Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Acenocoumarol-d4 is a deuterated form of Acenocoumarol, functioning primarily as a stable isotope. As an anticoagulant, it operates through Vitamin K antagonism, effectively inhibiting the MAPK/ERK/JNK signaling pathways. This compound has been shown to reduce the nuclear translocation of NF-κB p65 and activate the Akt/GSK3β signaling pathways. Furthermore, Acenocoumarol-d4 induces apoptosis in A549 cells and specifically arrests the cell cycle at the S phase, making it valuable for research in cancer biology and pharmacology. -
PLA₂ Inhibitor
MJ33 is a competitive inhibitor of phospholipase A₂ (PLA₂), specifically effective in inhibiting acidic PLA₂ activity. By blocking the PLA₂ activity of Prdx6, MJ33 significantly reduces reactive oxygen species (ROS) production, thereby alleviating lung oxidative damage associated with ischemia-reperfusion injury. Additionally, MJ33 suppresses the invasive, migratory, and adhesive characteristics of prostate cancer cells through the downregulation of key signaling pathways, including MAPK, AKT, NF-κB, and AP-1. This reagent is ideal for research focused on ROS-related diseases and prostate cancer dynamics. -
TLR2 Agonist
Pam2CSK4 is a TLR2 agonist that activates immune signaling pathways, leading to the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) in macrophage cell lines through TBK1 and MyD88. This compound stimulates the NF-κB and Bruton's tyrosine kinase pathways in platelets, enhancing interactions between platelets and endothelial cells. Pam2CSK4 promotes the expansion of myeloid-derived suppressor cells (MDSCs) and can suppress anti-tumor immune responses in the tumor microenvironment. Its applications span various diseases, including thromboinflammatory conditions, sepsis, atherosclerosis, and certain cancers, making it a valuable tool in immunological and therapeutic research. -
Osteoclastogenesis Inhibitor
Eudebeiolide B is an osteoclastogenesis inhibitor derived from Salvia plebeia R. Br. It functions by modulating RANKL-induced signaling pathways, including NF-κB, c-Fos, and calcium signaling. This compound is valuable for research into osteoclast-related diseases, providing insight into potential therapeutic strategies for bone resorption disorders. -
Apoptosis Inducer
Licoricidin (LCD) is a potent apoptosis inducer derived from Glycyrrhiza uralensis Fisch, demonstrating significant anti-cancer properties. It effectively inhibits SW480 colorectal cancer cells with an IC50 of 7.2 μM by promoting cell cycle arrest, apoptosis, and autophagy, making it a promising candidate for chemoprevention and chemotherapy. Additionally, Licoricidin suppresses lung metastasis through the inhibition of tumor angiogenesis and lymphangiogenesis, while improving the tumor microenvironment. In osteosarcoma models, Licoricidin enhances the cytotoxic effects of gemcitabine by inactivating the Akt and NF-κB signaling pathways. Furthermore, Licoricidin alleviates UVA-induced photoaging by scavenging reactive oxygen species and inhibiting MMP-1 activity, indicating its potential in topical anti-aging formulations. -
COX-2 Inhibitor
Withangulatin A is a selective inhibitor of cyclooxygenase-2 (COX-2), demonstrating significant potential in the modulation of inflammatory and tumorigenic processes. This compound also interferes with the MAPK, NF-κB, and Akt/mTOR/p70S6K signaling pathways, thereby exhibiting notable antitumor and anti-inflammatory activities. Additionally, Withangulatin A has been shown to possess trypanocidal effects, making it useful for research in cancer, inflammation, and parasitic diseases. -
Triterpenoids Compound
Lupenone is a lupine-type triterpenoid that operates primarily through the PI3K/Akt/mTOR and NF-κB signaling pathways. It exhibits significant biological activities, including anti-inflammatory, antiviral, antidiabetic, and anticancer properties. This compound is valuable in research related to inflammation, viral infections, diabetes, and cancer therapeutics. -
