-1-octanol is essential for researchers seeking to explore cellular pathways and therapeutic applications through the modulation of protein levels in various biological contexts. -
PROTAC Linker
Fmoc-12-aminododecanoic acid is a PROTAC linker characterized by an alkane chain with a terminal Fmoc-protected amine and a carboxylic acid group. This compound serves as a building block in the synthesis of PROTACs, facilitating targeted protein degradation studies. The Fmoc group can be readily deprotected in basic conditions, releasing a free amine for subsequent conjugations, while the terminal carboxylic acid allows for stable amide bond formation with primary amines using suitable coupling reagents. -
PROTAC Linker
3-Aminobicyclo[1.1.1]pentan-1-ol hydrochloride serves as a useful PROTAC linker, facilitating the development of PROTAC molecules. This compound aids in the targeted protein degradation process, thereby enabling investigations into protein function and regulation. Its role in synthesizing PROTACs makes it valuable for research applications focused on therapeutic interventions in diseases associated with protein dysregulation. -
PROTAC Linker
4-Bromobutoxy-tert-butyl-dimethylsilane is a specialized PROTAC linker designed for the synthesis of PROTAC molecules. This compound facilitates the development of targeted protein degradation strategies by effectively linking target proteins to E3 ligases. Its incorporation into PROTACs enhances the efficiency of protein modulation, making it a valuable tool for research in cellular biology and drug discovery. -
PROTAC Linker
9-(Boc-amino)nonanoic acid functions as a PROTAC linker, featuring an alkane chain that contains a terminal carboxylic acid and a Boc-protected amino group. This compound is instrumental in the synthesis of PROTACs, as its carboxylic acid can efficiently react with primary amines in the presence of coupling agents, such as EDC or HATU, to yield stable amide bonds. The Boc protecting group can be removed under mild acidic conditions, resulting in the formation of the free amine, facilitating subsequent chemical modifications. -
PROTAC Linker
4-tert-Butoxy-4-oxobutanoic acid serves as a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the ubiquitination and subsequent degradation of target proteins, thereby enabling selective modulation of protein levels within cellular systems. It is widely utilized in drug discovery and chemical biology research focused on targeted protein degradation. -
PROTAC Linker
tert-Butyl 4-(piperazin-1-yl)piperidine-1-carboxylate serves as a PROTAC linker, facilitating the design and synthesis of targeted protein degraders. This compound is essential for creating bifunctional molecules that promote ubiquitination and subsequent degradation of specific proteins within cellular environments. Its application in drug discovery and development is pivotal for advancing targeted therapies that can selectively remove pathogenic proteins. -
PROTAC Linker
p-(Methoxycarbonylmethyl)aniline serves as a versatile PROTAC linker facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in connecting target proteins with E3 ligases, thereby promoting selective degradation of specific proteins within cellular systems. Its application is essential in drug discovery and the study of protein dynamics, aiding researchers in understanding protein function and disease mechanisms. -
PROTAC Linker
3-((tert-Butyldimethylsilyl)oxy)propan-1-ol serves as a versatile PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in promoting targeted protein degradation by connecting ligand and E3 ligase components. Its unique structure enhances solubility and stability, making it essential for various applications in chemical biology and therapeutic development. -
PROTAC Linker
7-Aminoheptanoic acid serves as a versatile PROTAC linker, facilitating the synthesis of PROTAC molecules designed for targeted protein degradation. This compound enhances the development of bifunctional entities to modulate cellular pathways, making it valuable in therapeutic research aimed at cancer and other diseases. Its structural properties support the formation of linkers that connect E3 ligases to target proteins, playing a crucial role in advancing drug discovery efforts. -
PROTAC Linker
TCO-PEG3-amine is a polyethylene glycol (PEG)-based linker designed for use in proteolysis-targeting chimeras (PROTACs). This compound facilitates the synthesis of PROTACs, enabling targeted degradation of specific proteins within cells. Its unique structure promotes solubility and stability, making it a valuable tool in chemical biology and therapeutic research applications. -
PROTAC Linker
Tetrazine-Ph-acid is a specialized linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a tetrazine moiety capable of undergoing an inverse electron demand Diels-Alder (iEDDA) reaction with trans-cyclooctene (TCO) derivatives, facilitating selective and efficient protein degradation. Its application in the development of PROTACs enables researchers to explore targeted protein modulation and therapeutic interventions in various biological systems.
