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Catalog No.
Product Name
Application
Product Information
Citations
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Tubulin Inhibitor
ABI-274 is a potent tubulin inhibitor that targets the colchicine binding site. This compound significantly enhances cancer cell apoptosis in vitro when used in combination with vemurafenib, exhibiting strong synergistic effects. In vivo studies demonstrate its efficacy in vemurafenib-resistant xenograft models in nude mice, making ABI-274 a critical tool for research on melanoma and potential therapeutic strategies in resistant cancer forms. -
Tubulin Inhibitor
Tubulin inhibitor 8 (Compound 33b) is a potent inhibitor of tubulin polymerization, demonstrating an IC50 value of 0.73 μM. This compound effectively inhibits the growth of K562 cancer cells, achieving an IC50 of 14 nM. Tubulin inhibitor 8 is valuable for studies in cancer research, particularly in evaluating mechanisms of action related to cytoskeletal dynamics and potential therapeutic interventions in tumor proliferation. -
Tubulin Inhibitor
Tubulin Inhibitor 7 is a potent inhibitor of tubulin polymerization, targeting microtubule dynamics critical for cell division. With an IC50 of 0.52 μM, it effectively disrupts tubulin assembly, exhibiting significant anti-proliferative activity in various cancer cell lines. Notably, Tubulin Inhibitor 7 demonstrates an IC50 of 11 nM against K562 cells, making it a valuable tool for cancer research and studies focused on mitotic disruption. -
Tubulin Inhibitor
Tubulin Inhibitor 29 is a potent inhibitor of tubulin assembly, exhibiting an IC50 value of 1.2 µM. This compound demonstrates significant antiproliferative activity, with an IC50 value of 7.5 µM against MCF-7 breast cancer cells. By binding to the colchicine site on tubulin, Tubulin Inhibitor 29 disrupts microtubule dynamics, making it a valuable tool for cancer research and studies focused on cell cycle regulation. -
Microtubule Inhibitor
Cevipabulin fumarate dihydrate is a potent microtubule inhibitor targeting tubulin to disrupt microtubule dynamics. This orally administered antitumor compound demonstrates significant cytotoxic activity in human tumor cell lines, with an IC50 range of 18-40 nM. Cevipabulin is primarily used in cancer research to explore mechanisms of tumor cell proliferation and resistance, providing valuable insights for therapeutic development. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-63 is a potent inhibitor of tubulin polymerization, demonstrating an IC50 value of 0.29 μM in MES-SA cells. This compound disrupts microtubule dynamics, making it a valuable tool for cancer research. It aids in the exploration of cellular responses to tubulin modulation and contributes to the understanding of tumor biology and therapeutic strategies. -
Tubulin Inhibitor
Tubulin Inhibitor 26 is a potent indazole derivative targeting tubulin. It exhibits low nanomolar potency against various cancer cell lines, including HepG2, HCT116, SW620, HT29, and A549. This compound effectively induces G2/M phase arrest and promotes apoptosis in tumor cells. Furthermore, Tubulin Inhibitor 26 demonstrates the ability to suppress tumor growth in vivo while maintaining normal body weight in mice. -
Tubulin/FTase Inhibitor
Tubulin polymerization-IN-25 is a dual inhibitor targeting tubulin polymerization and farnesyl transferase (FTase), exhibiting IC50 values of 1.11 μM and 0.39 μM, respectively. This compound demonstrates significant cytotoxicity and potent antitumor activity, making it a valuable tool for cancer research. Its ability to disrupt microtubule dynamics and inhibit protein farnesylation underscores its potential in therapeutic applications focused on tumor growth suppression. -
Microtubule Synthesis Inhibitor
Antitumor agent-200 is a microtubule synthesis inhibitor that targets the colchicine site on tubulin, leading to G2/M cell cycle arrest and the generation of reactive oxygen species (ROS). This compound demonstrates significant inhibitory activity against MCF7/ADR and KBV200 cell lines exhibiting P-glycoprotein overexpression, with drug resistance indices of 0.83 and 0.58, respectively. In vivo studies using the MCF-7 xenograft model have shown that Antitumor agent-200 at a dosage of 25 mg/kg via intraperitoneal injection results in a tumor growth inhibition rate of 57.2%. This reagent is valuable for research in the oncology field, particularly in studies related to drug resistance and cancer treatment efficacy. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-87 is a potent inhibitor of tubulin polymerization. This compound disrupts the assembly of microtubules, resulting in G2/M cell cycle arrest and exhibiting significant anti-proliferative effects. It is particularly effective against ovarian cancer, providing valuable insights for research applications in cancer biology and therapeutic development. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-10 is a potent inhibitor of tubulin polymerization, exhibiting an IC50 of 4.25±0.75 μM. This compound demonstrates significant anti-tumor activity, making it a valuable tool for cancer research and studies focusing on microtubule dynamics. Its ability to disrupt tubulin assembly can be leveraged in the investigation of various cancer therapies. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-37 is an effective tubulin polymerization inhibitor, exhibiting an IC50 value of 2.3 μM. By binding to the colchicine site on tubulin, it disrupts the normal polymerization process and inhibits colchicine binding. This compound is valuable in cancer research, particularly in studying various lymphomas and their underlying mechanisms. -
Tubulin inhibitor
Tubulin Inhibitor 15 is a potent compound that disrupts microtubule dynamics by binding to tubulin. This reagent demonstrates significant antiproliferative activity, exhibiting cytotoxic effects specifically in HepG2 liver cancer cells. It is a valuable tool for research focused on cancer biology and the mechanisms of cell division and proliferation. -
Tubulin Inhibitor
BNZ-111 is an orally bioavailable inhibitor of tubulin, targeting microtubule dynamics. This compound exhibits significant antitumor activity, making it a valuable tool for cancer research. BNZ-111 can be utilized in studies focused on the mechanistic understanding of microtubule-targeting therapies and their potential clinical applications in oncology. -
Polymerization Inhibitor Prodrug
Tubulin Polymerization-IN-1 prodrug is a palladium-mediated inhibitor of tubulin polymerization, developed to target the colchicine binding site. This prodrug demonstrates significantly reduced cytotoxicity compared to its parent compound, offering a 68.3-fold reduction in toxicity while maintaining effectiveness upon activation by Pd resin. Mechanistic investigations align its anticancer activity with that of colchicine binding site inhibitors. In vivo studies have shown that treatment with Tubulin Polymerization-IN-1 prodrug results in a substantial inhibition of tumor growth (63.2%) following Pd resin activation. This compound holds potential for advancing research in anticancer therapeutics. -
Tubulin Inhibitor
Tubulin Inhibitor 44 is a potent inhibitor targeting tubulin, disrupting its function in microtubule dynamics. This compound exhibits significant cytotoxicity in cancer cell lines such as NCI-H460, BxPC-3, and HT-29, with IC50 values of 0.96 nM, 0.66 nM, and 0.61 nM, respectively. Its efficacy makes it a valuable tool for research in cancer biology and drug discovery focused on microtubule-targeting agents. -
Tubulin Inhibitor
Ohchinolide B is a potent tubulin inhibitor that effectively disrupts microtubule polymerization with an IC50 of 2.3 μM. This compound induces G2/M phase cell cycle arrest and activates mitochondrial apoptotic pathways, making it a valuable tool for studying cancer biology. Ohchinolide B is particularly promising for research involving solid tumors, including breast and lung cancer. -
Tubulin Inhibitor
3,3'-Dihydroxy-2,6-bis(4-hydroxybenzyl)-5-methoxybibenzyl is a potent tubulin inhibitor with an IC50 of 10 μM, effectively inhibiting tubulin polymerization. This stilbenoid compound enhances the cytotoxic effects of SN-38 in BCRP-transduced cancer cells, making it a valuable tool for cancer research. Its application is particularly relevant in the study of breast cancer, where it can help elucidate mechanisms of drug resistance and potential therapeutic strategies. -
Microtubule Inhibitor
Isodienestrol is a microtubule inhibitor that disrupts the normal function of the cytoskeletal structure. This compound is primarily utilized in cancer research, where it demonstrates potential effectiveness in inhibiting tumor cell proliferation and inducing apoptosis. Its mechanism of action makes it a valuable tool for investigating microtubule dynamics and their role in oncogenic processes. -
Tubulin Inhibitor
Tubulin Inhibitor 12 is a selective antagonist of tubulin with an IC50 value of 25.3 μM. This compound exhibits significant anti-tumor and anti-proliferative activities, making it a valuable tool for cancer research. It is ideally suited for studies focused on cell cycle regulation and mechanisms of tumor growth inhibition. -
