Catalog No.
Product Name
Application
Product Information
Citations
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Topoisomerase II Inhibitor
F-14512 hydrochloride is a potent inhibitor of topoisomerase II, functioning through the polyamine transport system (PTS) to selectively target cancer cells. By enhancing the binding affinity of polyamines to DNA, it effectively inhibits topoisomerase II activity, leading to significant cytotoxic effects in cells with elevated PTS activity and resulting in DNA damage. Additionally, F-14512 hydrochloride exhibits strong antitumor efficacy in the MX1 breast tumor xenograft model, making it a valuable reagent for cancer research, particularly in studies focusing on breast cancer. -
RNA Polymerase II Inhibitor
ε-Amanitin is a cyclic peptide that specifically inhibits RNA polymerase II activity by binding to the enzyme's active site. This potent inhibitor disrupts transcription elongation, making it a valuable tool for investigating gene expression mechanisms. ε-Amanitin is commonly utilized in research focused on transcription regulation, RNA processing, and studying the effects of transcriptional inhibition in various biological systems. -
DNA Synthesis/HSV/HIV-1 Inhibitor
16,16-Dimethyl prostaglandin A1 is a prostaglandin analog that primarily inhibits DNA synthesis. It demonstrates significant antiviral activity by reducing viral replication in both herpes simplex virus (HSV) and HIV-1 infection models. This compound serves as a valuable tool for research focused on cancer biology and viral pathogenesis. -
DNA Polymerase Inhibitor
ddhCTP is a nucleoside analog that acts as a selective inhibitor of DNA polymerase. It effectively disrupts DNA synthesis with Ki values of 1.32 μM for DNA polymerase beta and 0.034 μM for DNA polymerase gamma. This compound is valuable for research applications involving the study of DNA replication and polymerase-specific pathways, providing insights into cellular mechanisms and potential therapeutic targets. -
MTH1 Inhibitor
IACS-4619 is a highly selective inhibitor of the MTH1 enzyme (MutT homolog 1) with an IC50 of 0.2 nM. This 2-aminopyrimidine compound effectively blocks the hydrolysis of oxidized purine nucleotides, such as 8-oxo-dGTP, preventing the incorporation of these nucleotides into DNA. Notably, IACS-4619 demonstrates significant inhibition of endogenous MTH1 activity in MTH1-overexpressing U2OS cells without exhibiting antiproliferative or cytotoxic effects on various human cancer and normal cell lines. This reagent is applicable in oncology research targeting the MTH1 pathway. -
rRNA Synthesis Inhibitor
NusB-IN-1 is a potent inhibitor of bacterial rRNA synthesis, demonstrating significant antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Staphylococcus aureus (VRSA). This compound serves as a valuable tool in microbiological research and drug development targeting bacterial RNA synthesis mechanisms. Additionally, NusB-IN-1 features an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, facilitating its use in click chemistry applications. -
DNA/RNA Synthesis
RNAP-σ interaction inhibitor-2 targets the interaction between RNA polymerase and sigma factors, effectively disrupting transcription in bacterial systems. It demonstrates notable antimicrobial activity against Staphylococcus aureus, with a minimum inhibitory concentration (MIC) of 2 µg/mL. This compound is a valuable tool for studying DNA/RNA synthesis and exploring the mechanisms of bacterial gene regulation. -
DNA topoisomerase II Inhibitor
NSC 660028 is a potent inhibitor of DNA topoisomerase II, exhibiting an ID50 of 50 μM. This compound disrupts DNA topoisomerase II activity, leading to the induction of protein-linked DNA breaks. NSC 660028 is primarily utilized in cancer research to explore mechanisms of tumor cell proliferation and resistance. -
DNA Polymerase
DNA polymerase-IN-1 is a selective inhibitor of DNA polymerase with an IC50 of 20.7 μM. This compound exhibits significant antiproliferative activity against tumor cells, making it a valuable tool in cancer research. Its ability to disrupt DNA synthesis may provide insights into tumorigenesis and potential therapeutic strategies for cancer treatment. -
Dual MTH1/OGG1 Inhibitor
SU0383 is a dual inhibitor of MTH1 and OGG1, demonstrating IC50 values of 0.034 μM and 0.49 μM, respectively. This compound induces cytotoxicity in cancer cells and enhances their sensitivity to oxidative stress, while exhibiting minimal toxicity in normal cells. SU0383 is suitable for applications in cancer research, particularly in studies focused on oxidative stress responses and therapeutic strategies targeting DNA repair mechanisms. -
