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Catalog No.
Product Name
Application
Product Information
Citations
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Tubulin Inhibitor
Tubulin polymerization-IN-12 is a potent tubulin polymerization inhibitor with an IC50 of 0.75 μM. By disrupting normal tubulin assembly, it effectively arrests the cell cycle at the G2/M phase, leading to significant cytotoxic effects against cancer cells. This compound is valuable for research in cancer biology and the mechanisms of cell cycle regulation. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-16 is a potent tubulin polymerization inhibitor designed to disrupt microtubule dynamics. This compound demonstrates significant anti-cancer activity with IC50 values ranging from 0.084 to 0.221 μM, effectively inducing cell cycle arrest at the G2/M phase in SGC-7901 cells. Its ability to inhibit tubulin polymerization makes it a valuable tool for research in cancer biology and therapeutic development. -
Tubulin Polymerisation Inhibitor
N-Acetylcolchinol phosphate is a potent inhibitor of tubulin polymerization. It binds to the tubulin cytoskeleton in the endothelial cells of tumor blood vessels, disrupting microtubule dynamics. This compound is valuable in anti-cancer research, providing insights into tumor vasculature and potential therapeutic strategies. Its application facilitates the study of tumor progression and vascularization in various cancer models. -
Centrosomal Clustering Inhibitor
GF 15 is a centrosomal clustering inhibitor that acts by inducing multipolar spindles with an EC50 value of 900 nM. As a derivative of griseofulvin, it effectively inhibits tubulin polymerization at concentrations exceeding 25 μM. GF 15 demonstrates notable antitumor activity, significantly inhibiting tumor growth and improving survival rates in mouse xenograft models of human colon cancer and multiple myeloma. This reagent is valuable for researchers studying cellular mitosis and the mechanisms of cancer progression. -
Microtubule Inhibitor
IQTub4P is a potent microtubule inhibitor that disrupts microtubule structure and function. It exhibits significant cytotoxicity in HeLa cells with an EC50 value of 170 nM, highlighting its potential for targeting cancer cell proliferation. This compound demonstrates favorable tolerability in vivo, making it a valuable tool for studying microtubule dynamics and exploring therapeutic applications in cancer research. -
Microtubule Inhibitor
Desacetylvinblastine hydrazide is a microtubule inhibitor that disrupts mitotic spindle formation, effectively inhibiting cell division and promoting apoptosis in cancer cells. This compound demonstrates significant antitumor activity specifically against folate receptor (FR)-positive tumors. It is widely utilized in cancer research to investigate mechanisms of drug resistance and therapeutic efficacy in targeted cancer therapies. -
Microtubule Growth Inhibitor
α-Tubulin (residues 440–451) functions as a microtubule growth inhibitor by transiently interacting with the longitudinal polymerization interface of α-tubulin. This interaction effectively regulates the association and dissociation rates of tubulin at the growing ends of microtubules, leading to inhibited microtubule growth. This reagent can be utilized in studies exploring microtubule dynamics, cellular morphology, and potential therapeutic targets for diseases associated with abnormal microtubule formation. -
Tubulin Inhibitor
Tubulin Inhibitor 49 is a potent tubulin polymerization inhibitor with an IC50 value of 48 μM. This compound disrupts the microtubule network, leading to G2 phase cell cycle arrest and demonstrating cytotoxicity with an IC50 of 8.8 μM in HeLa cells. Tubulin Inhibitor 49 serves as a valuable tool for researching cervical cancer and understanding the mechanisms of microtubule dynamics in cancer cell proliferation. -
Tubulin Inhibitor
Tubulin polymerization-IN-48 is a potent inhibitor of tubulin polymerization, demonstrating the ability to disrupt microtubule networks. This compound exhibits significant anti-proliferative activity in neuroblastoma cancer cell lines, with IC50 values of 79 nM for Chp-134 and 165 nM for Kelly cells. Its mechanism makes it a valuable tool for research in cancer biology and cellular dynamics. -
Microtubule Polymerization Inhibitor
