Catalog No.
Product Name
Application
Product Information
Citations
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ACE Inhibitor
Fosfenopril is a potent angiotensin-converting enzyme (ACE) inhibitor. It exhibits anti-inflammatory properties by reducing lipopolysaccharide (LPS)-induced inflammation through the inhibition of TLR4/NF-κB signaling pathways in monocytes. This compound is valuable for research applications focused on cardiovascular diseases, inflammation, and the modulation of the immune response. -
RIPK1 PROTAC Degrader
R1-ICR-5 is a selective RIPK1 PROTAC degrader designed to mediate protein degradation via the VHL pathway. This compound promotes the degradation of RIPK1, subsequently dysregulating TNFR1 and TLR3/4 signaling pathways, enhancing the activity of NF-κB, MAPK, and IFN signaling. Additionally, R1-ICR-5 facilitates RIPK3 activation, leading to necroptosis. This reagent is applicable in research focused on triple-negative breast cancer and skin inflammation. -
Stable Isotope
Tris(2-chloroethyl)phosphate-d12 is a deuterium-labeled derivative of Tris(2-chloroethyl) phosphate, primarily utilized as a stable isotope in biological research. This compound serves as an organic phosphorus flame retardant and plasticizer, exhibiting hepatotoxicity through mechanisms such as increased reactive oxygen species (ROS) production, calcium ion influx, and mitochondrial membrane potential reduction. Additionally, it influences the TLR4/NF-κB signaling pathway, leading to liver inflammation and the development of obesity and fatty liver in experimental models. Tris(2-chloroethyl)phosphate-d12 is integral for studies focused on metabolic disorders and toxicity assessments. -
cAMP Agonist
Undecane is a potent cAMP agonist known for its anti-allergic and anti-inflammatory properties. It effectively inhibits degranulation and the release of key inflammatory mediators such as histamine and TNF-α. Additionally, undecane reverses the phosphorylation of p38, modulates NF-κB transcriptional activity, and targets cytokine and chemokine gene expression, including TARC, MDC, and IL-8. This compound is valuable for investigations into skin inflammatory disorders, particularly atopic dermatitis. -
PDE Inhibitor
Theophylline monohydrate is a potent phosphodiesterase (PDE) inhibitor that primarily targets PDE3, promoting relaxation of airway smooth muscle. This compound exhibits anti-inflammatory properties by increasing interleukin-10 (IL-10) levels and inhibiting the nuclear translocation of NF-κB. Additionally, Theophylline monohydrate is known to induce apoptosis in certain cell types. It is widely utilized in research related to asthma and chronic obstructive pulmonary disease (COPD). -
Apoptosis Inducer
Alphitolic acid, an apoptosis inducer, is a triterpene isolated from Quercus aliena. It functions by inhibiting Akt–NF-κB signaling pathways, promoting apoptosis and autophagy. Additionally, Alphitolic acid exhibits anti-inflammatory properties by down-regulating nitric oxide and TNF-α production. This compound is applicable in cancer and inflammation research. -
Anti-Inflammatory Agent
Kaempferol 3-O-sophoroside is an anti-inflammatory agent that functions primarily by inhibiting the toll-like receptors TLR2 and TLR4 associated with High mobility group box 1 (HMGB1). This compound displays notable anti-inflammatory and analgesic properties, primarily through the inhibition of NF-κB activation and the subsequent reduction of TNF-α production. Additionally, it promotes the synthesis of brain-derived neurotrophic factor (BDNF) and enhances autophagy via AMP-activated protein kinase (AMPK) activation, contributing to its antidepressant effects. Kaempferol 3-O-sophoroside is a valuable tool for research focused on inflammation and neurodegenerative diseases. -
CHIKV Virus Inhibitor
