Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linkers
Mal-PEG1-acid is a non-cleavable linker derived from polyethylene glycol (PEG) that serves as an effective reagent for antibody-drug conjugates (ADCs) and PROTAC synthesis. This compound facilitates the construction of PROTACs by providing a flexible linker that enhances target protein degradation through ubiquitin-proteasome pathways. Its application is crucial for developing novel therapeutics that utilize the PROTAC strategy in chemical biology and drug discovery. -
ADC/PROTAC Linker
Bis-PEG10-NHS ester is a cleavable linker designed for use in antibody-drug conjugate (ADC) and PROTAC synthesis. The compound features a polyethylene glycol (PEG) structure that enhances solubility and stability while promoting efficient drug delivery. Its primary mechanism involves facilitating the conjugation of drugs to antibodies or target proteins, making it essential in developing targeted therapies. Bis-PEG10-NHS ester is suitable for research applications aimed at improving therapeutic efficacy and specificity in drug development. -
PROTAC Linkers
H-Hyp-OMe hydrochloride is a non-cleavable linker designed for use in antibody-drug conjugates (ADCs) and also serves as an alkyl chain-based PROTAC linker. This versatile compound facilitates the synthesis of PROTACs, enabling the targeted degradation of specific proteins through the ubiquitin-proteasome system. H-Hyp-OMe hydrochloride is valuable in the development of therapeutic strategies aimed at selectively modulating protein function in various biological research applications. -
PROTAC/ADC Linker
Hydroxy-PEG4-acid is a non-cleavable linker featuring a four-unit polyethylene glycol (PEG) moiety, primarily utilized in the development of antibody-drug conjugates (ADCs). This linker is also applicable in the synthesis of PROTACs (proteolysis-targeting chimeras), facilitating targeted degradation of specific proteins. Its biocompatibility and structural versatility make it valuable in various chemical biology applications, particularly in therapeutic development and research focusing on targeted protein modulation. -
PROTAC Linkers
Propargyl-PEG2-NHBoc is a cleavable linker designed for use in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This PEG-based linker features an alkyne group, allowing for efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its unique properties support robust applications in drug development and targeted protein degradation research, making it a valuable tool for chemical biology studies. -
PROTAC Linker
Bis-PEG8-acid is a polyethylene glycol-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. This bifunctional linker facilitates the formation of PROTACs by providing a cleavable connection between the target protein and an E3 ligase. Additionally, Bis-PEG8-acid serves as a linker in the development of antibody-drug conjugates (ADCs), enhancing their stability and efficacy. Its application in chemical biology and therapeutic research supports innovative approaches in targeted protein degradation and drug delivery systems. -
ADC/PROTAC Linker
Amino-PEG9-acid is a PEG-based linker designed for use in antibody-drug conjugates (ADCs) and PROTACs. This non-cleavable linker facilitates the synthesis of PROTACs and enhances the stability and efficacy of ADC formulations. Its unique properties make it a valuable tool in the development of targeted therapies for various diseases, enabling precise delivery of therapeutic agents to specific cellular targets. -
ADC/PROTAC Linker
Propargyl-PEG8-NHS ester is a PEG-based linker specifically designed for antibody-drug conjugates (ADCs) and PROTACs. Its primary mechanism involves enabling the synthesis of these bioconjugates through a cleavable linker. This compound features an alkyne group that facilitates click chemistry, specifically the copper-catalyzed azide-alkyne cycloaddition (CuAAc), allowing for efficient conjugation with azide-containing molecules. It is a valuable tool for researchers in drug development and bioconjugation studies. -
ADC/PROTAC Linker
Propargyl-PEG6-acid is a PEG-based linker primarily utilized in the synthesis of proteolysis-targeting chimeras (PROTACs) and antibody-drug conjugates (ADCs). This cleavable linker facilitates the formation of ADCs and enables targeted protein degradation via a click chemistry reaction, leveraging its alkyne group for copper-catalyzed azide-alkyne cycloaddition (CuAAc). Its versatile applications in chemical biology make it a valuable tool for research in targeted therapeutics and bioconjugation strategies. -
PROTAC Linker
Fmoc-NH-PEG9-CH2CH2COOH is a cleavable linker designed for use in the synthesis of antibody-drug conjugates (ADCs) and PROTACs. This PEG-based compound facilitates the conjugation of therapeutic agents to targeted antibodies, enhancing efficacy and selectivity in drug delivery. Its unique structure allows for the effective modulation of protein degradation pathways, making it valuable for research applications in targeted protein degradation and drug development. -
ADC/PROTAC Linker
Propargyl-PEG8-NH2 is a PEG-based linker primarily used in antibody-drug conjugates (ADCs) and PROTAC synthesis. This non-cleavable linker enhances the stability of ADCs while facilitating the targeted delivery of therapeutic agents. Additionally, its alkyne functional group allows for copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it a valuable tool in click chemistry applications for bioconjugation and drug development. -
