Catalog No.
Product Name
Application
Product Information
Citations
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mGluR5 allosteric modulator
CDPPB is a selective, orally active allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5). It enhances AKT and ERK1/2 signaling and upregulates BDNF mRNA expression. CDPPB also inhibits caspase-3 activation and mitigates mitochondrial dysfunction, demonstrating therapeutic potential in improving cognitive impairment, depression, and Huntington’s disease. -
Caspase Inhibitor
Z-VA-DL-D-FMK is an irreversible caspase inhibitor that targets and binds to caspases, modulating their activity. This compound enhances the sensitivity of TNF-α, thereby influencing apoptotic pathways. Additionally, Z-VA-DL-D-FMK has been shown to activate HIV replication in infected T cells, such as ACH-2, making it valuable for studies in cell signaling and viral reactivation. -
Caspase-1 Inhibitor
Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-permeable inhibitor of caspase-1, a key enzyme involved in inflammatory processes and programmed cell death. This compound demonstrates significant antitumor activity by modulating inflammatory responses and apoptosis. It is suitable for research applications focused on understanding caspase-1's role in cancer biology and related inflammatory diseases. -
Caspase 2 siRNA
Cosdosiran is a chemically modified small interfering RNA (siRNA) that specifically targets and inhibits the expression of caspase 2 protein. This reagent is instrumental in researching nonarteritic anterior ischemic optic neuropathy and various optic neuropathies, including glaucoma, that lead to the degeneration of retinal ganglion cells. Cosdosiran facilitates the exploration of pathways involved in retinal cell survival and offers insights into potential therapeutic strategies for neurodegenerative eye diseases. -
Caspase Inhibitor
Ac-VEID-CHO is a potent peptide-derived caspase inhibitor that targets Caspase-3, Caspase-6, and Caspase-7, displaying IC50 values of 13.6 nM, 16.2 nM, and 162.1 nM, respectively. Additionally, it inhibits VEIDase activity with an IC50 of 0.49 µM. This compound is valuable for research into neurodegenerative diseases, including Alzheimer’s and Huntington’s disease, facilitating the study of apoptotic pathways and potential therapeutic interventions. -
Caspase-1 Inhibitor
Ac-Trp-Glu-His-Asp-Aldehyde is a selective inhibitor of caspase-1, demonstrating a remarkable Ki value of 56 pM. This compound plays a crucial role in the modulation of inflammatory processes by inhibiting the activation of caspase-1, an essential enzyme in the maturation of pro-inflammatory cytokines. It is widely utilized in research focused on innate immunity, inflammation, and therapeutic approaches for diseases driven by caspase-1 activity. -
Caspase Inhibitor
Ac-VAD-CMK is a pan-caspase inhibitor that effectively targets and inhibits various caspases, including caspases 1, 3, and 7. This compound is utilized in research to study apoptotic pathways and cell death mechanisms. Its application extends to investigating inflammation and neurodegenerative diseases where caspase activity is a critical factor. -
Caspase 4/5/9 Inhibitor
Ac-AAVALLPAVLLALLAP-LEHD-CHO is a potent inhibitor of caspases 4, 5, and 9. This compound demonstrates protective effects in MCF-7 cells treated with Neocarzinostatin, highlighting its potential applications in apoptosis research and cell survival studies. Its ability to modulate caspase activity makes it a valuable tool for investigating pathways related to cell death and disease mechanisms. -
Caspase-2/3 Inhibitor
Ac-VDVAD-CHO is a potent inhibitor of caspase-2 and caspase-3, with IC50 values of 46 nM and 15 nM, respectively. This compound effectively interferes with apoptotic signaling pathways, making it a valuable tool for research into cell death mechanisms. It is suitable for applications involving the study of apoptosis, neurodegeneration, and cancer. -
Caspase Inhibitor
Ac-VAD-CHO (Ac-Val-Ala-Asp-CHO) is a pan-caspase inhibitor that specifically targets and inhibits caspase activity. This compound effectively prevents the dissipation of mitochondrial membrane potential (MMP) and the release of cytochrome c in cells exposed to hypoxic conditions. Ac-VAD-CHO is widely used in research applications aimed at studying apoptosis and cell survival mechanisms. -
