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Catalog No.
Product Name
Application
Product Information
Citations
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β-microtubulin Inhibitor
Tubulin inhibitor 42 (Compound 14b) primarily targets β-microtubulin, exhibiting dose-dependent inhibition with an IC50 of 3.5 µM. This compound disrupts microtubule dynamics, leading to cancer cell cycle arrest in the G2/M phase and triggering apoptosis. Additionally, Tubulin inhibitor 42 demonstrates significant inhibitory effects on angiogenesis, both in vitro and in vivo, ultimately suppressing vascularization and tumor progression. -
Tubulin Inhibitor
SKLB0565 is a potent tubulin inhibitor that demonstrates significant anti-proliferative effects in colorectal carcinoma (CRC) cell lines, with IC50 values ranging from 0.012 μM to 0.081 μM. This compound induces G2/M phase cell cycle arrest and triggers mitochondria-mediated intrinsic apoptosis. Additionally, SKLB0565 effectively inhibits cell migration and disrupts tube formation in human umbilical vein endothelial cells (HUVECs), making it a valuable tool for cancer research and the study of tumor angiogenesis. -
Microtubulin Inhibitor
Microtubulin-IN-1 is a selective inhibitor of microtubulin that targets the colchicine-binding site, leading to disruption of microtubule integrity and upregulation of p53. It demonstrates significant antiproliferative activity across various cancer cell lines, with IC50 values of 2.4 nM for NCI-H460, 1.6 nM for BxPC-3, and 2.07 nM for HT-29. Microtubulin-IN-1 effectively induces cell cycle arrest at the G2/M phase and promotes apoptosis in NCI-H460 cells, making it a valuable tool for cancer research. -
Tubulin Inhibitor
Tubulin polymerization-IN-6 is a potent tubulin polymerization inhibitor with an IC50 of 1.09 μM. This compound effectively impairs cell migration and tube formation, playing a significant role in anti-angiogenesis. In vivo studies demonstrate that Tubulin polymerization-IN-6 substantially inhibits tumor growth in HT29 xenograft models using Balb/c nude mice, making it a valuable reagent for cancer research. -
VEGFR-2/β-tubulin Inhibitor
VEGFR-2-IN-22 is a dual inhibitor targeting VEGFR-2 and β-tubulin polymerization, demonstrating an IC50 of 19.82 nM against VEGFR-2. This compound promotes apoptosis, making it a valuable tool for studying angiogenesis and cancer biology. Its mechanism of action provides insights into vascular endothelial growth factor pathways and their role in tumor progression. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-17 is a potent inhibitor of tubulin polymerization, effectively disrupting microtubule dynamics. This compound induces depolymerization of tubulin, leading to apoptosis in cancer cells and inhibiting their migratory capabilities. Tubulin polymerization-IN-17 is valuable for research focused on cancer biology and therapies targeting microtubule dynamics. -
Tubulin polymerization inhibitor
Tubulin polymerization-IN-84 is a selective inhibitor of tubulin polymerization that targets the colchicine-binding site, exhibiting an IC50 of 10.9 μM. This compound demonstrates significant antiproliferative effects against various cancer cell lines, including Jurkat, B16-F10, HCT116, and MDA-MB-231, with IC50 values of 60 nM, 380 nM, 138 nM, and 1.054 μM, respectively. Tubulin polymerization-IN-84 induces G2/M-phase arrest and promotes apoptosis in B16-F10 cells, while also suppressing tumor growth in a B16-F10 melanoma model. Additionally, it enhances anti-tumor immunity in conjunction with PD-L1 monoclonal antibodies, making it a valuable reagent for research in T-cell acute lymphoblastic leukemia, melanoma, colon cancer, and breast cancer studies. -
microtubule assembly inhibitor
4-Demethylepipodophyllotoxin is a potent inhibitor of microtubule assembly. -
Microtubule Associated inhibitor
ABT-751 is an antimitotic agent, inhibits microtubule polymerization, binds to β-tubulin on the colchine site; blocks cell cycle at G2M phase and induces apoptosis. -