Osteoclastogenesis Inhibitor
Niloticin is a tetracyclic triterpenoid that serves as an osteoclastogenesis inhibitor. It exhibits significant anti-viral, antioxidative, and mosquitocidal properties. By obstructing the RANKL-RANK interaction, Niloticin effectively suppresses the activation of key signaling pathways, including AKT, MAPK, and NF-κB, which are crucial in osteoclast differentiation and function. This compound is valuable for research focused on bone metabolism and related disorders. -
Antiinflammatory Agent
Ethyl linoleate, an unsaturated fatty acid derivative, acts as an anti-inflammatory agent by inhibiting the Akt/GSK3β/β-catenin signaling pathway and blocking NF-κB activation. Additionally, it induces heme oxygenase-1 and inhibits tyrosinase, contributing to its whitening and anti-inflammatory properties. Ethyl linoleate promotes absorption of compounds and has notable implications for atherosclerosis research. Its applications extend to the study of various inflammatory diseases and cosmetic formulations. -
NF-κB Inhibitor
3,4,5-Tricaffeoylquinic acid is an NF-κB inhibitor known for its ability to suppress tumor necrosis factor-α-induced inflammatory mediators in keratinocytes through the inhibition of Akt and NF-κB signaling pathways. This compound also induces cell cycle arrest at the G0/G1 phase, facilitates actin cytoskeleton organization, and promotes chromatin remodeling and neuronal differentiation in human neural stem cells. Additionally, 3,4,5-Tricaffeoylquinic acid is valuable for research into aging-associated diseases. -
Anti-inflammatory Reagent
Syringaresinol is a lignan-type phytochemical that primarily targets anti-inflammatory pathways. It effectively inhibits the NF-κB and AKT signaling pathways in IL-1β-activated mouse chondrocytes, demonstrating significant anti-inflammatory activity. Additionally, Syringaresinol enhances the phosphorylation of AMPK and eNOS while increasing intracellular Ca2+ levels in HUVECs. Its ability to attenuate the progression of osteoarthritis in mouse models of DMM-induced osteoarthritis makes it a valuable reagent for research focused on OA. -
p38 MAPK Inhibitor
Licochalcone E is a flavonoid compound that functions as a p38 MAPK inhibitor. It effectively inhibits the transcriptional activities of NF-κB and AP-1 by disrupting AKT and MAPK activation pathways. This compound is valuable for research focused on inflammation, cancer, and signal transduction pathways, offering insights into cellular mechanisms influenced by MAPK signaling. -
Antitumor Agent
7-Methoxy-1-tetralone is an effective antitumor agent that targets cancer cell proliferation and migration. This compound induces apoptosis in hepatocellular carcinoma (HCC) cells and reduces the protein levels of NF-κB, MMP2, MMP9, and phosphorylated AKT. In vivo studies demonstrate its antitumor efficacy in nude mice, with no observed adverse effects on body weight or organ indices. -
HKv1.5 Current Blocker
Oxypeucedanin is a furanocoumarin derivative that acts as a potent blocker of the hKv1.5 current, with an IC50 of 76 nM. This compound demonstrates significant biological activities, including the induction of cell cycle arrest and apoptosis, as well as acting as a PI3K/AKT/NF-κB, MAPK, and ROS inhibitor. Its diverse applications include anticancer research, anti-inflammatory studies, antioxidant assays, and investigations into antiarrhythmic effects, making it a valuable reagent for various areas of biochemical research. -
Dopamine β-hydroxylase Inhibitor
Fusaric acid is a potent dopamine β-hydroxylase inhibitor that reduces endogenous levels of norepinephrine and epinephrine in various tissues, including the brain, heart, spleen, and adrenal glands. By inducing oxidative stress and apoptosis, fusaric acid disrupts mitochondrial integrity and activates key apoptosis-related proteases such as Caspase-3/7, -8, and -9. Additionally, fusaric acid regulates pivotal apoptotic proteins, inhibits fibrosis-related signaling pathways including NF-κB and TGF-β1/SMADs, and mitigates collagen deposition. Its applications extend to myocardial fibrosis and cardiac hypertrophy research, as well as studies on esophageal and liver cancers. -
