Catalog No.
Product Name
Application
Product Information
Citations
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ADC/PROTAC Linker
Propargyl-PEG4-thiol is a PEG-based linker specifically designed for use in the synthesis of PROTACs and non-cleavable antibody-drug conjugates (ADCs). This compound features an alkyne functional group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating precise conjugation with azide-containing molecules. Propargyl-PEG4-thiol is essential for advancing research in targeted protein degradation and therapeutic antibody development. -
ADC/PROTAC Linker
m-PEG7-MS is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This cleavable linker facilitates the development of targeted therapeutics by enabling controlled release of active compounds. Its versatile application supports research in targeted protein degradation and drug delivery systems, making it an essential reagent for advancing science in cancer therapy and other diseases. -
ADC/PROTAC Linker
DBCO-NHCO-PEG4-NHS ester is a versatile linker designed for use in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This PEG/alkyl/ether-based compound features a DBCO moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its cleavable nature enhances the functionality and targeting capabilities of therapeutic agents, making it essential for researchers involved in drug development and bioconjugation applications. -
ADC/PROTAC Linker
N-Boc-N-bis(PEG4-OH) is a PEG-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This cleavable linker also serves as a versatile component for the development of antibody-drug conjugates (ADCs). Due to its unique structure, it facilitates targeted drug delivery and enhances the efficacy of therapeutic agents in various biological applications. -
PROTAC Linkers
Bis-PEG7-acid is a polyethylene glycol (PEG) based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound enhances the solubility and stability of the PROTAC molecules, facilitating targeted protein degradation. Its application in chemical biology supports research focused on developing novel therapeutics through targeted ubiquitination pathways. -
ADC/PROTAC Linker
Propargyl-PEG9-bromide is a PEG-based linker utilized in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This non-cleavable linker facilitates the targeted delivery of therapeutics through its unique click chemistry capabilities, featuring an alkyne group suitable for copper-catalyzed azide-alkyne cycloaddition (CuAAc). Its applications extend to enhancing drug efficacy and specificity in chemical biology and therapeutic development. -
PROTAC Linkers
m-PEG4-Boc is a cleavable polyethylene glycol (PEG) linker with four ethylene glycol units, designed for use in the synthesis of antibody-drug conjugates (ADCs) and Proteolysis Targeting Chimeras (PROTACs). This versatile linker facilitates the development of ADCs by enabling site-specific conjugation, while also serving as a crucial component in PROTAC design for targeted protein degradation. Its functional properties contribute to the effectiveness and stability of various bioconjugates in chemical biology research. -
PROTAC linker
Boc-gly-PEG3-endo-BCN is a cleavable PEG-based linker designed for targeted protein degradation applications through PROTAC technology. Its biocompatible structure facilitates the synthesis of antibody-drug conjugates (ADCs) by serving as a versatile linker. The presence of a bicyclo[6.1.0]nonyne (BCN) group allows for efficient strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-containing molecules, making it a valuable reagent for click chemistry in biological research. -
ADC/PROTAC Linker
m-PEG5-MS is a PEG-based linker designed for antibody-drug conjugates (ADCs) and proteolysis-targeting chimeras (PROTACs). This cleavable linker facilitates the synthesis of PROTACs, enabling targeted degradation of specific proteins. Its key applications include drug development and cellular regulation studies, making it a versatile tool in therapeutic research and protein modulation. -
PROTAC Linker
Amino-PEG11-OH is a non-cleavable linker composed of an 11-unit polyethylene glycol (PEG) moiety designed for use in antibody-drug conjugates (ADCs) and PROTAC (Proteolysis Targeting Chimera) synthesis. This PEG-based linker facilitates the conjugation of drugs to antibodies, enhancing therapeutic efficacy while maintaining stability. Additionally, it serves as an effective component in the development of PROTACs, enabling targeted protein degradation for advanced molecular research applications. -
ADC/PROTAC Linker
Propargyl-PEG7-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This cleavable linker features an alkyne group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its versatility and efficiency make it a valuable tool in the development of targeted therapeutics and bioconjugates for cancer research and drug delivery applications. -
ADC/PROTAC Linker
N-Boc-N-bis(PEG2-OH) is a PEG-based linker designed for use in antibody-drug conjugates (ADCs) and PROTAC synthesis. This cleavable linker facilitates the precise attachment of therapeutic agents to antibodies, enhancing targeted drug delivery while minimizing off-target effects. Its structure allows for efficient conjugation and release of the active component, making it suitable for a variety of applications in drug development and molecular biology research. -