Ethyl palmitate, also known as Ethyl hexadecanoate, functions as a CHIKV virus inhibitor, exhibiting an EC50 value of 0.0068 μM. This compound has demonstrated the ability to reduce pro-inflammatory cytokines such as TNF-α and IL-6, along with downregulating NF-κB in endotoxemic rat models, indicating its potential for anti-inflammatory applications. Ethyl palmitate serves as a valuable tool for research in virology and inflammation-related studies. -
Anti-inflammatory Agent
Edpetiline is an anti-inflammatory agent that targets the inhibition of IκB phosphorylation, thereby preventing the nuclear translocation of NF-κB p65. This compound also inhibits p38 MAPK and ERK MAPK phosphorylation, leading to reduced intracellular ROS levels. Furthermore, Edpetiline downregulates pro-inflammatory cytokines such as TNF-α, IL-6, iNOS, and COX-2 while promoting the expression of the anti-inflammatory cytokine IL-4. It is suitable for research into conditions related to inflammation and oxidative stress. -
Phosphodiesterase 4 Inhibitor
Tanimilast is a selective phosphodiesterase 4 inhibitor that exhibits potent activity with an IC50 of 0.026 nM. By increasing intracellular cAMP levels, Tanimilast effectively disrupts the NF-κB signaling pathway, leading to significant anti-inflammatory effects. This compound is particularly applicable in the study of obstructive lung diseases, making it a valuable tool for research in pulmonary health and related therapies. -
MMP Inhibitor
Ecliptasaponin A is a pentacyclic triterpenoid saponin that functions as a robust inhibitor of matrix metalloproteinases (MMPs). It demonstrates significant anti-tumor properties by activating the ASK1/JNK pathway, leading to apoptosis and autophagy in lung cancer cells. Additionally, Ecliptasaponin A exerts anti-inflammatory and anti-fibrotic effects by inhibiting the HMGB1/TLR4/NF-κB signaling pathway, impacting COX-2 and MMP-9 expression. Its chondroprotective effects are attributed to the downregulation of MMP13 and modulation of inflammatory factors, while it also promotes ovarian function by enhancing ESR1 receptor expression. -
Chloride Channel Inhibitor
Shikonin is a potent inhibitor of the TMEM16A chloride channel, exhibiting an IC50 value of 6.5 μM. This compound functions as a specific inhibitor of pyruvate kinase M2 (PKM2) and also modulates inflammatory pathways by inhibiting TNF-α and NF-κB activation. In addition, Shikonin decreases exosome secretion by impairing glycolytic processes and effectively inhibits AIM2 inflammasome activation. Its diverse activities make it a valuable reagent for investigating cellular signaling and inflammatory responses in research applications. -
NF-κB Inhibitor
Malvidin-3-glucoside chloride is an orally active NF-κB inhibitor, primarily targeting inflammatory pathways induced by TNF-α. It effectively decreases IκB-α degradation and p65 nuclear translocation, consequently enhancing endothelial nitric oxide synthase (eNOS) activity and nitric oxide production. This compound exhibits significant anti-inflammatory and antioxidant properties by suppressing pro-inflammatory molecules such as MCP-1, ICAM-1, and IL-6, while also regulating intestinal microbiota and metabolites. Malvidin-3-glucoside chloride serves as a valuable tool for researching chronic inflammatory diseases, including atherosclerosis and inflammatory bowel disease, with potential applications in preventing vascular inflammation and promoting intestinal health. -
Flame-retardant Plasticizer
Tris(2-chloroethyl) phosphate (TCEP) is an organic phosphorus compound that functions primarily as a flame-retardant plasticizer. It exhibits hepatotoxic effects characterized by an increase in reactive oxygen species (ROS) and calcium ion influx, leading to mitochondrial membrane potential disruption, DNA damage, and programmed cell death. TCEP has been shown to directly interact with the farnesoid X receptor (FXR), promoting obesity and fatty liver development in murine models. Additionally, TCEP activates the TLR4/NF-κB signaling pathway, contributing to liver inflammation, making it relevant for studies on metabolic disorders and toxicology. -
