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Catalog No.
Product Name
Application
Product Information
Citations
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microtubule inhibitor
Nocodazole is a microtubule inhibitor; inhibits mitosis. Also inhibits autophagosome-lysosome fusion.- Chiao-Ping Chen, .et al. , Biomed Pharmacother, 2023, Oct:166:115389 PMID: 37659202
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microtubule inhibitor
Ixabepilone is an epothilone B analog- Dong-Sheng Cao, .et al. , Eur J Med Chem, 2020, Aug 1;199:112421 PMID: 32428794
- Hoque M, .et al. , Pharmacol Res, 2018, Aug;134:166-178 PMID: 29944980
- APRIL L. RISINGER, .et al. , Anticancer Res, 2015, Nov; 35(11): 5845-5850 PMID: 26504006
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Arp2/3 complex inhibitor
CK-666 is a cell-permeable inhibitor of actin-related protein Arp2/3 complex, and binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation.- Jie Wang, .et al. , Microorganisms, 2023, Jul 28;11(8):1916 PMID: 37630476
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Microtubule Associated inhibitor
Paclitaxel (Taxol) is a mitotic inhibitor that stabilizes microtubules and as a result, interferes with the normal breakdown of microtubules during cell division.- Onyinyechi Obidiro, .et al. , Journal of Biomedical Nanotechnology, 2026, 22(1):47-69 PMID: 42518749
- Ramisa Fariha, .et al. , Micromachines (Basel), 2026, Mar 9;17(3):332 PMID: 41900218
- Seungyeon Ryu, .et al. , Breast Cancer Res, 2025, Jun 23;27(1):113 PMID: 40551232
- Kai-Yue Cao, .et al. , Noncoding RNA Res, 2024, Nov 12;11:38-47 PMID: 39736854
- Laura Svajda, .et al. , Biomed Pharmacother, 2024, Nov:180:117601 PMID: 39476764
- Vijaya Bharti, .et al. , Cell Rep, 2022, Dec 20;41(12):111826 PMID: 36543138
- Yu Pan, .et al. , Nucleic Acids Res, 2021, Jan 11;49(1):38-52 PMID: 33290562
- Li-Li Li, .et al. , Nat Commun, 2020, Oct 9;11(1):5107 PMID: 33037199
- Baglo Y, .et al. , Photochem Photobiol, 2019, Dec 19 PMID: 31856423
- Owiti AO, .et al. , AAPS PharmSciTech, 2018, Nov;19(8):3534-3549 PMID: 30151731
- Owiti AO, .et al. , AAPS PharmSciTech, 2018, Oct;19(7):3110-3122 PMID: 30112614
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Microtubule Associated inhibitor
Cabazitaxel is a semi-synthetic derivative of a natural taxoid. Cabazitaxel in combination with prednisone is a treatment option for hormone-refractory prostate cancer following docetaxel-based treatment- Satoshi Endo, .et al. , J Biochem, 2021, Mar 17 PMID: 33729485
- Tomohiro Nabekura, .et al. , Biochem Biophys Rep, 2020, Mar; 21: 100727 PMID: 31993509
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Microtubule Associated inhibitor
Docetaxel (Taxotere) is an antineoplastic agent that acts by disrupting the microtubular network in cells that is essential for mitotic and interphase cellular functions.- Seungyeon Ryu, .et al. , Breast Cancer Res, 2025, Jun 23;27(1):113 PMID: 40551232
- Adi Jacob Berger, .et al. , Nat Cancer, 2021, 2, 1055-1070 PMID: 35121883
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Microtubule Associated inhibitor
Epothilone B is a macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis.- Yicheng Zhu, .et al. , Neurosci Res, 2021, Apr 17 PMID: 33864880
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microtubule dynamics inhibitor
Vinblastine sulfate inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer. -
microtubulin inhibitor
Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. -
β-tubulin polymerization inhibitor
Entasobulin is a β-tubulin polymerization inhibitor with potential anticancer activity. -
tubulin polymerization inhibitor
Soblidotin (Auristatin PE) is a novel synthetic Dolastatin 10 derivative and inhibitor of tubulin polymerization. -
β-tubulin polymerization inhibitor
Valecobulin (CKD516) is a valine prodrug of (S516) and a vascular disrupting agent (VDA). Valecobulin is a potent β-tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors. -
tubulin inhibitor
altobulin (HTI-286; SPA-110) is an analogue of Hemiasterlin; potent tubulin inhibitor; ADCs cytotoxin. -
tubulin inhibitor
Tubulin inhibitor 1 is a tubulin inhibitor, inhibits tubulin polymerization. -
tubulin polymerization inhibitor
MC-Sq-Cit-PAB-Dolastatin10 is a drug-linker conjugate for ADC with potent antitumor activity by using Dolastatin10 (a tubulin polymerization inhibitor), linked via the ADC linker MC-Sq-Cit-PAB. -
Microtubule inhibitor
VCP-Eribulin consists the ADCs linker (VCP) and Eribulin. Eribulin is a mechanistically unique microtubule inhibitor for cancer. VCP-Eribulin is an Eribulin-based drug for antibody conjugates. -
Microtubule inhibitor