Acodazole is a microtubule polymerization inhibitor that exhibits potent anticancer activity. By disrupting the assembly of microtubules, Acodazole interferes with mitotic spindle formation, leading to cell cycle arrest and apoptosis in cancer cells. This compound is valuable for research in cancer biology and for exploring novel therapeutic strategies targeting microtubule dynamics. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-36 is a potent inhibitor of tubulin polymerization, exhibiting an IC50 of 2.8 μM. This compound selectively binds to the colchicine site of tubulin, thereby obstructing colchicine binding and disrupting microtubule formation. Tubulin polymerization-IN-36 is valuable for researching various cancers, including lymphomas, and provides insights into the mechanisms of tumorigenesis and cell division. -
colchicine-binding site inhibitor (CBSI)
Antitumor agent-164 is a colchicine-binding site inhibitor (CBSI) that demonstrates significant potency against taxane-sensitive triple-negative breast cancer (TNBC). This compound serves as a next-generation derivative of VERU-111, enhancing its potential for targeted cancer therapy. Its mechanism of action involves disrupting microtubule dynamics, making it a valuable tool for investigating treatment responses and resistance mechanisms in breast cancer models. -
Microtubule/Tubulin Inhibitor
Denibulin is a microtubule-tubulin inhibitor that reversibly disrupts microtubule assembly, affecting the cytoskeleton of tumor vascular endothelial cells. This novel vascular-disrupting agent exhibits tolerability and shows potential for anti-vascular effects, making it a candidate for further research in cancer therapy applications. Its mechanism offers insights into the modulation of tumor vasculature, supporting its exploration in studies of tumor growth and metastasis. -
Microtubule Inhibitor
Microtubule Inhibitor 4 is a potent inhibitor of microtubule polymerization, targeting tubulin. This compound exhibits significant cytotoxic effects in various cancer cell lines, with IC50 values of 4.0 nM for NCI-H460, 3.2 nM for BxPC-3, and 2.1 nM for HT-29 cells. It is an essential tool for research in cancer biology and the evaluation of anti-cancer therapeutics. -
Tubulin Inhibitor
Tubulin Inhibitor 28 is a highly effective tubulin inhibitor, demonstrating an IC50 value of 1.2 µM. This compound exhibits significant anti-proliferative activity in MCF-7 breast cancer cell lines, making it a valuable tool for cancer research and studies focusing on cell division and cytoskeletal dynamics. Its ability to disrupt microtubule formation suggests potential applications in exploring therapeutic strategies for cancer treatment. -
MASTL Inhibitor
MASTL-IN-5 is a potent inhibitor of MASTL (microtubule-associated serine/threonine kinase-like) with a Ki of 0.018 nM. This compound selectively targets the kinase activity of MASTL, playing a critical role in regulating cell cycle progression and mitotic functions. MASTL-IN-5 is useful in research applications focused on cancer biology, particularly in studying the effects of MASTL inhibition on cell division and tumor proliferation. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-19 is a potent inhibitor of tubulin polymerization, acting on microtubule dynamics. This compound is relevant for studying the mechanisms underlying breast cancers and chemoresistant colon cancers, providing insights into tumor biology and potential therapeutic targets. Its specificity for tubulin makes it a valuable tool in cancer research and drug development. -
Cancer Cell Growth Inhibitor
PK-3 is a cancer cell growth inhibitor that targets tubulin. By binding to tubulin, PK-3 disrupts the microtubule network essential for mitosis, leading to cell death. This compound is valuable in research on chronic myeloid leukemia, facilitating studies on tumor cell dynamics and potential therapeutic strategies. -
Tubulin Polymerization Inhibitor
Glochidiol is an orally active inhibitor of tubulin polymerization, exhibiting an IC50 of 2.76 μM. This compound demonstrates significant anti-cancer activity and is utilized in research applications focused on cancer cell proliferation and microtubule dynamics. Glochidiol's mechanism of action makes it a valuable tool for studying cancer therapeutics and cell cycle regulation. -
Tubulin Polymerization Inhibitor