Metabolite of Vitamin C
L-Threonic acid magnesium, a metabolite of vitamin C, acts as a magnesium supplement that enhances brain magnesium levels. It is known to inhibit the TNF-α/NF-κB signaling pathway, making it relevant for research in neuroinflammatory conditions. This compound is particularly notable in studies related to Alzheimer’s disease and is bioavailable when administered orally. -
Amylase Substrate
Maltotetraose is a carbohydrate compound that serves as a substrate for enzyme-linked assays to measure amylase activity in biological fluids. Its primary biological activity includes the reduction of TNF-α-induced inflammatory responses through inhibition of NF-κB activity and decreased expression of ICAM-1. Additionally, maltotetraose inhibits PDGF-induced vascular smooth muscle cell migration and neovascularization. Its derivatives can also be utilized as probes for detecting bacterial infections by targeting the maltodextrin transporter, making maltotetraose a valuable tool in research related to atherosclerosis and inflammatory diseases. -
LT Inhibitor
Tryptanthrin is a potent inhibitor of leukotriene (LT) biosynthesis, targeting the inflammatory pathways involved in various diseases. This indole quinazoline compound exhibits significant anticancer properties by suppressing the expression of key inflammatory mediators such as NOS1, COX-2, and NF-κB. Additionally, Tryptanthrin modulates cytokine levels, influencing the expression of IL-2, IL-10, and TNF-α, making it a valuable reagent for research applications in inflammation and cancer biology. -
Pyrimidine Heterocyclic Compound
3-Methyluracil is a pyrimidine heterocyclic compound that exhibits anti-inflammatory activity. It is known to inhibit Luciferase activity induced by NF-κB and AP-1, leading to a reduction in the mRNA levels of COX-2 and TNF-α. This compound is valuable for research focused on inflammatory diseases and cellular signaling pathways involved in inflammation. -
TLR1/TLR2 Agonist
Diprovocim is a potent TLR1/TLR2 agonist that activates immune responses by inducing full agonist activity in human THP-1 cells, with an EC50 of 110 pM. This compound effectively stimulates TNF-α release from mouse macrophages at an EC50 of 1.3 nM. By activating downstream signaling pathways, including MAPK and NF-κB, Diprovocim demonstrates significant adjuvant activity in mice, enhancing cellular immune responses and making it a valuable tool for immunological research. -
MAO-A/B Inhibitor
1,4-Naphthoquinone serves as a potent inhibitor targeting monoamine oxidase A and B (MAO-A/B) with competitive inhibition of MAO-B (Ki=1.4 μM) and non-competitive inhibition of MAO-A (Ki=7.7 μM). This compound exhibits broad-spectrum biological activity, inhibiting various DNA polymerases alongside notable anti-tumor, anti-inflammatory, and antibacterial properties. Its mechanism includes the induction of oxidative stress, glutathione (GSH) depletion, suppression of DNA synthesis, and blockage of NF-κB nuclear translocation. 1,4-Naphthoquinone is applicable in research involving melanoma and colon cancer cell growth, endothelial cell function, and models of lipopolysaccharide (LPS)-induced inflammation. -
p300 Histone Acetylatransferase Inhibitor
Curcumin, a natural phenolic compound, functions as a specific inhibitor of the p300/CREB-binding protein histone acetyltransferase. It effectively represses the acetylation of both histone and nonhistone proteins, thereby modulating chromatin transcription. Curcumin exhibits significant biological activities, including anti-inflammatory, antioxidant, antiproliferative, and antiangiogenic effects, while also inhibiting NF-κB and MAPKs. Additionally, it promotes stabilization of the Nrf2 protein through modification of Keap1 cysteines, making it valuable for research in diverse therapeutic contexts. -
