Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
2-Oleoylglycerol-d5 is a deuterium-labeled derivative of 2-Oleoylglycerol, a known agonist of GPR119. It exhibits significant biological activity by activating human GPR119 with an EC50 of 2.5 μM in COS-7 cells, enhancing macrophage inflammatory responses and promoting fibrosis through the GPR119/TAK1/NF-κB/TGF-β1 signaling cascade. Additionally, this compound stimulates glucagon-like peptide 1 (GLP-1) secretion in vivo. 2-Oleoylglycerol-d5 is particularly useful for studying mechanisms underlying non-alcoholic steatohepatitis (NASH). -
Endogenous Metabolite
9,10-EpOME (9,10-Epoxyoctadecenoic acid) is a cytochrome P450-derived metabolite of linoleic acid. It is known to induce oxidative stress by activating the NF-κB and AP-1 transcription factors and facilitates the chemotaxis of human neutrophils. Additionally, 9,10-EpOME has been shown to induce mechanical and thermal pain in wild-type mice via the PKA pathway. This compound is useful for investigating mechanisms of inflammation and pain in research settings. -
Anti-inflammatory Agent
Anti-inflammatory Agent 58 is a potent inhibitor of IL-1β, demonstrating an IC50 of 1.08 μM. This compound effectively reduces pro-inflammatory gene expression, limits protein secretion, and inhibits NF-κB phosphorylation. It is suitable for research applications focused on inflammatory pathways and the modulation of immune responses. -
Anti-inflammatory Agent
Anti-inflammatory agent 59 is a selective inhibitor of interleukin-1 beta (IL-1β) with an IC50 of 2.28 μM. This compound effectively reduces pro-inflammatory gene expression and protein secretion while inhibiting NF-κB phosphorylation. It serves as a valuable tool in the study of inflammatory pathways and may aid in the development of new therapeutic strategies for inflammatory diseases. -
Anti-inflammatory Agent
Acutissimalignan B is a bioactive compound recognized for its role as an anti-inflammatory agent. It effectively reduces the mRNA expression of key inflammatory cytokines, including inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6). Additionally, Acutissimalignan B inhibits the phosphorylation of IκBα and the nuclear translocation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) p65, thereby demonstrating potential utility in neuroinflammation research and related disease models. -
NF-κB Inhibitor/TRP Modulator
Cannabitwinol is a selective NF-κB inhibitor and thermosensitive TRP modulator. It effectively inhibits TNFα-induced NF-κB-driven transcription and IL-8 release, exhibiting notable anti-inflammatory and antioxidant properties. Cannabitwinol selectively activates cold-activated TRP channels, such as TRPA1 (EC50 = 3.0 μM), while antagonizing TRPM8 (IC50 = 3.9 μM), with minimal interaction with heat-activated TRP channels like TRPV1 and TRPV2. This compound is applicable in research focused on inflammatory skin diseases, cold allodynia, and hyperalgesia. -
Anti-rotavirus Agent
Norkurarinol is a prenylated flavonoid with significant anti-rotavirus properties. Isolated from Sophora flavescens, it effectively inhibits mushroom tyrosinase DOPA oxidase activity, exhibiting an IC50 of 2.1 μM. Norkurarinol also suppresses poly(I:C)-induced NF-κB and AP-1 activation, while decreasing levels of pro-inflammatory cytokines such as TNF-α and IL-6. Furthermore, it inhibits the phosphorylation of key mitogen-activated protein kinases (p38, JNK, and ERK1/2) and promotes IRF3 phosphorylation, highlighting its potential in antiviral and anti-inflammatory research applications. -
Anti-Inflammatory Agent
Anti-inflammatory agent 102 is a selective inhibitor of the ASK1/p38 MAPKs/NF-κB signaling pathway, exerting notable anti-inflammatory effects. It significantly reduces the release of nitric oxide (NO), reactive oxygen species (ROS), and key inflammatory cytokines, including IL-6, TNF-α, and IL-1β. This compound is valuable for research applications focused on inflammatory diseases, particularly ulcerative colitis (UC). -
Anti-rheumatoid Arthritis Agent
Vitedoamine A is a phenylnaphthalene-type lignan alkaloid with a primary mechanism of IKKβ inhibition, exhibiting an IC50 value of 39 μM. It effectively suppresses the transcriptional activity of NF-κB, leading to decreased production of nitric oxide and reduced expression of inflammatory cytokines such as IL-1β, IL-6, and TNF-α. This compound demonstrates significant potential as an anti-rheumatoid arthritis agent, making it valuable for research focused on inflammatory pathways and therapeutic interventions in rheumatic diseases. -
