IHVR-19029 is a potent inhibitor of endoplasmic reticulum α-glucosidases I and II, exhibiting an IC50 of 0.48 μM for α-glucosidase I. This compound demonstrates significant antiviral activity by effectively blocking the replication of various hemorrhagic fever viruses, including Dengue virus (DENV), Ebola virus (EBOV), and Rift Valley fever virus. Research applications include the exploration of antiviral strategies, especially in combination therapies, such as enhancing the efficacy of Favipiravir.
IHVR-19029 is a potent inhibitor of endoplasmic reticulum α-glucosidases I and II, exhibiting an IC50 of 0.48 μM for α-glucosidase I. This compound demonstrates significant antiviral activity by effectively blocking the replication of various hemorrhagic fever viruses, including Dengue virus (DENV), Ebola virus (EBOV), and Rift Valley fever virus. Research applications include the exploration of antiviral strategies, especially in combination therapies, such as enhancing the efficacy of Favipiravir.
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