Catalog No.
Product Name
Application
Product Information
Citations
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COX Inhibitor
Pentagamavunon-1 (PGV-1) is a COX-2 inhibitor that modulates multiple molecular pathways to induce apoptosis. This Curcumin analog exhibits notable oral bioactivity and suppresses key angiogenic factors, including vascular endothelial growth factor (VEGF). Additionally, PGV-1 inhibits NF-κB activation, highlighting its potential in cancer research and therapeutic applications targeting inflammation and tumor progression. -
Eupatilin Derivative
Recoflavone, a synthetic derivative of the flavonoid eupatilin, primarily targets the NF-κB signaling pathway. It exhibits significant biological activities including anti-inflammatory and anti-tumor effects, as well as providing protective properties for gastric and intestinal mucosa. Additionally, Recoflavone promotes secretion in the ocular surface and salivary glands. This compound is valuable for researching conditions such as dry eye, gastric injuries, and intestinal injuries. -
Stable Isotope
12-HETE-d8 is a deuterated form of 12-HETE, a significant metabolite of arachidonic acid produced via 12-lipoxygenase (12-LOX) catalysis. This compound plays a critical role in modulating cell apoptosis in a dose-dependent manner, facilitating the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway. 12-HETE-d8 serves as a valuable tool in research focusing on its dual anti-thrombotic and pro-thrombotic effects, as well as its function as a neuromodulator in various biological contexts. -
Stable Isotope
Sodium propionate-13C is a stable isotope of the short-chain fatty acid sodium propionate, which acts primarily through the activation of PPAR-γ and inhibition of NF-κB signaling pathways. This compound exhibits significant biological activities, including induction of apoptosis and autophagy, as well as reductions in COX-2 expression and nitric oxide production. Key research applications include investigating its neuroprotective and antioxidant properties, along with its potential anticancer effects against glioblastoma. Additionally, sodium propionate-13C can be utilized in studies focused on spinal cord injury and Alzheimer's disease. -
Antifungal Agent
o-Vanillin is a naturally occurring compound primarily known for its antifungal properties. It effectively inhibits the mycelial growth of fungi by compromising the integrity of their cell walls and membranes. Additionally, o-Vanillin has been shown to inhibit NF-κB activation induced by Doxorubicin and 4-hydroperoxycyclophosphamide, making it a valuable reagent for research applications in fungal pathogenesis and cancer studies. -
Anti-bacterial/fungal Agent
Eugenol acetate is an antibacterial and antifungal agent that targets multiple biological pathways. It exhibits significant anti-inflammatory and antioxidant properties, acting through the inhibition of NF-κB while enhancing the expression of tumor suppressor proteins such as p53 and p21 (WAF1). Eugenol acetate is also implicated in cancer research, demonstrating the ability to prevent chemically induced skin cancer, inhibit cancer cell proliferation, and induce apoptosis in various cancer cell lines. Its diverse biological activities make it a valuable tool in chemical and biomedical research applications. -
MDA-9/Syntenin Inhibitor
PDZ1i (113B7) is a selective inhibitor of MDA-9/Syntenin, targeting its PDZ1 domain. This compound effectively inhibits radiation-induced invasion of glioblastoma (GBM) cells and enhances their radiosensitivity by disrupting key signaling pathways, including Src/EphA2, EGFRvIII/FAK, and NF-κB. PDZ1i also decreases the secretion of invasion-related proteases such as MMP-2, MMP-9, and ADAM9. Its anti-tumor efficacy has been demonstrated in nude mice models with intracranial U1242-luc and GBM xenografts, making PDZ1i a valuable tool for researching glioblastoma, as well as breast and prostate cancers. -
PARP1 Inhibitor