Bacterial Inhibitor
Bavachalcone is a bacterial inhibitor known for its multifaceted biological activities. It induces apoptosis and enhances autophagy in HepG2 cancer cells, contributing to its anticancer potential. Additionally, Bavachalcone demonstrates anti-neuroinflammatory and antidepressant effects through modulation of the NF-κB pathway. It also inhibits osteoclast differentiation by interfering with ERK and Akt signaling pathways, as well as the expression of c-Fos and NFATc1, and shows a significant inhibitory effect on BACE-1 activity in vitro. -
HBV Inhibitor
Isoscopoletin, also known as 6-Hydroxy-7-methoxycoumarin, primarily inhibits hepatitis B virus (HBV) replication. It demonstrates significant cytotoxic effects against human CCRF-CEM leukaemia cells and their multidrug-resistant subline, with IC50 values of 4.0 μM and 1.6 μM, respectively. Additionally, Isoscopoletin exhibits anti-inflammatory properties by modulating the MAPK/NF-κB/STAT/AKT signaling pathways, making it a valuable compound for research in virology and cancer biology. -
Anticancer/Anti-inflammatory/Anti-diabetic Agent
Phellopterin is a furocoumarin compound recognized for its anticancer, anti-inflammatory, and anti-diabetic activities. It functions as a partial agonist of central benzodiazepine receptors and demonstrates significant anti-inflammatory properties by modulating key pathways such as SIRT1 and TLR4/NF-κB, which may aid in conditions like chronic inflammation and atopic dermatitis. Additionally, Phellopterin has been shown to inhibit ovarian cancer progression through the PU.1/CLEC5A/PI3K-AKT signaling loop and promotes adipocyte differentiation, contributing to its anti-diabetic effects. This compound is valuable for research in cancer, inflammation, diabetes management, and antiviral studies. -
AChE Inhibitor
MR2938 is a potent acetylcholinesterase (AChE) inhibitor, exhibiting an IC50 of 5.04 μM. In addition to its enzymatic activity, MR2938 significantly reduces nitric oxide production, with an IC50 of 3.29 μM. This compound effectively mitigates neuroinflammation by inhibiting the MAPK/JNK and NF-κB signaling pathways. MR2938 is applicable for research focused on Alzheimer's disease and related neurodegenerative conditions. -
PDE Inhibitor
Theophylline L-lysine is a soluble derivative of Theophylline that primarily acts as a phosphodiesterase (PDE) inhibitor. It effectively inhibits PDE3 activity, which leads to relaxation of airway smooth muscle and exhibits anti-inflammatory properties through the enhancement of IL-10 levels and the inhibition of NF-κB nuclear translocation. Additionally, Theophylline L-lysine induces apoptosis, making it a valuable compound for research applications in asthma and chronic obstructive pulmonary disease (COPD). -
DOR Agonist
DOR Agonist 2 is a selective agonist of the Delta Opioid Receptor (DOR). It demonstrates the ability to inhibit TNF-α expression, prevent NF-κB translocation to the nucleus, and activate the G protein-mediated ERK1/2 signaling pathway. This compound is valuable in research focused on neurodegenerative diseases, facilitating studies on inflammation and neuroprotection mechanisms. -
AMPK Activator
Candidusin A is a potent AMPK activator with a KD of 47.28 nM, isolated from the marine fungus Aspergillus candidus. This compound demonstrates significant cytotoxicity, inducing apoptosis in human prostate cancer cell lines such as 22Rv1, PC-3, and LNCaP. Additionally, Candidusin A reduces the expression of adipogenesis-related genes and fat deposition, while negatively regulating the NF-κB-TNFα inflammatory axis to mitigate inflammation. Its diverse biological activities make Candidusin A a valuable tool for research into non-alcoholic steatohepatitis (NASH) and liver injury. -