Pyrimidine Nucleoside Antimetabolite
FF-10502 is a structural analog of Gemcitabine and functions as a pyrimidine nucleoside antimetabolite. It effectively inhibits DNA polymerase α and β, demonstrating significant anticancer activity, particularly in targeting dormant cells. This compound is valuable for research applications focused on cancer therapies and cellular dynamics related to quiescent tumor populations. -
EV71 3D Polymerase Inhibitor
DTriP-22 is a potent inhibitor of the enterovirus 71 (EV71) 3D polymerase, characterized by low toxicity. It demonstrates broad-spectrum antiviral activity against RNA viruses, particularly within the picornavirus family, while exhibiting no effects on DNA viruses. By targeting and inhibiting viral RNA synthesis during the early stages of replication, DTriP-22 serves as a valuable reagent in anti-enterovirus research applications. -
DNA Polymerase λ Inhibitor
Procaspase-IN-5 is a selective inhibitor of human DNA polymerase λ, with significant implications for cancer research. It exhibits a potent inhibitory effect on DNA polymerization and terminal deoxynucleotidyl transferase (TdT) activities, with IC50 values of 5.9 μM and 4.5 μM, respectively. This compound serves as a valuable tool for studying the mechanisms of DNA replication and repair in cancer cells. -
MTH1 Degrader
aTAG 2139 is a selective degrader targeting MTH1 via an aTAG-based mechanism. It demonstrates biological activity with a DC50 value of 1.1 nM and a Ki value of 2.1 nM for MTH1 inhibition. This compound is suitable for studies investigating the role of MTH1 in various cellular processes and therapeutic applications in cancer research. -
Topoisomerase II Inhibitor
KW-2170 hydrochloride is a potent topoisomerase II inhibitor that functions by stabilizing the topoisomerase II-DNA complex. This stabilization leads to DNA double-strand breaks, thereby inhibiting DNA replication and transcription, which ultimately results in tumor cell death. KW-2170 hydrochloride demonstrates broad-spectrum anti-tumor activity in various mouse and human tumor models, making it a valuable reagent for research related to solid tumors. -
Adenosine Analog
2'-Deoxy-5'-O-DMT-N6-Fmoc-adenosine 3'CE-phosphoramidite is an adenosine analog designed for use in oligonucleotide synthesis. This compound exhibits vasodilatory effects on smooth muscle tissues and has potential applications in inhibiting cancer progression. It serves as a valuable tool for researchers studying nucleotide signaling pathways and therapeutic interventions related to adenosine metabolism. -
DNA Synthesis Inhibitor
7U85 is a potent DNA synthesis inhibitor that targets the processes involved in DNA replication. Its primary mechanism disrupts nucleotide incorporation, thereby impeding cell proliferation. This compound demonstrates significant potential for research applications in breast cancer studies, offering insights into tumor growth and treatment resistance mechanisms. -
DNA Synthesis Inhibitor
Miboplatin (DWA-2114R) is a platinum-based compound that functions as a DNA synthesis inhibitor. It effectively diminishes the template activity of both prokaryotic and eukaryotic DNA polymerases, making it valuable for research focused on DNA replication processes. This compound is useful in studies exploring DNA damage response, cancer biology, and potential therapeutic applications in oncology. -
vRNA/cRNA Synthesis Product
pppApG is a pivotal nucleotide involved in the synthesis of both viral RNA (vRNA) and complementary RNA (cRNA). This compound serves as a critical starting substrate in the assembly of viral genomes, making it essential for influenza virus research and related studies. Its application supports investigations into viral replication mechanisms and the development of antiviral strategies. -
Polymerase
DNA polymerase is a crucial enzyme that targets DNA templates, facilitating the polymerization of deoxyribonucleotides (dNTPs) to synthesize and extend DNA strands with high fidelity and processivity. This enzyme is widely used in molecular biology applications, including DNA amplification, cloning, and sequencing. Its reliability and precision make DNA polymerase an essential tool in cancer research and various genomic studies. -
Topoisomerase Inhibitor
NSC 727357 is a potent topoisomerase inhibitor and DNA intercalator, exhibiting significant antitumor activity. It effectively inhibits cell proliferation and induces G1 phase cell cycle arrest. This compound is particularly relevant for cancer research, including studies focused on melanoma. -