DPQ hydrochloride is a potent and selective inhibitor of PARP-1 (poly(ADP-ribose) polymerase 1), effectively blocking PARP-1-mediated DNA damage repair and reducing NAD+/ATP consumption. This compound demonstrates significant anti-inflammatory properties by inhibiting the activation of the NF-κB pathway, leading to a decrease in pro-inflammatory cytokines such as TNF-α and IL-6, as well as mitigating oxidative stress. DPQ hydrochloride is ideal for research applications related to inflammation and can be utilized in studies of conditions such as acute lung injury, myocardial infarction, and neurodegenerative diseases. -
PARP-1 Inhibitor
DPQ is a selective inhibitor of PARP-1, effectively blocking PARP-1-mediated DNA repair mechanisms and reducing the consumption of NAD+ and ATP. This inhibition leads to a decrease in NF-κB pathway activation, resulting in lowered expression of pro-inflammatory cytokines such as TNF-α and IL-6, along with a reduction in oxidative stress levels. DPQ is applicable in research focused on inflammation-related conditions including acute lung injury, myocardial infarction, and neurodegenerative diseases. -
C/EBPβ Inhibitor
Helenalin acetate is a potent C/EBPβ inhibitor that also functions as a natural NF-κB inhibitor. It exhibits significant anti-inflammatory and anticancer properties, making it a valuable tool for research into inflammatory diseases and cancer biology. This compound can be utilized in studies aimed at understanding the regulation of gene expression mediated by C/EBPβ and its role in various pathological conditions. -
Anti-inflammatory Peptide
SAP15 is a synthetic anti-inflammatory peptide derived from human beta-defensin 3, comprising 15 amino acids. This peptide effectively penetrates cells to downregulate intracellular inflammation by inhibiting the phosphorylation of HDAC5, which in turn reduces the phosphorylation of NF-κB p65. In LPS-induced macrophages, SAP15 demonstrates significant anti-inflammatory activity, while also enhancing the expression of aggrecan and type II collagen, and decreasing osteocalcin levels in LPS-induced chondrocytes. SAP15 serves as a valuable tool in the exploration of inflammation regulation and the development of anti-inflammatory therapies for biomaterials. -
HDAC3 Inhibitor
HDAC3-IN-T247 is a potent and selective inhibitor of HDAC3 (histone deacetylase 3), demonstrating an IC50 of 0.24 µM. This compound selectively enhances the acetylation of NF-κB in HCT116 cells, making it valuable for studies in cancer and viral pathogenesis. HDAC3-IN-T247 exhibits significant anticancer properties by inhibiting the proliferation of cancer cells and can also activate HIV gene expression in latently infected cells, thus serving as a useful tool for investigations in oncology and HIV research. -
PROTAC HDAC Degrader
HD-TAC7 is a highly effective PROTAC HDAC degrader, specifically targeting histone deacetylases HDAC1, HDAC2, and HDAC3 with IC50 values of 3.6 μM, 4.2 μM, and 1.1 μM, respectively. This compound has demonstrated the ability to reduce NF-κB p65 levels in RAW 264.7 macrophages. HD-TAC7 is suitable for research applications focused on inflammatory diseases, including asthma and chronic obstructive pulmonary disease (COPD). -
Anti-inflammatory Agent
NPB-1575 is a potent, orally bioavailable anti-inflammatory agent that effectively targets neuroinflammation. It functions by activating the IRS2/Nrf2/NF-κB signaling axis, thereby combating ferroptosis and providing neuroprotection. NPB-1575 demonstrates efficacy in mitigating cerebral ischemic injury and enhancing neurological outcomes, making it a valuable tool for research focused on ischemic stroke and related neurodegenerative conditions. -
Ferroptosis Inhibitor
5-Hydroxy-6,7-dimethoxyflavone is a potent inhibitor of ferroptosis, acting primarily to mitigate H1N1 virus-induced cell death. This compound enhances the expression of SLC7A11 and GPX4, thereby providing protective effects against ferroptosis. Additionally, it reduces inflammatory responses and apoptosis by inhibiting the activation of NF-κB and p38 MAPK signaling pathways. 5-Hydroxy-6,7-dimethoxyflavone is valuable for research related to H1N1 influenza virus infection and ferroptosis regulation. -