SHP2 Inhibitor
SHP2-IN-45 is a highly selective allosteric inhibitor of SHP2 with potent oral bioavailability. This compound effectively downregulates the expression of pro-inflammatory cytokines, including IL-6, TNF-α, IL-1β, and iNOS, and inhibits the polarization of M1-type macrophages. Additionally, SHP2-IN-45 interferes with the NF-κB signaling pathway, making it a valuable tool for research in inflammation-related conditions such as sepsis and acute lung injury. -
ERα PRRTAC Degrader
GNE-5472 is a potent bifunctional degrader targeting estrogen receptor alpha (ERα) through the PRRTAC mechanism. By functioning as a pan-IAP antagonist, GNE-5472 inhibits cIAP1/2, thereby activating the non-classical NF-κB pathway, which leads to significant upregulation of TNFα expression. This compound effectively inhibits the proliferation of breast cancer cells and promotes apoptosis. GNE-5472 is valuable for research applications in the study of breast cancer and related signaling pathways. -
NF-κB Inhibitor
CKD-712 is a tetrahydroisoquinoline derivative that functions as a potent NF-κB inhibitor. This compound selectively inhibits MMP-9 while leaving MMP-2 unaffected and downregulates the expression of key inflammatory and cell cycle proteins such as TNF-α, IL-6, cyclin A, cyclin B, and CDK-1. By blocking NF-κB activation and its translocation to the nucleus, CKD-712 reduces levels of inflammatory factors and pro-tumor proteins, leading to G2/M phase arrest in cancer cells and inhibiting cell invasion. It is suitable for investigating sepsis, myocardial ischemia-reperfusion injury, and non-small cell lung cancer. -
Wnt/β-catenin/NF-κB/AP-1 Inhibitor
Chikusetsusaponin IVa methyl ester is a natural triterpenoid saponin that functions as a Wnt/β-catenin, NF-κB, and AP-1 inhibitor. It induces G0/G1 cell cycle arrest and apoptosis in colon cancer cells through the inhibition of the Wnt/β-catenin signaling pathway. Additionally, this compound significantly decreases the production of nitric oxide, prostaglandin E₂, and pro-inflammatory cytokines, while downregulating iNOS and COX-2 levels. Chikusetsusaponin IVa methyl ester is valuable for research focused on colorectal cancer and inflammatory processes. -
Stable Isotope
Theophylline-d3 is a deuterated form of theophylline, primarily used as a stable isotope in research applications. Theophylline functions as a potent phosphodiesterase inhibitor and adenosine receptor antagonist, contributing to its ability to relax airway smooth muscle. Additionally, it demonstrates anti-inflammatory effects by enhancing IL-10 production and inhibiting NF-κB nuclear translocation. This compound is valuable for studying asthma and chronic obstructive pulmonary disease (COPD) mechanisms and therapies. -
Anti-inflammatory Agent
Anti-inflammatory Agent 55 is a derivative of Coixol that primarily inhibits the NF-κB signaling pathway. It effectively reduces the expression of pro-inflammatory markers such as iNOS, TNF-α, IL-6, and IL-1β. This compound significantly decreases LPS-induced nitric oxide (NO) production in RAW264.7 macrophages with an IC50 value of 0.8 μM and demonstrates noteworthy in vivo anti-inflammatory effects in a mouse auricular edema model, making it a valuable tool for research in inflammation and immune responses. -
Alkylbenzene Phthalein
Cnidilide is a natural product of alkylphthalein that primarily targets the inhibition of pro-inflammatory pathways. It significantly reduces the production of nitric oxide (NO) and prostaglandin E2 (PGE2) by downregulating the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in response to lipopolysaccharide (LPS) stimulation. Additionally, Cnidilide suppresses the production of pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α. This compound specifically inhibits the phosphorylation of p38 MAPK and JNK, thereby blocking the signaling pathways mediated by AP-1 and NF-κB, making it a valuable tool for researching inflammation-related conditions. -
Stable Isotope