PROTAC Linker
Bis-PEG9-acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a cleavable structure, making it suitable for the development of antibody-drug conjugates (ADCs). Its unique properties facilitate targeted degradation of proteins, enabling efficient research in drug discovery and therapeutic development. -
PROTAC Linkers
Azido-PEG4-CH2-Boc functions as a cleavable linker primarily utilized in the synthesis of antibody-drug conjugates (ADCs) and PROTACs. This versatile reagent incorporates a PEG spacer and an azide group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions. Its effective application in the development of novel bioconjugates and protein degradation-based therapeutic strategies makes it a valuable tool in chemical biology and drug development research. -
PROTAC/ADC Linker
NH2-PEG5-OH is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs) and antibody-drug conjugates (ADCs). This non-cleavable linker, incorporating a five-unit polyethylene glycol (PEG) structure, enhances the stability and solubility of biologically active compounds. Researchers utilize NH2-PEG5-OH to facilitate targeted degradation of proteins or deliver cytotoxic agents via ADCs, improving therapeutic efficacy in various applications. -
PROTAC Linkers
N3-PEG3-CH2CH2-Boc is a cleavable linker designed for use in PROTAC synthesis, specifically serving as a 3-unit polyethylene glycol (PEG) intermediary. This compound facilitates the formation of antibody-drug conjugates (ADCs) and supports click chemistry applications through its azide group. It readily participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-functionalized molecules and can also engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups, proving valuable in diverse chemical research applications. -
ADC/PROTAC Linker
Propargyl-PEG6-NHS ester is a cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs) and PROTACs. This PEG-based reagent features an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating the conjugation of biomolecules. Its versatility as a click chemistry reagent enhances the development of targeted therapies in chemical biology and drug discovery applications. -
ADC/PROTAC Linker
Amino-PEG5-C2-acid is a PEG-based linker designed for use in the synthesis of PROTACs and non-cleavable antibody-drug conjugates (ADCs). This compound facilitates the conjugation of active pharmaceutical ingredients to antibodies, thereby enhancing target specificity and therapeutic efficacy. Its unique structure allows for optimal stability and performance in bioconjugation applications, making it a valuable tool for researchers in drug development and targeted therapy. -
PROTAC/ADC Linker
Amino-PEG4-CH2COOH is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs) and serves as a non-cleavable four-unit PEG linker for antibody-drug conjugates (ADCs). This compound facilitates the formation of stable conjugates, thereby enhancing the delivery of therapeutic agents to targeted cells. Its unique properties support research applications in targeted protein degradation and ADC development, contributing to advancements in cancer therapy and drug efficacy. -
PROTAC Linkers
NH-bis-PEG2 is a non-cleavable linker featuring a two-unit polyethylene glycol (PEG) structure, primarily utilized in the development of antibody-drug conjugates (ADCs). This PEG-based linker is also applicable in the synthesis of PROTACs, facilitating targeted protein degradation. Its chemical properties allow for improved solubility and stability, making it a valuable tool in drug development and biochemical research. -
ADC/PROTAC Linker
N-Boc-PEG7-alcohol is a PEG-based linker primarily utilized in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This cleavable linker facilitates targeted drug delivery by enhancing the solubility and stability of therapeutic compounds. Its versatile applications in chemical biology make it a valuable tool for researchers aiming to develop novel targeted therapies. -
ADC/PROTAC Linker
m-PEG10-amine is a non-cleavable 10 unit polyethylene glycol (PEG) linker designed for use in the synthesis of antibody-drug conjugates (ADCs) and PROTACs (Proteolysis Targeting Chimeras). This linker enhances the solubility and stability of conjugated biomolecules, facilitating targeted delivery and improved therapeutic efficacy. It is particularly valuable in research applications focusing on ADC development and targeted protein degradation strategies. -
PROTAC Linkers
Propargyl-PEG4-Tos is a PEG-based linker specifically designed for the synthesis of PROTACs (proteolysis-targeting chimeras). It serves as a cleavable linker in antibody-drug conjugates (ADCs), facilitating targeted delivery of therapeutic agents. This compound features an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc), allowing for efficient conjugation with azide-containing molecules. Its versatile applications make it a valuable tool in chemical biology and drug development research. -
ADC/PROTAC Linker
N-Boc-PEG6-alcohol is a PEG-based linker designed for antibody-drug conjugate (ADC) and PROTAC applications. This cleavable linker facilitates the synthesis of PROTACs, allowing for targeted degradation of specific proteins. Its unique structure provides enhanced solubility and stability, making it suitable for various biochemical studies focused on targeted therapies and protein regulation. -
