Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
t-Boc-N-amido-PEG5-acetic acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a terminal carboxylic acid, facilitating conjugation with targeting ligands and degradation tags. It exhibits key biological activity in promoting targeted protein degradation, making it a valuable tool in drug discovery and development research applications. -
PROTAC Linker
3-Iodopropan-1-ol is a PROTAC linker characterized by its role in the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligase, promoting their ubiquitination and subsequent degradation. It is a valuable tool in research applications aimed at exploring targeted protein degradation and elucidating cellular pathways. -
PROTAC Linker
m-PEG7-thiol is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound exhibits excellent solubility and flexibility, facilitating the efficient conjugation of target proteins with E3 ligases. It serves as a crucial component in the development of novel therapeutic modalities that harness the ubiquitin-proteasome system for targeted protein degradation in various research applications. -
PROTAC Linker
Tetrazine-Ph-NHCO-C3-NHS ester serves as a PEG-based PROTAC linker, facilitating the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features a Tetrazine group that enables a selective inverse electron demand Diels-Alder reaction (iEDDA) with TCO-containing molecules. It is instrumental in developing targeted protein degradation strategies in chemical research, enhancing the precision of therapeutic interventions. -
PROTAC Linker
Fmoc-NH-PEG8-NHS ester is a polyethylene glycol (PEG) linker designed for use in PROTAC (PROteolysis TArgeting Chimeras) synthesis. This compound facilitates the conjugation of target proteins to E3 ligases, enhancing targeted protein degradation. Its long PEG chain improves solubility and bioavailability, making it a valuable tool in chemical biology and drug discovery applications focused on modulating protein levels within cells. -
PROTAC Linker
Amino-PEG2-C2-hydrazide-Boc is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the efficient conjugation of target proteins to E3 ligases, enhancing the degradation of specific proteins through the ubiquitin-proteasome pathway. Its versatile structure allows for a variety of applications in chemical biology and drug discovery, particularly in targeted protein degradation research. -
PROTAC Linker
DBCO-PEG3-NHS is a PROTAC linker featuring an alkynyl (DBCO) and N-hydroxysuccinimide (NHS) ester group, facilitating the chemical modification of proteins and antibodies. This reagent is instrumental in the synthesis of PROTACs, enhancing targeted protein degradation applications, as well as contributing to drug delivery systems and the development of biosensors and diagnostic assays. It allows for precise conjugation chemistry, enabling innovative research in therapeutic development and biomolecular interactions. -
PROTAC Linkers
Biotin-PEG8-amine is a biotinylated linker with a polyethylene glycol (PEG) moiety designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound enhances the solubility and stability of PROTAC molecules, facilitating targeted protein degradation in cellular studies. Its biotin functionality also allows for efficient capture and purification of PROTACs via streptavidin-based methods, enabling exploration of protein interactions and functional assays in chemical biology. -
PROTAC Linker
Azido-PEG10-NHS ester is a PEG-based linker designed for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, making it a versatile tool for chemical biology applications. -
PROTAC Linker
Tert-Butyl 8-hydroxyoctanoate functions as a PROTAC linker, facilitating the synthesis of various PROTACs, including PROTAC CDK Degrader-1. This compound exhibits potent anti-tumor activity through targeted degradation of cyclin-dependent kinases (CDKs), making it a valuable tool for cancer research and therapeutic development. Its role in PROTAC design enhances the specificity and efficacy of targeted protein degradation strategies. -
PROTAC Linker
Biotin-PEG4-methyltetrazine is a PEG-based PROTAC linker designed for the synthesis of targeted protein degradation molecular constructs. This compound features a tetrazine moiety that facilitates click chemistry via an inverse electron demand Diels-Alder reaction (iEDDA) with trans-cyclooctene (TCO) derivatives. Its biological activity allows for the selective recruitment of E3 ligases, making it a valuable tool for researchers studying protein regulation and degradation pathways. This reagent is essential for the development of innovative therapies utilizing PROTAC technology. -
PROTAC Linker
Bromo-PEG3-C2-acid is a polyethylene glycol (PEG)-based linker designed for PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the formation of PROTACs by providing a suitable structure for the recruitment of E3 ligases and target proteins, enabling targeted degradation in cellular systems. It is suitable for use in research applications focused on protein degradation and modulation of cellular pathways. -
PROTAC Linker
Aminooxy-PEG1-propargyl is a PEG-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. Featuring an alkyne group, it facilitates click chemistry and can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), allowing for precise conjugation with azide-containing molecules. This compound is valuable for researchers engaged in the development of targeted protein degradation strategies. Its versatility makes it an essential tool for advancing chemical biology applications. -
