Catalog No.
Product Name
Application
Product Information
Citations
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Dopamine D2 Receptor Antagonist
Lensiprazine is a potent dopamine D2 receptor antagonist that also functions as a serotonin reuptake inhibitor. This compound is primarily utilized in research focusing on psychiatric disorders, including bipolar disorder and schizophrenia, facilitating the exploration of neurochemical pathways involved in these conditions. Its dual action provides valuable insights into the modulation of neurotransmitter systems. -
D2 Dopamine Receptor Blocker
Savoxepin mesylate is a selective antagonist of the D2 dopamine receptor, exhibiting antipsychotic properties. It specifically targets dopamine D2 receptors in the hippocampus while sparing those in the striatum, thereby minimizing the likelihood of extrapyramidal side effects. This selective action makes Savoxepin mesylate a valuable tool for research addressing dopaminergic signaling and its implications in neuropsychiatric disorders. -
D2 Receptor Antagonist
(S)-Remoxipride hydrochloride hydrate is a selective antagonist of the dopamine D2 receptor, exhibiting an IC50 value of 1.57 μM. This compound is primarily utilized in the study of psychotic disorders, providing a valuable tool for understanding the mechanisms underlying dopamine-related pathologies and developing therapeutic strategies. Its specificity for the D2 receptor makes it an important reagent in neuropharmacology research. -
Dopamine Antagonist
Milenperone is a potent dopamine antagonist that primarily targets dopamine receptors. Its biological activity allows for the modulation of dopaminergic signaling, making it valuable in research focusing on neurological disorders. Milenperone is particularly useful in studies investigating the mechanisms underlying conditions related to dopamine dysregulation. -
Drug Derivative
4-EEC hydrochloride is a synthetic stimulant that acts as a releasing agent for norepinephrine and dopamine. It exhibits neurochemical properties that can influence mood and cognitive function. This compound is primarily used in research applications related to neuropharmacology and the study of stimulant drugs. -
D2 Receptor Antagonist
Desethoxy Quetiapine dihydrochloride is a selective antagonist of the dopamine D2 receptor, exhibiting an IC50 value of 1330 nM. This compound effectively inhibits Apomorphine-induced climbing and swimming behavior in murine models, making it valuable for investigating neuropharmacological activity and the modulation of dopaminergic signaling. Its utility in behavioral studies supports research into the therapeutic effects of D2 receptor antagonism in psychiatric disorders. -
Dopamine D1 Antagonist
SKF 83509 is a selective dopamine D1 antagonist with a Ki value of 70.2 nM, demonstrating no activity at dopamine D2 receptors. This compound is primarily utilized in neuropharmacological research to investigate the role of dopamine D1 receptors in various neurological conditions. SKF 83509 aids in the exploration of dopaminergic signaling pathways and contributes to studies focused on drug addiction, schizophrenia, and other dopamine-related disorders. -
D4 Receptor Antagonist
Sonepiprazole hydrochloride is a selective antagonist of the D4 dopamine receptor, exhibiting Ki values of 3.6 nM for the rat D4 dopamine receptor and 10.1 nM for the human D4.2 dopamine receptor. This compound demonstrates significant selectivity, with much higher Ki values of 5147 nM and 7430 nM for the rat D2 dopamine and Histamine H1 receptors, respectively. Sonepiprazole hydrochloride is useful for investigating the role of D4 receptors in neurological disorders and may have applications in psychopharmacology research. -
Dopamine D2 Receptor Agonist
FR 64822 is a potent dopamine D2 receptor agonist that demonstrates significant antinociceptive activity in preclinical models, such as rats and mice, via indirect stimulation of these receptors. In addition to its analgesic properties, FR 64822 has been shown to facilitate penile erection in juvenile rats and mitigate scopolamine-induced amnesia during passive avoidance tasks. Its diverse biological activities make it a valuable tool for research in neuropharmacology and behavioral studies. -
D3 Receptor Agonist
(+)-UH 232 is a partially selective agonist of the D3 dopamine receptor, exhibiting an intrinsic activity of 0.2-0.4. This compound effectively antagonizes quinpirole-induced mitogenesis, with a reported Ki value of 9.4 nM. It is utilized in research to explore D3 receptor signaling and its implications in various neurobiological processes. -
Antipsychotic Agent
Butaclamol is an antipsychotic agent that functions primarily as a D2 dopamine receptor antagonist. This compound exhibits significant neuroleptic activity, making it a valuable tool in the study of psychotic disorders. It is utilized in research to explore the mechanisms underlying dopaminergic signaling and its implications in various neuropsychiatric conditions. -
