Catalog No.
Product Name
Application
Product Information
Citations
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Serotonin Receptor Antagonist
Trazodone is a triazolopyridine derivative that primarily functions as a serotonin receptor antagonist and reuptake inhibitor. It exhibits significant antidepressant and sleep-inducing activities, making it valuable in the study of mood disorders and insomnia. Additionally, Trazodone demonstrates antagonistic effects on α1- and α2-adrenergic receptors as well as histamine H1 receptors, while displaying minimal anticholinergic activity. -
Stable Isotope
Perphenazine-d6 fumarate is a deuterated derivative of Perphenazine, primarily acting as a dopamine D2 and D3 receptor antagonist with Ki values of 0.56 nM and 0.43 nM, respectively. Additionally, it demonstrates affinity for the 5-HT2A and Alpha-1A adrenergic receptors. This compound exhibits notable biological activities, including the inhibition of cancer cell proliferation and the induction of apoptosis. Perphenazine-d6 fumarate is useful in research addressing mental health disorders, cancer mechanisms, and inflammatory processes. -
Dopamine Receptor Antagonist
Perphenazine dihydrochloride is a potent antagonist of dopamine receptors, primarily targeting D2 and D3 subtypes, with Ki values of 0.56 nM and 0.43 nM, respectively. Additionally, it exhibits activity against 5-HT2A and α1A adrenergic receptors. This compound demonstrates significant biological activity by inhibiting cancer cell proliferation and inducing apoptosis. Perphenazine dihydrochloride is particularly useful in research focused on mental disorders, oncology, and inflammatory processes. -
Stable Isotope
D-Mannitol-d is a deuterium-labeled form of D-Mannitol, a polyol with significant applications in both food and pharmaceutical research. It functions primarily as an osmotic diuretic, utilized to alleviate tissue edema, while also promoting the absorption of calcium and magnesium through cecal fermentation. Additionally, D-Mannitol-d is instrumental in studies related to metabolic processes, including the induction of brown fat formation via β3-adrenergic receptor activation, potentially contributing to improved insulin sensitivity and reduced blood glucose levels. Its unique properties make it valuable for maintaining osmotic pressure in plant cell cultures, particularly when cellular integrity is compromised. -
α-1A Adrenergic Receptor Agonist
Dabuzalgron hydrochloride is a selective agonist of the α-1A adrenergic receptor, primarily indicated for the management of urinary incontinence. This compound has demonstrated protective effects against Doxorubicin-induced cardiotoxicity by maintaining mitochondrial integrity and function. Its pharmacological properties make it a valuable tool in research focused on adrenergic signaling and cardiac health. -
Stable Isotope
D-Mannitol-d2 is a deuterium-labeled derivative of D-Mannitol, primarily used as a stable isotope in various research applications. D-Mannitol is an osmotic diuretic with significant biological activity, promoting calcium and magnesium absorption while reducing tissue edema. Additionally, it has been shown to enhance brown adipocyte formation and improve insulin sensitivity by activating the β3-adrenergic receptor pathway, leading to the conversion of white fat cells into brown fat. This compound is particularly useful in studies involving osmotic pressure regulation and cellular protection in plant and mammalian cell cultures. -
Noradrenergic Reuptake Inhibitor
Maprotiline is a selective noradrenergic reuptake inhibitor that exhibits significant antidepressant activity and also shows promise in antitumor and neuropathic pain relief. It facilitates cancer cell apoptosis through modulation of the ERK signaling pathway and interaction with cellular retinoic acid-binding protein 1 (CRABP1). This compound is valuable for research in mental health disorders, oncology, and pain management. -
Stable Isotope
D-Mannitol-13C,d2 is a stable isotope-labeled form of D-Mannitol, which serves as an osmotic diuretic and explores its role in cellular osmoregulation. D-Mannitol is utilized in various research applications, including the study of calcium and magnesium absorption, as well as promoting brown adipose tissue formation through the activation of β3-adrenergic receptors. It is also valuable in plant cell culture, helping maintain osmotic balance and protecting cells, particularly when cell walls are compromised. This reagent is essential for researchers investigating metabolic pathways, therapeutic interventions, and plant physiology. -