Microtubule Assembly Inhibitor
Myoseverin B is a microtubule assembly inhibitor that effectively disrupts tubulin polymerization with an IC50 of 2 μM. This compound demonstrates low cytotoxicity across various cell types, making it a valuable tool in cellular studies. Myoseverin B is primarily utilized in research focused on antitumor mechanisms and the exploration of microtubule dynamics in cancer biology. -
Tubulin polymerization Inhibitor
Tubulin polymerization-IN-29 is a potent inhibitor of tubulin polymerization, effectively disrupting microtubule dynamics. This compound demonstrates significant antiproliferative activity and is capable of inducing cell cycle arrest in HeLa cells at the G2/M phase. It serves as a valuable tool for research involving cancer biology and cell proliferation studies. -
Tubulin Polymerization Inhibitor
Tubulin Polymerization-IN-52 is a selective inhibitor of tubulin polymerization, demonstrating an IC50 of 2.9 μM. This compound disrupts microtubule dynamics, making it a valuable tool for studying cytoskeletal function and cell division. Its inhibitory effects on tubulin polymerization can be leveraged in cancer research and investigations into related disorders. -
Angiogenesis inhibitors
Denibulin hydrochloride is an anti-angiogenic agent that targets and disrupts the formation of blood vessels in solid tumors. This compound demonstrates significant anticancer activity by promoting rapid closure of tumor-associated vasculature, which can lead to a dose-dependent reduction in tumor cell viability. Denibulin hydrochloride enhances the efficacy of radiation and cisplatin chemotherapy, making it a valuable tool for research in cancer therapeutics and vasculature dynamics. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-55 is a potent inhibitor of tubulin polymerization, disrupting microtubule dynamics. This reagent exhibits significant antiproliferative activity against various cancer cell lines, including A549, K562, HepG2, MDA-MB-231, and HFL-1, with IC50 values of 8, 3, 9, 24, and 62 nM, respectively. It serves as a valuable tool for researchers studying cancer biology and cellular mechanisms involving microtubules. -
Tubulin Polymerization/Akt Pathway Inhibitor
KS-99 is an inhibitor that targets both tubulin polymerization and the Akt signaling pathway. This compound demonstrates significant biological activity by inhibiting cancer cell proliferation and inducing apoptosis in various cancer cell types. KS-99 is suitable for research applications involving colorectal cancer, breast cancer, lung epithelial cancer, and melanoma. -
Microtubule Inhibitor
Taxinine B is a microtubule inhibitor derived from the Japanese Yew (Taxus cuspidata). It effectively inhibits CaCl2-induced depolymerization of microtubules, contributing to its potential in cancer research. Taxinine B may also be valuable for overcoming multidrug resistance in tumor cells, making it a significant compound for studies focused on cancer treatment and cellular mechanisms. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-77 is a potent inhibitor of tubulin polymerization, specifically targeting the microtubule dynamics crucial for cell division. This compound exhibits notable anti-glioblastoma activity by inducing G2/M phase arrest and promoting apoptosis in glioblastoma cells. Additionally, Tubulin polymerization-IN-77 is characterized by significant permeability across the blood-brain barrier and effectively reduces tumor cell migration, making it a valuable reagent for cancer research applications focused on glioblastoma therapeutics. -
Microtubule Inhibitor
JC168 is a phenyl analog of peloruside that acts as a microtubule inhibitor. It exhibits significant antiproliferative and anticancer activities by promoting tubulin polymerization, thus disrupting microtubule dynamics. This compound is valuable for research on microtubule-associated disorders and offers potential insights into cancer biology. -
Microtubule Inhibitor
Anticancer agent 98 is a microtubule inhibitor that disrupts tubulin polymerization with a Kd of 16.9 μM. This compound demonstrates significant antiproliferative activity against various tumor cell lines and exhibits an anti-angiogenic effect in vitro. Additionally, Anticancer agent 98 shows favorable stability in human and mouse liver microsomes, with a half-life greater than 300 minutes, making it a valuable candidate for further research in cancer therapeutics. -
Tubulin Inhibitor
