Ac-VDQQD-pNA

Catalog No.: A25311
Caspase 2 substrate
Ac-VDQQD-pNA is a selective substrate for Caspase 2, designed to facilitate the study of caspase activity. Upon cleavage by Caspase 2, it yields a yellow chromophore, p-nitroaniline (pNA), which can be quantitatively measured. This reagent is ideal for research applications focused on apoptosis, cell signaling, and the functional characterization of caspases.
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5mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAc-VDQQD-pNA is a selective substrate for Caspase 2, designed to facilitate the study of caspase activity. Upon cleavage by Caspase 2, it yields a yellow chromophore, p-nitroaniline (pNA), which can be quantitatively measured. This reagent is ideal for research applications focused on apoptosis, cell signaling, and the functional characterization of caspases.
Product Information
Catalog NumA25311
FormulaC31H43N9O14
Molecular Weight765.73
CAS Number189684-52-4
SequenceAc-Val-Asp-Gln-Gln-Asp-{pNA}
Sequence shorteningAc-VDQQD-{pNA}
SMILESO=[N+]([O-])C(C=C1)=CC=C1NC([C@H](CC(O)=O)NC([C@H](CCC(N)=O)NC([C@H](CCC(N)=O)NC([C@H](CC(O)=O)NC([C@H](C(C)C)NC(C)=O)=O)=O)=O)=O)=O
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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