E3 Ligase Ligand and PROTAC Linker
(S)-Deoxy-thalidomide-2,7-diazaspiro[3.5]nonane-CH2-Me-PIP-Boc serves as an E3 ligase ligand and a PROTAC linker, facilitating targeted protein degradation. It is integral to the development of PROTAC K-Ras Degrader-3, demonstrating potential in cancer research. This compound is designed to help elucidate molecular mechanisms and therapeutic pathways involved in oncogenesis. -
PROTAC linker
Leukotriene B4 (LTB4) is a potent chemoattractant and activator of leukocytes, playing a critical role in mediating inflammatory responses. As an alkyl chain-based PROTAC linker, LTB4 is essential for the synthesis of PROTACs, enabling targeted protein degradation in research applications. This compound is valuable for studies focused on inflammation, immune response, and the development of therapeutic interventions in related diseases. -
PROTAC Linker
(2E,9Z)-Octadeca-2,9-dienoic acid serves as a PROTAC linker in chemical research applications. This polyunsaturated fatty acid plays a critical role in lipoxygenase-dependent metabolic processes, facilitating the study of enzyme-modulating pathways. Its unique structure enables the development of targeted protein degradation strategies in cellular systems. -
PROTAC Linkers
m-PEG-NHS ester (MW 5000) is a PEGylated linker that facilitates the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an N-hydroxysuccinimide (NHS) functional group, enabling efficient coupling to amine-containing substrates. Its hydrophilic nature enhances solubility and improves pharmacokinetic properties, making it an essential tool for researchers in targeted protein degradation and therapeutic development. -
PROTAC Linkers
DSPE-PEG-Biotin, MW 2000 is a polyethylene glycol (PEG) based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of biotin to target proteins, enhancing their recognition and degradation by the cellular proteasome. Its application in PROTAC technology supports the development of novel therapeutics by enabling targeted protein modulation in cellular research. -
PROTAC linker
DSPE-PEG8-Mal is a PEG-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound facilitates the development of PROTACs by enhancing their solubility and stability. Its primary mechanism involves forming a covalent bond with target proteins, thus enabling targeted degradation. DSPE-PEG8-Mal is essential for researchers investigating novel therapeutic strategies via targeted protein degradation. -
PROTAC Linker
8-Hydroxyoctanoic acid is a versatile PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins through its ability to connect ligand and E3 ligase components. It is a valuable tool for researchers in drug discovery and cellular biology, enabling studies on targeted protein degradation mechanisms and therapeutic applications. -
PROTAC Linker
Boc-NH-bicyclo[1.1.1]pentane-C-NH2 functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is essential for linking a target protein to an E3 ligase, thereby promoting ubiquitination and subsequent degradation of the target protein. It is valuable in various research applications, including targeted protein degradation studies and exploring protein homeostasis mechanisms. -
PROTAC Linker
4-(2-Bromoethyl)phenol is a versatile PROTAC linker utilized in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target binding moieties to E3 ligase ligands, enabling targeted protein degradation. It is instrumental in the development of innovative therapeutic strategies through modulation of cellular pathways in various biological research applications. -
PROTAC Linker
4-Bromo-1-trimethylsilyl-1-butyne serves as a versatile linker for the development of PROTAC (proteolysis-targeting chimera) molecules. Its unique structural features facilitate the conjugation of target ligands, thereby enabling the selective degradation of proteins through the ubiquitin-proteasome system. This compound is critical for advancing research in targeted protein degradation and enhancing therapeutic strategies in cancer and other diseases. -
PROTAC Linker
N-Fmoc-8-aminooctanoic acid serves as a versatile PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkane chain that includes a terminal Fmoc-protected amine and a carboxylic acid group. The Fmoc group can be removed under basic conditions to yield a free amine amenable for further modifications. Additionally, the carboxylic acid can react with primary amines in the presence of coupling agents, such as EDC or HATU, to establish stable amide bonds, thus enhancing the structural diversity of PROTAC molecules for targeted protein degradation studies. -
PROTAC Linkers
Boc-NH-PEG2-C2-NHS ester is an alkyl/ether-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables the conjugation of target proteins with E3 ligases, thereby promoting targeted degradation pathways. Its application in chemical biology allows for the development of innovative therapeutic strategies through the modulation of protein levels within cells. -
PROTAC Linker
Azido-PEG6-azide is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Featuring an azide functional group, it facilitates click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) groups, making it a versatile tool for targeted protein degradation studies. -
PROTAC Linkers