Microtubule Inhibitor
CYT997 is a novel anti-cancer vascular disrupting agent (VDA). In vitro, CYT997 is shown to potently inhibit the proliferation of vascular endothelial growth factor-stimulated human umbilical vein endothelial cells (IC(50) 3.7 ?? 1.8 nM) and cause significant morphological changes at 100 nM, including membrane blebbing. -
Microtubule Associated inhibitor
Epothilone A acts by stabilising microtubule formation at the taxol binding site and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity. -
KSP Inhibitor
Ispinesib (SB-715992) is a potent inhibitor of kinesin spindle protein, a kinesin motor protein essential for the formation of a bipolar mitotic spindle and cell cycle progression through mitosis. -
Microtubule Inhibitor
NPI-2358 is a synthetic analog of NPI-2350, a natural product isolated from Aspergillus sp., which depolymerizes microtubules in A549 human lung carcinoma cells. -
Tubulin inhibitor
Vincristine is a mitotic inhibitor, and is used in cancer chemotherapy. -
Microtubule Associated inhibitor
Vinflunine Tartrate is a tartrate salt of vinflunine that destabilizes microtubules with an IC50 of 18.8 nM and interferes with the dynamics of microtubules during cell division. -
KSP inhibitor
KSP inhibitor ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5) with potential antineoplastic activity. -
MPS1 kinase inhibitor
BAY 1217389 is a potent, and selective inhibitor of the monopolar spindle 1 (MPS1) kinase with an IC50 value less than 10 nM. -
Mps1 inhibitor
Empesertib (BAY 1161909) is a potent Mps1 inhibitor, with an IC50 of < 1 nM. -
tubulin polymerisation inhibitor
Lexibulin 2Hcl (CYT-997 2Hcl) is a potent tubulin polymerisation inhibitor with IC50 of 10-100 nM in cancer cell lines; with potent cytotoxic and vascular disrupting activity in vitro and in vivo. -
αVβ3 integrin inhibitor
Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM. -
auristatin microtubule inhibitor
PF-06380101 (Aur0101), an auristatin microtubule inhibitor, is a cytotoxic Dolastatin 10 analogue. -
microtubule assembly and microtubule dynamics inhibitor
Tasidotin hydrochloride is a peptide analog of the antimitotic depsipeptide dolastatin 15, as an inhibitor of microtubule assembly and microtubule dynamics. -
α4 integrin receptor inhibitor
Carotegrast is an orally available α4 integrin receptor inhibitor with anti-inflammatories activities. -
mitosis-specific kinesin Eg5 inhibitor
Litronesib is a selective mitosis-specific kinesin Eg5 inhibitor, with antitumor activity. -
bovine tubulin oxidation inhibitor
Takeda103A is a potent GRK2-dependent bovine tubulin oxidation inhibitor. -
integrin-ligand interactions inhibitor
RGD peptide (GRGDNP) acts as an inhibitor of integrin-ligand interactions and plays an important role in cell adhesion, migration, growth, and differentiation. -
myosin-II inhibitor
2,3-Butanedione monoxime (BDM, Diacetyl monoxime, Diacetylmonoxime) is the well-characterized, low-affinity, non-competitive inhibitor of skeletal muscle myosin-II and inhibits skeletal and cardiac muscle contraction. -
microtubulin inhibitor
Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. -
β-tubulin polymerization inhibitor
Entasobulin is a β-tubulin polymerization inhibitor with potential anticancer activity. -
Kif15 inhibitor
Kif15-IN-2 is an inhibitor of the mitotic kinesin Kif15, and is used for the research of cellular proliferative diseases. -
Kif15 inhibitor
Kif15-IN-1 is an inhibitor of the mitotic Kinesin family member 15 (Kif15), and is used for the research of cellular proliferative diseases. -
tubulin polymerization inhibitor
Soblidotin (Auristatin PE) is a novel synthetic Dolastatin 10 derivative and inhibitor of tubulin polymerization. -
β-tubulin polymerization inhibitor
Valecobulin (CKD516) is a valine prodrug of (S516) and a vascular disrupting agent (VDA). Valecobulin is a potent β-tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors. -
tubulin inhibitor
altobulin (HTI-286; SPA-110) is an analogue of Hemiasterlin; potent tubulin inhibitor; ADCs cytotoxin.
