Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
MS-PEG3-O-MS is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligase binding domains, enabling selective degradation of specific proteins. Its application in PROTAC development aids in exploring targeted protein degradation for therapeutic interventions in various disease models. -
PROTAC Linker
trans-Boronic acid pinacol-pyrazole-C-cyclobutane-O-piperidine-Boc serves as a PROTAC linker, facilitating targeted protein degradation through the development of proteolysis-targeting chimeras (PROTACs). This compound is instrumental in the synthesis of PROTAC SMARCA2/4-degrader-35, enhancing the selective degradation of specific proteins associated with various cellular processes. Its application in research enables the exploration of protein functions and therapeutic strategies in the field of targeted protein modulation. -
PROTAC Linker
(4-Bromobutyl)boronic acid serves as a PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables efficient targeting and degradation of specific proteins by linking E3 ligases to the protein of interest. Its versatility supports research applications in targeted protein degradation and the development of innovative therapeutic strategies in drug discovery. -
PROTAC Linkers
NH2-PEG6-C1-Boc is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. It facilitates the construction of bifunctional molecules that recruit E3 ligases to target proteins for degradation, thereby enabling targeted protein modulation. This reagent is essential for researchers developing novel therapeutic strategies in targeted protein degradation and related fields. -
PROTAC Linker
1,4-Bis((tetrahydrofuran-2-yl)oxy)butane serves as a PROTAC (Proteolysis Targeting Chimera) linker, facilitating the development of novel PROTACs for targeted protein degradation. Its structural characteristics enhance the conjugation of target proteins with E3 ligases, enabling the selective ubiquitination and proteasomal degradation of specific cellular proteins. This compound is valuable for researchers investigating targeted therapeutics and studying complex biological pathways involving protein regulation. -
PROTAC Linker
4-Mercaptobutanoic acid is a versatile PROTAC linker utilized in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the recruitment of E3 ligases and enables targeted degradation of specific proteins, making it a valuable tool in chemical biology and drug discovery. Its application in PROTAC technology aids in the development of innovative therapeutic strategies for various diseases. -
PROTAC Linker
Tert-butyl (7-bromoheptyl)(methyl)carbamate serves as an effective PROTAC linker, facilitating the development of proteolysis-targeting chimeras. Its unique structural properties enhance the binding affinity and stability of protein targets, making it valuable in pharmacological research. This compound is pivotal in the synthesis of novel PROTACs aimed at targeted protein degradation, advancing therapeutic strategies in various diseases. -
PROTAC Linker
Methyl (1S,2R)-2-(2-hydroxyethyl)cyclopropane-1-carboxylate serves as a PROTAC linker, facilitating the development of PROTAC molecules that induce targeted degradation of specific proteins. Its structural properties support the effective conjugation of targeting moieties to E3 ligase recruiters, enhancing the efficiency of protein modulation in cellular contexts. This compound is suitable for research applications in drug discovery and the study of protein homeostasis. -
PROTAC Linker
1'-[(tert-Butoxy)carbonyl]-[1,3'-biazetidine]-3-carboxylic acid serves as a PROTAC linker essential for the development of targeted protein degradation strategies. By facilitating the assembly of E3 ligase and target proteins, this compound enhances the efficacy of PROTACs in modulating cellular protein levels. Its unique structural properties make it a valuable tool for chemical biology research focused on targeted therapies. -
PROTAC Linker
TCO4-PEG2-Maleimide is a versatile PROTAC linker that facilitates targeted protein degradation pathways. Its structural components, including TCO and Maleimide moieties, enable efficient "click" chemistry interactions with tetrazine groups and thiol groups, as well as "mercapto-acrylamide" reactions. This reagent is a valuable tool for researchers developing bifunctional molecules for targeted degradation studies in various biological systems. -
PROTAC Linker
4-(4-Methoxyphenyl)-1-butanol serves as a PROTAC linker facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is essential in the synthesis of PROTACs, which are designed to selectively degrade specific proteins within cells, thus advancing research in targeted protein degradation and therapeutic interventions. Its unique structure allows for optimal integration into various PROTAC constructs, enhancing their efficacy in biological applications. -
PROTAC Linker
Boc-NH-C5-NH-Me is a PROTAC linker designed to facilitate the development of proteolysis-targeting chimeras (PROTACs). This compound enhances the efficacy of targeted degradation by linking E3 ligases to target proteins. It is instrumental in chemical biology research, particularly in studies focusing on targeted protein degradation and the modulation of cellular pathways. -
PROTAC Linker
