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Catalog No.
Product Name
Application
Product Information
Citations
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KIF18A Inhibitor
KIF18A-IN-10 is a potent inhibitor of KIF18A, exhibiting an IC50 value of 23.8 nM. This compound demonstrates significant anticancer activity, with IC50 values under 100 nM in ovarian cancer OVCAR3 and breast cancer MDA-MB-157 cell lines. KIF18A-IN-10 is a valuable tool for research investigating the role of KIF18A in cancer biology and potential therapeutic strategies. -
KSP Inhibitor
KSP-IA is a potent inhibitor of kinesin spindle protein (KSP), exhibiting an IC50 value of 3.6 nM. This compound effectively disrupts cell mitosis, making it a valuable tool for research in cancer biology and cellular division mechanisms. Its specificity for KSP underscores its potential in exploring therapeutic strategies that target mitotic processes. -
Eg5 Inhibitor
Terpendole E is a specific inhibitor of the mitotic kinesin Eg5, targeting its motor and microtubule-stimulated ATPase activities in human cells. This compound effectively induces the formation of a monoastral spindle during the M phase of the cell cycle, making it a valuable tool for investigating mitotic processes. Terpendole E is suitable for research applications focused on cancer biology and drug discovery targeting cell division. -
CENP-M Inhibitor
Cenpemlin is a selective inhibitor of CENP-M, specifically disrupting the CENP-M/CENP-L interaction. This compound is valuable for studying centromere-kinetochore dynamics and assembly during cell division, providing insights into the mechanisms underlying chromosomal segregation. Research involving Cenpemlin can enhance the understanding of mitotic processes and potential therapeutic targets in cancer. -
Kinesin Inhibitor
MKLP2-IN-1 is a selective inhibitor of the kinesin MKLP2, demonstrating significant oral bioavailability. This compound effectively inhibits the microtubule-stimulated ATPase activity of recombinant MKLP2 in vitro, contributing to its potential as a therapeutic agent. In vivo studies reveal that MKLP2-IN-1 suppresses tumor growth in a mouse model of Calu-6 lung cancer, showcasing its relevance in cancer research and treatment strategies targeting kinesin-driven processes. -
KIF18A Inhibitor
KIF18A-IN-15 is a selective KIF18A inhibitor that demonstrates potent activity with IC50 values ranging from 0.01 to 0.1 μM. This compound effectively reduces the viability of OVCAR-3 cells, making it a valuable tool in cancer research. KIF18A-IN-15 can be utilized in studies related to various tumor models, including colon, breast, and lung cancers, facilitating the exploration of KIF18A's role in tumor growth and progression. -
KIF18A Inhibitor
KIF18A-IN-18 is a selective inhibitor of KIF18A, a motor protein involved in chromosome segregation during cell division. This compound has demonstrated the ability to disrupt KIF18A’s function, making it a valuable tool for studying chromosomal instability in tumors. Its application extends to research focused on understanding the mechanisms of tumorigenesis and potential therapeutic strategies in the context of cancer. -
HSET Inhibitor
CCT369834 is an ATP-competitive inhibitor of HSET, exhibiting an IC50 of 39 nM. This compound is a trans-cyclooctene-tagged probe that demonstrates specific co-localization with HSET on mitotic spindles. CCT369834 serves as a valuable tool for studying the role of HSET in cancer research and may contribute to understanding its function in mitotic processes. -
KIF18A Inhibitor
KIF18A-IN-16 is a potent inhibitor of KIF18A, a kinesin motor protein involved in mitotic spindle assembly and chromosome segregation. This compound has demonstrated significant biological activity in preclinical models and is valuable for research applications in oncology, particularly in the study of various cancer types, including colon, breast, and lung cancer. Its ability to disrupt KIF18A function makes it a promising candidate for investigating novel therapeutic strategies in cancer treatment. -
KSP Inhibitor
CK0106023 is a selective allosteric inhibitor of kinesin spindle protein (KSP) with a Ki value of 12 nM. This compound induces mitotic arrest and growth inhibition across various tumor cell lines, demonstrating significant antitumor activity. Additionally, CK0106023 has shown efficacy in preclinical models, specifically in tumor-bearing mice, making it a valuable reagent for cancer research and therapeutic development. -