HDAC6 Inhibitor
HDAC6-IN-71 is a selective inhibitor of histone deacetylase 6 (HDAC6), exhibiting an IC50 of 13.68 nM for HDAC6 and 443.12 nM for HDAC1. This compound effectively reduces nitric oxide production in mouse macrophages, with an IC50 of 2.31 μM. By inhibiting the HDAC6-NF-κB signaling pathway, HDAC6-IN-71 leads to decreased phosphorylation of IκB-α and IKK-α/β, and downregulates the expression of key inflammatory mediators such as COX-2 and iNOS. Its efficacy has been demonstrated in models of ulcerative colitis, highlighting its potential for therapeutic applications in inflammatory diseases. -
HDACs/NF-κB Dual Inhibitor
Homobutein is a natural chalcone that functions as a potent dual inhibitor of histone deacetylases (HDACs) and nuclear factor kappa B (NF-κB), exhibiting IC50 values of 190 μM and 38 μM, respectively. This compound also acts as a chelator for iron (II and III) cations and demonstrates a range of biological activities, including anticancer, anti-inflammatory, antiparasitic, and antioxidant effects. Homobutein is valuable for research applications involving cellular signaling pathways and the investigation of potential therapeutic strategies in cancer and inflammatory diseases. -
Anti-inflammatory Peptide
SAP15 is a synthetic anti-inflammatory peptide derived from human beta-defensin 3, comprising 15 amino acids. This peptide effectively penetrates cells to downregulate intracellular inflammation by inhibiting the phosphorylation of HDAC5, which in turn reduces the phosphorylation of NF-κB p65. In LPS-induced macrophages, SAP15 demonstrates significant anti-inflammatory activity, while also enhancing the expression of aggrecan and type II collagen, and decreasing osteocalcin levels in LPS-induced chondrocytes. SAP15 serves as a valuable tool in the exploration of inflammation regulation and the development of anti-inflammatory therapies for biomaterials. -
HDAC3 Inhibitor
HDAC3-IN-T247 is a potent and selective inhibitor of HDAC3 (histone deacetylase 3), demonstrating an IC50 of 0.24 µM. This compound selectively enhances the acetylation of NF-κB in HCT116 cells, making it valuable for studies in cancer and viral pathogenesis. HDAC3-IN-T247 exhibits significant anticancer properties by inhibiting the proliferation of cancer cells and can also activate HIV gene expression in latently infected cells, thus serving as a useful tool for investigations in oncology and HIV research. -
PROTAC HDAC Degrader
HD-TAC7 is a highly effective PROTAC HDAC degrader, specifically targeting histone deacetylases HDAC1, HDAC2, and HDAC3 with IC50 values of 3.6 μM, 4.2 μM, and 1.1 μM, respectively. This compound has demonstrated the ability to reduce NF-κB p65 levels in RAW 264.7 macrophages. HD-TAC7 is suitable for research applications focused on inflammatory diseases, including asthma and chronic obstructive pulmonary disease (COPD). -
Anti-inflammatory Agent
NPB-1575 is a potent, orally bioavailable anti-inflammatory agent that effectively targets neuroinflammation. It functions by activating the IRS2/Nrf2/NF-κB signaling axis, thereby combating ferroptosis and providing neuroprotection. NPB-1575 demonstrates efficacy in mitigating cerebral ischemic injury and enhancing neurological outcomes, making it a valuable tool for research focused on ischemic stroke and related neurodegenerative conditions. -
Ferroptosis Inhibitor
5-Hydroxy-6,7-dimethoxyflavone is a potent inhibitor of ferroptosis, acting primarily to mitigate H1N1 virus-induced cell death. This compound enhances the expression of SLC7A11 and GPX4, thereby providing protective effects against ferroptosis. Additionally, it reduces inflammatory responses and apoptosis by inhibiting the activation of NF-κB and p38 MAPK signaling pathways. 5-Hydroxy-6,7-dimethoxyflavone is valuable for research related to H1N1 influenza virus infection and ferroptosis regulation. -
Stable Isotope