NSC 330770 is a potent inhibitor of tubulin polymerization, exhibiting an IC50 value of 2 μM. This compound enhances GTPase activity and promotes the formation of abnormal polymer structures in tubulin. NSC 330770 has valuable applications in cancer research and studies examining microtubule dynamics. -
Tubulin Inhibitor
Phomopsinamine A is a potent tubulin inhibitor that effectively disrupts tubulin polymerization, exhibiting an IC50 of 0.53 μM. It inhibits the binding of Vinblastine to tubulin (IC50 = 0.56 μM) while enhancing the binding of Colchicine to tubulin (IC50 = 0.32 μM). This compound is valuable for studies investigating microtubule dynamics and their role in cellular processes, making it a useful tool in cancer research and the exploration of cytoskeletal modulation. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-30 is an effective inhibitor of tubulin polymerization, specifically targeting the colchicine binding site. By disrupting microtubule organization, it induces cell cycle arrest at the G2/M phase. This compound demonstrates significant antiproliferative activity against various cancer cell lines, including SGC-7901, A549, and HeLa, with respective IC50 values of 2.16, 2.21, and 0.403 μM, making it a valuable tool for cancer research applications. -
Microtubule Polymerization Inhibitor
N-Deacetylcolchicine tartrate is a microtubule polymerization inhibitor that effectively disrupts microtubule dynamics, exhibiting an IC50 of 3 μM against bovine brain microtubules. As a derivative of Colchicine, it enhances the GTPase activity of microtubules. This compound is valuable for cancer research, facilitating investigations into microtubule-related pathways and potential therapeutic interventions. -
Tubulin Inhibitor
N-Deacetylthiocolchicine is a potent tubulin inhibitor with an IC50 value of 2.2 nM in multidrug-resistant MDA-MB 231 breast cancer cells. This compound exerts its antiproliferative effects by binding to tubulin, disrupting microtubule assembly, and causing cell cycle arrest during mitosis. N-Deacetylthiocolchicine is a valuable tool for investigating therapeutic strategies in malignancies, particularly breast cancer. -
Microtubule/Tubulin Inhibitor
Sudocetaxel is a microtubule depolymerization inhibitor that targets tubulin, impairing microtubule dynamics. This compound is particularly useful in drug delivery systems that are pH-sensitive, enhancing the therapeutic efficacy of docetaxel. It holds potential applications in cancer research, providing insights into microtubule-targeting therapies. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-21 is a potent tubulin polymerization inhibitor that disrupts microtubule assembly, leading to compromised cellular integrity. This compound demonstrates significant anti-cancer activity by interfering with glucose metabolism and cellular proliferation. It is suitable for research applications aimed at understanding cancer biology and the mechanisms of tubulin-targeting therapies. -
PLK-1/Tubulin Inhibitor
3,4,3'-Tri-O-methylflavellagic acid is a flavonoid compound that functions as an inhibitor of polo-like kinase-1 (PLK-1) and αβ-tubulin at the colchicine binding site. This compound disrupts microtubule assembly dynamics and modulates kinase activity, making it valuable for research into cancer cell proliferation and anti-nociceptive properties. Its unique biological activities make it a significant reagent for studies focused on cancer therapies and pain management. -
Tubulin Inhibitor
Tubulin-IN-52 is a potent tubulin inhibitor that exhibits notable cytotoxicity against various cancer cell lines, including prostate, lung, and ovarian cancers, with an impressive IC50 range of 0.9-3.8 mM in highly aggressive cancer models. This compound effectively inhibits the growth of established tumors while displaying minimal toxicity to normal cells. Tubulin-IN-52 serves as a valuable tool for investigating cancer biology and exploring potential therapeutic strategies in oncology research. -
Tubulin Inhibitor
BKS3031A is a potent αβ-tubulin inhibitor that targets the colchicine binding site, effectively disrupting microtubule assembly dynamics. This compound demonstrates significant biological activity in modulating cellular processes such as mitosis and intracellular transport. BKS3031A is valuable for research applications in cancer biology and studies involving cytoskeletal dynamics. -
Microtubulin Inhibitor