Undecane-d24 is a deuterium-labeled derivative of undecane that serves as a stable isotope for tracer studies. As a potent cAMP agonist, undecane exhibits significant anti-allergic and anti-inflammatory effects by inhibiting degranulation and the release of histamine and TNF-α. It effectively reverses elevated p38 phosphorylation and NF-κB activity, regulating the expression of key cytokines and chemokines, including TARC, MDC, and IL-8. This compound is valuable for research into skin inflammatory conditions, such as atopic dermatitis. -
PPARγ Activator
12-Nitrolinoleate is a potent peroxisome proliferator-activated receptor γ (PPARγ) activator derived from linoleic acid through nitration. It effectively induces PPARγ-dependent gene expression in MCF-7 cells, demonstrating an EC50 of 0.045 μM. Additionally, 12-Nitrolinoleate exhibits anti-inflammatory properties by inhibiting NF-κB transcription in RAW 264.7 cells, along with reducing levels of pro-inflammatory cytokines such as IL-6, TNF-α, and CCL2 in response to LPS stimulation. This compound is valuable for research applications focused on metabolic regulation and inflammation. -
Anti-inflammatory Agent
Lucidone is an anti-inflammatory agent derived from the fruit of Lindera erythrocarpa Makino. It effectively inhibits lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production in RAW 264.7 mouse macrophages, while also reducing tumor necrosis factor-alpha (TNF-α) secretion and the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Additionally, Lucidone prevents the translocation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and inhibits signaling pathways mediated by c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38MAPK). It also exhibits inhibitory activity against the Dengue virus (DENV), with an EC50 value of 25 μM. -
Anti-inflammatory Agent
Anti-inflammatory agent 54, a derivative of Coixol, targets the NF-κB signaling pathway to exert its anti-inflammatory effects. This compound effectively downregulates pro-inflammatory mediators including iNOS, TNF-α, IL-6, and IL-1β. Notably, anti-inflammatory agent 54 inhibits lipopolysaccharide (LPS)-induced nitric oxide production in RAW264.7 macrophages with an IC50 of 2.4 μM and demonstrates significant in vivo anti-inflammatory activity in a mouse model of auricular edema. -
NF-κB Inhibitor
N,N-Diethylacetamide is an NF-κB inhibitor that exhibits significant anti-inflammatory activity. By inhibiting the NF-κB pathway, it effectively suppresses the expression of nitric oxide (NO) and inducible nitric oxide synthase (iNOS), as well as downregulating pro-inflammatory cytokines such as TNF-α and IL-6, all while leaving the MAPK pathway unaffected. This compound is valuable in research studies focused on inflammatory responses associated with conditions such as preterm birth. -
Stable Isotope
Theophylline-13C2,d6 is a stable isotope-labeled form of Theophylline (1,3-Dimethylxanthine), primarily acting as a phosphodiesterase (PDE) inhibitor and adenosine receptor antagonist. This reagent enhances anti-inflammatory responses by increasing IL-10 levels and inhibiting NF-κB nuclear translocation, while also promoting apoptosis. It serves as a valuable tool for research into airway smooth muscle relaxation and the treatment of respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD). -
Antioxidant/Anti-inflammatory/Anti-fibrotic Agent
7-O-Galloyl-D-sedoheptulose is a polyphenolic compound recognized for its antioxidant, anti-inflammatory, and anti-fibrotic properties. It lowers serum levels of glucose, leptin, insulin, and pro-inflammatory cytokines such as TNF-α and IL-6, while increasing adiponectin levels. This compound effectively reduces reactive oxygen species (ROS) and lipid peroxidation by inhibiting the expression of NADPH oxidase components. Additionally, it down-regulates NF-κB signaling and relevant fibrotic markers, highlighting its potential applications in studying type 2 diabetes and associated complications in hepatic and pancreatic tissues. -
