Protein Kinase A (PKA)



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Catalog No. Product Name Application Product Information
A15914

Dibutyryl-cAMP

PKA activator
Dibutyryl-cAMP is a cell-permeable PKA activator by mimicing the action of endogenous cAMP.
A16017

6-Bnz-cAMP sodium salt

PKA-selective activator
6-Bnz-cAMP is a PKA-selective activator. It regulates the PKA dependent signaling pathways.
A14868

PKA inhibitor fragment (6-22) amide

PKA inhibitor
PKA inhibitor fragment (6-22) amide is a synthetic peptide that acts as a protein kinase inhibitor.
A16028

cAMPS-Rp, triethylammonium salt

reversible PKA inhibitor
Rp-cAMPS is a cell-permeable and reversible inhibitor of PKA (protein kinase A) (Ki = 11 uM). Rp-cAMPS is resistant to hydrolysis by phosphodiesterases and is noncompetitive with respect to ATP.
A13584

A-3 Hydrochloride

PKA, PKG, Casein Kinase I and II inhibitor
A-3 Hydrochloride is an inhibitor of PKA (cAMP-dependent protein kinase, Ki=4.3μM) and cGMP-dependent protein kinase, Ki=3.8μM, PKC (protein kinase C, Ki=47μM), casein kinase I and II, and MLCK (myosin light chain kinase) ( Ki=7.4μM).
A16031

PKI 14-22 amide, myristoylated

PKA inhibitor
PKI 14-22 amide, myristoylated is a useful heat stable cAMP-dependent protein kinase inhibitor. This is often used to study PKA in cellular systems in-vitro.
A16052

cGMP Dependent Kinase Inhibitor Peptid

PKG/PKA inhibitor
cGMP Dependent Kinase Inhibitor Peptid is a specific cGKI (cyclic GMP-dependent protein kinase) inhibitor. Data indicates that it does not block cyclic GMP-dependent protein kinase phosphorylation of intact histones and has been used to study Plasmodium falciparum.
A16189

CCG215022

GRK2/5 inhibitor
CCG215022 is a potent GRK2 and GRK5 inhibitor. CCG215022 exhibited nanomolar IC50 values against both GRK2 and GRK5 and good selectivity against other closely related kinases such as GRK1 and PKA.
A16016

KT 5720

PKA inhibitor
KT 5720 is prepared by a modificiation of K-252a (sc-200517), which is synthesized by the fungus Nocardiopsis sp.
A11034 SALE

A-674563

Akt inhibitor
A-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively.
A15910

8-Bromo-cAMP

rprotein kinase A activator
8-Bromo-cAMP is a cell perbeable cyclic AMP (cAMP) analog and a PKA activator.
A15006

AT7867 2HCl

Akt inhibitor
AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively, little activity outside the AGC kinase family.
A14307

NH125

eEF-2 inhibitor
NH125 is a selective eEF-2 kinase inhibitor.
A12464

AT13148

multi-AGC kinase inhibitor
AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors.
A11935 SALE

H 89 2HCl

PKA inhibitor
H 89 dihydrochloride is a cell-permeable, selective, reversible, ATP-competitive and potent inhibitor of protein kinase.
A10286 SALE

Daphnetin

EGFR, PKA,PKC inhibitor
Daphnetin is a coumarin analog that acts as an inhibitor of several protein kinases. It inhibits EGFR kinase (IC50 = 7.67 µM), PKA (IC50 = 9.33 µM), and PKC (IC50 = 25 µM), in vitro. The inhibition of EGFR kinase by daphnetin was competitive to ATP and non-competitive to the peptide substrate. Also acts as a potent antioxidant and anti-malarial agent.
A16222

Synaptamide

-
Synaptamide is a potent mediator for neurogenic differentiation of NSCs acting through PKA/CREB activation.

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