Stable Isotope
(±)-Epicatechin-13C3 is a stable isotope-labeled form of (±)-Epicatechin, which primarily interacts with cyclooxygenase-1 (COX-1). This compound exhibits significant inhibition of COX-1 activity, with an IC50 value of 3.2 μM. Additionally, (±)-Epicatechin is known to suppress the IL-1β-induced expression of inducible nitric oxide synthase (iNOS) by preventing the nuclear translocation of the p65 subunit of NF-κB. These properties make (±)-Epicatechin-13C3 valuable for studies focused on inflammation and signal transduction pathways. -
Stable Isotope
Sulfasalazine-d4 is a deuterium-labeled derivative of the anti-rheumatic agent Sulfasalazine, primarily used in the investigation of rheumatoid arthritis and ulcerative colitis. This compound is known to inhibit NF-κB activity and serves as a type 1 ferroptosis inducer. Its stable isotope labeling enhances analytical techniques, aiding in the study of pharmacokinetics and metabolic pathways associated with Sulfasalazine's biological effects. -
Apoptosis/Autophagy Inducer
Formosanin C is a diosgenin saponin that functions primarily as an apoptosis and autophagy inducer. It exhibits notable anti-tumor activities through mechanisms such as blocking the cell cycle, inhibiting metastasis, and promoting ferroptosis. Additionally, Formosanin C can suppress the NF-κB signaling pathway, providing anti-inflammatory effects while enhancing immune cell activity. This compound is relevant for research in anti-inflammatory, antifungal, and anti-cancer applications, particularly concerning lung, liver, breast, and colorectal cancers. -
Na+ Channel Blocker
Lidocaine hydrochloride hydrate is a sodium channel blocker that selectively inhibits voltage-gated sodium channels, demonstrating use dependence. It has been shown to reduce growth, migration, and invasion of gastric carcinoma cells by up-regulating miR-145 expression, which subsequently leads to the inactivation of the MEK/ERK and NF-κB signaling pathways. Additionally, as an amide derivative, lidocaine hydrochloride hydrate has potential applications in the study of ventricular arrhythmias. -
P2X7 Antagonist
Bullatine A is a potent P2X7 antagonist with significant anti-inflammatory and anti-nociceptive properties. It effectively inhibits ATP-induced BV-2 cell apoptosis and modulates inflammatory responses mediated by P2X receptors. Bullatine A has demonstrated the ability to reduce glioma cell growth by targeting SIRT6, alleviate pain hypersensitivity in rodent models, and mitigate systemic inflammation via the ROS/JNK/NF-κB pathway. Additionally, it has shown potential in improving behavioral outcomes in models of chronic social defeat stress. This compound is valuable for research in inflammation, glioblastoma, and depression. -
NF-κB Inhibitor
Ginsenoside Rg6 is an NF-κB inhibitor that effectively attenuates TNF-α-induced NF-κB transcriptional activity, exhibiting an IC50 of 29.34 μM in HepG2 cells. In addition to its role in modulating NF-κB activity, Ginsenoside Rg6 demonstrates significant apoptotic effects, making it a valuable tool for research in inflammation and cancer biology. -
Antipsychotic Agent
Penfluridol is a potent, long-acting antipsychotic agent that primarily targets D2-like dopamine receptors. It exhibits significant anti-inflammatory properties by inhibiting TNFα-induced NF-κB activation and demonstrates efficacy in models of arthritis and colitis. Additionally, Penfluridol acts as a Ca2+-calmodulin inhibitor, inducing apoptosis and autophagy in various cellular contexts. This compound is utilized in research focusing on chronic schizophrenia, acute psychosis, Tourette syndrome, autoimmune diseases, and it also shows antibacterial activity against E. faecalis with a minimum inhibitory concentration of 7.81 μg/ml. -
Pharmaceutical Excipient