ADC/PROTAC Linker
Bis-PEG2-PFP ester is a non-cleavable linker that comprises two units of polyethylene glycol (PEG) and is essential for the synthesis of antibody-drug conjugates (ADCs). Its unique structure makes it suitable for use in peptide-based PROTACs (Proteolysis Targeting Chimeras), facilitating targeted degradation of specific proteins. This reagent supports advanced research in the fields of targeted therapy and protein regulation. -
ADC/PROTAC Linker
m-PEG9-Amine is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This cleavable linker facilitates the attachment of biomolecules, enabling targeted protein degradation and precise delivery of therapeutic agents. m-PEG9-Amine is essential for advancing research in targeted therapy and bioconjugation applications. -
ADC/PROTAC Linker
Bis-PEG17-NHS ester is a PEG-based linker designed for efficient conjugation in both PROTAC and antibody-drug conjugate (ADC) synthesis. Its NHS ester functionality allows for selective coupling to amine-containing molecules, facilitating the development of targeted therapies. This reagent is particularly useful in the development of PROTACs for targeted protein degradation and in the construction of ADCs that deliver cytotoxic agents to specific cancer cells. -
ADC/PROTAC Linker
N-Boc-PEG9-alcohol is a polyethylene glycol (PEG)-based linker utilized in the synthesis of antibody-drug conjugates (ADCs) and PROTACs. This cleavable linker facilitates the conjugation of bioactive molecules, enhancing the pharmacokinetic properties of ADCs. Its application extends to the development of targeted degraders, making it a valuable tool in chemical biology and drug discovery research. -
PROTAC Linkers
N-Succinimidyl 3-(Bromoacetamido)propionate is a versatile PEG-based linker designed for PROTAC (proteolysis-targeting chimeras) synthesis. This compound facilitates the effective conjugation of small molecules to target proteins, enabling targeted protein degradation. Additionally, it serves as a cleavable linker for the development of antibody-drug conjugates (ADCs), enhancing therapeutic efficacy in cancer research. This reagent is essential for studies focused on protein modulation and targeted therapies. -
ADC/PROTAC Linker
DBCO-NHCO-PEG4-acid is a PEG-based linker designed for application in antibody-drug conjugates (ADCs) and PROTAC synthesis. This linker features a DBCO group that participates in strain-promoted alkyne-azide cycloaddition (SPAAC), facilitating selective conjugation with azide-containing molecules. Its chemical properties make it ideal for developing targeted therapeutics that can modulate protein levels in biological research, enhancing experimental outcomes in drug discovery and development. -
PROTAC Linker
5-Hydroxypentanoic acid serves as a versatile PROTAC linker, playing a crucial role in targeted protein degradation technology. This compound facilitates the synthesis of PROTAC AR-V7 degrader-1, contributing to innovative research in protein regulation and therapeutic development. Its structural characteristics enhance the design of bifunctional molecules for selective protein degradation, making it a valuable reagent in life sciences research. -
ADC/PROTAC Linker
Amino-PEG10-OH is a non-cleavable, 10-unit polyethylene glycol (PEG) linker primarily utilized in the development of antibody-drug conjugates (ADCs). This versatile linker also serves a critical role in the synthesis of proteolysis-targeting chimeras (PROTACs). Its hydrophilic properties enhance solubility and stability, making it suitable for diverse applications in chemical biology and therapeutic development. -
PROTAC Linkers
DBCO-NHCO-PEG12-biotin is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs through its reactive DBCO moiety. This compound engages in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-bearing molecules, allowing for precise conjugation in chemical biology applications. Its utility in targeted protein degradation research makes it a valuable tool for biochemists developing innovative therapeutic strategies. -
PROTAC Linkers
Carboxyfluorescein-PEG12-NHS is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). It enables the formation of covalent bonds with target proteins, facilitating the selective degradation of unwanted intracellular proteins. This reagent is valuable for researchers exploring targeted protein degradation and developing novel therapeutics in cancer and other diseases. -
PROTAC Linker
(Rac)-Biotin-PEG3-oxyamine hydrochloride is a PEG-based linker specifically designed for the development of PROTAC (Proteolysis Targeting Chimera) molecules. This compound facilitates the conjugation of biotin to target proteins, enhancing their degradation via the ubiquitin-proteasome pathway. It is valuable in research applications focused on targeted protein degradation and the study of protein-protein interactions. -
PROTAC Linker
8-Hydroxyoctanoic acid is a versatile PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins through its ability to connect ligand and E3 ligase components. It is a valuable tool for researchers in drug discovery and cellular biology, enabling studies on targeted protein degradation mechanisms and therapeutic applications. -