Haloperidol Analogue
Deschlorohaloperidol is a potent analogue of Haloperidol, primarily acting as a dopamine D2 receptor (D2R) antagonist. This compound exhibits significant antipsychotic activity, making it valuable in research focused on schizophrenia and related disorders. Its structural modifications enhance its efficacy for investigating dopamine signaling pathways and therapeutic interventions in psychiatric conditions. -
D4 Receptor Ligand
U-101958 maleate is a highly selective antagonist for the dopamine D4 receptor, exhibiting an IC50 of 2.7 nM. In HEK-293 cells expressing the human recombinant D4.4 receptor, U-101958 behaves as an agonist, demonstrating its versatile interaction with this target. This compound is primarily utilized in research related to antipsychotic effects and the modulation of dopaminergic signaling pathways. -
Dopamine Receptor Modulator
Ordopidine hydrochloride is a modulator of dopamine receptors that demonstrates an ED50 of 68 μmol/kg for increasing DOPAC levels in the rat striatum. This compound is valuable in research applications focused on neurological disorders and dopamine-related signaling pathways. Its ability to influence dopamine metabolism makes it a useful tool for exploring the role of dopamine in various physiological and pathological conditions. -
Dopamine Receptor Agonist
PF-592379 is a selective agonist of the dopamine D3 receptor, exhibiting an EC50 of 21 nM. This compound demonstrates significant potential in modulating dopaminergic signaling pathways, making it valuable for research applications related to neuroinflammatory disorders and addiction. Its ability to influence dopamine receptor activity makes PF-592379 a useful tool for studying the role of dopamine in various physiological and pathological processes. -
Dopamine Receptor Antagonist
Benzamide Derivative 1 is a dopamine receptor antagonist with potential applications in the treatment of gastrointestinal disorders. This compound, derived from patent EP0213775A1, compound 18, exhibits key biological activity by modulating dopamine signaling pathways. Its role in gastrointestinal function makes it a valuable tool for researchers investigating the interplay between dopamine receptors and gut health. -
Dopamine Receptor Agonist
U91356 is a selective dopamine receptor agonist that targets D1-like receptors. This compound has been shown to enhance dopaminergic signaling, making it useful in studies investigating neurological disorders such as schizophrenia and Parkinson's disease. U91356 facilitates the exploration of dopamine-related pathways and receptor interactions in various biological systems. -
Stable Isotope
rac-Rotigotine-d3 methyl ether is a deuterium-labeled analogue of the dopamine agonist rotigotine, targeting dopamine D2 and D3 receptors. This stable isotope is primarily utilized in pharmacokinetic studies and metabolic research, enabling precise tracking of rotigotine's distribution and metabolism in biological systems. Its application enhances the understanding of dopamine receptor activity and drug interactions. -
Stable Isotope
Apomorphine hydrochloride-d4 is a deuterium-labeled derivative of Apomorphine hydrochloride, designed as a stable isotope for metabolic studies. This compound serves as a valuable tool in pharmacokinetic and drug metabolism research, enabling precise tracking of Apomorphine in biological systems. Its application extends to studies on dopamine receptor modulation and related neurological pathways, facilitating a deeper understanding of dopaminergic signaling and its implications in various disorders. -
Stable Isotope
trans-Dihydro Tetrabenazine-d7 is a deuterium-labeled stable isotope of (2S,3S,11bS)-3-Isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-ol. It serves as a valuable tool for isotopic labeling in biochemical research. Its distinct mass characteristics facilitate studies on pharmacokinetics, metabolism, and drug interactions, particularly in the context of neuropharmacology and the investigation of dopamine receptors. -
Drug Impurity
Ropinirole impurity 3 is a characterized impurity associated with the dopamine receptor agonist Ropinirole. This compound is crucial for assessing the purity and quality of Ropinirole in pharmaceutical formulations. It aids in the development and validation of analytical methods required for regulatory compliance in drug manufacturing. -
Drug Impurity
Fluphenazine decanoate impurity 8 is a known impurity associated with Fluphenazine decanoate, an antipsychotic medication primarily targeting dopamine receptors. This compound can be utilized in analytical research to evaluate the purity of pharmaceutical formulations and support drug development processes. Its presence may affect pharmacokinetics and pharmacodynamics, making it essential for quality control and safety assessments in therapeutic applications. -
Racemate
