Catalog No.
Product Name
Application
Product Information
Citations
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ADC/PROTAC Linker
m-PEG12-OH is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras) and antibody-drug conjugates (ADCs). This non-cleavable linker consists of a 12-unit polyethylene glycol chain, facilitating stable conjugation in bioconjugation applications. Its properties enable efficient delivery of biologically active drugs to target cells, making it suitable for research in targeted therapy and drug development. -
PROTAC Linker
Tr-PEG2-OH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This non-cleavable linker, featuring a two-unit PEG structure, facilitates the development of antibody-drug conjugates (ADCs). Its key biological activity includes promoting targeted protein degradation and enhancing the solubility and pharmacokinetics of conjugated molecules, making it a valuable tool in chemical biology and therapeutic research applications. -
ADC/PROTAC Linker
Propargyl-PEG8-acid is a PEG-based linker designed for use in antibody-drug conjugates (ADCs) and PROTAC synthesis. It features an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating the conjugation of azide-containing biomolecules. Its utility in creating cleavable linkers makes it valuable for targeted drug delivery applications, particularly against Gram-negative bacterial infections. This versatile reagent supports the development of innovative therapeutic strategies in chemical biology and drug discovery. -
PROTAC Linkers
Mal-PEG1-acid is a non-cleavable linker derived from polyethylene glycol (PEG) that serves as an effective reagent for antibody-drug conjugates (ADCs) and PROTAC synthesis. This compound facilitates the construction of PROTACs by providing a flexible linker that enhances target protein degradation through ubiquitin-proteasome pathways. Its application is crucial for developing novel therapeutics that utilize the PROTAC strategy in chemical biology and drug discovery. -
ADC/PROTAC Linker
Bis-PEG10-NHS ester is a cleavable linker designed for use in antibody-drug conjugate (ADC) and PROTAC synthesis. The compound features a polyethylene glycol (PEG) structure that enhances solubility and stability while promoting efficient drug delivery. Its primary mechanism involves facilitating the conjugation of drugs to antibodies or target proteins, making it essential in developing targeted therapies. Bis-PEG10-NHS ester is suitable for research applications aimed at improving therapeutic efficacy and specificity in drug development. -
PROTAC Linkers
H-Hyp-OMe hydrochloride is a non-cleavable linker designed for use in antibody-drug conjugates (ADCs) and also serves as an alkyl chain-based PROTAC linker. This versatile compound facilitates the synthesis of PROTACs, enabling the targeted degradation of specific proteins through the ubiquitin-proteasome system. H-Hyp-OMe hydrochloride is valuable in the development of therapeutic strategies aimed at selectively modulating protein function in various biological research applications. -
PROTAC/ADC Linker
Hydroxy-PEG4-acid is a non-cleavable linker featuring a four-unit polyethylene glycol (PEG) moiety, primarily utilized in the development of antibody-drug conjugates (ADCs). This linker is also applicable in the synthesis of PROTACs (proteolysis-targeting chimeras), facilitating targeted degradation of specific proteins. Its biocompatibility and structural versatility make it valuable in various chemical biology applications, particularly in therapeutic development and research focusing on targeted protein modulation. -
PROTAC Linkers
Propargyl-PEG2-NHBoc is a cleavable linker designed for use in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This PEG-based linker features an alkyne group, allowing for efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its unique properties support robust applications in drug development and targeted protein degradation research, making it a valuable tool for chemical biology studies. -
PROTAC Linker
Bis-PEG8-acid is a polyethylene glycol-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. This bifunctional linker facilitates the formation of PROTACs by providing a cleavable connection between the target protein and an E3 ligase. Additionally, Bis-PEG8-acid serves as a linker in the development of antibody-drug conjugates (ADCs), enhancing their stability and efficacy. Its application in chemical biology and therapeutic research supports innovative approaches in targeted protein degradation and drug delivery systems. -
ADC/PROTAC Linker