Bis-PEG12-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and stability of PROTACs, facilitating the targeted degradation of specific proteins within cells. Bis-PEG12-acid is ideal for research applications focused on proteostasis, targeted therapy development, and the study of protein function through degradation mechanisms. -
PROTAC Linkers
m-PEG7-alcohol is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of proteolysis targeting chimeras (PROTACs). This compound facilitates the development of innovative therapeutic strategies by linking target proteins to E3 ligases, enhancing protein degradation. Its unique structure offers improved solubility and biocompatibility, making it suitable for various chemical biology applications. This linker is essential for researchers aiming to manipulate protein levels within cellular environments. -
PROTAC Linkers
HO-PEG11-OH is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the effective conjugation of target proteins to E3 ligases, enhancing the recruitment and degradation of specific proteins via the ubiquitin-proteasome pathway. HO-PEG11-OH is valuable in research applications focusing on targeted protein degradation, therapeutic development, and cellular signaling studies. -
PROTAC Linker
Mal-PEG8-acid is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis, facilitating targeted protein degradation. This compound enhances the solubility and stability of PROTACs while promoting efficient cellular uptake. It is a valuable tool in chemical biology for studying protein interactions and developing therapeutic agents targeting specific proteins for degradation. -
PROTAC Linkers
Amino-PEG6-amine is a polyethylene glycol (PEG) compound featuring a six-unit linker that serves as an essential component in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its primary mechanism involves facilitating the conjugation of target proteins to E3 ligases, enabling selective degradation pathways. This reagent is crucial for advancing research in targeted protein degradation and protein engineering applications. -
PROTAC Linker
Azide-PEG4-Tos is a PEG-based PROTAC linker known for facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). Featuring an azide functional group, it participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing compounds, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN derivatives. This compound is valuable for researchers focusing on targeted protein degradation and drug development through the innovative PROTAC technology. -
PROTAC Linkers
Biotin-PEG4-SH is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules. This compound facilitates the conjugation of biotin to target proteins, enabling targeted degradation through the ubiquitin-proteasome pathway. Its primary applications include the development of novel PROTACs for targeted protein modulation in various biological studies and therapeutic investigations. -
PROTAC Linker
Biotin-PEG-Biotin is a polyethylene glycol (PEG) linkage compound designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This bifunctional linker enhances the solubility and bioavailability of target proteins, facilitating efficient degradation through the ubiquitin-proteasome system. Its primary applications include the development of novel therapeutic agents for targeted protein degradation in various diseases, including cancer and neurodegenerative disorders. -
PROTAC Linker
Thiol-PEG3-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). Its thiol moiety provides a reactive site for conjugation, facilitating the development of novel therapeutics that leverage targeted degradation mechanisms. This compound is essential for enhancing the solubility and stability of PROTACs, making it a valuable tool in chemical biology and drug discovery applications. -
PROTAC Linker
Amino-PEG12-alcohol is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). It facilitates the selective degradation of target proteins by linking an E3 ligase ligand with a target protein binder. This reagent is valuable for research applications in targeted protein degradation and developing novel therapeutic strategies. -
PROTAC Linker
m-PEG5-acid is a polyethylene glycol-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing the formation of PROTACs and promoting targeted protein degradation. m-PEG5-acid is instrumental in advancing research in protein modulation and therapeutic development. -
PROTAC Linker
Diethylene glycol bis(p-toluenesulfonate) is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the targeted degradation of specific proteins by bridging an E3 ligase and a protein of interest, enabling the selective modulation of cellular pathways. Its application is particularly relevant in drug discovery and development aimed at treating diseases associated with protein dysregulation. -
PROTAC Linkers
Boc-NH-PEG6-CH2COOH is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins and E3 ligases, thereby enabling targeted protein degradation. It is essential for researchers developing PROTACs to study protein function and regulation in various biological contexts. -
PROTAC Linker
tert-Butyl 5-bromoisoindoline-2-carboxylate serves as a PROTAC linker, facilitating targeted protein degradation mechanisms. This compound is instrumental in synthesizing various PROTACs, including the HSD17B13 degrader 1, which enables the modulation of protein levels within biological systems. Its structural properties make it a valuable tool in research applications focused on targeted therapy development and protein regulation studies.