(±)-Epicatechin-13C3 is a stable isotope-labeled form of (±)-Epicatechin, which primarily interacts with cyclooxygenase-1 (COX-1). This compound exhibits significant inhibition of COX-1 activity, with an IC50 value of 3.2 μM. Additionally, (±)-Epicatechin is known to suppress the IL-1β-induced expression of inducible nitric oxide synthase (iNOS) by preventing the nuclear translocation of the p65 subunit of NF-κB. These properties make (±)-Epicatechin-13C3 valuable for studies focused on inflammation and signal transduction pathways. -
Stable Isotope
Sulfasalazine-d4 is a deuterium-labeled derivative of the anti-rheumatic agent Sulfasalazine, primarily used in the investigation of rheumatoid arthritis and ulcerative colitis. This compound is known to inhibit NF-κB activity and serves as a type 1 ferroptosis inducer. Its stable isotope labeling enhances analytical techniques, aiding in the study of pharmacokinetics and metabolic pathways associated with Sulfasalazine's biological effects. -
Apoptosis/Autophagy Inducer
Formosanin C is a diosgenin saponin that functions primarily as an apoptosis and autophagy inducer. It exhibits notable anti-tumor activities through mechanisms such as blocking the cell cycle, inhibiting metastasis, and promoting ferroptosis. Additionally, Formosanin C can suppress the NF-κB signaling pathway, providing anti-inflammatory effects while enhancing immune cell activity. This compound is relevant for research in anti-inflammatory, antifungal, and anti-cancer applications, particularly concerning lung, liver, breast, and colorectal cancers. -
Na+ Channel Blocker
Lidocaine hydrochloride hydrate is a sodium channel blocker that selectively inhibits voltage-gated sodium channels, demonstrating use dependence. It has been shown to reduce growth, migration, and invasion of gastric carcinoma cells by up-regulating miR-145 expression, which subsequently leads to the inactivation of the MEK/ERK and NF-κB signaling pathways. Additionally, as an amide derivative, lidocaine hydrochloride hydrate has potential applications in the study of ventricular arrhythmias. -
P2X7 Antagonist
Bullatine A is a potent P2X7 antagonist with significant anti-inflammatory and anti-nociceptive properties. It effectively inhibits ATP-induced BV-2 cell apoptosis and modulates inflammatory responses mediated by P2X receptors. Bullatine A has demonstrated the ability to reduce glioma cell growth by targeting SIRT6, alleviate pain hypersensitivity in rodent models, and mitigate systemic inflammation via the ROS/JNK/NF-κB pathway. Additionally, it has shown potential in improving behavioral outcomes in models of chronic social defeat stress. This compound is valuable for research in inflammation, glioblastoma, and depression. -
NF-κB Inhibitor
Ginsenoside Rg6 is an NF-κB inhibitor that effectively attenuates TNF-α-induced NF-κB transcriptional activity, exhibiting an IC50 of 29.34 μM in HepG2 cells. In addition to its role in modulating NF-κB activity, Ginsenoside Rg6 demonstrates significant apoptotic effects, making it a valuable tool for research in inflammation and cancer biology. -
Antipsychotic Agent
Penfluridol is a potent, long-acting antipsychotic agent that primarily targets D2-like dopamine receptors. It exhibits significant anti-inflammatory properties by inhibiting TNFα-induced NF-κB activation and demonstrates efficacy in models of arthritis and colitis. Additionally, Penfluridol acts as a Ca2+-calmodulin inhibitor, inducing apoptosis and autophagy in various cellular contexts. This compound is utilized in research focusing on chronic schizophrenia, acute psychosis, Tourette syndrome, autoimmune diseases, and it also shows antibacterial activity against E. faecalis with a minimum inhibitory concentration of 7.81 μg/ml. -
Pharmaceutical Excipient