Kinesin Inhibitor
4'-Methoxy-S-trityl-L-cysteinol is an allosteric inhibitor targeting vertebrate Kinesin Spindle Protein (KSP). This compound demonstrates enhanced inhibitory activity against NCI60 tumor cell lines, attributed to modifications in its trityl and cysteine groups. It exhibits an EC50 of 28 μM for bipolar spindle formation, indicating superior potency compared to its parent compound and monastrol. This makes it a valuable tool for investigating KSP's role in mitosis and potential therapeutic strategies in cancer research. -
Kinesin Inhibitor
Monastroline (HR22C16) is a selective inhibitor of the mitotic kinesin Eg5, which plays a critical role in mitosis and cell division. This compound effectively disrupts mitotic processes, making it a valuable tool for studying cell cycle regulation and kinesin function in cancer research and related fields. Monastroline demonstrates strong cell permeability, facilitating its use in cellular assays to explore the therapeutic potential of kinesin inhibition. -
Kinesin-13 Inhibitor
DHTP is a selective allosteric inhibitor of the kinesin-13 family of microtubule depolymerases, targeting ATPase activity and microtubule depolymerization. It inhibits Kif2a and MCAK with IC50 values of 1.2 μM and 4.6 μM, respectively, without affecting other kinesin families. By modulating microtubule dynamics in cells, DHTP results in reduced microtubule activity, linking kinesin-13 overexpression to cancer progression and resistance to Paclitaxel. This compound is suitable for cancer research applications. -
SKP Inhibitor
KSP-IN-1 is a potent kinesin spindle protein (KSP) inhibitor, exhibiting an IC50 of 450 nM. This compound effectively disrupts mitotic spindle formation, thereby hindering cell division. KSP-IN-1 is valuable for researchers investigating cancer mechanisms and the role of mitotic regulation in oncology. -
Kinesin-5 Inhibitor
NSC-80141 is a selective inhibitor of kinesin-5, targeting the human kinesin-5 (HsEg5) with an IC50 of 9.4 μM, while exhibiting weaker inhibition against Plasmodium kinesin-5 (PvEg5) at an IC50 of 27.3 μM. This compound is valuable for research applications focused on differentiating human kinesin-5 from its Plasmodium counterpart, making it a useful tool for studying cellular transport mechanisms and potential therapeutic interventions in parasitic infections. -
PAK4 Inhibitor
CZh226 is a selective inhibitor of PAK4 with an IC50 of 0.0111 μM and a Ki of 0.009 μM. This compound effectively inhibits PAK4 activity, leading to decreased phosphorylation of its downstream signaling molecules. CZh226 has demonstrated the ability to inhibit the migration and invasion of tumor cells, making it a valuable reagent for research related to lung cancer and other PAK4-mediated pathways. -
Tubulin Inhibitor
ON 01500 is a potent tubulin inhibitor with a Kd of 21 nM, demonstrating significant microtubule-destabilizing effects in cellular environments. This compound is valuable for investigating mechanisms underlying cancer biology and the role of microtubule dynamics in cellular processes. Research applications include elucidating the effects of microtubule disruption on tumor growth and progression. -
Plant Microtubule Inhibitor
Oryzalin is a dinitroaniline herbicide that functions as a plant microtubule inhibitor. It binds to tubulin, disrupting microtubule polymerization in plant cells, which subsequently impairs chromosome migration. Oryzalin also serves as an effective reagent for inducing chromosome doubling, making it valuable for various research applications in plant biology and genetics. -
Tubulin Polymerization Inhibitor
ER-076349 is a potent inhibitor of tubulin polymerization that effectively induces G2-M cell cycle arrest and disrupts mitotic spindle formation. This compound demonstrates significant anti-cancer activity by inhibiting the growth of various human tumor xenografts. As an analog of Halichondrin B, ER-076349 serves as a valuable reagent for research focused on cancer biology and therapeutic development targeting microtubule dynamics. -
Tubulin Inhibitor
Vindesine sulfate is a potent tubulin inhibitor with a Ki of 0.110 μM. It exhibits significant anti-proliferative activity in vitro and demonstrates antitumor effects in vivo, making it a valuable tool for cancer research. This compound is utilized in studies exploring microtubule dynamics and the mechanisms of action in various tumor models. -
