Ac-FLTD-CMK is a selective inhibitor of inflammatory caspases, specifically targeting caspases-1, -4, -5, and -11, with IC50 values of 46.7 nM, 1.49 μM, and 329 nM, respectively. This compound is derived from gasdermin D (GSDMD) and does not inhibit apoptotic caspases such as caspase-3. Ac-FLTD-CMK is instrumental in research applications focused on inflammatory processes, providing valuable insights into caspase-mediated pathways and their implications in various diseases.
Ac-FLTD-CMK is a selective inhibitor of inflammatory caspases, specifically targeting caspases-1, -4, -5, and -11, with IC50 values of 46.7 nM, 1.49 μM, and 329 nM, respectively. This compound is derived from gasdermin D (GSDMD) and does not inhibit apoptotic caspases such as caspase-3. Ac-FLTD-CMK is instrumental in research applications focused on inflammatory processes, providing valuable insights into caspase-mediated pathways and their implications in various diseases.
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