Sodium benzoate functions as a pharmaceutical excipient with multiple roles, including serving as an antibacterial agent and preservative. It enhances the stability, solubility, and processability of drug formulations while potentially influencing the absorption, distribution, metabolism, and elimination (ADME) of co-administered compounds. Additionally, sodium benzoate activates the NF-κB signaling pathway, induces apoptosis, and has been studied for its immunosuppressive effects as well as reproductive toxicity. Its applications extend to research in colon cancer and immune diseases. -
Antibiotic
Lambertellin is an antibiotic with bactericidal and fungicidal properties. It demonstrates significant anti-inflammatory activity in LPS-stimulated RAW 264.7 macrophage cells by modulating the MAPK and NF-κB signaling pathways. This compound is valuable for research focused on antimicrobial resistance and inflammatory responses. -
Radical Scavenger
Rubiadin is a polyketide-derived compound that acts as a free radical scavenger, effectively inhibiting the activation of the NF-κB signaling pathway. Its biological activities include the inhibition of osteoclast formation, bone resorption, lipid peroxidation, and cancer cell proliferation, along with the reduction of pro-inflammatory cytokine levels and induction of cancer cell apoptosis. Rubiadin demonstrates a diverse range of applications in research related to osteoporosis, inflammatory diseases, viral infections such as hepatitis B, various cancers, and both fungal and bacterial infections. -
Antifungal Agent
Sulconazole is a potent antifungal agent belonging to the imidazole class, primarily known for its ability to inhibit fungal growth. It exerts its effects by blocking the NF-κB/IL-8 signaling pathway, which is implicated in cancer stem cell formation and tumor progression. Additionally, Sulconazole shows potential for applications in breast cancer research, highlighting its dual role as both an antifungal and an anti-tumor compound. -
Anti-Inflammatory Agent
Nepetoidin B is an anti-inflammatory agent that exerts its effects by modulating the NF-κB and Nrf2/HO-1 signaling pathways. In addition to its anti-inflammatory properties, Nepetoidin B also demonstrates antifungal and antibacterial activities. This natural compound, derived from Salvia plebeia R. Br., is suitable for research applications focused on inflammation and infectious diseases. -
Fungal Metabolite
Heveadride is a fungal metabolite that functions as an antifungal agent. It exhibits activity against a range of filamentous fungi as well as certain human pathogenic yeasts. Additionally, Heveadride has been shown to induce down-regulation of TNFα-induced NF-κB activity in human chronic myeloid leukemia cells, with an IC50 of 82.7 μM, making it a valuable tool for research in antifungal treatments and cancer biology. -
CXCR Inhibitor
Corydalmine, a CXCR inhibitor, demonstrates significant antifungal activity by inhibiting spore germination in various plant pathogenic and saprophytic fungi. Additionally, it serves as an oral analgesic agent, exhibiting potent analgesic effects. Corydalmine has been shown to alleviate Vincristine-induced neuropathic pain in murine models through the inhibition of the NF-κB-dependent CXCL1/CXCR2 signaling pathway, making it a valuable tool for pain research and therapeutic applications. -
CYP51/PD-L1 Inhibitor
CYP51/PD-L1-IN-3 is a dual inhibitor targeting CYP51 and PD-L1, exhibiting potent antifungal activity with IC50 values of 0.205 μM and 0.039 μM, respectively. This compound induces early apoptosis in fungal cells by reducing levels of intracellular IL-2, NLRP3, and NF-κBp65 proteins. Additionally, CYP51/PD-L1-IN-3 causes mitochondrial damage and reactive oxygen species (ROS) accumulation, ultimately resulting in fungal lysis and cell death. This compound serves as a valuable tool for research in fungal infections and immune modulation. -
CYP51/PD-L1 Inhibitor