Sodium benzoate functions as a pharmaceutical excipient with multiple roles, including serving as an antibacterial agent and preservative. It enhances the stability, solubility, and processability of drug formulations while potentially influencing the absorption, distribution, metabolism, and elimination (ADME) of co-administered compounds. Additionally, sodium benzoate activates the NF-κB signaling pathway, induces apoptosis, and has been studied for its immunosuppressive effects as well as reproductive toxicity. Its applications extend to research in colon cancer and immune diseases. -
Antibiotic
Lambertellin is an antibiotic with bactericidal and fungicidal properties. It demonstrates significant anti-inflammatory activity in LPS-stimulated RAW 264.7 macrophage cells by modulating the MAPK and NF-κB signaling pathways. This compound is valuable for research focused on antimicrobial resistance and inflammatory responses. -
Radical Scavenger
Rubiadin is a polyketide-derived compound that acts as a free radical scavenger, effectively inhibiting the activation of the NF-κB signaling pathway. Its biological activities include the inhibition of osteoclast formation, bone resorption, lipid peroxidation, and cancer cell proliferation, along with the reduction of pro-inflammatory cytokine levels and induction of cancer cell apoptosis. Rubiadin demonstrates a diverse range of applications in research related to osteoporosis, inflammatory diseases, viral infections such as hepatitis B, various cancers, and both fungal and bacterial infections. -
Antifungal Agent
Sulconazole is a potent antifungal agent belonging to the imidazole class, primarily known for its ability to inhibit fungal growth. It exerts its effects by blocking the NF-κB/IL-8 signaling pathway, which is implicated in cancer stem cell formation and tumor progression. Additionally, Sulconazole shows potential for applications in breast cancer research, highlighting its dual role as both an antifungal and an anti-tumor compound. -
Anti-Inflammatory Agent
Nepetoidin B is an anti-inflammatory agent that exerts its effects by modulating the NF-κB and Nrf2/HO-1 signaling pathways. In addition to its anti-inflammatory properties, Nepetoidin B also demonstrates antifungal and antibacterial activities. This natural compound, derived from Salvia plebeia R. Br., is suitable for research applications focused on inflammation and infectious diseases. -
Fungal Metabolite
Heveadride is a fungal metabolite that functions as an antifungal agent. It exhibits activity against a range of filamentous fungi as well as certain human pathogenic yeasts. Additionally, Heveadride has been shown to induce down-regulation of TNFα-induced NF-κB activity in human chronic myeloid leukemia cells, with an IC50 of 82.7 μM, making it a valuable tool for research in antifungal treatments and cancer biology. -
CXCR Inhibitor
Corydalmine, a CXCR inhibitor, demonstrates significant antifungal activity by inhibiting spore germination in various plant pathogenic and saprophytic fungi. Additionally, it serves as an oral analgesic agent, exhibiting potent analgesic effects. Corydalmine has been shown to alleviate Vincristine-induced neuropathic pain in murine models through the inhibition of the NF-κB-dependent CXCL1/CXCR2 signaling pathway, making it a valuable tool for pain research and therapeutic applications. -
CYP51/PD-L1 Inhibitor
CYP51/PD-L1-IN-3 is a dual inhibitor targeting CYP51 and PD-L1, exhibiting potent antifungal activity with IC50 values of 0.205 μM and 0.039 μM, respectively. This compound induces early apoptosis in fungal cells by reducing levels of intracellular IL-2, NLRP3, and NF-κBp65 proteins. Additionally, CYP51/PD-L1-IN-3 causes mitochondrial damage and reactive oxygen species (ROS) accumulation, ultimately resulting in fungal lysis and cell death. This compound serves as a valuable tool for research in fungal infections and immune modulation. -
CYP51/PD-L1 Inhibitor