Anti-inflammatory/hepatoprotective Agent
Isostrictiniin is a polyphenolic compound derived from Nymphaea candida, functioning as an anti-inflammatory and hepatoprotective agent. It enhances the expression of Nrf2 and HO-1 while inhibiting Keap1, leading to the reduction of phosphorylation levels of key proteins such as JNK, ERK1/2, p38, IκBα, and NF-κB p65. Isostrictiniin effectively decreases pro-inflammatory cytokines such as IL-1β, IL-6, TNF-α, and PGE2, demonstrating protective effects against acute lung injury induced by LPS and acute alcoholic liver injury. Its multifaceted activities encompass anti-inflammatory, antioxidant, and anti-fibrotic properties, making it a valuable tool in biochemical research. -
STING Activator
c-(2'FdAMP-2'FdIMP) is a cyclic dinucleotide (CDN) that functions as a STING activator. It effectively stimulates STING-dependent signaling pathways, including IRF and NF-κB, leading to enhanced immune responses. This compound is valuable for research into STING-based immunotherapy applications, particularly in the context of cancer and infectious disease studies. -
NF-κB Inhibitor
Bengamide B is a potent inhibitor of NF-κB with an IC50 of 85 nM. This compound effectively reduces LPS-induced expression of pro-inflammatory cytokines, including TNF-α, IL-6, and MCP-1, demonstrating significant anti-inflammatory activity. Additionally, Bengamide B displays antitumor efficacy, with an IC50 of 2 nM against HCT-116 colorectal cancer cells, making it a valuable reagent for research in inflammation and oncology. -
Flavone Glycosides
Quercetagitrin, a flavone glycoside, is derived from the African marigold (Tagetes erecta) and exhibits notable anti-inflammatory properties. It effectively inhibits Tau accumulation, reversing neuroinflammation and cognitive deficits in P301S-Tau transgenic mouse models by suppressing NF-κB activation. Additionally, Quercetagitrin acts as a dual-target inhibitor of PTPN6 (IC50 = 1 μM) and PTPN9 (IC50 = 1.7 μM). This compound enhances glucose uptake in mature C2C12 myoblasts, making it relevant for studies related to Alzheimer’s disease and type 2 diabetes. -
SEAP Inhibitor
Cycloepoxydon is a potent inhibitor of secreted alkaline phosphatase (SEAP) expression, targeting both NF-κB and AP-1 signaling pathways. It effectively reduces PMA-induced SEAP expression with IC50 values ranging from 1-2 μg/mL (4.2-8.4 μM) for NF-κB and 3-5 μg/mL (12.6-21 μM) for AP-1. This compound is valuable for research applications involving inflammation, cancer biology, and signal transduction studies. -
STAT3 Agonist
ML115 is a selective agonist of the signal transducer and activator of transcription 3 (STAT3) with an EC50 of 2 nM. It enhances the expression of BCL3, a STAT3-dependent oncogene, while demonstrating inactivity towards related targets such as STAT1, STAT5, and NF-κB. ML115 has been shown to counterbalance the effects of Ginsenoside Rc on cell viability and inflammatory responses in LPS-stimulated H9c2 and RAW264.7 cells, impacting oxidative stress markers. This compound is valuable for investigating mechanisms in breast and prostate cancer research. -
NF-κB Inhibitor
2,4,5-Trimethoxybenzoic acid is an NF-κB inhibitor with notable anti-inflammatory properties. This compound, derived from purple perilla extracts, effectively inhibits LPS-induced inflammatory responses by blocking the activation of NF-κB and STAT signaling pathways. It has been shown to suppress M1 macrophage phenotype-mediated inflammation, making it a valuable tool for research into diabetes and related inflammatory conditions. -
Anti-inflammation Agent
Thienodolin is an alkaloid with potent anti-inflammatory properties, targeting the inhibition of nitric oxide production in LPS-stimulated RAW 264.7 murine macrophage cells, exhibiting an IC50 value of 17.2 μM. It effectively suppresses inducible nitric oxide synthase (iNOS), prevents IκBα degradation, and reduces NF-κB p65 nuclear translocation while modulating the phosphorylation of STAT1 at Tyr701. Thienodolin serves as a valuable tool for research into inflammatory processes and pathways. -
Anti-inflammatory/antibacterial Agent