(±)-Levomepromazine is a racemic mixture primarily targeting dopamine receptors. It exhibits notable antipsychotic activity, making it relevant for research in psychiatry and neuropharmacology. Its effects on neurotransmitter pathways are valuable for studying various psychiatric disorders and the mechanisms of psychotropic agents. -
Dopamine Receptor Antagonist
Droperidol is a butyrophenone compound primarily acting as a dopamine receptor antagonist. It inhibits the activation of GABA(A) and neuronal nicotinic acetylcholine receptors (nAChR), demonstrating IC50 values of 12.6 nM and 5.8 μM, respectively. This compound exhibits notable anesthetic and sedative properties, making it useful in research related to neuropharmacology and anesthesiology. -
Dopamine Receptor Inhibitor
Fluphenazine dihydrochloride is a potent dopamine receptor antagonist primarily targeting dopamine D2 receptors in the mesolimbic, nigrostriatal, and tuberoinfundibular pathways. This phenothiazine derivative also exhibits the ability to inhibit neuronal voltage-gated sodium channels. Its key biological activities include the suppression of Methylphenidate-induced stereotyped behaviors and climbing in murine models. Fluphenazine dihydrochloride is widely utilized in research related to psychosis, diabetic peripheral neuropathy, and may also have implications for the inhibition of SARS-CoV-2. -
D2/D3 Dopamine Receptor Antagonist
Tiapride hydrochloride is a selective antagonist of the D2 and D3 dopamine receptors, exhibiting IC50 values of 110-320 nM and 180 nM, respectively. This compound is recognized for its anti-dyskinetic and anxiolytic activities, making it valuable in neurological research. Tiapride hydrochloride is utilized as a neuroleptic agent, contributing to studies on movement disorders and anxiety-related conditions. -
Dopamine Receptor Antagonist
Clebopride malate is an orally active antagonist of dopamine D2 receptors, exhibiting significant antiemetic and prokinetic properties. This compound is useful in research focused on functional gastrointestinal disorders, providing valuable insights into dopaminergic modulation in gastrointestinal motility and emesis. Clebopride malate may serve as an important tool for understanding the underlying mechanisms of these conditions. -
Antipsychotic Agent
Dixyrazine is a phenothiazine derivative that functions as an antipsychotic agent through its antagonism of dopamine receptors. It has demonstrated efficacy in preventing brain edema induced by intracarotid injection of protamine sulfate. This compound is relevant for research applications in neuropharmacology and the investigation of psychotropic mechanisms. -
Catecholamine Neurotransmitter
Dopamine is a catecholamine neurotransmitter primarily produced in the substantia nigra, ventral tegmental area, and hypothalamus. It is essential for various neural processes and physiological functions. Dopamine exerts its biological effects predominantly through D2 dopamine receptors, leading to endocytosis of VEGFR2, which is vital for angiogenesis. This compound is widely utilized in research focusing on neurological disorders, cardiovascular functions, and cellular signaling pathways. -
Dopamine Receptor Antagonist
Fluphenazine is a potent dopamine receptor antagonist primarily targeting postsynaptic dopamine D2 receptors in the mesolimbic, nigrostriatal, and tuberoinfundibular pathways. This phenothiazine derivative exhibits substantial biological activity by inhibiting dopamine signaling, making it useful for studying psychosis and diabetic peripheral neuropathy. Additionally, Fluphenazine has shown potential in inhibiting SARS-CoV-2, contributing to its relevance in current research focused on neuropharmacology and viral pathogenesis. -
Dopamine Receptor D2 Antagonist
Promazine is a dopamine receptor D2 antagonist that primarily functions by inhibiting dopaminergic neurotransmission. This compound is utilized in research related to psychotic disorders and provides insights into dopamine-mediated pathways. Its application extends to studying the neuropharmacology of antipsychotic treatments and understanding the mechanisms underlying various psychiatric conditions. -
Dopamine Receptor Antagonist
Thioridazine is a dopamine receptor D2 antagonist known for its potent antipsychotic and anxiolytic properties. In addition to its neuropharmacological effects, Thioridazine significantly inhibits the PI3K-Akt-mTOR signaling pathway, exhibiting anti-angiogenic activity. It has demonstrated antiproliferative effects and the ability to induce apoptosis in various cancer cell types, with a particular efficacy in targeting cancer stem cells (CSCs). These characteristics make Thioridazine a valuable compound for research in neurobiology and cancer therapeutics. -
Dopamine Receptor Antagonist
N-(p-Aminophenethyl)spiperone is a selective antagonist of D2-like dopamine receptors. This compound binds specifically to the ligand recognition sites of functional D2 and D3 receptors, making it a valuable tool for researchers studying dopamine signaling pathways. N-(p-Aminophenethyl)spiperone is primarily used for labeling, localizing, and identifying D2 and D3 dopamine receptors in various biological systems. -