ALB-109564 hydrochloride, a tubulin inhibitor, effectively disrupts mitosis in cancer cells, leading to cytotoxicity. This compound is utilized in research focused on cancer biology and treatment strategies, particularly in studies examining the mechanisms of cell division and potential therapeutic interventions for tumor growth. Its ability to impair microtubule dynamics makes it a valuable tool for investigating novel anti-cancer modalities. -
Tubulin Inhibitor
Neuroinflammatory-IN-3 is a tubulin inhibitor that exhibits anti-neuroinflammatory properties. It acts by preventing tubulin polymerization, which disrupts microtubule dynamics. This compound has demonstrated potential as an effective antitumor agent, making it valuable for research in cancer biology and neuroinflammatory diseases. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-8 is a potent inhibitor of tubulin polymerization, primarily targeting microtubule dynamics. It effectively induces G2/M phase cell cycle arrest in HCT116 tumor cells, demonstrating a significant inhibitory potency with an IC50 value of 12.7 μM. This compound is valuable for research applications in cancer biology, particularly in studies focused on tumor cell proliferation and microtubule-targeting therapies. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-20 is a potent inhibitor of tubulin polymerization, targeting the assembly of microtubules crucial for cell division. This compound exhibits significant potential in the study of breast cancers and chemoresistant colon cancers, facilitating research into mechanisms of resistance and offering insights for therapeutic strategies. Its effectiveness in disrupting microtubule dynamics makes it a valuable tool for cancer research applications. -
Melanoma Inhibitor
Anti-melanoma agent 3 is a 2-aryl-4-benzoyl-imidazole (ABI) derivative designed to inhibit melanoma xenografts. This compound demonstrates significant anticancer activity by targeting the colchicine binding site, leading to the inhibition of tubulin polymerization. It is particularly useful in research focused on developing effective treatments for melanoma by disrupting cellular mitosis and tumor growth. -
Tubulin Inhibitor
Tubulin Inhibitor 20 is a potent inhibitor of tubulin, disrupting microtubule dynamics and thereby affecting cellular processes such as mitosis and intracellular transport. This compound demonstrates significant anti-cancer activity, making it a valuable tool for research into cancer biology and therapeutic development. Its ability to inhibit tubulin polymerization positions it as a critical reagent for studies aimed at understanding tumor progression and the mechanisms of action of anti-cancer therapies. -
Tubulin Inhibitor
Cemadotin hydrochloride is a potent tubulin inhibitor that disrupts microtubule dynamics, leading to cell cycle arrest in the mitotic phase. With a Ki value of 1 μM, it effectively inhibits cell proliferation in vitro and reduces tumor xenograft growth in murine models. This compound is an important tool for investigating anticancer mechanisms and potential therapeutic applications in cancer research. -
Tubulin Inhibitor
IKP-104 is a potent tubulin inhibitor with an IC50 of 1.31 μM, targeting microtubule polymerization to arrest cells in mitosis during the M phase. This compound induces cytoskeletal microtubule depolymerization, effectively inhibiting the growth of various mouse and human tumor cell lines. Additionally, IKP-104 demonstrates notable anti-tumor effects in mouse ascites tumors and lung cancer models, making it a valuable tool for research in leukemia, lung cancer, and melanoma. -
Microtubule Inhibitor
(Rac)-Deox B 7,4 is a homoisoflavanoid compound that acts as a microtubule inhibitor by binding near the colchicine site, disrupting microtubule polymerization and leading to reversible G2 phase arrest. This compound exhibits potent nanomolar anti-leukemic activity, making it a valuable tool for research into cancer therapeutics and cellular dynamics. Its ability to modulate cytoskeletal functions holds promise for studies related to cell cycle regulation and tumor progression. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-15 is a selective inhibitor of tubulin polymerization, effectively disrupting microtubule dynamics. This compound exhibits significant potential in cancer research by hindering cell division and inducing apoptosis in tumor cells. It can be utilized to study the mechanisms of cancer progression and the role of microtubules in cellular processes. -
Tubulin Inhibitor