Epothilone E is a microtubulin inhibitor that disrupts microtubule protein function, leading to the blockage of cell division. This compound exhibits significant anti-tumor activity and is valuable for research applications in cancer biology, particularly in studies focused on cell cycle regulation and mitotic progression. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-18 is a potent inhibitor of tubulin polymerization, targeting the microtubule dynamics essential for cellular structure and function. This compound exhibits significant anti-proliferative activity, making it valuable for research applications in breast cancer and chemoresistant colon cancer. Its ability to disrupt microtubule formation provides insights into the mechanisms of cancer cell growth and resistance, facilitating the development of new therapeutic strategies. -
Microtubule/Tubulin Inhibitor
Tubulin polymerization-IN-42 is an indole-substituted furanone that acts as a potent inhibitor of tubulin polymerization. Its primary mechanism targets microtubule dynamics, thereby interrupting the mitotic spindle formation. This compound exhibits significant anti-cancer activity, making it a valuable tool for research into cancer therapeutics and the study of microtubule-related cellular processes. -
Microtubule Inhibitor
Microtubule Inhibitor 6 targets the microtubule assembly process, demonstrating strong inhibitory activity. It exhibits cytotoxic effects with IC50 values of 14.0 nM in NCI-H460 cells, 6.6 nM in BxPC-3 cells, and 7.0 nM in HT-29 cells. This compound effectively inhibits microtubule polymerization, making it a valuable reagent for cancer research focused on cell proliferation and mitosis. -
Tubulin Polymerization Inhibitor
Tubulin Polymerization-IN-90 is a selective inhibitor of tubulin polymerization, targeting the nocodazole-binding site on β-tubulin. By disrupting microtubule formation, it induces the release of extracellular vesicles marked by CD63 and promotes IL-8 secretion from cells. This compound has demonstrated reduced viability in various cancer cell lines and is particularly relevant for research applications in acute T-lymphoblastic leukemia and other malignancies characterized by aberrant tubulin dynamics. -
Microtubule/Tubulin Inhibitor
Dolastatinol is a synthetic analog of dolastatin 10 that acts as a potent inhibitor of tubulin polymerization. Its low nanomolar activity effectively disrupts microtubule formation, leading to significant effects on cell division and proliferation. This compound is valuable for research applications in cancer biology and studies investigating microtubule dynamics. -
Tubulin Inhibitor
J-30 is a potent tubulin inhibitor that selectively interferes with microtubule polymerization, demonstrating an IC50 of 15-20 nM. By inducing G2/M phase arrest, J-30 exhibits significant potential in the study of solid tumors, including gastric and oral cancers. This compound serves as a valuable tool for researchers investigating the mechanisms of cancer cell proliferation and progression. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-7 is an effective inhibitor of tubulin polymerization, disrupting microtubule dynamics. This compound demonstrates significant potential in cancer research by interfering with cellular division and tumor growth. It is a valuable tool for investigating mechanisms of tumorigenesis and evaluating therapeutic strategies targeting tubulin. -
Tubulin inhibitor
Tubulin inhibitor 16 is a potent compound targeting tubulin, effectively disrupting microtubule dynamics. It demonstrates significant antiproliferative activity and exhibits cytotoxic effects in HepG2 hepatic cancer cells. This reagent is valuable for research applications focusing on cancer cell biology and the mechanistic study of tubulin modulation. -
Tubulin Inhibitor
Tubulin Inhibitor 25 is a potent inhibitor of tubulin polymerization, with an IC50 value of 0.98 μM. It demonstrates significant activity against the HT29 cancer cell line, effectively inhibiting cell migration and tube formation, which are critical processes in angiogenesis. This compound is valuable for research applications related to cancer biology and investigations into anti-angiogenic therapies. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-50 is a potent inhibitor of tubulin polymerization, exhibiting an IC50 of 5.05 μM in SK-Mel-28 cells. This compound effectively induces cell cycle arrest in the G2/M phase, making it a valuable tool for studying the mechanisms of cell division and tumor biology. Its application in research can aid in the development of novel therapeutic strategies targeting proliferative diseases. -