Plumericin is an anti-inflammatory and antibacterial agent that primarily targets key signaling pathways involved in inflammation and cellular stress response. It has been shown to reduce apoptosis, activate Nrf-2, and inhibit both NF-κB and AhR activation, while also blocking STAT3 signaling. Plumericin exhibits inhibitory effects on Mycobacterium tuberculosis growth, making it a valuable compound for studying chronic kidney disease, vascular diseases, inflammatory bowel diseases, peritonitis, and tuberculosis. -
CRFR Agonist
Urocortin II, human is a selective agonist of the type-2 corticotropin-releasing factor (CRF2) receptor, exhibiting key biological activities that include promoting satiety and providing neuroprotective effects. This peptide also demonstrates bactericidal and antiparasitic properties, as well as pro-inflammatory activity. Additionally, Urocortin II, human can activate the NF-κB pathway and ERK1/2 MAP kinase, making it relevant for research in pulmonary arterial hypertension and cardiac protection. Its diverse applications extend to studies in infection, inflammation, metabolic disorders, neurological conditions, and cardiovascular diseases. -
Flavones
Flavanone is a naturally occurring flavone that functions as an inhibitor of human estrogen synthetase (aromatase). It targets the ERK/p38/NF-κB signaling pathway, demonstrating potential in mitigating oncogenic processes. Flavanone has shown oral bioactivity and possesses antitumor efficacy, making it a valuable reagent for research in cancer biology and hormone-related studies. -
Anti-inflammatory Agent
Fluorofenidone is an orally active anti-inflammatory agent that exhibits anti-fibrotic and antioxidant properties. It functions by downregulating ACSL4 expression, upregulating GPX4, and inhibiting the NF-κB signaling pathway, thereby alleviating inflammation and fibrosis. In preclinical models, Fluorofenidone has demonstrated efficacy in ameliorating cholestasis and fibrosis by modulating the hepatic Erk/Egr-1 signaling and TGFβ1/Smad pathways. This compound is particularly relevant for research into chronic obstructive pulmonary disease (COPD), pulmonary interstitial fibrosis (PIF), and non-small cell lung cancer (NSCLC). -
Essential Amino Acid
L-Cysteine hydrochloride hydrate is an essential amino acid that serves as a precursor for biologically active molecules, including hydrogen sulfide (H2S), glutathione, and taurine. It modulates the CBS/H2S pathway and has been shown to inhibit NF-κB activation, as well as regulate insulin and ghrelin secretion. This compound is involved in reducing blood glucose levels, vascular inflammation markers, and appetite, while also being noted for its potential to induce kidney damage. Its applications extend to research on neurological diseases and diabetes. -
NF-κB Activator
Isochamaejasmin is a biflavonoid that acts as a potent activator of NF-κB. It exhibits significant anti-cancer properties by inducing apoptosis through the mitochondrial pathway and causing DNA damage in AW1 cells. In addition, Isochamaejasmin demonstrates moderate antiplasmodial activity against P. falciparum with an IC50 of 7.3 μM, while maintaining relatively low cytotoxicity (CC50 of 29.0 μM), making it valuable for various biological research applications. -
Antitumor Agent
SpiD3, a spirocyclic dimer, functions as an antitumor agent with significant inhibitory effects on malignant B-cell proliferation. It suppresses NF-κB activation independently of tumor microenvironment-related stimuli, promoting apoptosis and inhibiting protein synthesis in chronic lymphocytic leukemia (CLL) cells. SpiD3 is suitable for research focused on the mechanisms of CLL and the development of targeted therapies. -
S100P Inhibitor
5-Methyl cromolyn disodium is a selective inhibitor of the S100P protein, targeting its interaction with the receptor for advanced glycation end-products (RAGE). It effectively suppresses NF-κB activity and cell proliferation while enhancing Gemcitabine-induced apoptosis. In preclinical mouse models, 5-Methyl cromolyn disodium demonstrates significant anti-tumor effects by reducing growth and metastasis of pancreatic ductal adenocarcinoma (PDAC), ultimately extending survival. This compound serves as a valuable tool for investigating pancreatic cancer mechanisms and potential therapeutic approaches. -
Xanthonoid Compound