β1-adrenoceptor Antagonist
Landiolol is a highly selective, ultra-short-acting antagonist of β1-adrenergic receptors. By competitively inhibiting these receptors, Landiolol effectively reduces heart rate and myocardial oxygen demand while minimally affecting cardiac ion channels and exhibiting a weak negative inotropic effect. Its ability to inhibit TNF-α-induced mitochondrial hyperactivity and reactive oxygen species production makes it valuable in models of sepsis, where it can mitigate renal injury. Landiolol is applicable in research involving perioperative tachycardia management and investigations into sepsis-related acute kidney injury. -
Dopamine Receptors Blocker
Trifluoperazine is an antipsychotic agent primarily acting as a blocker of central dopamine receptors. It exhibits significant activity as a potent α1-adrenergic receptor antagonist and a NUPR1 inhibitor, demonstrating anticancer properties. Additionally, Trifluoperazine functions as a calmodulin inhibitor and inhibits P-glycoprotein, contributing to its diverse biological effects. This compound is utilized in research on schizophrenia and shows potential as a reversible inhibitor of influenza virus morphogenesis. -
Formoterol Enantiomer
(S,S)-Formoterol is the (S,S)-enantiomer of Formoterol, primarily targeting beta-2 adrenergic receptors. This compound has been shown to enhance IL-4 production in mast cells, contributing to inflammatory responses associated with asthma. Its activities make it valuable for research in respiratory pharmacology and the study of asthma pathophysiology. -
Stable Isotope
Promethazine-d4 hydrochloride is a deuterated form of Promethazine hydrochloride, a first-generation antihistamine that primarily functions as a strong antagonist of the H1 receptor. It also exhibits moderate antagonistic activity at mACh receptors, alongside a moderate affinity for 5-HT2A, 5-HT2C, D2, and α1-adrenergic receptors. This stable isotope is useful for tracing studies, pharmacokinetic research, and metabolite identification in biological samples. -
α1-Adrenergic Receptor Antagonist
Atiprosine is a selective α1-adrenergic receptor antagonist with a pA2 value of 8.11. In addition to its primary action, Atiprosine also exhibits antagonistic activity against α2-adrenergic receptors, 5-HT₂ receptors, and H₁ receptors, with pA2 values of 6.04, 6.87, and 7.32, respectively. This compound demonstrates antihypertensive and hypotensive effects in preclinical studies involving rats, dogs, and monkeys. Atiprosine is applicable in research focused on cardiovascular and mental health disorders. -
H2 Histamine Receptors/ α2-AR/5-HT2(B,C) Serotonin Receptors Ligand
Platelet aggregation-IN-3 is a ligand for H2 histamine receptors, α2-adrenergic receptors (α2-AR), and 5-HT2(B,C) serotonin receptors. This compound effectively inhibits platelet aggregation induced by ADP and collagen and modulates tumor cell-induced platelet aggregation (TCIPA). Platelet aggregation-IN-3 shows potential for applications in antiplatelet therapy for cardiovascular diseases and in the prevention of cancer-related thrombosis and tumor metastasis. - Alfuzosin (provided as the hydrochloride salt) is an α1 receptor antagonist used to treat benign prostatic hyperplasia (BPH). It works by relaxing the muscles in the prostate and bladder neck, making it easier to urinate.
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β1 adrenergic receptor blocker
Bisoprolol is a drug belonging to the group of beta blockers, a class of drugs used primarily in cardiovascular diseases. More specifically, it is a selective type β1 adrenergic receptor blocker. -
Alpha adrenergic agonist
Clonidine is classified as a centrally acting alpha adrenergic agonist.Clonidine acts centrally as an imidazoline receptor agonist. -
Adrenergic Receptor agonist
Detomidine is a sedative with analgesic properties. α2-adrenergic agonists produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors, thus inducing a negative feedback response, reducing production of excitatory neurotransmitters. -
Adrenoceptors agonist
Dobutamine is a direct-acting agent whose primary activity results from stimulation of the β1-adrenoceptors of the heart, increasing contractility and cardiac output. -
noradrenalin re-uptake inhibitor
Maprotiline hydrochloride is a selective noradrenalin re-uptake inhibitor. - Naftopidil (Flivas) is a selective α1-adrenergic receptor antagonist or alpha blocker with a Ki of 58.3 nM.