Caspase-3 Substrate
Ac-LEVDGWK(Dnp)-NH2 is a synthetic substrate for Caspase-3, designed to facilitate the measurement of Caspase-3 enzymatic activity. Its use in research enables the study of apoptosis and cellular signaling pathways, providing insights into the role of Caspase-3 in various biological processes. This substrate can be employed in assays to quantify Caspase-3 activity in different biological samples. -
Caspase-9 Substrate
Z-VAD-AMC is a potent substrate for caspase-9, facilitating the study of apoptosis mechanisms. It exhibits high specificity for this caspase, enabling accurate monitoring of caspase activity in cellular assays. Researchers commonly utilize Z-VAD-AMC in studies focusing on programmed cell death, cellular stress responses, and therapeutic interventions targeting apoptotic pathways. -
Caspase Inhibitor
Ac-LEHD-CHO is a selective inhibitor of caspase-8 and caspase-9. It effectively blocks apoptosis in hepatocytes and prevents hepatotoxicity induced by GalN/TNF-α. This compound is valuable for research applications involving cell death pathways and liver-related diseases. -
Caspase Substrate
(Asp)2-Rhodamine 110 is a fluorescent substrate specifically designed for caspase activity detection. This compound is cleaved by active caspases, resulting in the release of a fluorescent signal that allows for real-time monitoring of apoptosis in various biological systems. It is widely utilized in research applications focused on cell death mechanisms and therapeutic interventions targeting apoptosis. -
Caspase-2 Substrate
Ac-VDVAD-pNA is a specific substrate for caspase-2, designed to facilitate the assessment of caspase-2 activity in various biological samples. This reagent releases a chromogenic product upon cleavage by active caspase-2, making it useful for both in vitro and in vivo studies. It serves as a vital tool in research applications focused on apoptotic pathways and caspase-related signaling mechanisms. -
Caspase 3 Inhibitor, GSDME Inhibitor
Ac-DMLD-CMK is a potent inhibitor of caspase 3 and GSDME, functioning by binding directly to the catalytic domain of caspase-3. This compound effectively obstructs caspase-3-mediated cleavage of GSDME, thereby modulating the caspase 3-GSDME signaling pathway. Its primary biological activity includes the reduction of pyroptosis and apoptosis, as well as the suppression of inflammatory cytokines such as LDH, IL-6, IL-1β, and IL-18. Ac-DMLD-CMK shows potential in mitigating renal function decline, renal tubular epithelial cell damage, and chemotherapeutic nephrotoxicity. -
Thioredoxin-Caspase 3 Disruptor
KEA1-97 is a selective disruptor of the thioredoxin-caspase 3 interaction, exhibiting an IC50 of 10 μM. This compound effectively disrupts the binding of thioredoxin to caspase 3, leading to the activation of caspases and subsequent induction of apoptosis, while preserving thioredoxin's enzymatic function. KEA1-97 is valuable for research into apoptosis mechanisms and therapeutic strategies targeting cell death pathways. -
Caspase-1 Inhibitor
CZL80 is a potent caspase-1 inhibitor with an IC50 of 0.01 μM, capable of penetrating the blood-brain barrier. This compound is valuable for studying inflammatory pathways in neurological disorders, notably in the context of febrile seizures and their correlation with increased susceptibility to epilepsy. Research applications include investigating the role of caspase-1 in neuroinflammation and other brain-related pathologies. -
Caspase-1 Fluorogenic Substrate
Ac-Trp-Glu-His-Asp-AMC is a specific fluorogenic substrate designed for caspase-1 detection and activity measurement. This compound exhibits high sensitivity and selectivity for caspase-1, enabling the quantitative assessment of apoptotic processes and inflammatory pathways. Its application in fluorescence assays facilitates the study of caspase-1's role in various biological contexts, including immune responses and cell death mechanisms. -
Granzyme B/Caspase-8 Substrate
Z-IETD-pNA is a specific substrate for caspase-8 and granzyme B, designed for colorimetric detection. Upon hydrolysis by caspase-8, this compound releases para-nitroaniline (pNA), facilitating the measurement of enzyme activity. It is widely utilized in research applications focusing on apoptosis and immune responses, enabling the study of cell death mechanisms and the role of granzyme B in cytotoxicity. -