PROTAC Linker
Boc-NH-bicyclo[1.1.1]pentane-C-NH2 functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is essential for linking a target protein to an E3 ligase, thereby promoting ubiquitination and subsequent degradation of the target protein. It is valuable in various research applications, including targeted protein degradation studies and exploring protein homeostasis mechanisms. -
PROTAC Linker
4-(2-Bromoethyl)phenol is a versatile PROTAC linker utilized in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target binding moieties to E3 ligase ligands, enabling targeted protein degradation. It is instrumental in the development of innovative therapeutic strategies through modulation of cellular pathways in various biological research applications. -
PROTAC Linker
4-Bromo-1-trimethylsilyl-1-butyne serves as a versatile linker for the development of PROTAC (proteolysis-targeting chimera) molecules. Its unique structural features facilitate the conjugation of target ligands, thereby enabling the selective degradation of proteins through the ubiquitin-proteasome system. This compound is critical for advancing research in targeted protein degradation and enhancing therapeutic strategies in cancer and other diseases. -
PROTAC Linker
N-Fmoc-8-aminooctanoic acid serves as a versatile PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkane chain that includes a terminal Fmoc-protected amine and a carboxylic acid group. The Fmoc group can be removed under basic conditions to yield a free amine amenable for further modifications. Additionally, the carboxylic acid can react with primary amines in the presence of coupling agents, such as EDC or HATU, to establish stable amide bonds, thus enhancing the structural diversity of PROTAC molecules for targeted protein degradation studies. -
PROTAC Linkers
Boc-NH-PEG2-C2-NHS ester is an alkyl/ether-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables the conjugation of target proteins with E3 ligases, thereby promoting targeted degradation pathways. Its application in chemical biology allows for the development of innovative therapeutic strategies through the modulation of protein levels within cells. -
PROTAC Linker
Azido-PEG6-azide is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Featuring an azide functional group, it facilitates click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) groups, making it a versatile tool for targeted protein degradation studies. -
PROTAC Linkers
Bis-PEG12-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and stability of PROTACs, facilitating the targeted degradation of specific proteins within cells. Bis-PEG12-acid is ideal for research applications focused on proteostasis, targeted therapy development, and the study of protein function through degradation mechanisms. -
PROTAC Linkers
m-PEG7-alcohol is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of proteolysis targeting chimeras (PROTACs). This compound facilitates the development of innovative therapeutic strategies by linking target proteins to E3 ligases, enhancing protein degradation. Its unique structure offers improved solubility and biocompatibility, making it suitable for various chemical biology applications. This linker is essential for researchers aiming to manipulate protein levels within cellular environments. -
PROTAC Linkers
HO-PEG11-OH is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the effective conjugation of target proteins to E3 ligases, enhancing the recruitment and degradation of specific proteins via the ubiquitin-proteasome pathway. HO-PEG11-OH is valuable in research applications focusing on targeted protein degradation, therapeutic development, and cellular signaling studies. -
PROTAC Linker
Mal-PEG8-acid is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis, facilitating targeted protein degradation. This compound enhances the solubility and stability of PROTACs while promoting efficient cellular uptake. It is a valuable tool in chemical biology for studying protein interactions and developing therapeutic agents targeting specific proteins for degradation. -
PROTAC Linkers
Amino-PEG6-amine is a polyethylene glycol (PEG) compound featuring a six-unit linker that serves as an essential component in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its primary mechanism involves facilitating the conjugation of target proteins to E3 ligases, enabling selective degradation pathways. This reagent is crucial for advancing research in targeted protein degradation and protein engineering applications. -
PROTAC Linker
Azide-PEG4-Tos is a PEG-based PROTAC linker known for facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). Featuring an azide functional group, it participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing compounds, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN derivatives. This compound is valuable for researchers focusing on targeted protein degradation and drug development through the innovative PROTAC technology. -
PROTAC Linkers
