Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone

Catalog No.: A25322
Caspase-3 Inhibitor
Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone is a potent and cell-permeable inhibitor of caspase-3, acting through irreversible binding to the activated form in apoptotic cells. This reagent exhibits significant fluorescence, allowing for quantitative analysis via flow cytometry, microwell plate readers, or fluorescence microscopy. Its application is crucial for studying apoptosis and characterizing caspase-3 activity in various biological systems.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionFluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone is a potent and cell-permeable inhibitor of caspase-3, acting through irreversible binding to the activated form in apoptotic cells. This reagent exhibits significant fluorescence, allowing for quantitative analysis via flow cytometry, microwell plate readers, or fluorescence microscopy. Its application is crucial for studying apoptosis and characterizing caspase-3 activity in various biological systems.
Product Information
Catalog NumA25322
FormulaC43H45FN4O16
Molecular Weight892.83
CAS Number1926163-65-6
Sequence{Fluorescein-6-carbonyl}-{Asp(OMe)}-{Glu(OMe)}-Val-{dl-Asp(OMe)}-{Fluoromethylketone}
Sequence shortening{Fluorescein-6-carbonyl}-{Asp(OMe)}-{Glu(OMe)}-V-{dl-Asp(OMe)}-{Fluoromethylketone}
SMILESO=C1OC2(C=3C1=CC=C(C(N[C@H](C(N[C@H](C(N[C@H](C(NC(CC(OC)=O)C(CF)=O)=O)C(C)C)=O)CCC(OC)=O)=O)CC(OC)=O)=O)C3)C=4C(OC=5C2=CC=C(O)C5)=CC(O)=CC4
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