Mal-PEG2-VCP-Eribulin consists the ADCs linker (Mal-PEG2-VCP) and Eribulin. Eribulin is a mechanistically unique microtubule inhibitor for cancer. Mal-PEG2-VCP-Eribulin is an Eribulin-based drug for antibody conjugates. -
oral α and β tubulin inhibitor
VERU-111 is a novel, oral α and β tubulin inhibitor that blocks tubulin polymerization and is not a substrate for multi-drug resistance mechanisms. -
Microtubule assembly inhibitor
Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 8.79?nM, and exhibits a broad-spectrum anthelmintic activity. -
Microtubule polymerization inhibitor
Cucurbitacin B, a natural triterpenoid is well-known for its strong anticancer activity, and recent studies showed that the compound inhibits JAK/STAT3 pathway. Also it is an potent Microtubule polymerization inhibitor -
tubulin polymerization inhibitor
Crolibulin, also known as EPC2407 and crinobulin, is a small molecule tubulin polymerization inhibitor with potential antineoplastic activity. -
Microtubule/Tubulin Inhibitor
Tubulysin B is a potent microtubule destabilizing agent that selectively inhibits tubulin polymerization. Naturally derived from the myxobacteria Archangium geophyra and Angiococcus disciformis, it exhibits high cytotoxicity with IC50 values in the picomolar range across various cancer cell lines, including those exhibiting multidrug resistance. This compound is valuable for studies focused on cancer biology, specifically in elucidating mechanisms of cell cycle arrest and apoptosis. -
Src/Tubulin Inhibitor
KX2-361 is an inhibitor of Src-kinase and tubulin polymerization. This compound exhibits significant anti-tumor activity and induces apoptosis in glioblastoma (GBM) cells. With good oral bioavailability and the ability to cross the blood-brain barrier in murine models, KX2-361 is a valuable tool for investigating Src-related signaling pathways and therapeutic strategies in cancer research. -
Tubulin/JAK2-IN-1 inhibitor, Antitumor
Tubulin/JAK2-IN-1 is a dual inhibitor targeting Janus kinase 2 (JAK2) and microtubules, exhibiting potent antitumor activity. This compound demonstrates significant antiproliferative effects against various cancer cell lines, making it a valuable tool in cancer research. Its dual mechanism of action supports investigations into therapies that disrupt cell division and signaling pathways in malignancies. -
Tubulin Inhibitor
Antiproliferative agent-30 is a tubulin inhibitor that disrupts tubulin assembly and effectively inhibits FLT3 and Abl1 activity. This compound demonstrates impressive antiproliferative effects against various cancer cell lines, exhibiting IC50 values of 0.054 nM, 0.008 nM, and 0.144 nM for HCT-116, K562, and MV-4-11 cells, respectively. Additionally, Antiproliferative agent-30 shows potential in targeting acute myeloid leukemia (AML) cells with FLT3-ITD-TKD mutations, highlighting its significance in cancer research and potential therapeutic applications. -
Microtubule Inhibitor
MPT0B002 is a potent microtubule inhibitor that targets tubulin polymerization, leading to significant anticancer effects. This compound induces apoptosis and effectively arrests the cell cycle at the G2/M phase. MPT0B002 is useful in various cancer research applications, providing insights into microtubule dynamics and the mechanisms of tumor cell proliferation. -
Tubulin/VEGFR Inhibitor
Tubulin/VEGFR-2-IN-2 is an orally active inhibitor targeting tubulin and VEGFR-2, exhibiting IC50 values of 3.27 μM and 0.09 μM, respectively. This compound demonstrates significant antitumor activity by enhancing reactive oxygen species generation, disrupting mitochondrial membrane potential, inducing apoptosis, and arresting the cell cycle. Additionally, Tubulin/VEGFR-2-IN-2 possesses anti-angiogenic effects, impairing endothelial cell migration, invasion, and tube formation in vitro. It effectively suppresses angiogenesis, tumor growth, and metastasis in vivo, making it a valuable tool for research involving non-small cell lung cancer, breast cancer, gastric cancer, and lymphoma. -
Tubulin polymerization Inhibitor
Tubulin polymerization-IN-11 is a potent inhibitor of tubulin polymerization with an IC50 value of 3.4 μM. It demonstrates significant antiproliferative activity by inducing apoptosis and causing cell cycle arrest at the G2/M phase. Mechanistically, Tubulin polymerization-IN-11 reduces the expression levels of cyclin B1, phosphorylated cdc2, and Bcl-2 while increasing the expression of cleaved PARP, making it valuable for research in cancer biology and cell cycle regulation. -
Tubulin Polymerization Inhibitor
Tubulin Inhibitor 17 is a potent tubulin polymerization inhibitor, demonstrating an IC50 value of 12.38 µM. This compound exhibits significant anticancer activity by inducing apoptosis in tumor cells. It is suitable for research applications focused on cancer biology and the study of microtubule dynamics.