Tubulin Assembly Inhibitor
Avanbulin is a potent tubulin assembly inhibitor that targets the Colchicine binding site on tubulin. It effectively inhibits tubulin polymerization at a temperature of 37 °C, exhibiting an IC50 value of 1.4 μM and an apparent Kd of 244 nM for tubulin binding. This compound is valuable for research applications in cancer biology and the study of cell division mechanisms. -
sGC Inhibitor
Methylene blue hydrate is a selective inhibitor of soluble guanylyl cyclase (sGC), as well as monoamine oxidase A (MAO-A) and nitric oxide synthase (NOS). This compound exhibits significant biological activities, including the modulation of the nitric oxide syntase/guanylate cyclase signaling pathway, which results in decreased prepulse inhibition. Methylene blue hydrate also acts as a REDOX cycling agent capable of crossing the blood-brain barrier, demonstrating neuroprotective effects such as inhibition of Tau aggregation, reduction of cerebral edema, and attenuation of neuroinflammation through the modulation of microglial activation. These properties make it valuable for research in neurodegenerative diseases and neuroinflammation studies. -
β-tubulin Polymerization Inhibitor
Valecobulin hydrochloride is a potent β-tubulin polymerization inhibitor that serves as a vascular disrupting agent. It demonstrates significant antitumor activity against both murine and human solid tumors, making it an important tool for cancer research. Valecobulin hydrochloride is utilized in studies focused on understanding tumor vascularization and therapeutic strategies aimed at disrupting the tumor microenvironment. -
Plant Microtubule Polymerization Inhibitor
Amiprofos methyl is a phosphoric amide herbicide that functions as a potent inhibitor of plant microtubule polymerization. This compound disrupts microtubule dynamics in plant cells, leading to significant impairments in cell division and growth. Its specific activity makes it a valuable tool for research into the mechanisms of herbicide action and the cellular processes regulated by microtubules in plant biology. -
TG Inhibitor
NC9 (Cbz-Lys(Acr)-PEG2-dansyl) is an irreversible inhibitor of transglutaminase (TG), a crucial enzyme in various biological processes. This compound effectively inhibits osteoblast differentiation and mineralization while also destabilizing microtubules. NC9 is valuable for research focused on osteoblast differentiation and the underlying mechanisms governing bone formation. -
Microtubule/Tubulin Inhibitor
TN-16 is a potent microtubule polymerization inhibitor with an IC50 value ranging from 0.4 to 1.7 µM. It targets tubulin to disrupt microtubule dynamics, thereby affecting cellular processes such as mitosis and intracellular transport. TN-16 is useful in research applications exploring cancer biology and cellular function, making it an important tool for studying the role of microtubules in various diseases. -
Microtubule/Tubulin Inhibitor
Pironetin is an α/β unsaturated lactone derived from Streptomyces species that acts as a potent microtubule/tubulin inhibitor. By binding to α-tubulin, Pironetin effectively inhibits microtubule polymerization, leading to cell cycle arrest and exhibiting significant antitumor activity. This compound is valuable for research into cancer biology and the mechanisms of microtubule dynamics. -
Microtubule/Tubulin Inhibitor
Taccalonolide B is a microtubule stabilizer that targets tubulin, exhibiting notable antitumor activity. This compound demonstrates efficacy in vitro against cell lines with overexpression of P-glycoprotein (Pgp) and multidrug-resistance protein 7 (MRP7). Taccalonolide B effectively inhibits the growth of SK-OV-3 cells, yielding an IC50 value of 208 nM, making it a valuable tool for cancer research and drug resistance studies. -
Microtubule/Tubulin Inhibitor
OXi8007 is a water-soluble phosphate proagent of OXi8006, functioning as a microtubule/tubulin inhibitor. This compound effectively disrupts microtubule dynamics, leading to inhibition of cell proliferation and promotion of apoptotic processes. OXi8007 is widely utilized in cancer research and investigations focusing on the modulation of cytoskeletal structures. -
Tubulin Inhibitor
Podophyllotoxone is a natural compound derived from the roots of Dysosma versipellis that acts as a tubulin inhibitor. It effectively disrupts tubulin polymerization, thereby interfering with the processes of cell division and inducing anti-cancer effects. This compound is utilized in cancer research to study its potential therapeutic applications in various malignancies. -