Amino-PEG9-acid is a PEG-based linker designed for use in antibody-drug conjugates (ADCs) and PROTACs. This non-cleavable linker facilitates the synthesis of PROTACs and enhances the stability and efficacy of ADC formulations. Its unique properties make it a valuable tool in the development of targeted therapies for various diseases, enabling precise delivery of therapeutic agents to specific cellular targets. -
ADC/PROTAC Linker
Propargyl-PEG8-NHS ester is a PEG-based linker specifically designed for antibody-drug conjugates (ADCs) and PROTACs. Its primary mechanism involves enabling the synthesis of these bioconjugates through a cleavable linker. This compound features an alkyne group that facilitates click chemistry, specifically the copper-catalyzed azide-alkyne cycloaddition (CuAAc), allowing for efficient conjugation with azide-containing molecules. It is a valuable tool for researchers in drug development and bioconjugation studies. -
ADC/PROTAC Linker
Propargyl-PEG6-acid is a PEG-based linker primarily utilized in the synthesis of proteolysis-targeting chimeras (PROTACs) and antibody-drug conjugates (ADCs). This cleavable linker facilitates the formation of ADCs and enables targeted protein degradation via a click chemistry reaction, leveraging its alkyne group for copper-catalyzed azide-alkyne cycloaddition (CuAAc). Its versatile applications in chemical biology make it a valuable tool for research in targeted therapeutics and bioconjugation strategies. -
PROTAC Linker
Fmoc-NH-PEG9-CH2CH2COOH is a cleavable linker designed for use in the synthesis of antibody-drug conjugates (ADCs) and PROTACs. This PEG-based compound facilitates the conjugation of therapeutic agents to targeted antibodies, enhancing efficacy and selectivity in drug delivery. Its unique structure allows for the effective modulation of protein degradation pathways, making it valuable for research applications in targeted protein degradation and drug development. -
ADC/PROTAC Linker
Propargyl-PEG8-NH2 is a PEG-based linker primarily used in antibody-drug conjugates (ADCs) and PROTAC synthesis. This non-cleavable linker enhances the stability of ADCs while facilitating the targeted delivery of therapeutic agents. Additionally, its alkyne functional group allows for copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it a valuable tool in click chemistry applications for bioconjugation and drug development. -
PROTAC Linker
Bis-PEG9-acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a cleavable structure, making it suitable for the development of antibody-drug conjugates (ADCs). Its unique properties facilitate targeted degradation of proteins, enabling efficient research in drug discovery and therapeutic development. -
PROTAC Linkers
Azido-PEG4-CH2-Boc functions as a cleavable linker primarily utilized in the synthesis of antibody-drug conjugates (ADCs) and PROTACs. This versatile reagent incorporates a PEG spacer and an azide group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions. Its effective application in the development of novel bioconjugates and protein degradation-based therapeutic strategies makes it a valuable tool in chemical biology and drug development research. -
PROTAC/ADC Linker
NH2-PEG5-OH is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs) and antibody-drug conjugates (ADCs). This non-cleavable linker, incorporating a five-unit polyethylene glycol (PEG) structure, enhances the stability and solubility of biologically active compounds. Researchers utilize NH2-PEG5-OH to facilitate targeted degradation of proteins or deliver cytotoxic agents via ADCs, improving therapeutic efficacy in various applications. -
PROTAC Linkers
N3-PEG3-CH2CH2-Boc is a cleavable linker designed for use in PROTAC synthesis, specifically serving as a 3-unit polyethylene glycol (PEG) intermediary. This compound facilitates the formation of antibody-drug conjugates (ADCs) and supports click chemistry applications through its azide group. It readily participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-functionalized molecules and can also engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups, proving valuable in diverse chemical research applications. -
ADC/PROTAC Linker
Propargyl-PEG6-NHS ester is a cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs) and PROTACs. This PEG-based reagent features an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating the conjugation of biomolecules. Its versatility as a click chemistry reagent enhances the development of targeted therapies in chemical biology and drug discovery applications. -
ADC/PROTAC Linker
Amino-PEG5-C2-acid is a PEG-based linker designed for use in the synthesis of PROTACs and non-cleavable antibody-drug conjugates (ADCs). This compound facilitates the conjugation of active pharmaceutical ingredients to antibodies, thereby enhancing target specificity and therapeutic efficacy. Its unique structure allows for optimal stability and performance in bioconjugation applications, making it a valuable tool for researchers in drug development and targeted therapy. -