CYP51/PD-L1-IN-2 is a quinazoline compound that functions as a dual inhibitor of CYP51 and PD-L1, exhibiting IC50 values of 0.263 μM and 0.017 μM, respectively. It displays notable antifungal activity by triggering early apoptosis in fungal cells, leading to significant reductions in intracellular IL-2, NLRP3, and NF-κBp65 protein levels. Additionally, CYP51/PD-L1-IN-2 induces mitochondrial damage and reactive oxygen species (ROS) accumulation, culminating in fungal lysis and subsequent cell death. This compound is valuable for research exploring antifungal mechanisms and cancer immunotherapy. -
CYP51/PD-L1 Inhibitor
CYP51/PD-L1-IN-1 is a dual inhibitor targeting both CYP51 and PD-L1, exhibiting an IC50 of 0.884 μM for CYP51 and 0.083 μM for PD-L1. This quinazoline compound demonstrates notable antifungal activity by inducing early apoptosis in fungal cells while significantly reducing intracellular levels of IL-2, NLRP3, and NF-κBp65. Additionally, CYP51/PD-L1-IN-1 contributes to mitochondrial damage and reactive oxygen species (ROS) accumulation, ultimately leading to fungal lysis and cell death. This compound is valuable for research focused on antifungal therapies and immune modulation. -
CXCR Inhibitor
Corydalmine hydrochloride is a potent CXCR inhibitor that demonstrates significant biological activity by inhibiting spore germination in certain plant pathogenic and saprophytic fungi. Additionally, it exhibits notable analgesic properties, effectively alleviating Vincristine-induced neuropathic pain in murine models. This effect is mediated through the inhibition of the NF-κB-dependent CXCL1/CXCR2 signaling pathway, highlighting its potential applications in pain management research and fungal inhibition studies. -
Antifungal Agent
o-Vanillin is a naturally occurring compound primarily known for its antifungal properties. It effectively inhibits the mycelial growth of fungi by compromising the integrity of their cell walls and membranes. Additionally, o-Vanillin has been shown to inhibit NF-κB activation induced by Doxorubicin and 4-hydroperoxycyclophosphamide, making it a valuable reagent for research applications in fungal pathogenesis and cancer studies. -
Anti-bacterial/fungal Agent
Eugenol acetate is an antibacterial and antifungal agent that targets multiple biological pathways. It exhibits significant anti-inflammatory and antioxidant properties, acting through the inhibition of NF-κB while enhancing the expression of tumor suppressor proteins such as p53 and p21 (WAF1). Eugenol acetate is also implicated in cancer research, demonstrating the ability to prevent chemically induced skin cancer, inhibit cancer cell proliferation, and induce apoptosis in various cancer cell lines. Its diverse biological activities make it a valuable tool in chemical and biomedical research applications. -
MDA-9/Syntenin Inhibitor
PDZ1i (113B7) is a selective inhibitor of MDA-9/Syntenin, targeting its PDZ1 domain. This compound effectively inhibits radiation-induced invasion of glioblastoma (GBM) cells and enhances their radiosensitivity by disrupting key signaling pathways, including Src/EphA2, EGFRvIII/FAK, and NF-κB. PDZ1i also decreases the secretion of invasion-related proteases such as MMP-2, MMP-9, and ADAM9. Its anti-tumor efficacy has been demonstrated in nude mice models with intracranial U1242-luc and GBM xenografts, making PDZ1i a valuable tool for researching glioblastoma, as well as breast and prostate cancers. -
PARP1 Inhibitor
DPQ hydrochloride is a potent and selective inhibitor of PARP-1 (poly(ADP-ribose) polymerase 1), effectively blocking PARP-1-mediated DNA damage repair and reducing NAD+/ATP consumption. This compound demonstrates significant anti-inflammatory properties by inhibiting the activation of the NF-κB pathway, leading to a decrease in pro-inflammatory cytokines such as TNF-α and IL-6, as well as mitigating oxidative stress. DPQ hydrochloride is ideal for research applications related to inflammation and can be utilized in studies of conditions such as acute lung injury, myocardial infarction, and neurodegenerative diseases.