Microtubule Inhibitor
Taccalonolide AJ is a microtubule stabilizing compound with significant antiproliferative properties. This semi-synthetic reagent demonstrates high potency against cancer cells, exhibiting an IC50 of 4.2 nM in HeLa cell lines. Its mechanism of action involves the stabilization of microtubules, making it a valuable tool for research in cancer biology and therapeutic development. -
Tubulin Inhibitor
Phomopsin A is a cyclic hexapeptide mycotoxin that functions as a noncompetitive inhibitor of tubulin. It disrupts the binding of vincristine to tubulin, which is essential for microtubule dynamics. This compound is valuable in research exploring cell division and cancer biology, particularly in studies investigating the mechanistic action of tubulin-targeting agents. -
NQO1 Inhibitor
Diminutol is a selective inhibitor of NADP-dependent quinone oxidoreductase (NQO1), an enzyme implicated in critical cellular processes such as microtubule morphogenesis and cell division. This compound has significant potential for research applications related to cancer biology and cellular dynamics, providing insights into the role of NQO1 in various pathological states. Its ability to modulate NQO1 activity makes it a valuable tool for studying the enzymatic pathways associated with oxidative stress and cellular proliferation. -
Tubulin Inhibitor
Tubulin polymerization-IN-75 is a selective inhibitor of tubulin polymerization, demonstrating an IC50 of 30 μM. This compound significantly reduces the proliferation of cancer cell lines Huh7 and 293T, exhibiting IC50 values of 14.3 μM and 13.8 μM, respectively. It serves as a valuable tool for research aimed at investigating the mechanisms of cancer cell growth and the modulation of the cytoskeleton. -
β-tubulin Inhibitor
Icafolin-methyl is an inhibitor of β-tubulin, targeting the colchicine binding site to prevent tubulin polymerization. This compound exhibits powerful post-emergence herbicidal activity against a range of weeds, including resistant strains such as ryegrass and darnel, making it suitable for application in both cool-season and warm-season cropping systems. Icafolin-methyl is valuable for research into herbicide mechanisms and the development of novel weed management strategies. -
Tubulin Inhibitor
DJ101 is a potent tubulin inhibitor that binds to the colchicine site, effectively overcoming taxane resistance in cancer cells. This compound demonstrates significant biological activity by inhibiting tumor growth in melanoma and lung metastasis. DJ101 is a valuable reagent for research applications focused on prostate cancer and related pathways. -
Microtubule/Tubulin Inhibitor
Curvulin is a microtubule/tubulin inhibitor that disrupts microtubule assembly, affecting cytoskeletal integrity and cellular dynamics. It also inhibits the expression of inducible nitric oxide synthase (iNOS), thereby modulating nitric oxide production. This compound is useful for research in cell biology, cancer studies, and investigations involving inflammation and nitric oxide signaling pathways. -
Centrosome Clustering Inhibitor
CCCI-01 is a centrosome clustering inhibitor that selectively targets cancer cells. It disrupts centrosome clustering, presenting potential as a non-cross-resistant anti-cancer agent. This compound is useful for research applications aimed at understanding cell division anomalies and developing new therapeutic strategies for cancer treatment. -
Tubulin Inhibitor
Tubulin Inhibitor 24 is a potent agent targeting tubulin polymerization. This compound effectively induces cell cycle arrest at the G2/M phase in a concentration-dependent manner, demonstrating significant antitumor activity. Its low toxicity profile makes it a valuable tool for cancer research applications. -
Tubulin Inhibitor
Tubulin polymerization-IN-47 is a potent inhibitor of tubulin polymerization, specifically targeting mitotic processes. This compound demonstrates significant inhibitory effects on neuroblastoma cancer cell proliferation, exhibiting IC50 values of 7 nM and 12 nM against the Chp-134 and Kelly cell lines, respectively. It is a valuable tool for research in cancer biology, particularly in the study of cell division and the mechanisms of tumor growth. -
Tubulin Polymerization Inhibitor