PROTAC/ADC Linker
Amino-PEG4-CH2COOH is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs) and serves as a non-cleavable four-unit PEG linker for antibody-drug conjugates (ADCs). This compound facilitates the formation of stable conjugates, thereby enhancing the delivery of therapeutic agents to targeted cells. Its unique properties support research applications in targeted protein degradation and ADC development, contributing to advancements in cancer therapy and drug efficacy. -
PROTAC Linkers
NH-bis-PEG2 is a non-cleavable linker featuring a two-unit polyethylene glycol (PEG) structure, primarily utilized in the development of antibody-drug conjugates (ADCs). This PEG-based linker is also applicable in the synthesis of PROTACs, facilitating targeted protein degradation. Its chemical properties allow for improved solubility and stability, making it a valuable tool in drug development and biochemical research. -
ADC/PROTAC Linker
N-Boc-PEG7-alcohol is a PEG-based linker primarily utilized in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This cleavable linker facilitates targeted drug delivery by enhancing the solubility and stability of therapeutic compounds. Its versatile applications in chemical biology make it a valuable tool for researchers aiming to develop novel targeted therapies. -
ADC/PROTAC Linker
m-PEG10-amine is a non-cleavable 10 unit polyethylene glycol (PEG) linker designed for use in the synthesis of antibody-drug conjugates (ADCs) and PROTACs (Proteolysis Targeting Chimeras). This linker enhances the solubility and stability of conjugated biomolecules, facilitating targeted delivery and improved therapeutic efficacy. It is particularly valuable in research applications focusing on ADC development and targeted protein degradation strategies. -
PROTAC Linkers
Propargyl-PEG4-Tos is a PEG-based linker specifically designed for the synthesis of PROTACs (proteolysis-targeting chimeras). It serves as a cleavable linker in antibody-drug conjugates (ADCs), facilitating targeted delivery of therapeutic agents. This compound features an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc), allowing for efficient conjugation with azide-containing molecules. Its versatile applications make it a valuable tool in chemical biology and drug development research. -
ADC/PROTAC Linker
N-Boc-PEG6-alcohol is a PEG-based linker designed for antibody-drug conjugate (ADC) and PROTAC applications. This cleavable linker facilitates the synthesis of PROTACs, allowing for targeted degradation of specific proteins. Its unique structure provides enhanced solubility and stability, making it suitable for various biochemical studies focused on targeted therapies and protein regulation. -
PROTAC Linker
N-(Azido-PEG3)-N-Fluorescein-PEG3-acid is a PEG-based linker utilized in PROTAC technology, featuring azide, fluorescein, and carboxylic acid functionalities. This compound serves as a versatile click chemistry reagent capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing partners, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. Its unique properties make it suitable for applications in tandem with targeted protein degradation and fluorescent labeling studies in chemical biology. -
PROTAC Linker
Biotin-PEG-azide (MW 1000) is a PEG-based linker designed for PROTAC synthesis, featuring an azide functional group. This versatile compound can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with alkyne-containing molecules, as well as in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalized compounds. Its unique properties make it suitable for applications in targeted protein degradation research and other areas of chemical biology. -
ADC/PROTAC Linkers
Glucocorticoid receptor agonist-1 phosphate(2,6-difluoro) Ala-Ala-Br serves as a versatile drug-linker conjugate for antibody-drug conjugate (ADC) applications. This reagent enables the synthesis of conjugates targeting the CD40 antigen, facilitating the development of targeted therapies. Its unique structure supports the design of PROTACs and other innovative bio-conjugates, contributing to advances in cancer research and immunotherapy. -
PROTAC Linkers
Fmoc-NH-PEG5-CH2COOH is a cleavable linker specifically designed for use in antibody-drug conjugates (ADCs) and as a PEG-based link in the synthesis of PROTACs. This compound facilitates the efficient conjugation of therapeutic agents to antibodies, enhancing targeted delivery. Its unique structure allows for controlled release, making it valuable in the development of innovative therapeutic strategies in drug discovery and bioconjugation research. -