SPA107 is a tubulin inhibitor that prevents tubulin polymerization, demonstrating potent antimitotic activity with an IC50 of 0.5 nM. In addition, SPA107 exhibits significant cytotoxic effects in p53 mutated MCF-7 cells, with an IC50 of 0.5 nM. This compound is valuable for research in cancer biology, particularly in studies focused on mitotic disruption and the mechanisms underlying drug resistance. -
Tubulin Inhibitor
HD-800 is a potent tubulin inhibitor, exhibiting an IC50 of 4.3 nM and an EC50 for depolymerization of 24 nM. This compound is valuable for generating the radioactive tracer [11C]HD-800, which is capable of penetrating the blood-brain barrier. [11C]HD-800 serves as a useful tool for positron emission tomography (PET) applications in studying various neurological disorders. -
Tubulin Inhibitor
isoCA-4 is a tubulin polymerization inhibitor derived from Combretastatin A4. It exhibits significant anti-proliferative activity, making it a valuable tool for studying cancer cell growth and metastasis. This compound can be utilized in research applications focused on tumor biology and the development of novel cancer therapeutics. Its mechanism of action provides insights into disrupting microtubule dynamics in cellular systems. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-27 is a selective inhibitor of tubulin polymerization, disrupting microtubule dynamics and thereby arresting the cell cycle at the G2/M phase. This compound induces apoptosis in cancer cells, making it a valuable tool for studying cell cycle regulation and apoptosis mechanisms in various research applications. It is suitable for investigations into cancer biology and therapeutic strategies targeting microtubule assembly. -
Microtubule Inhibitor
Tubulozole is a synthetic microtubule inhibitor that exerts its effects by disrupting microtubule dynamics, leading to cell cycle arrest and apoptosis in cancer cells. It is primarily utilized in research focused on cancer biology, particularly in the study of tumor growth and metastasis. Tubulozole's ability to inhibit microtubule polymerization makes it a valuable tool in the investigation of novel therapeutic strategies for cancer treatment. -
Microtubule Polymerization Inhibitor
Bruceoside D is a microtubule polymerization inhibitor derived from the quassinoid glucoside found in Brucea javanica. This compound exhibits cytotoxic effects against several cancer cell lines, including leukemia (CCRF-CEM), non-small cell lung cancer (A549), and ovarian cancer (OVCAR-3). Bruceoside D is a valuable tool for researchers investigating potential cancer therapeutics and the mechanisms underlying tumor cell growth and proliferation. -
Microtubule Inhibitor
ER-67880 is a potent microtubule inhibitor that disrupts microtubule dynamics with an IC50 of 9.5 μM. This compound demonstrates significant anti-proliferative effects against KB, Colon 38, and P338 cancer cell lines, with IC50 values of 0.55, 0.2, and 0.76 μg/mL, respectively. It causes G2/M phase cell cycle arrest and results in altered DNA replication patterns, alongside the down-regulation of G1 phase-related genes. ER-67880 is applicable in various cancer research studies, including those focused on nasopharyngeal carcinoma and murine adenocarcinoma. -
Microtubule/Tubulin Inhibitor
BP-M345 is a potent microtubule/tubulin inhibitor that effectively targets cancer cells while demonstrating low toxicity to non-tumor cells. This compound exhibits significant antiproliferative activity, with a GI50 value ranging from 0.17 to 0.45 μM, making it an important tool for cancer research and therapeutic studies. Its ability to selectively inhibit cancer cell proliferation positions BP-M345 as a valuable reagent for exploring cancer biology and potential treatment options. -
Tubulin Inhibitor
Tubulin inhibitor 18 is a potent inhibitor of tubulin, primarily functioning through disruption of microtubule polymerization. As a chalcone derivative, it exhibits significant anti-proliferative activity in various cancer cell lines. This compound is valuable for research applications targeting cancer diseases, enabling further investigation into tubulin dynamics and therapeutics. -
Inhibitors of Tubulin Polymerization
KGP591 is a potent inhibitor of tubulin polymerization with an IC50 of 0.57 µM. It effectively induces G2/M phase stagnation, inhibits cell migration, and disrupts microtubule structure and cell morphology in MDA-MB-231 human breast cancer cells. Additionally, KGP591 exhibits notable antitumor activity in an orthotopic kidney cancer model (RENCA), making it a valuable reagent for cancer research applications.