4-(2-Aminoethoxy)benzoic acid hydrochloride is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins, making it a valuable tool in targeted protein modulation research. Its unique structure enables efficient conjugation to E3 ligase ligands and protein of interest, supporting applications in drug discovery and development focused on protein degradation strategies. -
PROTAC Linker
Methyl 6-{[(tert-butoxy)carbonyl]amino}spiro[3.3]heptane-2-carboxylate functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras. This compound enhances the selective degradation of proteins by incorporating E3 ligase-recruiting elements, thereby contributing to targeted protein modulation in research. Its utility in synthesizing advanced PROTACs makes it a valuable reagent for biochemical studies focused on targeted protein degradation. -
PROTAC Linker
3,3'-(Piperazine-1,4-diyl)dipropanoic acid functions as a PROTAC linker, facilitating the development of Proteolysis Targeting Chimeras (PROTACs) for targeted protein degradation. This compound allows for the effective conjugation of ligands to E3 ligases, thereby enhancing the specificity and efficacy of PROTAC molecules in various biological research applications. Its unique structure supports the exploration of protein modulation strategies in cellular assays and therapeutic contexts. -
PROTAC Linker
Methyl 2-(4-(hydroxymethyl)phenyl)acetate serves as a PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This reagent aids in the selective degradation of target proteins, making it valuable in chemical biology and therapeutic research. Its effectiveness enhances the development of innovative strategies for targeted protein modulation and degradation in various disease models. -
PROTAC Linker
(6R,8S,10R,11S,13S,14R)-17-(2-Acetoxyacetyl)-11-hydroxy-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate serves as a PROTAC linker facilitating the bioconjugation of target proteins for targeted protein degradation. This compound provides a scaffold for the development of innovative PROTACs, enabling researchers to explore the modulation of protein levels within cellular systems. Its structural features are designed to enhance the efficiency and specificity of protein targeting in therapeutic applications. -
PROTAC Linker
tert-Butyl 4-(3-bromopropyl)piperazine-1-carboxylate oxalate serves as a versatile PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in enhancing the degradation of target proteins via the ubiquitin-proteasome pathway. Its structural features support effective assembly of tandem moieties, making it essential for research applications in targeted protein degradation and related therapeutic strategies. -
PROTAC Linkers
Mal-PEG4-Glu(OH)-NH-m-PEG24 is a PEG-derived linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the efficient assembly of PROTAC molecules, enabling targeted protein degradation through the recruitment of E3 ligases. Research applications include studying protein regulation, exploring new therapeutic strategies for diseases, and advancing drug discovery efforts. -
PROTAC Linker
tert-Butyl 2,7-diazaspiro[4.4]nonane-2-carboxylate oxalate(2:1) serves as a PROTAC linker facilitating the development of proteolysis-targeting chimeras (PROTACs). This reagent plays a crucial role in selective degradation of target proteins via the ubiquitin-proteasome system. It is essential in research applications aimed at investigating targeted protein degradation and exploring therapeutic pathways in various diseases. -
PROTAC Linker
Boc-NH-PEG2-CH2COOH (dicyclohexylamine) serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). It enhances the solubility and stability of the resultant molecules, thereby improving their biochemical properties. This linker is pivotal for research applications that aim to regulate protein degradation through targeted proteolysis. -
PROTAC Linker
3-(4-Bromophenoxy)propanenitrile functions as a PROTAC linker, facilitating the design and synthesis of targeted protein degraders. Its unique structure allows for effective conjugation to protein-targeting moieties, enhancing the stability and efficacy of PROTACs in selective protein degradation studies. This compound is essential for research applications in drug discovery and development, particularly in the field of therapeutic interventions targeting specific proteins. -
PROTAC Linker
Boc-2-(piperazin-1-yl)acetic acid dihydrate is a versatile PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in enabling the selective degradation of target proteins through the recruitment of E3 ligases. Its application in chemical biology research supports the development of novel therapeutics aimed at various diseases by harnessing targeted protein degradation strategies. -
PROTAC Linker
2-(1-((Benzyloxy)carbonyl)piperidin-4-yl)acetic acid functions as a PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in enhancing the specificity and efficacy of targeted protein degradation in research applications. Its structural properties enable effective conjugation to various proteins, making it an essential tool in drug discovery and development. -
PROTAC Linker
4-Chlorobutanal is a versatile PROTAC linker that serves as a critical component in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins through the recruitment of E3 ligases, making it an invaluable tool for investigating protein function and regulation. Its unique structure allows for effective conjugation with various target ligands, advancing research in targeted protein degradation and therapeutic development. -
PROTAC Linker
