NF-κB

Inhibitory Selectivity
Catalog No.Inhibitor Name NF-κBOther
A12748QNZ (EVP4593)
****
TNF-α
A14142JSH-23
**
A14278SC75741
***
A13698Caffeic Acid Phenethyl Ester
A10077Andrographolide
A15046CID-2858522
***
A16301(+)-DHMEQ
A16302(-)-DHMEQ
A16306Pyrrolidinedithiocarbamate ammonium
A10698Parthenolide
p53,MDM2 ubiquitination,HDAC1

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A16301

(+)-DHMEQ

NF-kB inhibitor
The (+)-DHMEQ, the distomer of DHMEQ, is a inhibitor of NF-kB.
A16302

(-)-DHMEQ

NF-kB inhibitor
(-)-DHMEQ, the eutomer of DHMEQ , is a newly developed NF-kB inhibitor, inhibits nuclear factor kB activation with IC50 value of 20 ug/mL, the activity is stronger than (+)-DHMEQ (HY-14645A).
A16303 SALE

Adjudin

-
Adjudin is a drug which is under development as a potential non-hormonal male contraceptive drug, which acts by blocking the production of sperm in the testes, but without affecting testosterone production.
A10077 SALE

Andrographolide

Apoptosis Inducer
Andrographolide is an interesting pharmacophore with anticancer and immunomodulatory activities and hence has the potential for being developed as a cancer therapeutic agent.
A13698 SALE

Caffeic Acid Phenethyl Ester

-
Caffeic acid phenethyl ester is a potent and specific inhibitor of NF-κB activation
A15046

CID-2858522

NF-κB inhibitor
CID-2858522 selectively inhibits the NF-κB pathway (IC50 < 0.1 uM for PMA-stimulated IL-8 production) induced by PKC, operating downstream of PKC but upstream of IKKbeta, without inhibiting other NF-kappaB activation pathways.
A16304

Didox

ribonucleotide reductase inhibitor
Didox is a strong inhibitor of ribonucleotide reductase (RR) that interferes with DNA synthesis and repair by blocking the production of deoxyribonucleotides and has demonstrated antitumor effects for decades.
A13405

HDAC inhibitor

HDAC inhibitor
N/A
A14142 SALE

JSH 23

NF-κB inhibitor
JSH 23 is an inhibitor of NF-??B, blocking its translocation into the nucleus (IC50 = 7.1 ?M)
A10698 SALE

Parthenolide ((-)-Parthenolide)

-
Parthenolide ((-)-Parthenolide) is a sesquiterpene lactone which occurs naturally in the plant feverfew (Tanacetum parthenium).
A16306

Pyrrolidinedithiocarbamate ammonium

NF-kB inhibitor
Pyrrolidinedithiocarbamate ammonium is a selective NF-kB inhibitor, inhibits translation of nitric oxide synthase mRNA to prevent induction.
A12748 SALE

QNZ (EVP4593)

NF-κB inhibitor
QNZ inhibits the activation of the transcription factor NF-κB and has been used to investigate NF-κB signaling.
A14278

SC75741

NF-κB inhibitor
SC75741 is a potent NF-??B inhibitor with EC50 of 200 nM.
A16233

Tomatidine

ERK/Akt/NF-kB inhibitor
Tomatidine inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-kB. possess anti-inflammatory properties.
A15781

UF010

HADC inhibitor
UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 uM, 0.1 uM, 0.5 uM and 1.5 uM for HDACs 3, 2, 1 and 8, respectively. It has > 6-fold selectivity over other HDACs.

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