Triptolide Derivative
Omtriptolide sodium is a derivative of triptolide that acts primarily as an immunosuppressive and anti-inflammatory agent. Its mechanism includes inhibition of T cell activation and proliferation, induction of T cell apoptosis, and suppression of pro-inflammatory cytokines such as IL-2, IFN-γ, and TNF-α through targeting transcription factors like NF-κB. This compound is valuable for research applications focusing on obstructive airway diseases, pulmonary fibrosis, and graft-versus-host disease. -
ADAM17 (TACE) Inhibitor
BMS-561392 is a selective inhibitor of ADAM17 (TACE), effectively modulating the secretion of TNF-α through the regulation of key signaling pathways, including p44 MAPK and NF-κB. This compound has been shown to influence the survival of central nervous system cells, such as oligodendrocytes and microglia, by promoting microglial apoptosis and exacerbating astrogliosis in mouse spinal cord injury models. BMS-561392 is valuable for research applications focused on spinal cord injury and inflammatory diseases. -
PDE Inhibitor
Theophylline sodium glycinate is a potent phosphodiesterase (PDE) inhibitor with significant effects on airway smooth muscle relaxation. It acts primarily by inhibiting PDE3, which contributes to its anti-inflammatory properties through the upregulation of IL-10 and the inhibition of NF-κB translocation into the nucleus. Additionally, Theophylline sodium glycinate has been shown to induce apoptosis. This reagent is valuable for research applications related to asthma and chronic obstructive pulmonary disease (COPD). -
Anti-inflammatory/Anti-tumor/Anti-mite Agent
2′-Hydroxy-5′-methoxyacetophenone is an acetophenone derivative that modulates inflammatory responses primarily through inhibition of the NF-κB signaling pathway. This compound demonstrates significant anti-tumor properties, particularly against ovarian cancer, and exhibits acaricidal activity. Additionally, it effectively inhibits enzymes such as α-amylase, collagenase, and aldose reductase with IC50 values of 0.928 μM, 3.264 μM, and 20.046 μM, respectively, indicating its potential in diabetes research. -
PTEN/NF-κB Inhibitor
Coelonin is a dihydrophenanthrene that functions as a potent PTEN and NF-κB inhibitor. It demonstrates significant anti-inflammatory activity by inhibiting LPS-induced PTEN phosphorylation. Coelonin negatively regulates the PI3K/AKT pathway, leading to decreased NF-κB activation and p27Kip1 degradation. Additionally, it promotes the stabilization of IκBα by inhibiting its phosphorylation and degradation, thereby increasing its expression. This compound is valuable for research applications focused on inflammation and related signaling pathways. -
Anti-inflammatory Analgesic/Anti-tumor/Diuretic Agent
Hecogenin acetate is an orally active steroid saponin aglycone that functions primarily as an anti-inflammatory and analgesic agent. It exerts its biological effects by inhibiting the phosphorylation of NF-κB and p38 MAPK signaling pathways, antagonizing TRPA1/TRPM8 channels, and reducing the production of pro-inflammatory cytokines. Additionally, Hecogenin acetate demonstrates neuroprotective and anti-tumor properties, inhibits reactive oxygen species (ROS) production, and downregulates MMP-2 expression. This compound also enhances gastric mucosal defense and promotes ulcer healing while potentially restoring antibiotic sensitivity when used in combination with specific antibiotics. -
IRAK4 PROTAC Degrader
FIP22 is a potent and selective degrader of IRAK4 utilizing the PROTAC technology. It functions by inducing degradation through the formation of a ternary complex consisting of IRAK4, FIP22, and CRBN, with an EC50 of 12.63 nM. This mechanism effectively inhibits IRAK4-mediated signaling pathways, including NF-κB and MAPK pathways, making FIP22 valuable for research into conditions such as atopic dermatitis, where IRAK4 plays a critical role. -
Stable Isotope