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5-HT1A and α1-adrenergic receptor antagonist
Naftopidil 2HCl is a selective 5-HT1A and α1-adrenergic receptor antagonist with IC50 of 0.1 μM and 0.2 μM, respectively. -
alpha-1 adrenergic agonist
Oxymetazoline is a selective alpha-1 agonist and partial alpha-2 agonist topical decongestant, used in the form of Oxymetazoline hydrochloride. -
α-adrenergic (AR) antagonist/CaM inhibitor
Phenoxybenzamine is a cell-permeable, non-specific, irreversible α-adrenergic (AR) antagonist that also acts as an CaM inhibitor. -
α2 adrenergic agonist
Rilmenidine is a second-generation imidazoline-α2 adrenergic agonist. -
Adrenergic Receptor agonist
Salbutamol sulfate (Albuterol) is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease. -
α1-adrenoceptor antagonist
Silodosin(Rapaflo) is an α1-adrenoceptor antagonist with high uroselectivity. It causes practically no orthostatic hypotension (in contrast to other α1 blockers). -
Adrenergic Receptor agonist
Synephrine (Oxedrine) is an amine compound commonly used for weight loss. - Piribedil D8 is the deuterium labeled Piribedil, which is an antiparkinsonian agent.
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vasopressor/antihypotensive agent
Midodrine D6 hydrochloride is deuterium labeled Midodrine, which is a vasopressor/antihypotensive agent. - Indoramin D5 is deuterium labeled Indoramin, which is a piperidine antiadrenergic agent.
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β1-selective adrenergic receptor agonist
Norepinephrine hydrochloride (Levarterenol hydrochloride; L-Noradrenaline hydrochloride) is a β1-selective adrenergic receptor agonist with EC50 of 5.37 μM. - Bretylium (tosylate) is an inhibitor of the presynaptic release of vasoconstrictor neurotransmitters.
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β-adrenoceptor antagonist
(+)-Penbutolol is a β-adrenoceptor antagonist, with an IC50 of 0.74 μM. -
beta-adrenoceptor agonist
Bambuterol ((??)-Bambuterol; KWD-2183) is a long acting beta-adrenoceptor agonist (LABA) used in the treatment of asthma; it also is a prodrug of terbutaline. -
β-adrenergic receptor (βAR) antagonist
(R)-Propranolol hydrochloride is a less active enantiomer of the β-adrenoceptor antagonist propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively.
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alpha2-Adrenergic receptor agonist
Flutonidine is an alpha2-Adrenergic receptor agonist. -
beta-adrenoceptor antagonist
DL 071-IT is a potent non-selective beta-adrenoceptor antagonist. . -
Adrenergic Receptor Antagonist
Propranolol hydrochloride is a nonselective β-adrenergic receptor antagonist that effectively crosses the blood-brain barrier. It exhibits high affinity for both β1AR and β2AR receptors, with Ki values of 1.8 nM and 0.8 nM, respectively, and inhibits [3H]-DHA binding in rat brain membranes with an IC50 of 12 nM. This reagent is widely used in research related to hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy. -
Antihypertensive Agent
Indoramin is an orally active antihypertensive agent targeting the α1A-adrenoceptor. This compound works by selectively blocking α1-adrenoceptors, leading to vasodilation and a reduction in blood pressure. Indoramin is utilized in cardiovascular research to study blood pressure regulation and the mechanisms of hypertension. -
β2-Adrenergic Receptor Agonist
Levalbuterol hydrochloride is a potent β2-adrenergic receptor agonist and the active (R)-enantiomer of Salbutamol. It exhibits enhanced bronchodilator activity, making it a valuable reagent in respiratory research. Primarily, it is utilized in studies focusing on the treatment of chronic obstructive pulmonary disease (COPD) and other airway obstruction disorders. -
α-adrenergic Receptor Agonist
Naphazoline (Naphthazoline) hydrochloride is a potent α-adrenergic receptor agonist. Naphazoline hydrochloride reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline hydrochloride reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF. Naphazoline hydrochloride can be used for non-bacterial conjunctivitis research.