Boc-PEG4-I is a polyethylene glycol (PEG) based linker specifically designed for the synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules. It enables the effective conjugation of target proteins and E3 ligases, facilitating the development of novel therapeutics aimed at selective protein degradation. This linker is essential for researchers focusing on targeted protein modulation in various disease models. -
PROTAC Linker
6-(((Benzyloxy)carbonyl)amino)hexyl 4-methylbenzenesulfonate is a versatile PROTAC linker designed to facilitate the synthesis of targeted protein degraders. This compound effectively bridges the ligands to the target protein, enhancing the selective degradation of unwanted proteins through the ubiquitin-proteasome pathway. It is an essential component for researchers investigating targeted protein degradation and developing innovative therapeutic strategies. -
PROTAC Linker
Oct-7-yn-1-yl 4-methylbenzenesulfonate is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). Its structural features facilitate the conjugation of target proteins, enhancing selective degradation pathways. This reagent is applicable in drug discovery and development, particularly in studies aimed at targeted protein degradation for therapeutic interventions. -
PROTAC Linker
5-((tert-Butyldimethylsilyl)oxy)pentan-1-amine serves as a PROTAC (Proteolysis Targeting Chimera) linker, facilitating the design and synthesis of advanced PROTACs. This compound is integral in the development of bifunctional molecules that promote targeted protein degradation, contributing significantly to research in targeted therapies and protein modulation. Its unique structural properties allow for optimal integration into PROTAC designs, enhancing their efficacy in various biological applications. -
PROTAC Linker
Bis-(N,N'-PEG4-NHS ester)-Cy5 is a PEG-based PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). Its efficient conjugation capabilities allow for the precise assembly of target-specific proteins and E3 ligases, enhancing protein degradation potential in cellular systems. This linker is essential for researchers aiming to explore targeted protein degradation mechanisms in various therapeutic contexts. -
PROTAC Linker
Phenylmethyl N-(2-aminoethyl)-N-methylcarbamate is a linker specifically designed for the synthesis of PROTAC (Proteolysis Targeting Chimeras). By facilitating the recruitment of E3 ligases, this compound enhances the targeted degradation of proteins, making it valuable for research in protein modulation and therapeutic interventions. Its application in PROTAC development supports advancements in drug discovery and cancer therapeutics. -
PROTAC Linker
Benzyl (5-aminopentyl)carbamate is a PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). This compound is integral in designing bifunctional molecules that can induce targeted degradation of specific proteins, offering valuable applications in drug discovery and therapeutic development. Its structural properties enhance the stability and efficacy of PROTAC constructs, making it essential for researchers investigating targeted protein degradation mechanisms. -
PROTAC Linker
tert-Butyl 4-oxobutanoate is a PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). This compound serves as a crucial building block for synthesizing potent bifunctional molecules, enabling targeted protein degradation in various biological contexts. Its applications span drug discovery and chemical biology, making it a valuable reagent for researchers investigating novel therapeutic strategies. -
PROTAC Linker
tert-Butyl 3,3-difluoro-4-((methylsulfonyloxy)methyl)piperidine-1-carboxylate serves as a specialized PROTAC linker, facilitating the development of targeted protein degradation therapeutics. This compound enhances the stability and efficacy of PROTACs by promoting effective ternary complex formation between E3 ligases and target proteins. Its application in chemical biology underscores its importance in novel therapeutic strategies aimed at selectively degrading specific proteins involved in various diseases. -
PROTAC Linker
Tert-butyl 2-(2-aminoethyl)-2,8-diazaspiro[4.5]Decane-8-carboxylate is a versatile PROTAC linker designed to facilitate the development of proteolysis-targeting chimeras (PROTACs). This compound enhances the connectivity between target proteins and E3 ubiquitin ligases, promoting targeted protein degradation. Its unique structure allows for the fine-tuning of PROTAC properties, making it a valuable tool in drug discovery and therapeutic development aimed at modulating protein levels within cellular systems. -
PROTAC Linker
1-Isothiocyanato-PEG3-azide is a versatile PEG-based PROTAC linker that facilitates the synthesis of proteolysis targeting chimeras (PROTACs). This compound features an azide group that enables copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with entities possessing DBCO or BCN groups. Its utility in conjugation chemistry supports various applications in chemical biology and drug development. -
PROTAC Linker
2-(5-Bromopentyl)-1,3-dioxolane serves as a versatile PROTAC linker, enabling the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the modulation of protein degradation pathways, making it a valuable tool for research in targeted protein degradation and therapeutic development. Its unique structure supports the construction of effective PROTACs for various biological targets, advancing studies in cellular regulation and treatment strategies. -