1,4-Naphthoquinone-d6 is the deuterated form of 1,4-Naphthoquinone, a potent inhibitor targeting multiple enzymes including DNA polymerases, NF-κB, and monoamine oxidases (MAO-A/B). It exhibits broad-spectrum biological activity, demonstrating antibacterial properties, anti-biofilm effects, and the ability to inhibit tumor cell proliferation, induce apoptosis, and promote necrosis. Additionally, 1,4-Naphthoquinone-d6 has applications in research focused on anti-tumor and anti-inflammatory mechanisms, particularly in melanoma and colon cancer cell studies, as well as LPS-induced inflammation models. Its role in oxidative stress induction and glutathione depletion further supports its potential in diverse therapeutic investigations. -
Mulberroside A Cis-isomer
cis-Mulberroside A is the cis-isomer of Mulberroside A, a principal bioactive compound found in mulberry (Morus alba L.). This compound exhibits anti-inflammatory activity by downregulating the expression of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6, while also inhibiting NALP3 activation, caspase-1, and NF-κB pathways, alongside the phosphorylation of ERK, JNK, and p38. Additionally, cis-Mulberroside A demonstrates inhibitory activity against mushroom tyrosinase with an IC50 value of 53.6 μM, making it valuable for research in inflammation and pigmentation disorders. -
CD40 Inhibitor
KGYY15 is a CD40-targeting peptide that specifically functions as a CD40 inhibitor, exhibiting a weak inhibition of the CD40-CD40L interaction with an IC50 of over 1 mM. At a concentration of 100 μM, KGYY15 can activate the NF-κB pathway by approximately 33%. This compound is valuable for research applications aimed at understanding the modulation of immune responses and investigating the role of CD40 signaling in various biological contexts. -
Apoptosis Inducer
Crebanine is an isoquinoline-like alkaloid that acts as an apoptosis inducer through antagonism of the α7-nAChR, exhibiting an IC50 value of 19.1 μM. This compound suppresses cancer cell proliferation, migration, and invasion while triggering a reactive oxygen species (ROS) burst that promotes apoptosis. Additionally, Crebanine modulates critical signaling pathways including AKT/FoxO3a, NF-κB, and MAPK, and demonstrates antioxidant properties in microglia by reducing ROS and lipid peroxidation. With applications in studying hepatocellular carcinoma, cerebral ischemia, and Alzheimer's disease, Crebanine may also ameliorate cognitive deficits and ischemia-reperfusion brain damage in rodent models. -
CD40-CD40L Blocker
DRI-C25441 is a potent inhibitor of the CD40-CD40L interaction, demonstrating an IC50 value of 0.36 μM. This compound effectively suppresses immune responses triggered by alloantigens and inhibits CD40L-induced activation of the NF-κB signaling pathway. DRI-C25441 is commonly utilized in research related to immune disorders, making it a valuable tool for elucidating mechanisms of immune regulation. -
Antibiotic
Ceftiofur sodium is an antibiotic that acts as a cell wall synthesis inhibitor by targeting bacterial penicillin-binding proteins (PBPs). It exhibits bactericidal activity through the inhibition of peptidoglycan synthesis, resulting in bacterial cell lysis. Additionally, Ceftiofur sodium has anti-inflammatory properties by inhibiting the activation of NF-κB and MAPKs, which decreases the secretion of pro-inflammatory cytokines including TNF-α, IL-1β, and IL-6. This compound is applicable in research related to antibiotic resistance and inflammatory responses. -
TNF-α Inhibitor
IA-14069 is an orally active inhibitor of tumor necrosis factor-α (TNF-α), directly targeting TNF-α and interfering with TNF-α-mediated signaling pathways, including p-IκBα and NF-κB p65 activities. This compound demonstrates a suppressive effect on Dextran sodium sulfate (DSS)-induced colitis, making it valuable for research into inflammatory conditions. IA-14069 is particularly relevant for studies focused on rheumatoid arthritis (RA) and inflammatory bowel disease (IBD).