NS5B Polymerase Inhibitor
A-837093 sodium is a potent inhibitor of the hepatitis C virus (HCV) nonstructural protein 5B (NS5B) polymerase, exhibiting high selectivity and oral bioavailability. It demonstrates strong inhibitory activity against HCV genotypes 1a (IC50 = 1.25 nM) and 1b (IC50 = 0.33 nM). A-837093 sodium has shown antiviral efficacy in in vivo studies involving HCV-infected chimpanzees, making it a valuable tool for research focused on HCV infection and therapeutic development. -
RNA Synthesis Inhibitor
Nitracrine dihydrochloride hydrate is an RNA synthesis inhibitor that covalently and reversibly binds to DNA, forming covalent adducts within biological systems. This 1-nitroacridine derivative exhibits potent hypoxia-selective activity in vitro and serves as an effective antitumor agent. Its cytotoxic properties extend to a wide range of cell types, making it a valuable compound for cancer research and studies focusing on DNA-targeting agents. -
DNA/RNA Synthesis Chemical
5-Propargylamino-3'-azidomethyl-dCTP is a nucleoside analog utilized primarily in DNA and RNA synthesis. This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted azide-alkyne cycloaddition (SPAAC) with alkyne-containing molecules. Its chemical properties make it a valuable tool for applications in click chemistry, particularly in the development of bioconjugates and in DNA sequencing technologies. -
MTH1 Ligand
MTH1 Ligand 1 is a specific ligand that targets the MTH1 protein, playing a crucial role in cellular pathways associated with nucleotide metabolism and cancer cell survival. This compound is instrumental in the synthesis of PROTAC aTAG 2139, facilitating targeted protein degradation in research applications. Its selectivity for MTH1 makes it a valuable tool for investigating therapeutic strategies aimed at mitigating oncogenic processes. -
DNA/RNA Synthesis Inhibitor
Ara-ATP is a structural analog of ATP that functions as an inhibitor of poly(A) polymerase activity through competitive interaction with ATP. This inhibition disrupts the biosynthesis of RNA, making Ara-ATP valuable for studies on RNA processing and regulation. It is particularly useful in examining mechanisms of gene expression and RNA metabolism in various cellular contexts. -
MTH1 aTAG inhibitor
MTH1 degrader-1 is a potent degrader targeting MTH1 through a PROTAC mechanism. This compound facilitates the selective degradation of MTH1, making it a valuable tool for studying the role of MTH1 in cancer metabolism and therapy resistance. Key applications include the development of PROTACs and the synthesis of related compounds, such as PROTAC aTAG 4531. -
Topoisomerase Inhibitor
Netropsin is a small-molecule minor-groove binder that functions as a topoisomerase inhibitor. It effectively inhibits the catalytic activity of isolated topoisomerase, disrupting the stabilization of cleavable complexes associated with both topoisomerase I and II. Additionally, Netropsin exhibits antibacterial and antiviral properties, making it a valuable tool for research in the fields of microbiology and virology. -
DNA Synthesis Inhibitor
2-Keto-D-galactose, also known as D-Galactosone, functions as a potent inhibitor of DNA synthesis. It displays significant biological activity by inhibiting the proliferation of Ehrlich ascites tumor cells in vitro, making it a valuable reagent for cancer research and studies involving cell growth regulation. This compound can be utilized to investigate the mechanisms of DNA synthesis disruption and its effects on tumor cell dynamics. -
RNA Polymerase Inhibitor
Adafosbuvir is a uridine-based nucleotide analog that serves as a potent RNA polymerase inhibitor targeting the NS5B protein of Hepatitis C virus (HCV). It exhibits significant antiviral activity by effectively inhibiting HCV replication. This compound is primarily utilized in research applications aimed at understanding HCV biology and developing antiviral therapies. -
Polθ Polymerase Inhibitor
Polθ-IN-9 is a selective inhibitor of Pol θ polymerase, demonstrating an IC50 value of 9.6 nM and a Kd of 47.5 nM, with no significant inhibitory effects on other human DNA polymerases such as Pol α, Pol ε, Pol γ, Pol λ, and Pol μ. This compound exhibits potent antiproliferative activity in DLD1 BRCA2 knockout cells (IC50 = 2.9 μM) and MDA-MB-436 cells (IC50 = 4.9 μM), while also increasing DNA damage and γH2AX levels. In addition, Polθ-IN-9 has shown to inhibit tumor growth in conjunction with Olaparib in the MDA-MB-436 xenograft model, making it a valuable tool for studying homologous recombination-deficient cancers, including breast cancer. -