CYP51/PD-L1-IN-2 is a quinazoline compound that functions as a dual inhibitor of CYP51 and PD-L1, exhibiting IC50 values of 0.263 μM and 0.017 μM, respectively. It displays notable antifungal activity by triggering early apoptosis in fungal cells, leading to significant reductions in intracellular IL-2, NLRP3, and NF-κBp65 protein levels. Additionally, CYP51/PD-L1-IN-2 induces mitochondrial damage and reactive oxygen species (ROS) accumulation, culminating in fungal lysis and subsequent cell death. This compound is valuable for research exploring antifungal mechanisms and cancer immunotherapy. -
CYP51/PD-L1 Inhibitor
CYP51/PD-L1-IN-1 is a dual inhibitor targeting both CYP51 and PD-L1, exhibiting an IC50 of 0.884 μM for CYP51 and 0.083 μM for PD-L1. This quinazoline compound demonstrates notable antifungal activity by inducing early apoptosis in fungal cells while significantly reducing intracellular levels of IL-2, NLRP3, and NF-κBp65. Additionally, CYP51/PD-L1-IN-1 contributes to mitochondrial damage and reactive oxygen species (ROS) accumulation, ultimately leading to fungal lysis and cell death. This compound is valuable for research focused on antifungal therapies and immune modulation. -
CXCR Inhibitor
Corydalmine hydrochloride is a potent CXCR inhibitor that demonstrates significant biological activity by inhibiting spore germination in certain plant pathogenic and saprophytic fungi. Additionally, it exhibits notable analgesic properties, effectively alleviating Vincristine-induced neuropathic pain in murine models. This effect is mediated through the inhibition of the NF-κB-dependent CXCL1/CXCR2 signaling pathway, highlighting its potential applications in pain management research and fungal inhibition studies. -
food flavouring
2',5'-Dihydroxyacetophenone (DHAP, 2-Acetylhydroquinone, Quinacetophenone) is a mixture of dihydroxyacetophenone isomers is used in food flavouring. 2',5'-Dihydroxyacetophenone significantly inhibits NO production via the suppression of iNOS expression. 2',5'-Dihydroxyacetophenone significantly decreases levels of the pro-inflammatory cytokines TNF-α and IL-6 by blocking the ERK1/2 and NF-κB signaling pathways. -
NF-κB activation inhibitor
Caffeic acid phenethyl ester is a potent and specific inhibitor of NF-κB activation - Lipoic Acid, also known as R-(+)-alpha-Lipoic acid, is an organosulfur compound derived from octanoic acid. It is made in animals normally, and is essential for aerobic metabolism. It is also manufactured and is available as a dietary supplement in some countries where it is marketed as an antioxidant, and is available as a pharmaceutical drug in other countries.
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oncometabolite
Fumaric acid is a fundamental unit of nucleic acids.. It is a oncometabolite or an endogenous, cancer causing metabolite. High levels of this organic acid can be found in tumors or biofluids surrounding tumors. Its oncogenic action appears to due to its ability to inhibit prolyl hydroxylase-containing enzymes. - 4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities.
- CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB.
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Smurf1 inhibitor
Smurf1-IN-A01 (A01) is an ubiquitin ligase Smad ubiquitination regulatory factor-1 (Smurf1) inhibitor with a kd of 3.664 nM, which increases BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation. - Dexanabinol exhibits not only the antioxidant and neuroprotective activities in brain but also anti-inflammatory activity by inhibiting NF-κB and decreasing cytokines such as TNFα and interleukin-6, which could ensure the integrity of BBB and reduce cell apoptosis and death.
- Dehydrocostus Lactone inhibits NF kappa B activation by preventing TNF-α induced degradation and phosphorylation.
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NF-κB inhibitor
CID-2858522 selectively inhibits the NF-κB pathway (IC50 < 0.1 uM for PMA-stimulated IL-8 production) induced by PKC, operating downstream of PKC but upstream of IKKbeta, without inhibiting other NF-kappaB activation pathways. -
antiinflammatory agent
Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia with antiinflammatory and antioxidant properties. Homoplantaginin could inhibit TNF-α and IL-6 mRNA expression, IKKβ and NF-κB phosphorylation.