ADC/PROTAC Linker
DBCO-NHCO-PEG4-NH-Boc is a versatile PROTAC linker featuring a cleavable structure designed for the synthesis of PROTACs and antibody-drug conjugates (ADCs). This compound utilizes a DBCO moiety, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its PEG4 spacer enhances solubility and stability, making it suitable for various biological applications in drug development and therapeutic research. -
ADC/PROTAC Linker
DBCO-NHCO-PEG4-amine is a PEG-based linker designed for use in antibody-drug conjugates (ADCs) and PROTACs. This cleavable linker facilitates the conjugation of payloads such as MMAE to antibodies, enhancing targeted delivery to cancer cells. It has demonstrated compelling biological activities, with EC50 values of 280 nM and 22 nM for DBCO-VCpAB MMAE and DBCO-TRX MMAE, respectively, in SKBR3 cells, making it a valuable tool for researchers investigating targeted therapies. -
ADC/PROTAC Linker
Tr-PEG3-OH is a non-cleavable linker comprised of a three-unit polyethylene glycol (PEG) chain, designed for use in the synthesis of antibody-drug conjugates (ADCs). This compound enhances the solubility and stability of ADCs, facilitating targeted delivery of cytotoxic agents to specific cells. Its applications extend to PROTAC (proteolysis-targeting chimera) technology, enabling the development of innovative therapies that harness targeted protein degradation. -
ADC/PROTAC Linker
Propargyl-PEG7-acid is a PEG-based linker designed for use in antibody-drug conjugates (ADCs) and proteolysis-targeting chimeras (PROTACs). It features a propargylic group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc), enabling effective conjugation to azide-containing molecules. This compound serves as a cleavable linker, providing versatility in drug delivery systems and targeted therapy research. Propargyl-PEG7-acid is essential for studies focusing on the development of innovative therapeutic modalities through advanced chemical synthesis techniques. -
PROTAC Linkers
DBCO-N-bis(PEG4-NHS ester) is a bifunctional polyethylene glycol (PEG) linker featuring two NHS ester groups and a dibenzocyclooctyne (DBCO) moiety. This reagent facilitates protein modification and labeling, enhancing bioconjugation applications. As a click chemistry tool, DBCO-N-bis(PEG4-NHS ester) enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, making it valuable for constructing PROTAC molecules and other bioorthogonal conjugates in various biochemical research settings. -
ADC/PROTAC Linker
Azido-PEG4-Val-Cit-PAB-OH is a cleavable polyethylene glycol (PEG) linker designed for use in antibody-drug conjugates (ADCs) and proteolysis-targeting chimeras (PROTACs). This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN moieties. Its versatility as a click chemistry reagent supports diverse applications in chemical biology and drug development. -
PROTAC Linkers
m-PEG11-acid is a non-cleavable linker composed of 11 ethylene glycol units, functioning as a versatile agent in the synthesis of antibody-drug conjugates (ADCs) and PROTACs. This polyethylene glycol (PEG)-based linker enhances the solubility and pharmacokinetics of the conjugates while facilitating targeted degradation of proteins in research applications. m-PEG11-acid is crucial for investigating the mechanisms of protein regulation and therapeutic strategies in drug discovery. -
ADC/PROTAC Linker
m-PEG4-MS is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This cleavable linker facilitates the precise delivery of therapeutic agents, enhancing the stability and efficacy of the resulting compounds. Its application in PROTAC development and ADC formulation supports research into targeted protein degradation and innovative cancer therapies. -
ADC/PROTAC Linker
m-PEG7-Amine is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) and antibody-drug conjugate (ADC) synthesis. This cleavable linker facilitates the targeted degradation of specific proteins, enhancing the efficacy of PROTACs. Its versatile application makes it an essential component in developing therapeutic modalities aimed at selective protein modulation and cancer treatment. -
PROTAC Linkers
m-PEG10-alcohol is a non-cleavable linker comprised of a decaethylene glycol unit, primarily used in the design of antibody-drug conjugates (ADCs). This PEG-based compound serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras. Its structure enhances solubility and stability, making it suitable for various chemical biology applications, including targeted protein degradation studies. -
PROTAC Linkers
