Fig. 1 · Structure
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U-101958 maleate
D4 Receptor Ligand
U-101958 maleate is a highly selective antagonist for the dopamine D4 receptor, exhibiting an IC50 of 2.7 nM. In HEK-293 cells expressing the human recombinant D4.4 receptor, U-101958 behaves as an agonist, demonstrating its versatile interaction with this target. This compound is primarily utilized in research related to antipsychotic effects and the modulation of dopaminergic signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 224170-09-6 |
| Applications | D4 Receptor Ligand |
| Formula | C25H33N3O5 |
| Molecular Weight | 455.55 |
| Synonyms | PNU-101958 maleate |
| SMILES | CC(C)OC1=CC=CN=C1N(C)C2CCN(CC2)CC3=CC=CC=C3.O=C(/C=C\C(O)=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.