Caspase Like Protease Inhibitor
Ac-YVAD-FMK is a selective inhibitor of caspase 1-like proteases. It functions by covalently modifying the active site cysteine, thus blocking the enzymatic activity of these proteases. This compound is valuable in the study of inflammation and cell death pathways, particularly in research focused on the mechanisms of pyroptosis and other caspase-associated processes. -
Caspase Inhibitor
Z-LEED-FMK is a selective inhibitor of caspase-4 and caspase-13. This compound effectively inhibits the processing of caspase-1 in macrophages infected with S. typhimurium, making it a valuable tool for studying apoptosis and inflammatory pathways. Its specificity and inhibitory effects are significant for research applications in cell death mechanisms and inflammatory response investigations. -
Caspase Activator
15-Acetoxyscirpenol is a potent caspase activator that induces apoptosis through the activation of multiple caspases, with effects that are independent of caspase-3. This mycotoxin significantly inhibits the growth of Jurkat T cells in a dose-dependent manner. Its ability to modulate apoptosis makes it a valuable tool for research in cancer biology and cell signaling pathways. -
Caspase 8 Inhibitor
Boc-AEVD-CHO is a selective inhibitor of Caspase 8, a crucial enzyme involved in apoptotic pathways. This compound is valuable for investigating the mechanisms of apoptosis as well as the roles of Caspase 8 in various immune and inflammatory diseases. Researchers can utilize Boc-AEVD-CHO to better understand cellular processes related to programmed cell death and inflammation regulation. -
Caspase-1 Substrate
Z-YVAD-pNA (Z-Tyr-Val-Ala-Asp-pNA) is a substrate specifically designed for caspase-1 activity. This compound is pivotal in studying inflammation and cell death pathways, as it is cleaved by caspase-1 during the activation of inflammatory caspases. Z-YVAD-pNA serves as an essential tool in research focused on apoptosis, pyroptosis, and other caspase-related signaling mechanisms. Its use can aid in the development of therapeutic strategies targeting inflammatory diseases. -
Caspase-1 Substrate
Ac-VAD-pNA is a synthetic substrate specifically designed for the detection of caspase-1 activity. This compound enables the assessment of caspase-1 enzymatic function, making it a valuable tool for studying apoptotic and inflammatory pathways. Its utility in various research applications includes investigating mechanisms of cell death and inflammatory responses, facilitating advancements in therapeutic strategies targeting these processes. -
Caspase-3 Fluorogenic Substrate
Mca-DEVDAP-K(Dnp)-OH is a fluorogenic substrate specifically designed for the quantification of caspase-3 activity. Utilizing the caspase-3 recognition sequence DEVD, this substrate facilitates the detection of caspase-3-mediated apoptosis in various biological samples. It is widely applied in research focused on programmed cell death and can be utilized in high-throughput screening assays to evaluate the efficacy of anti-apoptotic and pro-apoptotic compounds. -
Caspase 3 Inhibitor
Cimiside E, a caspase 3 inhibitor, is a triterpene xyloside known for its pro-apoptotic effects on gastric cancer cells, displaying an IC50 value of 14.58 μM. This compound induces cell cycle arrest in the G2/M phase and mediates apoptosis via activation of the caspase cascade across both extrinsic and intrinsic pathways. Cimiside E is a valuable tool in cancer research, particularly in studies focusing on apoptosis and cell cycle modulation. -
Caspase-8 Inhibitor
IETD-CHO is a selective inhibitor of caspase-8, a crucial enzyme in the apoptotic signaling pathway. By blocking caspase-8 activity, this reagent prevents the activation of downstream effector caspases, allowing for the study of programmed cell death mechanisms. IETD-CHO is widely used in research applications focused on apoptosis, inflammation, and related cell signaling processes. -
Caspase-3 Activator
Caspase-3 activator 3 is a potent inducer of apoptosis, specifically targeting caspase-3 in HL-60 and K562 leukemia cell lines. This compound demonstrates significant antileukemic activity, with IC50 values of 42.89 μM for HL-60 cells and 33.61 μM for K562 cells. It serves as an important tool for investigating apoptotic pathways and evaluating potential therapeutic strategies in leukemia research. -