PROTAC Linker
HS-PEG5-CH2CH2NH2 hydrochloride is a PROTAC linker designed to facilitate the degradation of target proteins via the proteasome pathway. As part of the polyethylene glycol (PEG) class, this compound provides favorable solubility and biocompatibility, making it an ideal choice for synthesizing PROTAC molecules. Its application supports studies in targeted protein degradation and therapeutic development in various diseases. -
PROTAC Linker
(9H-Fluoren-9-yl)methyl (3-aminopropyl)carbamate hydrochloride serves as a PROTAC linker, facilitating the development of targeted protein degradation strategies. This compound plays a crucial role in the synthesis of PROTAC molecules, enabling the selective recruitment of E3 ubiquitin ligases to target proteins for ubiquitination and subsequent degradation. Its application in research is essential for advancing studies in targeted protein modulation and therapeutic interventions in various diseases. -
PROTAC Linker
Bis(2,5-dioxopyrrolidin-1-yl) succinate serves as a versatile PROTAC linker, facilitating the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound enhances the precision and efficacy of targeted protein degradation by promoting the recruitment of E3 ubiquitin ligases to specific protein targets. Its application in chemical biology allows for the investigation of protein dynamics and modulation of cellular pathways for therapeutic development. -
PROTAC Linker
10-Aminodecan-1-ol is a versatile PROTAC linker utilized in the synthesis of Proteolysis Targeting Chimeras (PROTACs). Its structure facilitates the efficient conjugation of target proteins to E3 ligases, enabling targeted degradation pathways. This compound is essential for researchers focusing on targeted protein degradation and related therapeutic applications. -
PROTAC Linker
Fmoc-NH-PEG2-C2-NH2 hydrochloride is a PROTAC linker designed to facilitate the synthesis of PROTAC compounds. This bifunctional molecule enables the conjugation of target proteins to E3 ligases, promoting targeted protein degradation. Its applications extend to chemical biology and drug discovery, allowing researchers to explore novel therapeutic strategies through the modulation of protein levels within cellular systems. -
PROTAC Linker
(4-(((tert-Butoxycarbonyl)amino)methyl)phenyl)boronic acid functions as a PROTAC linker, facilitating the design and synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound is crucial for achieving selective degradation of target proteins, thereby enabling studies in targeted protein modulation and therapeutic development. Its robust chemical properties make it suitable for advancing research in protein homeostasis and cellular regulation. -
PROTAC Linker
Ethyl 3-bromopropanoate is a versatile PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the construction of bifunctional molecules that promote targeted degradation of specific proteins, thereby providing a powerful tool for studying protein function and regulation. Its application in chemical biology may enhance the development of therapeutics aimed at previously undruggable targets. -
PROTAC Linker
2-(Prop-2-yn-1-yloxy)tetrahydro-2H-pyran serves as a versatile linker for PROTAC (Proteolysis-Targeting Chimera) synthesis. This compound facilitates the functionalization of target proteins through targeted protein degradation, offering significant potential in therapeutic research and drug development. It is particularly valuable in studies focused on the modulation of protein expression and the development of novel biotherapeutics. -
PROTAC Linker
1'-(tert-Butoxycarbonyl)-[1,4'-bipiperidine]-4-carboxylic acid is a PROTAC linker designed to facilitate the development of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in the synthesis of PROTACs by connecting E3 ligases and target proteins, thereby promoting targeted protein degradation. It is valuable in various research applications, including drug discovery and molecular biology studies focused on protein regulation and degradation pathways. -
PROTAC Linker
Benzyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate serves as a PROTAC linker that is crucial for the design and synthesis of targeted protein degradation (TPD) bioconjugates. This compound facilitates the conjugation of E3 ligase recruiting elements to target proteins, thereby enabling the degradation of unwanted proteins within cells. Its structural characteristics make it a valuable tool for researchers exploring the therapeutic potential of PROTAC technology in various diseases. -
PROTAC Linker
2-((tert-Butoxycarbonyl)amino)ethyl 4-methylbenzenesulfonate serves as a PROTAC linker essential for the construction of proteolysis-targeting chimeras (PROTACs). This compound facilitates the targeted degradation of proteins, enabling researchers to modulate cellular processes by selectively eliminating specific proteins of interest. Its application in PROTAC synthesis supports studies in drug discovery and the development of innovative therapeutic strategies. -
PROTAC Linker
