Fig. 1 · Structure
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Sonepiprazole hydrochloride
D4 Receptor Antagonist
Sonepiprazole hydrochloride is a selective antagonist of the D4 dopamine receptor, exhibiting Ki values of 3.6 nM for the rat D4 dopamine receptor and 10.1 nM for the human D4.2 dopamine receptor. This compound demonstrates significant selectivity, with much higher Ki values of 5147 nM and 7430 nM for the rat D2 dopamine and Histamine H1 receptors, respectively. Sonepiprazole hydrochloride is useful for investigating the role of D4 receptors in neurological disorders and may have applications in psychopharmacology research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 170857-36-0 |
| Applications | D4 Receptor Antagonist |
| Formula | C21H28ClN3O3S |
| Molecular Weight | 437.98 |
| Synonyms | PNU-101387G hydrochloride; U-101387G hydrochloride |
| SMILES | O=S(C1=CC=C(N2CCN(CC[C@H]3C4=CC=CC=C4CCO3)CC2)C=C1)(N)=O.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.