Catalog No.
Product Name
Application
Product Information
Citations
-
DNA Alkylator/Crosslinker Inducer
Anticancer agent 11 functions as a DNA alkylator and crosslinker inducer, exhibiting broad-spectrum anticancer activity. This compound inhibits angiogenesis and promotes the formation of DNA cross-links, leading to disruptions in DNA replication and repair processes. It has potential applications in cancer research, particularly in the study of tumor biology and the development of novel therapeutic strategies. -
DNA Alkylator/Crosslinker Control
4-Ketocyclophosphamide is an inactive metabolite that serves as a control for the alkylating agent Cyclophosphamide, functioning as a DNA alkylator and crosslinker. This compound is utilized in research to investigate the mechanisms of action and toxicity of alkylating agents, aiding in the study of cancer therapies and the development of related pharmaceuticals. Its role in understanding the cellular responses to DNA damage makes it valuable for both preclinical and clinical research applications. -
DNA Alkylator/Crosslinker
Brostallicin is a DNA alkylator and crosslinker known for its potent cytotoxic properties. It effectively induces DNA damage, leading to apoptosis in cancer cells, while exhibiting low myelotoxicity. This compound is primarily utilized in cancer research to explore mechanisms of DNA repair and resistance to therapeutic agents. Its unique profile makes it a valuable tool for advancing studies in oncology and molecular biology. -
DNA Alkylator/Crosslinker Chemical
Canfosfamide hydrochloride functions as a DNA alkylator and crosslinker. Upon activation by the enzyme glutathione S-transferase P1-1 (GSTP1-1), it generates an active anticancer alkylating agent alongside a glutathione derivative. This compound is primarily utilized in cancer research to investigate its therapeutic potential and mechanisms of action in tumor cell lines. -
SIRT2/Hsp70 Inhibitor
YM-08 is a selective inhibitor of SIRT2 and Hsp70, exhibiting an IC50 of 19.9 μM for SIRT2. This compound effectively penetrates the blood-brain barrier, making it a valuable tool for studying neurodegenerative diseases and cellular stress responses. Its dual inhibitory activity allows for investigation into SIRT2 and Hsp70's roles in various biological processes and potential therapeutic applications. -
HSP70/SIRT2 Inhibitor
HSP70/SIRT2-IN-2 is a dual inhibitor targeting SIRT2 and HSP70, demonstrating an IC50 of 45.1±5.0 μM for SIRT2. This compound exhibits significant antitumor activity, making it a valuable tool for cancer research. Its ability to simultaneously inhibit these two proteins positions HSP70/SIRT2-IN-2 as a useful candidate for studies focused on tumor progression and potential therapeutic strategies. -
HDAC1/HDAC2 Inhibitor
MRLB-223 is a selective inhibitor of HDAC1 and HDAC2, demonstrating potent activity against tumor cells. It induces histone hyperacetylation and activates the intrinsic apoptotic pathway, leading to tumor cell apoptosis and degradation of Bcr-Abl in a caspase-dependent manner. Notably, MRLB-223 mediates p53-independent cell death in Bcr-Abl-expressing myeloid cells and shows efficacy in animal models of Eμ-myc lymphoma. This compound is valuable for research focusing on the mechanisms of lymphomagenesis and therapeutic strategies for Eμ-myc lymphoma. -
ATR Inhibitor
ART0380 is a potent and selective ATR kinase inhibitor that targets the ATR-ATRIP complex. With an IC50 of 51.7 nM, ART0380 effectively inhibits ATR-dependent Chk1 serine 345 phosphorylation, leading to cell cycle disruption and DNA damage. This compound exhibits significant antitumor activity in preclinical models featuring various ataxia-telangiectasia mutated (ATM) gene alterations. ART0380 is applicable for cancer research, particularly in studies related to colorectal and prostate cancer. -
RNA-dependent RNA-polymerases Inhibitor
GS-443902 trisodium is a potent inhibitor of RNA-dependent RNA polymerases (RdRp), specifically targeting respiratory syncytial virus (RSV) and hepatitis C virus (HCV) RdRp with IC50 values of 1.1 μM and 5 μM, respectively. As the active triphosphate metabolite of Remdesivir (GS-5734), this compound is essential for research focused on viral replication mechanisms and the development of antiviral therapies. Its ability to effectively inhibit RdRp activity makes it a valuable tool for studies in virology and drug discovery. -
mtDNA Synthesis Inhibitor
Alovudine (3'-Fluoro-3'-deoxythymidine) is an inhibitor of mitochondrial DNA (mtDNA) synthesis and serves as a marker for DNA synthesis. This compound demonstrates reduced susceptibility to inflammatory changes compared to traditional markers, making it a more reliable biomarker in pancreatic cancer studies. Additionally, Alovudine exhibits significant anti-orthopoxvirus and anti-leukemic activities, providing valuable insights for ongoing research in virology and oncology. -
RNA Polymerase II/III Inhibitor
β-Amanitin is a cyclic peptide toxin that specifically targets and inhibits RNA Polymerase II and III, crucial enzymes in eukaryotic transcription. By obstructing these polymerases, β-Amanitin effectively halts protein synthesis, making it a valuable reagent in research focused on gene expression and transcription regulation. Additionally, its ability to induce cytotoxicity positions β-Amanitin as a potential component in antibody-drug conjugates (ADCs) for targeted therapeutic applications. -
DNA Polymerase Substrate