Tovophyllin A is a xanthonoid compound that primarily targets neuroprotection through the activation of the Akt/GSK3β signaling pathway. This compound demonstrates significant neuroprotective effects against Parkinson's disease and induces Nrf2 activation to safeguard against liver injury in mouse models. Additionally, Tovophyllin A exhibits anti-inflammatory properties by inhibiting NF-κB activation and the subsequent release of pro-inflammatory cytokines, while also reducing apoptotic cell death. Its antiplasmodial and cytotoxic activities against lung epithelial and breast cancer cells further establish Tovophyllin A as a valuable reagent for research in diverse applications, including neurodegenerative diseases, liver injury, acute respiratory conditions, and cancer. -
NF-κB Inhibitor
NF-κB-IN-5 is a potent inhibitor of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) that acts by directly interacting with the NF-κB complex. This compound demonstrates significant antitumor activity across multiple human cancer cell lines, including HCT116, U87-MG, HepG2, BGC823, and PC9, with IC50 values ranging from 2.02 to 5.35 μM. NF-κB-IN-5 also promotes apoptosis in U87-MG cells and induces cell cycle arrest in the G0/G1 phase, positioning it as a valuable tool for cancer research and therapeutic development. -
Antitumor
CLEFMA is a curcuminoid known for its antitumor properties. It exhibits significant inhibition of tumor growth, primarily through the modulation of NF-κB pathways, leading to anti-inflammatory and anti-metastatic effects. This compound is utilized in research related to cancer biology and therapeutic development. -
Apoptosi
NF023 is a selective inhibitor of X-BIR1/TAB1 assembly, impacting apoptosis by disrupting XIAP-mediated NF-κB activation. This compound modulates cell survival signaling pathways and demonstrates potential as a P2X1 adenylate receptor antagonist. NF023 may enhance the efficacy of pro-apoptotic therapies, offering a promising avenue for cancer treatment and suppression. -
c-Myc Inhibitor
EP12 is a selective c-Myc inhibitor that stabilizes c-Myc G-quadruplexes. This compound induces apoptosis and causes DNA damage in multiple myeloma cells, effectively inhibiting their growth. Additionally, EP12 disrupts the nuclear translocation of P65/P50 by interfering with the NF-κB signaling pathway, highlighting its potential in cancer research and therapeutic applications. -
Neuroprotective Agent
Tricin 7-O-β-D-glucopyranoside functions as a potent neuroprotective agent, exhibiting significant oral bioavailability. This compound induces apoptosis and effectively reduces the expression levels of TNF-α mediated phospho-IκB-α, phospho-NF-κB, and HMGB1. Its activities make it a valuable reagent for research into neurodegenerative diseases and related biological pathways. -
Antioxidant Agent
Antioxidant agent-5 is a potent antioxidant that targets oxidative stress pathways. It effectively inhibits oxidized low-density lipoprotein (oxLDL)-induced apoptosis and the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in vascular endothelial cells. This compound suppresses oxLDL-mediated reactive oxygen species (ROS) production and nuclear translocation of NF-κB, providing protective effects against oxLDL-induced endothelial injury through the activation of the Nrf2/HO-1 antioxidant pathway. Research applications include studies on cardiovascular health and endothelial function. -
IRAK4 Inhibitor
Emavusertib phosphate is a potent inhibitor of IRAK4, exhibiting an IC50 of 57 nM. This compound effectively disrupts NF-κB and MyD88 signaling pathways, leading to a significant reduction in pro-inflammatory cytokines such as IL-6 and IL-10. Emavusertib phosphate demonstrates both anti-inflammatory and anti-proliferative effects on cancer cells, promoting apoptosis and showcasing antitumor activity in preclinical mouse models. Its applications extend to investigating inflammatory diseases and cancer therapies. -
Stable Isotope
N-Oxide Lidocaine-d10 is a deuterium-labeled derivative of Lidocaine, which primarily targets voltage-gated sodium channels, inhibiting their activity in a complex, use-dependent manner. This compound exhibits significant biological activity, notably reducing the growth, migration, and invasion of gastric carcinoma cells by up-regulating miR-145 expression and subsequently inactivating the MEK/ERK and NF-κB signaling pathways. N-Oxide Lidocaine-d10 is valuable for research into ventricular arrhythmias and related cardiac applications. -