Caspase-1 Fluorogenic Substrate
Ac-WEHD-AFC is a fluorogenic substrate specifically designed for the detection of caspase-1 activity. This compound enables the quantitative measurement of caspase-1 enzymatic function, making it a valuable tool in studies related to tumorigenesis and inflammatory processes. Its sensitive fluorescence readout facilitates the assessment of caspase-1 involvement in various biological systems. -
Caspase-9 Inhibitor
Caspase-9 Inhibitor III (Ac-LEHD-cmk) targets and inhibits caspase-9, a critical component of the apoptotic pathway. This reagent demonstrates protective effects against ischemia-reperfusion-induced myocardial injury, making it valuable for studying cardiac apoptosis and related pathological conditions. It can be utilized in research focused on cellular survival mechanisms and the modulation of programmed cell death. -
Caspase Inhibitor
Ac-FLTD-CMK is a selective inhibitor of inflammatory caspases, specifically targeting caspases-1, -4, -5, and -11, with IC50 values of 46.7 nM, 1.49 μM, and 329 nM, respectively. This compound is derived from gasdermin D (GSDMD) and does not inhibit apoptotic caspases such as caspase-3. Ac-FLTD-CMK is instrumental in research applications focused on inflammatory processes, providing valuable insights into caspase-mediated pathways and their implications in various diseases. -
Caspase-4 inhibitor
Z-LEVD-FMK is a cell-permeable inhibitor of caspase-4, a key player in the apoptotic signaling pathway. This reagent effectively blocks endoplasmic reticulum stress-induced apoptosis in cancer cells, making it a valuable tool for studying cell death mechanisms and developing therapeutic strategies in oncology research. Its specificity for caspase-4 facilitates investigations into its role in various cellular stress responses. -
Caspase-3/7 Substrate
Ac-Asp-Glu-Val-Asp-pNA is a specific substrate for caspase-3/7, facilitating the study of apoptosis and cellular signaling pathways. This peptidic compound is cleaved by caspase-3/7, resulting in the release of p-nitroaniline (pNA), which can be quantitatively measured. Its use is critical in research applications focused on understanding programmed cell death and evaluating the activity of caspases in various biological contexts. -
Caspase 2 substrate
Ac-VDQQD-pNA is a selective substrate for Caspase 2, designed to facilitate the study of caspase activity. Upon cleavage by Caspase 2, it yields a yellow chromophore, p-nitroaniline (pNA), which can be quantitatively measured. This reagent is ideal for research applications focused on apoptosis, cell signaling, and the functional characterization of caspases. -
Caspase-3 Activator
Caspase-3 Activator 2 is a potent activator of caspase-3, a key executioner of apoptosis. This compound effectively induces apoptotic cell death in cancer cell lines, demonstrating cytotoxicity with IC50 values of 33.52 μM against HL-60 cells and 76.90 μM against K562 cells. Its applications are significant in cancer research, particularly in studies investigating apoptotic pathways and therapeutic interventions. -
Caspase Inhibitor
Z-VAD-CHO is a potent, irreversible inhibitor of caspases, primarily targeting caspase-1 with a Ki value of 0.008 μM. This compound effectively modulates apoptotic pathways and is instrumental in studies related to inflammation and cell death. Z-VAD-CHO is widely utilized in research to investigate the role of caspases in various cellular processes and disease models. -
Caspase-1/3 Inhibitor
Z-YVAD-CMK is a potent inhibitor of caspase-1 and caspase-3, key enzymes involved in the apoptosis and inflammatory processes. By selectively blocking these caspases, Z-YVAD-CMK is invaluable for research applications focused on cell death pathways and inflammatory responses. It is particularly useful in studies investigating the role of caspases in disease models, including neurodegeneration and cancer. -
MMP-3/Caspase-1 Inhibitor
Berkeleyamide B is a dual inhibitor of matrix metalloproteinase-3 (MMP-3) and caspase-1, targeting key enzymes involved in inflammation and tissue remodeling. This compound demonstrates significant biological activity in modulating apoptotic pathways and inflammatory responses. Berkeleyamide B is applicable in research focused on cancer and inflammatory diseases, including conditions such as rheumatoid arthritis. -
Caspase-3 Inhibitor