Bacterial RNA Polymerase Inhibitor
Tirandamycin A is a potent bacterial RNA polymerase inhibitor. It exhibits significant antibacterial and antiamoebic activity, making it a valuable tool for research into bacterial inhibition mechanisms. This compound is useful for studies examining bacterial resistance and the development of new antibiotics. -
Cytidine Analog
2'-Deoxy-5'-O-DMT-N4-Fmoc-5-methylcytidine 3'-CE-phosphoramidite is a cytidine analog that acts as an inhibitor of DNA methyltransferases. This compound is valuable for research applications in epigenetics and cancer biology, displaying potential anti-metabolic and anti-tumor activities. Its ability to modify DNA methylation patterns makes it a useful tool in studies aimed at understanding gene regulation and cellular responses. -
RNA Synthesis Inhibitor
Nitracrine hydrochloride is an RNA synthesis inhibitor that targets hypoxic cancer cells through its platinum-based structure. It demonstrates significant cytotoxicity against the Chinese hamster ovary cell line AA8 under low oxygen conditions, primarily by forming covalent adducts with DNA. This compound's mechanism involves reductive metabolism, leading to the formation of alkylating agents that enhance its reactivity with DNA. By inhibiting RNA synthesis, Nitracrine hydrochloride contributes to its overall anti-tumor efficacy, making it a valuable reagent for cancer research. -
DNA/RNA Synthesis Chemical
DMT-dU-CE Phosphoramidite is a versatile nucleotide building block utilized in DNA and RNA synthesis. This compound serves as an essential reagent for incorporating 5-(Dimethoxytrityl)-modified deoxyuridine into oligonucleotide sequences. Its application extends to DNA sequencing and various molecular biology techniques, facilitating precise synthesis of nucleic acids for research and therapeutic purposes. -
Topoisomerase II/DNA Polymerase Inhibitor
Epolactaene is a potent inhibitor of Topoisomerase II and DNA Polymerases, exhibiting IC50 values of 10 µM for Topoisomerase II, 25 µM for DNA Polymerase α, and 94 µM for DNA Polymerase β. Its ability to interfere with these key enzymes makes Epolactaene valuable for studying DNA replication and repair mechanisms. This compound is suitable for research applications involving cancer biology and the investigation of DNA-targeting therapies. -
Strand-displacement Activity Of DNA Polymerase Inhibitor
NSC666715 is a specific inhibitor of the strand-displacement activity of DNA polymerase. This compound enhances the effects of Temozolomide by inducing DNA damage, promoting cell senescence, and triggering apoptosis. NSC666715 serves as a valuable tool for research in colorectal cancer, aiding in the investigation of DNA repair mechanisms and therapeutic responses. -
DNA Polymerase-α Inhibitor
PHYLPA-8 is a selective inhibitor of DNA polymerase-α, targeting the enzyme's active site to restrict its function. This compound demonstrates unique structural features that influence its binding efficacy, allowing it to modulate DNA replication processes. PHYLPA-8 is suitable for research applications involving the study of DNA synthesis, repair mechanisms, and the evaluation of polymerase activity in various biological systems. -
DNA Synthesis Inhibitor
Methyl 3-oxodecanoate is a DNA synthesis inhibitor targeting protein synthesis at the level of translation initiation. This compound exhibits biological activity against human pathogens, including fluorescent haplophyllum and its culture supernatant. It serves as a valuable reagent for research applications focused on understanding virulence factors and mechanisms of DNA synthesis inhibition. -
DNA Polymerase Inhibitor
Lucidenic acid O acts as a potent inhibitor of DNA polymerases, targeting calf DNA polymerase-α, rat DNA polymerase-β, and HIV-1 reverse transcriptase. Its inhibitory activity is characterized by IC50 values of 42 μM, 99 μM, and 69 μM, respectively. This compound is valuable for research applications focusing on DNA replication and viral infections, offering insights into the mechanisms of polymerase inhibition. -
DNA Synthesis Substrate
5-Fluoro-2′-deoxy-UTP sodium serves as a nucleotide substrate in DNA synthesis. It incorporates into DNA strands during replication and transcription, providing a means to study nucleic acid processes and investigate mutations. This reagent is essential for applications such as polymerase chain reactions and other molecular biology techniques that require modified nucleotides. -