Microtubule Inhibitor
BMS-184476 is a selective microtubule inhibitor that demonstrates potent antitumor activity. It effectively induces G2/M phase arrest and promotes apoptosis in tumor cells, making it a valuable tool for investigating mechanisms of cancer cell proliferation and survival. This compound shows promise for research into solid tumors, particularly non-small cell lung cancer. -
Microtubule/Tubulin Inhibitor
Ceratamine A is a microtubule/tubulin inhibitor derived from the marine sponge Pseudoceratina sp. This antimitotic heterocyclic alkaloid demonstrates significant cytotoxicity against various human cancer cell lines, making it a valuable tool for cancer research. Its ability to interfere with microtubule dynamics underscores its potential for studying cancer cell proliferation and treatment responses. -
Microtubule Inhibitor
Erbulozole is a microtubule inhibitor that disrupts the dynamic instability of microtubules, leading to impaired cell division and potential antitumoral effects. This compound has been utilized in research focused on cancer biology and may serve as a prototype for developing novel therapeutics targeting microtubule dynamics in tumor cells. -
Microtubule Depolymerization Inhibitor
7-Acetyl paclitaxel is a microtubule depolymerization inhibitor that effectively prevents calcium-induced microtubule depolymerization. This compound demonstrates a significant reduction in the growth of J774.2 macrophages, with an IC50 of approximately 60 nM, and promotes elevated levels of nitric oxide (NO) and tumor necrosis factor (TNF) in isolated mouse peritoneal macrophages. Its pharmacological properties make it a valuable tool for investigating microtubule dynamics and immune response modulation in experimental settings. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-57 is a potent tubulin polymerization inhibitor affecting microtubule dynamics. This α-naphthoxy-substituted carbendazim derivative induces mitotic arrest, effectively inhibiting proliferation in cancer cells. It demonstrates promising potential for research applications in cancer biology and therapeutic development. -
Microtubule/Tubulin Inhibitor
Tubulin Inhibitor 9 is a microtubule-targeting compound that selectively inhibits tubulin polymerization. Demonstrating potent anticancer activity, this compound achieves an IC50 of 0.9 nM in the MDA-MB 231 breast cancer cell line. It serves as a valuable tool for investigating microtubule dynamics and evaluating potential therapeutic strategies in cancer research. -
Microtubule/Tubulin Inhibitor
Cis-Trismethoxy resveratrol acts as a microtubule/tubulin inhibitor, demonstrating potent anti-mitotic properties. It effectively inhibits tubulin polymerization with an IC50 value of 4 μM. This compound is valuable for research applications focused on cell division, cancer biology, and the study of microtubule dynamics. -
Mitotic Inhibitor
MT-7 is a potent mitotic inhibitor that exhibits significant antiproliferative activity. It effectively induces cell cycle arrest at the G2/M phase, leading to a specific and reversible mitotic arrest. Additionally, MT-7 inhibits the polymerization of cellular microtubules, making it a valuable tool for researchers investigating cell division and cancer biology. -
Microtubule/Tubulin Inhibitor
2-Methylthiophenothiazine is a potent tubulin inhibitor known for its ability to disrupt microtubule dynamics. This compound has demonstrated potential anticancer activity by inhibiting tubulin aggregation, which may ultimately affect cell proliferation and survival. It is a valuable tool for research into cancer biology and for studies focusing on microtubule-targeting therapeutics. -
Microtubule Inhibitor
T900607 is a microtubule inhibitor that disrupts microtubule polymerization, thereby exerting its anti-tumor effects. This compound has demonstrated significant potential in cancer research by inducing cell cycle arrest and apoptosis in various tumor cell lines. Its mechanism of action is valuable for investigating microtubule dynamics and exploring therapeutic strategies for cancer treatment.