PROTAC Linker
tert-Butyl ((3-oxocyclobutyl)methyl)carbamate serves as a specialized PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs). It plays a crucial role in selective protein degradation strategies, enhancing the efficacy of targeted therapeutic interventions. This compound is instrumental in advancing research in drug discovery and the development of innovative treatment modalities. -
PROTAC Linker
HO-PEG6-CH2COOH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of different protein-targeting moieties, enabling the selective degradation of target proteins through the ubiquitin-proteasome pathway. Its incorporation into PROTACs allows for enhanced solubility and improved cellular uptake, making it a valuable tool in targeted protein degradation research. -
PROTAC Linker
Methyl 4-formylbicyclo[2.2.2]octane-1-carboxylate serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enhances the efficacy of targeted protein degradation by providing a scaffold for the assembly of target proteins and E3 ligase recognition elements. It is an essential reagent for researchers investigating novel therapeutic strategies utilizing the PROTAC technology. -
PROTAC Linker
tert-Butyl 4-(2-((methylsulfonyl)oxy)ethyl)piperidine-1-carboxylate is a PROTAC linker specifically designed for the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, enabling selective degradation of undesirable proteins within cells. Its application is essential in drug discovery and development for addressing therapeutic targets that are challenging to inhibit with conventional small molecules. -
PROTAC Linker
Cis-Methyl 3-aminocyclobutanecarboxylate hydrochloride serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is crucial for creating targeted protein degradation molecules, enhancing the specificity and efficacy of therapeutic agents in biological research. Its role in the synthesis of innovative PROTACs makes it valuable for studies in targeted protein modulation and drug discovery. -
PROTAC Linker
3-(Hydroxyimino)-2,2,4,4-tetramethylcyclobutan-1-one is a versatile PROTAC linker utilized in the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the targeted degradation of specific proteins through the recruitment of E3 ubiquitin ligases. Its unique structure enhances bioconjugation capabilities, making it an essential tool for researchers investigating targeted protein degradation and therapeutic applications in various disease models. -
PROTAC Linkers
Fmoc-NH-PEG3-C2-NH2 is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound enhances the solubility and overall pharmacokinetic properties of PROTACs, facilitating their application in targeted protein degradation research. By incorporating this linker, researchers can develop more effective PROTACs for the modulation of specific protein targets, contributing to advancements in therapeutic strategies. -
Click Chemical
(S,E)-Cyclooct-2-enol is a click chemistry reagent that serves as a versatile linker in the synthesis of PROTAC (Proteolysis Targeting Chimera) molecules. The compound features a TCO (trans-cyclooctene) moiety, which is capable of undergoing an inverse electron demand Diels-Alder reaction (iEDDA) with tetrazine-modified partners. This property is essential for the development of targeted protein degradation strategies in chemical biology research. -
PROTAC Linker
Ethyl 3-(4-bromophenyl)propanoate is a versatile PROTAC linker used in the synthesis of proteolysis-targeting chimeras (PROTACs). It facilitates the selective degradation of target proteins by linking an E3 ligase ligand to a target protein ligand. This compound plays a crucial role in drug development, enabling researchers to explore novel approaches in targeted protein degradation. -
PROTAC Linker
N3-C5-O-C-Boc is a versatile PROTAC linker designed to facilitate the synthesis of targeted protein degraders. It plays a critical role in the development of PROTAC SARS-CoV-2 Mpro degrader-3, enabling precise modulation of protein levels in cell-based systems. This compound is suitable for research applications focusing on protein degradation pathways and therapeutic strategies against viral targets. -
PROTAC Linker
Cbz-NH-PEG5-CH2COOH is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ubiquitin ligases, promoting selective degradation pathways. Its hydrophilic properties enhance solubility and improve pharmacokinetic profiles, making it a valuable tool in targeted protein degradation research and drug development. -
PROTAC Linker
Benzyl 5-Bromopentanoate is a PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). This compound is essential for the conjugation of target proteins to ubiquitin ligases, enabling the degradation of specific proteins within a cellular context. Research applications include the study of targeted protein degradation mechanisms and the design of novel PROTACs for therapeutic interventions. -
PROTAC Linker
Benzyl 4-(4-((Tert-butoxycarbonyl)amino)butyl)piperazine-1-carboxylate functions as a PROTAC linker, facilitating the development of targeted protein degradation therapeutics. This compound is essential in the synthesis of PROTACs, enabling the selective modulation and degradation of specific proteins within cellular systems. Its utilization in research expands the exploration of protein dynamics and therapeutic interventions in various biological contexts.