Biotin-PEG4-SH is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules. This compound facilitates the conjugation of biotin to target proteins, enabling targeted degradation through the ubiquitin-proteasome pathway. Its primary applications include the development of novel PROTACs for targeted protein modulation in various biological studies and therapeutic investigations. -
PROTAC Linker
Biotin-PEG-Biotin is a polyethylene glycol (PEG) linkage compound designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This bifunctional linker enhances the solubility and bioavailability of target proteins, facilitating efficient degradation through the ubiquitin-proteasome system. Its primary applications include the development of novel therapeutic agents for targeted protein degradation in various diseases, including cancer and neurodegenerative disorders. -
PROTAC Linker
Thiol-PEG3-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). Its thiol moiety provides a reactive site for conjugation, facilitating the development of novel therapeutics that leverage targeted degradation mechanisms. This compound is essential for enhancing the solubility and stability of PROTACs, making it a valuable tool in chemical biology and drug discovery applications. -
PROTAC Linker
Amino-PEG12-alcohol is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). It facilitates the selective degradation of target proteins by linking an E3 ligase ligand with a target protein binder. This reagent is valuable for research applications in targeted protein degradation and developing novel therapeutic strategies. -
PROTAC Linker
m-PEG5-acid is a polyethylene glycol-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing the formation of PROTACs and promoting targeted protein degradation. m-PEG5-acid is instrumental in advancing research in protein modulation and therapeutic development. -
PROTAC Linker
Diethylene glycol bis(p-toluenesulfonate) is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the targeted degradation of specific proteins by bridging an E3 ligase and a protein of interest, enabling the selective modulation of cellular pathways. Its application is particularly relevant in drug discovery and development aimed at treating diseases associated with protein dysregulation. -
PROTAC Linkers
Boc-NH-PEG6-CH2COOH is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins and E3 ligases, thereby enabling targeted protein degradation. It is essential for researchers developing PROTACs to study protein function and regulation in various biological contexts. -
PROTAC Linker
tert-Butyl 5-bromoisoindoline-2-carboxylate serves as a PROTAC linker, facilitating targeted protein degradation mechanisms. This compound is instrumental in synthesizing various PROTACs, including the HSD17B13 degrader 1, which enables the modulation of protein levels within biological systems. Its structural properties make it a valuable tool in research applications focused on targeted therapy development and protein regulation studies. -
PROTAC Linker
t-Boc-N-amido-PEG5-acetic acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a terminal carboxylic acid, facilitating conjugation with targeting ligands and degradation tags. It exhibits key biological activity in promoting targeted protein degradation, making it a valuable tool in drug discovery and development research applications. -
PROTAC Linker
3-Iodopropan-1-ol is a PROTAC linker characterized by its role in the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligase, promoting their ubiquitination and subsequent degradation. It is a valuable tool in research applications aimed at exploring targeted protein degradation and elucidating cellular pathways. -
PROTAC Linker
m-PEG7-thiol is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound exhibits excellent solubility and flexibility, facilitating the efficient conjugation of target proteins with E3 ligases. It serves as a crucial component in the development of novel therapeutic modalities that harness the ubiquitin-proteasome system for targeted protein degradation in various research applications. -
PROTAC Linker
Tetrazine-Ph-NHCO-C3-NHS ester serves as a PEG-based PROTAC linker, facilitating the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features a Tetrazine group that enables a selective inverse electron demand Diels-Alder reaction (iEDDA) with TCO-containing molecules. It is instrumental in developing targeted protein degradation strategies in chemical research, enhancing the precision of therapeutic interventions. -
PROTAC Linker
Fmoc-NH-PEG8-NHS ester is a polyethylene glycol (PEG) linker designed for use in PROTAC (PROteolysis TArgeting Chimeras) synthesis. This compound facilitates the conjugation of target proteins to E3 ligases, enhancing targeted protein degradation. Its long PEG chain improves solubility and bioavailability, making it a valuable tool in chemical biology and drug discovery applications focused on modulating protein levels within cells. -
PROTAC Linker
Amino-PEG2-C2-hydrazide-Boc is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the efficient conjugation of target proteins to E3 ligases, enhancing the degradation of specific proteins through the ubiquitin-proteasome pathway. Its versatile structure allows for a variety of applications in chemical biology and drug discovery, particularly in targeted protein degradation research.