Methyl 4-(2-hydroxyethyl)benzoate serves as a PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs). This compound is integral in the design of bifunctional molecules that promote targeted degradation of specific proteins, thereby enabling the study of protein function and the development of therapeutic strategies. Its utility in the synthesis of advanced PROTAC structures enhances research applications in cellular biology and drug discovery. -
PROTAC Linker
tert-Butyl 6-hydroxy-2-azaspiro[3.4]octane-2-carboxylate serves as a key linker in the development of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing protein degradation pathways. It is suitable for applications in targeted protein degradation research, enabling the exploration of therapeutic strategies for various diseases by modulating protein levels within cells. -
PROTAC Linker
2-(4-Cyanophenyl)acetic acid functions as a versatile PROTAC linker, integral to the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of heterobifunctional molecules that induce ubiquitin-mediated degradation of target proteins, enabling selective modulation of protein levels. Its application in chemical biology research supports the development of targeted therapies and enhances investigations into protein degradation pathways. -
PROTAC Linker
Boc-bipiperidine-NH2 serves as a PROTAC linker, facilitating the development of targeted protein degraders. This reagent is crucial in constructing bifunctional molecules that engage specific E3 ligases and target proteins for degradation. Its application in PROTAC synthesis opens avenues for innovative therapeutic strategies aimed at modulating protein levels in various biological pathways. -
PROTAC Linker
14-Hydroxytetradecanoic acid is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates targeted protein degradation, an essential mechanism in the study of proteostasis and disease modulation. Its role in linking ligands to E3 ligase components makes it a valuable tool for researchers investigating therapeutic strategies in cancer and other diseases. -
PROTAC Linker
tert-Butyl (4-aminobutyl)carbamate hydrochloride is a PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in the design of bifunctional molecules that promote targeted degradation of proteins, enabling advanced studies in cellular signaling and protein homeostasis. Its use in the development of selective proteolysis tools enhances the potential for therapeutic interventions in a variety of diseases through targeted protein modulation. -
PROTAC Linker
tert-Butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate is a versatile PROTAC linker utilized for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of ligand-recruiting units to E3 ligase components, enabling targeted protein degradation. Its application in chemical biology research supports the development of novel therapeutic strategies by enhancing the specificity and efficacy of PROTAC formulations. -
PROTAC Linker
Trans-1,4-Bis(hydroxymethyl)cyclohexane serves as an effective linker for PROTAC (proteolysis targeting chimera) synthesis. Its structural characteristics facilitate the conjugation of ligands and E3 ligase Recruiters to target proteins, enhancing targeted protein degradation pathways. This compound is valuable in the development of PROTACs for research applications focusing on ubiquitin-proteasome system modulation and therapeutic intervention in various diseases. -
PROTAC Linker
6-Amino-1-hexyne serves as a versatile PROTAC linker, facilitating the development of targeted protein degraders. This compound enhances the stability and efficacy of PROTACs, promoting selective degradation of target proteins within cellular environments. Its application is essential in research focused on protein homeostasis and therapeutic interventions in various diseases. -
PROTAC Linker
1-(tert-Butoxycarbonyl)-3,3-difluoropiperidine-4-carboxylic acid is a specialized PROTAC linker designed for the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates the efficient conjugation of target proteins to E3 ligases, enhancing targeted protein degradation. It is an essential building block for researchers engaged in studying protein regulation and degradation pathways in various biological contexts. -
PROTAC Linker
1-Boc-4-cyanopiperidine is a versatile PROTAC linker that facilitates the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound plays a critical role in enhancing target specificity and promoting efficient protein degradation through the ubiquitin-proteasome system. Its utility in chemical biology makes it an essential component for researchers developing targeted therapies. -
PROTAC Linker
[(5-Bromopentyl)oxy](tert-butyl)dimethylsilane serves as a powerful PROTAC linker, facilitating the development of PROTAC molecules for targeted protein degradation. Its structure enables efficient conjugation, enhancing the efficacy and biological activity of PROTACs in various cellular contexts. This compound is particularly valuable for researchers exploring therapeutic strategies that involve targeted modulation of protein levels. -
PROTAC Linker
tert-Butyl 4-(methylamino)butylcarbamate serves as a key PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound is crucial for the development of targeted protein degradation strategies, enabling researchers to investigate protein function and therapeutic interventions in various cellular contexts. Its versatile structure supports the effective conjugation of target ligands and E3 ligase recruiters in PROTAC assembly, making it an important tool in chemical biology research. -