HCV NS5B Polymerase Inhibitor
RG7109 is a potent inhibitor of hepatitis C virus (HCV) NS5B polymerase, demonstrating EC50 values of 1.1 nM for HCV genotype 1a (H77) and 1.0 nM for genotype 1b (Con1). This compound exhibits favorable pharmacokinetic properties, making it a valuable tool for anti-HCV research. RG7109 is applicable in studies aimed at understanding HCV replication and developing antiviral strategies. -
Nucleoside Antimetabolite/Analog
3'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite is a nucleoside antimetabolite that serves as an adenine nucleotide monomer precursor in the solid-phase synthesis of oligonucleotides. This compound features trityl (Tr), cyanoethyl (CE), and dimethylformamidine (DMF) protecting groups, making it ideal for producing modified oligonucleotides, including those with specific DNA chain end modifications. Applications include oligonucleotide synthesis, probe design, and chain-termination sequencing, where it plays a crucial role in enhancing the specificity and performance of nucleic acid-based assays. -
RNA Polymerase Inhibitor
Favipiravir sodium is a potent inhibitor of viral RNA polymerase, effectively converted to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP demonstrates significant inhibition of influenza virus RNA-dependent RNA polymerase (RdRP) with an IC50 value of 341 nM. This compound is primarily utilized in research focused on antiviral mechanisms and the development of treatments against RNA virus infections. -
DNA/RNA Synthesis Inhibitor
F-ara-EdU is a potent DNA and RNA synthesis inhibitor that functions as a valuable probe for monitoring cell proliferation and DNA replication. This highly stable compound selectively binds to DNA and RNA in cells, enabling the quantification of DNA synthesis rates. Additionally, F-ara-EdU is instrumental in investigating the mechanisms underlying DNA repair and damage, making it an essential tool for researchers studying cellular responses to genomic instability. -
DNA Polymerase β Inhibitor
3′-Amino-2′,3′-dideoxy-CTP is a nucleoside triphosphate analogue that functions as a selective inhibitor of DNA polymerase β. This compound is particularly useful in studies related to DNA repair mechanisms and cellular responses to DNA damage. Its ability to inhibit polymerase activity makes it a valuable tool for researching the role of DNA polymerase β in various biological processes and cancer biology. -
DNA Synthesis Inhibitor
Cytarabine 5’-monophosphate is a DNA synthesis inhibitor that acts as a metabolite of the nucleoside analog Cytarabine. It is phosphorylated by deoxycytidine kinase and subsequently incorporated into DNA by DNA polymerase α, effectively reducing the rate of DNA synthesis. At a concentration of 15 mM, it shows inhibitory effects on nuclear and mitochondrial DNA replication in Saccharomyces cerevisiae. Additionally, at doses ranging from 3.5 to 75.1 mg/kg, it contributes to improved survival rates in L1210 leukemia mouse models, making it a valuable compound for cancer research applications. -
RNA Polymerase Inhibitor
RNA polymerase-IN-4 is a potent inhibitor of RNA polymerase, exhibiting an EC50 of 22.81 nM. This compound demonstrates significant anti-influenza virus activity with an EC50 of 3.76 nM and displays relatively low cytotoxicity, with a CC50 of 29.91 μM. RNA polymerase-IN-4 is suitable for research applications focused on viral infections, particularly those related to influenza virus. -
RNA polymerase Inhibitor
RNA polymerase-IN-1 is a selective inhibitor of DNA-dependent RNA polymerase, which is crucial for the transcription process in cells. This compound has demonstrated effective inhibition of CYP isozymes, highlighting its potential in studying the role of RNA polymerase in transcription regulation and drug metabolism. RNA polymerase-IN-1 is valuable for research applications focused on gene expression and the modulation of metabolic pathways. -
eIF4E Inhibitor
Antiproliferative agent-64 is a potent inhibitor of eukaryotic translation initiation factor 4E (eIF4E), which disrupts the secondary structure of mRNA to effectively inhibit protein translation. This compound exhibits significant biological activity by targeting the 5' untranslated region (5'UTR) of c-Myc with an EC50 of 1.2 nM and the 5'UTR encoding tubulin with an EC50 of 40 nM. Antiproliferative agent-64 also demonstrates considerable antiproliferative effects on MDA-MB-231 cancer cells, with an EC50 of 7 nM, making it a valuable tool for cancer research and the study of translation regulation.