Antiproliferative agent-14 is a potent tubulin polymerization inhibitor with an IC50 of 3.41 μM. This compound demonstrates significant antiproliferative activity, effectively disrupting cell cycle progression by arresting cells at the G2/M phase. It is a valuable tool for studying tumor biology and the mechanisms underlying cell division in cancer research. -
Tubulin/NEDDylation Inhibitor
Tubulin/NEDDylation-IN-1 (compound C11) is a potent dual inhibitor targeting tubulin and NEDDylation, exhibiting an IC50 of 2.40 μM for tubulin. This compound effectively disrupts microtubule dynamics and inhibits the NEDDylation process, a crucial post-translational modification involving the attachment of the ubiquitin-like protein NEDD8 to target proteins. By forming hydrogen bonds with key residues in tubulin and the NEDD8 activating enzyme (NAE) through its methoxy and dithiocarbamate functionalities, Tubulin/NEDDylation-IN-1 demonstrates significant anti-proliferative activity and serves as a valuable tool for research investigating cellular proliferation and microtubule regulation. -
Tubulin Inhibitor
Tubulin Inhibitor 6 targets tubulin polymerization, displaying potent inhibitory activity across various cancer cell lines. It demonstrates an IC50 of 0.87 μM for tubulin polymerization and effectively inhibits the growth of K562 cells with an IC50 of 840 nM. This compound is useful for research applications focused on elucidating mechanisms of cancer cell proliferation and treatment strategies. -
Ubulin Polymerization Inhibitor
Tubulin polymerization-IN-51 is a potent tubulin polymerization inhibitor, exhibiting an IC50 value ranging from 2.55 to 17.89 μM in SK-Mel-28 cells. This compound effectively disrupts microtubule assembly, making it a valuable tool for cancer research. Its application in various experimental settings allows for the exploration of mechanisms underlying tumor cell proliferation and metastasis. -
Microtubule/Tubulin Inhibitor
OSIP-486823 is a novel tubulin inhibitor that disrupts microtubule dynamics. It demonstrates significant biological activity by affecting protein kinase G (PKG) pathways alongside its microtubule-interfering properties. This dual action positions OSIP-486823 as a valuable tool for studying cell division, cytoskeletal organization, and various signaling pathways in cancer research and other related fields. -
Tubulin Inhibitor
Tesetaxel is a taxane tubulin inhibitor that demonstrates oral activity and effective brain penetration. It inhibits tubulin depolymerization with an IC50 of 0.44 μM, leading to a reduction in cancer cell proliferation. This compound exhibits potent antitumor effects, particularly against P-glycoprotein-positive cancer cells, making it valuable for research applications related to solid tumors, liver metastasis, and advanced breast cancer. -
Tubulin Polymerization Inhibitor
S516 is a potent tubulin polymerization inhibitor with an IC50 of 4.29 μM. This active metabolite of CKD-516 exhibits significant antitumor activity, making it a valuable tool for cancer research. Its ability to disrupt microtubule dynamics may provide insights into cell cycle regulation and potential therapeutic strategies against cancer. -
Tubulin Polymerisation Inhibitor
Tubulin Inhibitor 27 (DYT-1) is a potent tubulin polymerisation inhibitor with an IC50 value of 25.6 μM. This compound exhibits significant anti-angiogenic and antitumor activities, making it valuable for research into cancer biology and potential therapeutic applications. Its ability to disrupt microtubule dynamics can aid investigations into cellular processes related to tumor growth and metastasis. -
Microtubule Inhibitor
Microtubule Inhibitor 5 is a potent agent targeting microtubules, demonstrating significant cytotoxicity with an IC50 value of 154.5 nM in NCI-H460 cells. This compound exhibits favorable cell permeability, making it suitable for various research applications related to cancer biology and cell division. It provides valuable insights for studies investigating the mechanisms of microtubule disruption and its implications in tumor growth inhibition. -
Tubulin Inhibitor
Tubulin Inhibitor 22 is a potent inhibitor of tubulin, demonstrating significant anti-angiogenic and anti-cancer properties. It effectively arrests the MGC-803 cell cycle at the G2/M phase, leading to a dose-dependent induction of Caspase-mediated apoptosis through mitochondrial dysfunction. This compound is valuable for research applications in cancer biology and the study of cell cycle regulation.