PROTAC Linker
7-Amino-1-heptanol is a versatile PROTAC linker utilized in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the formation of innovative drug conjugates by linking target proteins to E3 ligases, thereby enhancing targeted degradation processes. Its application is essential in drug discovery and development, particularly in the area of targeted protein modulation. -
PROTAC Linker
(9H-Fluoren-9-yl)methyl (2-bromoethyl)carbamate is a specialized PROTAC linker designed to facilitate the development of Proteolysis Targeting Chimeras (PROTACs). This compound serves as a critical building block in the synthesis of PROTACs, enabling targeted protein degradation for therapeutic applications. Its unique structure enhances the efficacy of target protein recruitment, making it a valuable tool in chemical biology and drug discovery research. -
PROTAC Linker
6-Chloro-1-hexyne functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in the synthesis of PROTACs, enabling targeted protein degradation pathways for therapeutic applications. Researchers utilize 6-Chloro-1-hexyne to enhance the efficacy of drug candidates by improving selectivity toward unwanted proteins. -
PROTAC Linker
9-Aminononanoic acid serves as a versatile PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkane chain with terminal carboxylic acid and amine groups, allowing for reactive coupling with various functional groups, including carboxylic acids and activated NHS esters. Its amino group can efficiently form stable amide bonds, making it a valuable tool for research applications focused on targeted protein degradation pathways. -
PROTAC Linker
1-(Piperidin-4-yl)azetidin-3-ol acts as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enables the conjugation of targeting ligands to E3 ligase, essential for targeted protein degradation research. Its utility in synthesizing innovative PROTACs makes it valuable for studies aimed at modulating protein levels within various biological contexts. -
PROTAC Linker
tert-Butyl pent-4-ynoate is a PROTAC linker utilized in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the targeted degradation of specific proteins, enabling researchers to explore protein function and regulation. It is particularly valuable in studies related to drug discovery, cancer research, and therapeutic development. -
PROTAC Linker
3-(Piperidin-4-yl)propan-1-ol serves as a versatile linker in the synthesis of PROTAC molecules, facilitating targeted protein degradation. This compound features a piperidine moiety that enhances its suitability for creating sophisticated bifunctional constructs. Its unique structural properties allow researchers to explore new avenues in targeted therapeutics, contributing to advancements in drug development and cellular regulation. -
PROTAC Linker
endo-BCN-PEG2-C2-NHS ester functions as a PEG-based PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This linker is designed to enhance target specificity and efficacy in targeted protein degradation research. Its properties make it suitable for studies focusing on cellular signaling, protein homeostasis, and therapeutic interventions in various diseases. -
PROTAC Linker
Brigatinib C functions as a PROTAC linker, facilitating the targeted degradation of proteins through the ubiquitin-proteasome system. It plays a crucial role in the design of proteolysis-targeting chimeras (PROTACs), enhancing their ability to selectively eliminate disease-related proteins. This compound is essential for researchers studying targeted protein degradation and may contribute to the development of innovative therapeutic strategies in various disease models. -
PROTAC Linker
Bis-Mal-Lysine-PEG4-TFP ester is a PEG-based linker designed for use in PROTAC synthesis. This compound facilitates the conjugation of target proteins to E3 ligases, enabling targeted protein degradation through the recruitment mechanism inherent to PROTAC technology. It serves as a critical building block for researchers investigating targeted therapy strategies and efficient modulation of protein levels in cellular systems. -
PROTAC Linker
Br-PEG4-CH2-Boc is a polyethylene glycol (PEG)-based linker designed for PROTAC (proteolysis targeting chimera) applications. This versatile linker facilitates the conjugation of targeting ligands to E3 ligase recruiters, enabling the selective degradation oftarget proteins. It is suitable for synthesizing various PROTAC molecules, allowing researchers to investigate protein function and develop therapeutic agents that leverage targeted protein degradation mechanisms. -
PROTAC Linker
Propargyl-PEG3-bromide is a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. It plays a crucial role in constructing bivalent small molecules for targeted protein degradation studies, making it a valuable tool in chemical biology and therapeutic research applications. -
PROTAC Linker
Boc-NH-PEG5-CH2CH2COOH is a PEG-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimeras). This compound facilitates the development of bifunctional molecules that can selectively target and degrade specific proteins, thereby enabling advanced studies in targeted protein degradation and therapeutic applications. Its incorporation in PROTAC design may enhance solubility and bioavailability of the resultant complexes, making it a valuable tool in chemical biology research.