IRAK4 Inhibitor
Emavusertib maleate is a potent inhibitor of IRAK4, demonstrating an IC50 of 57 nM, and FLT3. This orally bioavailable compound inhibits NF-κB and MyD88 signaling pathways, effectively reducing the production of pro-inflammatory cytokines such as IL-6 and IL-10. Its anti-inflammatory and anti-proliferative properties make it a valuable tool for cancer research, promoting apoptosis in cancer cells and demonstrating antitumor activity in preclinical mouse models. -
Stable Isotope
Sodium propionate-13C-1 is a stable isotope-labeled derivative of sodium propionate, functioning primarily as a short-chain fatty acid. It is synthesized by intestinal bacteria through dietary fiber metabolism and exhibits multiple biological activities, including increased PPAR-γ expression and inhibition of NF-κB activation, COX-2 expression, and NO production. Additionally, sodium propionate induces apoptosis and autophagy while demonstrating neuroprotective, antioxidant, and anti-inflammatory properties. Its applications span various research areas, including spinal cord injury, Alzheimer's disease, and glioblastoma, presenting potential avenues for therapeutic exploration. -
NF-κB Inhibitor
Amorfrutin A is an NF-κB inhibitor that inhibits TNF-α-induced IκBα degradation, p65 nuclear translocation, and DNA-binding activity of the NF-κB complex. This compound promotes apoptosis in HeLa cells by enhancing the proteolytic activities of caspase-3 and PARP. Its mechanism suggests potential research applications in studying inflammation, cancer biology, and cell death pathways. -
IRAK4 Inhibitor
Emavusertib tosylate is a potent inhibitor of IRAK4, displaying an IC50 of 57 nM. By targeting IRAK4 and FLT3, it effectively disrupts NF-κB and MyD88 signaling pathways, resulting in the reduction of pro-inflammatory cytokines such as IL-6 and IL-10. This compound demonstrates significant anti-inflammatory and anti-proliferative properties against cancer cells, promoting apoptotic mechanisms. Additionally, Emavusertib tosylate has shown noteworthy antitumor activity in preclinical mouse models, making it a valuable reagent for cancer research and inflammation studies. -
TAK1 Inhibitor
Triptriolide is a TAK1 inhibitor that plays a pivotal role in regulating apoptosis in mouse podocytes. It enhances cell survival and protects podocyte function by modulating the Bcl-2 family proteins and inhibiting Caspase-3 activity. Additionally, Triptriolide activates the TAK1-NF-κB signaling pathway, leading to the upregulation of podocin. This reagent is relevant for studies focusing on kidney health and podocyte resilience under stress conditions. -
Stable Isotope
Lidocaine-d6 is a deuterated form of Lidocaine, serving as a stable isotope for metabolic studies and analytical applications. Lidocaine primarily targets sodium channels, exhibiting voltage-dependent inhibition. In cancer research, it has been shown to reduce growth, migration, and invasion of gastric carcinoma cells by up-regulating miR-145, which leads to the inactivation of the MEK/ERK and NF-κB signaling pathways. This compound is also relevant for studies on ventricular arrhythmias, providing insights into cardiac electrophysiology. -
Stable Isotope
Carbocisteine-13C3-1 is a stable isotope-labeled derivative of Carbocisteine, primarily targeting mucolytic activity. This compound is known to inhibit the phosphorylation of NF-κB p65 and ERK1/2, modulating the interplay between Nrf2 and HO-1. Additionally, Carbocisteine exhibits apoptotic inhibition properties. It is widely employed in research related to chronic obstructive pulmonary disease (COPD) and other respiratory conditions. -
Antimalarial
Quinacrine methanesulfonate is a potent orally active antimalarial compound that also exhibits antitumor properties. This reagent functions through the inhibition of NF-κB signaling and the activation of p53 pathways, leading to apoptosis in cancer cells. Its dual activity makes it valuable for studying both malaria pathogenesis and cancer biology. -
Stable Isotope