Stable Isotope
7-Benzyloxy-N-des[[2-(2-hydroxy)ethoxy]ethyl] Quetiapine-d8 is a deuterium-labeled derivative of Quetiapine, a psychopharmacological agent primarily targeting serotonin and dopamine receptors. This stable isotope is utilized in pharmacokinetic studies to accurately track drug metabolism and bioavailability. It serves as a valuable tool for researchers investigating the pharmacodynamics and pharmacogenomics of antipsychotic therapies. -
Stable Isotope
Chlorproethazine-d10 hydrochloride is a deuterium-labeled derivative of Chlorproethazine hydrochloride, functioning as a stable isotope. This compound is primarily utilized in pharmacokinetic studies and drug metabolism research, allowing for enhanced tracking and quantification in biological systems. Its incorporation of deuterium facilitates improved analytical precision in investigations involving the pharmacodynamics of antagonists at dopamine receptors. -
Antipsychotic Agent
Clopipazan is a potent antipsychotic agent that primarily targets dopamine receptors in the brain. Its primary mechanism of action involves modulating dopaminergic activity, which contributes to its therapeutic effects in the treatment of various psychiatric disorders, including schizophrenia. Clopipazan is utilized in research to explore neural pathways and potential therapeutic interventions for mental health conditions. -
Antipsychotic Agent
Clomacran is a potent antipsychotic agent that primarily targets dopamine receptors in the brain, particularly the D2 receptor. It exhibits significant efficacy in alleviating symptoms associated with various psychotic disorders. This compound is widely utilized in preclinical research to investigate its neuropharmacological effects and potential therapeutic applications in the treatment of schizophrenia and other related conditions. -
Phenethylamine
α-Ethyl 2C-D hydrochloride is a phenethylamine derivative that acts primarily on serotonin and dopamine receptors. This compound exhibits significant psychoactive properties and has been utilized in research to explore the effects of amphetamines and their analogs. It serves as a reference standard in drug discrimination studies, particularly for understanding the pharmacological profiles of MDMA. -
Antianxiety Compound
Fluprazine is an anxiolytic compound that primarily targets neurotransmitter systems to alleviate anxiety symptoms. This compound exhibits key biological activity in modulating serotonin and dopamine receptors, making it relevant in the study of various psychiatric disorders. Researchers utilize Fluprazine for investigating therapeutic approaches in anxiety and related mood disorders. -
Amino Acid Derivatives
Boc-Leu-OH hydrate (N-Boc-L-leucine monohydrate) is a protected form of the amino acid leucine, featuring a Boc protecting group. It serves as a useful intermediate in peptide synthesis, particularly for the generation of L-prolyl-L-leucyl-glycinamide, a peptide mimetic known for its modulatory effects on dopamine receptors. This compound is valuable in research focused on neuropharmacology and peptide therapeutics. -
LAI Antipsychotic
Aripiprazole Lauroxil is a long-acting injectable antipsychotic targeting dopamine receptors D2 and D4. It is an N-acyloxymethyl proagent of Aripiprazole, which undergoes enzymatic cleavage by esterases in the body to yield N-hydroxymethyl aripiprazole and lauric acid, further converting to aripiprazole and formaldehyde. This compound exhibits therapeutic activity in the management of schizophrenia and is utilized in research related to psychotropic medications and long-term treatment strategies. -
Antipsychotic Agent
Carphenazine is a phenothiazine antipsychotic agent that primarily targets dopamine receptors in the central nervous system. It exhibits significant antipsychotic activity, making it useful for studying the mechanisms underlying chronic schizophrenic psychoses. This compound is employed in research to better understand therapeutic interventions for various psychotic disorders. -
Active Compound
Fluphenazine enanthate is a long-acting injectable antipsychotic compound that primarily targets dopamine receptors. It is utilized in the treatment of schizophrenia, providing sustained therapeutic effects that assist in managing acute and chronic symptoms of the disorder. Researchers can explore its pharmacological properties and effects on neurotransmitter dynamics in various experimental models related to psychosis and mental health disorders. -
Anti-Schizophrenia Agent
Zuclopenthixol decanoate is an antipsychotic compound that primarily targets dopamine receptors in the central nervous system. This long-acting formulation is utilized in research focused on schizophrenia and other serious mental health disorders, offering insights into therapeutic interventions and treatment protocols. Its sustained release properties allow for improved management of symptoms, making it valuable in preclinical and clinical studies.