Caspase-3-IN-3 is a selective inhibitor of caspase-3, a crucial executioner enzyme in the apoptosis pathway. This compound has been shown to enhance cellular ATP levels, inhibit caspase-3 activity, and reduce nitrite production. Additionally, Caspase-3-IN-3 mitigates cytokine-induced apoptosis and restores insulin secretion stimulated by glucose, making it a valuable tool for research in apoptosis, metabolic disorders, and cellular energy regulation. -
Caspase-3 Inhibitor
Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone is a potent and cell-permeable inhibitor of caspase-3, acting through irreversible binding to the activated form in apoptotic cells. This reagent exhibits significant fluorescence, allowing for quantitative analysis via flow cytometry, microwell plate readers, or fluorescence microscopy. Its application is crucial for studying apoptosis and characterizing caspase-3 activity in various biological systems. -
Caspase Inhibitor
VX-166 is a pan caspase inhibitor that modulates apoptosis by targeting caspase enzymes. This compound is instrumental in investigating Non-Alcoholic Fatty Liver Disease (NAFLD), nonalcoholic steatohepatitis (NASH), and alcoholic steatohepatitis (ASH), as well as other conditions characterized by liver fibrosis, steatosis, or inflammation. Its ability to inhibit caspase activity makes it a valuable tool for research in liver pathology and related diseases. -
Fluorogenic Caspase-3/7 Substrate
Z-DEVD-R110 is a fluorogenic substrate specifically designed for the detection of caspase-3 and caspase-7 activity. Composed of two DEVD peptide sequences linked to the rhodamine 110 fluorophore, this reagent is valuable for studying apoptotic processes in various biological systems. Its ability to provide quantitative measurements of caspase activity makes it an essential tool in apoptosis research and related studies. -
Caspase-1/ACE-2 Fluorogenic Substrate
Mca-YVADAP-Lys(Dnp)-OH is a fluorogenic substrate designed for the characterization of caspase-1 and angiotensin-converting enzyme 2 (ACE2) activity. This compound enables the detection of enzymatic activity through fluorescence, making it valuable for studies focused on apoptosis and cardiovascular signaling pathways. It is suitable for use in various assays aimed at exploring the roles of these enzymes in cellular processes and disease states. -
Caspase 3/7 Inhibitor
CAY10406 is a selective inhibitor of caspase 3 and caspase 7. This compound effectively reduces the expression of the 28-kDa IL-1β fragment, making it useful for studies related to apoptosis and inflammatory processes. Notably, CAY10406 exhibits minimal cytotoxicity at concentrations up to 10 μM, allowing for safer applications in cellular assays. -
MMP-3/Caspase-1 Inhibitor
Berkeleyamide C is a selective inhibitor of matrix metalloproteinase-3 (MMP-3) and caspase-1. This compound effectively blocks MMP-3-mediated tumor cell invasion and metastasis, while also inhibiting the abnormal activation of inflammation and apoptosis associated with caspase-1. Berkeleyamide C is valuable for research applications focused on cancer biology and inflammation-related diseases. -
Caspase-6 Inhibitor
ED11 is a selective inhibitor of caspase-6, demonstrating an IC50 of 12.12 nM. By competing with Huntingtin (Htt) for the active site of caspase-6, ED11 effectively reduces Htt cleavage. Notably, ED11 possesses the ability to cross the blood-brain barrier, making it a valuable reagent for research into Huntington's disease and related neurodegenerative disorders. -
Caspase-3 Activator
Caspase-3 Activator 4 is a potent activator of caspase-3 that effectively crosses the blood-brain barrier. This compound exhibits significant antiproliferative activity and induces apoptosis in various cell types. Additionally, Caspase-3 Activator 4 enhances the gene expression of TNF-α while reducing the protein expression of cleaved caspases 3, underscoring its potential in apoptosis-related research applications. -
Caspase-9 Inhibitor
Z-LEHD-FMK TFA is a selective and irreversible inhibitor of caspase-9, primarily involved in the apoptosis pathway. This compound demonstrates significant neuroprotective effects, particularly in models of spinal cord injury, and has been shown to mitigate lethal reperfusion injury. It is a valuable tool for research focused on therapeutic strategies against apoptotic cell death and neuroprotection.