(2R,4R)-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride functions as a non-cleavable linker in the development of antibody-drug conjugates (ADCs). Furthermore, it serves as an alkyl chain-based PROTAC linker, facilitating the synthesis of PROTACs. This compound plays a crucial role in advancing targeted protein degradation research, contributing to the exploration of innovative therapeutic strategies. -
PROTAC Linker
PC Alkyne-PEG4-NHS ester is a cleavable linker designed for use in the synthesis of antibody-drug conjugates (ADCs). Functioning as a PROTAC linker, this reagent features an alkyne group and participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions. Its unique structure enhances the specificity and efficiency of conjugating azide-containing molecules, making it valuable for various chemical biology applications, including targeted drug delivery and proteolysis targeting chimera (PROTAC) development. -
PROTAC Linker
TCO-PEG4-DBCO is a versatile PROTAC linker known for its ability to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a DBCO moiety that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds, while the TCO component allows for inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine derivatives. TCO-PEG4-DBCO finds applications in the development of antibody-drug conjugates (ADCs), enhancing the precision and efficacy of targeted therapeutics. Its unique chemical properties make it a valuable tool for researchers in chemical biology and drug development. -
ADC/PROTAC Linker
Propargyl-PEG8-bromide is a PEG-based linker designed for use in antibody-drug conjugates (ADCs) and PROTAC synthesis. This non-cleavable linker includes an alkyne group, enabling its application in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc). Its versatility makes it a valuable tool for researchers in the development of targeted therapeutics and for probing protein degradation mechanisms. -
PROTAC Linkers
m-PEG10-acid is a polyethylene glycol (PEG) linker designed for use in the synthesis of antibody-drug conjugates (ADCs) and PROTACs (Proteolysis Targeting Chimeras). This non-cleavable 10-unit PEG linker enhances solubility and stability, facilitating effective delivery of therapeutic agents to targeted cells. The compound is instrumental in chemical biology applications, aiding in the development of novel targeted therapies and research into protein degradation mechanisms. -
PROTAC Linkers
N-Bromoacetyl-β-alanine is a versatile PROTAC linker that functions through targeted protein degradation pathways. This compound facilitates the synthesis of PROTACs, enabling the development of novel therapeutic strategies. Additionally, N-Bromoacetyl-β-alanine serves as a cleavable linker for antibody-drug conjugates (ADCs), enhancing the delivery of cytotoxic agents to specific cancer cells. Its utility in these applications makes it a valuable tool in chemical biology research. -
PROTAC Linker
β-D-tetraacetylgalactopyranoside-PEG1-N3 serves as a cleavable linker in PROTAC (proteolysis-targeting chimera) research, facilitating the synthesis of antibody-drug conjugates (ADCs). This compound features an azide group that allows for click chemistry applications, including copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with partners containing DBCO or BCN moieties, making it a versatile tool for bioconjugation and targeted drug delivery studies. -
ADC/PROTAC Linker
m-PEG8-MS is a polyethylene glycol (PEG)-based linker designed for use in antibody-drug conjugates (ADCs) and proteolysis-targeting chimeras (PROTACs). This cleavable linker facilitates the effective synthesis of ADCs, enhancing drug delivery specificity and potency. Its versatile applications in chemical biology allow for targeted degradation of selected proteins, making it a valuable tool in therapeutic development and research. -
ADC/PROTAC Linker
Propargyl-PEG1-SS-PEG1-C2-Boc is a versatile alkyl/ether-based linker with applications in PROTAC and antibody-drug conjugate (ADC) synthesis. This cleavable linker features an alkyne group, enabling its use in click chemistry via copper-catalyzed azide-alkyne cycloaddition (CuAAc). Propargyl-PEG1-SS-PEG1-C2-Boc is instrumental in the development of targeted therapeutic strategies, making it valuable for researchers in drug design and bioconjugation studies. -
PROTAC Linker
Tr-PEG8-OH is a non-cleavable linker composed of an 8 unit polyethylene glycol (PEG) chain, primarily utilized in the synthesis of PROTACs (proteolysis-targeting chimeras) and antibody-drug conjugates (ADCs). This PEG-based linker facilitates the development of optimized bioconjugates, enhancing their pharmacokinetic profiles and therapeutic efficacy. Tr-PEG8-OH is particularly valuable for research applications focusing on targeted protein degradation and drug delivery systems.