Propanoic acid-13C3 is a stable isotope-labeled derivative of propanoic acid, targeting metabolic pathways involving short-chain fatty acids. This compound demonstrates significant biological activity by enhancing PPAR-γ expression, inhibiting NF-κB activation, and downregulating COX-2 and nitric oxide production. Additionally, propanoic acid-13C3 has been shown to induce apoptosis and autophagy, display neuroprotective effects, and exhibit anti-inflammatory properties. Its applications extend to research in spinal cord injury, Alzheimer's disease, and glioblastoma therapy, making it a valuable tool for metabolic and neurological studies. -
IRAK4 Inhibitor
Emavusertib mesylate is a potent inhibitor of IRAK4, demonstrating an IC50 of 57 nM. This orally active compound effectively disrupts the NF-κB and MyD88 signaling pathways, leading to a reduction in pro-inflammatory cytokines such as IL-6 and IL-10. Emavusertib mesylate displays anti-inflammatory and anti-proliferative properties against cancer cells, promoting apoptosis. Additionally, it has shown significant antitumor activity in mouse models, making it valuable for cancer research and therapeutic studies targeting inflammatory pathways. -
Biochemical Assay Reagent
Chitin, derived from crab carapace, is a long-chain polymer of N-acetylglucosamine featuring β-(1-4) linkages. This biopolymer serves as a biochemical assay reagent and is noted for its ability to inhibit the activation of NF-κB p65, as well as alter its translocation to the nucleus. Chitin also interacts with the cell wall of Candida species, exhibiting antifungal and anti-inflammatory properties. It is valuable for research into gastric ulcers and candidiasis, contributing to the understanding of related pathophysiological processes. -
RelA/p65 Ligand
MMH-165-26 is a ligand targeting RelA/p65, playing a crucial role in modulating nuclear factor kappa B (NF-κB) signaling. This compound significantly reduces the expression levels of RelA/p65 and exhibits notable cytotoxicity in MEC-1 cells, with an LC50 of 0.37 μM. MMH-165-26 is a valuable tool for the development of proteolysis-targeting chimeras (PROTACs), such as JP-163-16, enhancing its utility in cancer research and therapeutic applications. -
Stable Isotope
Lidocaine-d6 hydrochloride is a deuterium-labeled derivative of Lidocaine, primarily targeting voltage-gated sodium channels. It exhibits significant biological activity by inhibiting the growth, migration, and invasion of gastric carcinoma cells through the up-regulation of miR-145 and the subsequent inactivation of the MEK/ERK and NF-κB signaling pathways. This reagent is vital for research in electrophysiological studies and cancer biology, particularly in investigating sodium channel modulation and tumorigenesis mechanisms. -
NF-κB/MAPK/FAK/Akt Inhibitor
Ephemeranthol A is an inhibitor of NF-κB, MAPK, FAK, and Akt signaling pathways. This phenanthrene compound demonstrates notable anti-inflammatory effects through the inhibition of NF-κB and MAPK pathways in macrophages. Additionally, Ephemeranthol A induces apoptosis and inhibits metastasis in non-small cell lung cancer by suppressing FAK/Akt signaling and epithelial-mesenchymal transition (EMT) processes. It is applicable for research into acute and chronic inflammatory diseases as well as non-small cell lung cancer. -
Anticancer Peptide
CIGB-552 is a cell-penetrating peptide that targets tumor cells to exert anti-cancer effects, demonstrating an IC50 of 23 μM in H460 lung cancer cells. This peptide enhances the expression of the protein COMMD1 and significantly inhibits the NF-κB signaling pathway, leading to increased apoptosis in tumor cells. Additionally, CIGB-552 induces the accumulation of reactive oxygen species (ROS) and exhibits both anti-inflammatory and anti-angiogenic properties. It is particularly relevant for research into lung and colon cancers. -
Nitric oxide and hydrogen sulfide-releasing hybrid molecules
NOSH-aspirin (NBS-1120) is a hybrid molecule designed to release both nitric oxide and hydrogen sulfide. This compound demonstrates potent inhibition of pancreatic cancer cell proliferation and induces apoptosis, making it a valuable tool in cancer research. Additionally, NOSH-aspirin has been shown to suppress NF-κB and FoxM1 activity in mouse models of pancreatic cancer. Its neuroprotective effects are evident in rat models of Parkinson's disease, where it alleviates motor deficits and reduces neuroinflammation associated with microglial and astrocytic activation. NOSH-aspirin is suitable for studies involving pancreatic cancer and neurodegenerative disorders.