2'-Deoxyadenosine-5'-triphosphate trisodium is a critical substrate for DNA polymerase, facilitating DNA synthesis and replication processes. It serves as a vital component in molecular biology research, particularly in studies related to genetic immunodeficiency disorders, such as adenosine deaminase deficiency and purine nucleotide phosphorylase deficiency. This nucleotide is essential for in vitro applications involving DNA amplification and manipulation. -
RSV Polymerase Inhibitor
JNJ-8003 is a highly potent, orally active non-nucleoside inhibitor of respiratory syncytial virus (RSV) polymerase, exhibiting an IC50 of 0.29 nM. It specifically targets the L protein of the polymerase complex, effectively blocking the transcription and replication of the viral genome by inhibiting RNA-dependent RNA polymerase (RdRp) activity, with an IC50 of 0.67 nM. In vitro studies demonstrate subnanomolar efficacy, and it has shown significant effectiveness in mouse and neonatal lamb models. JNJ-8003 is a valuable reagent for investigating RSV biology and developing antiviral therapies. -
Purine Nucleoside Analog
2-Thiouridine is a purine nucleoside analog that enhances the stability of U:A base pairs while destabilizing U:G wobble base pairs. This modification significantly boosts the efficiency and accuracy of nonenzymatic replication of mixed-sequence A/U-containing RNA templates. Additionally, 2-Thiouridine exhibits notable antiviral activity against a range of positive-sense single-stranded RNA viruses, including Dengue Virus (DENV2), Zika Virus (ZIKV), Yellow Fever Virus (YFV), Japanese Encephalitis Virus (JEV), West Nile Virus (WNV), Chikungunya Virus (CHIKV), and various human coronaviruses, such as SARS-CoV and MERS-CoV. -
Topoisomerase Inhibitor
Hycanthone is a potent topoisomerase inhibitor that functions as a thioxanthenone DNA intercalator. It effectively inhibits RNA synthesis and the activity of DNA topoisomerases I and II, leading to a reduction in nucleic acid biosynthesis. Additionally, Hycanthone demonstrates significant inhibition of apurinic endonuclease-1 (APE1) through direct protein binding, with a binding affinity (KD) of 10 nM. This compound is recognized as a bioactive metabolite of Lucanthone and is noted for its anti-schistosomal properties, making it valuable in related research applications. -
DNA Polymerase β Inhibitor
Prunasin is a specific inhibitor of DNA Polymerase β, showing an IC50 value of 98 μM in rat models. As an orally active cyanogenic glucoside and a principal metabolite of Amygdalin, Prunasin exhibits notable anti-inflammatory and anti-fibrotic properties. This compound is valuable for research into conditions such as liver fibrosis, facilitating investigations into therapeutic strategies targeting DNA repair and fibrotic processes. -
Topoisomerase Inhibitor
Netropsin dihydrochloride is a potent topoisomerase inhibitor that functions as a minor-groove binder. It effectively inhibits the catalytic activity of isolated topoisomerases, disrupting the stabilization of cleavable complexes associated with topoisomerase I and II in the nucleus. Additionally, netropsin dihydrochloride exhibits notable antibacterial and antiviral properties, making it valuable for various research applications, including studies on DNA topology and therapeutic interventions against microbial infections. -
Telomerase Inhibitor
Braco-19 trihydrochloride is a potent telomerase inhibitor that disrupts telomerase capping and catalytic activity. By acting as a G-quadruplex binding ligand, Braco-19 stabilizes G-quadruplex formation at the 3' telomeric DNA overhang, leading to rapid cellular senescence or selective cell death. Additionally, Braco-19 demonstrates efficacy as an inhibitor of HAdV virus replication, making it a valuable tool for research in cancer biology and virology. -
Polθ/PARP Inhibitor
Polθ/PARP-IN-1 is a potent dual inhibitor targeting DNA polymerase theta (Polθ) and poly (ADP-ribose) polymerase (PARP), exhibiting IC50 values of 45.6 nM and 5.4 nM, respectively. This compound demonstrates significant antiproliferative activity by inducing apoptosis and cell cycle arrest at the G2/M phase, leading to DNA damage. Polθ/PARP-IN-1 is applicable in cancer research and may contribute to therapeutic strategies targeting tumorigenesis. -
Thermostable DNA Polymerase
Taq DNA polymerase is a thermostable DNA polymerase that plays a crucial role in polymerase chain reaction (PCR) amplification. Its inherent heat resistance allows for the efficient synthesis of DNA at elevated temperatures, making it ideal for applications requiring robust amplification of nucleic acids. Taq DNA polymerase is widely utilized in molecular biology research, including cloning, gene expression analysis, and genetic fingerprinting, due to its high fidelity and activity. -
DNA Polymerase Inhibitor
3,4-Dihydroxybenzylamine hydrobromide is a DNA polymerase inhibitor that exhibits cytotoxic effects in melanoma cells. This compound demonstrates significant growth inhibitory activity across various melanoma cell lines, with efficacy correlated to the levels of tyrosinase activity. Its unique mechanism makes it a valuable tool for investigating cellular processes related to DNA replication and repair in cancer research. -
DNA Synthesis Inhibitor
Cytarabine triphosphate trisodium is a competitive inhibitor of DNA synthesis, functioning as an active metabolite of Cytarabine. It is used primarily in research to assess the chemosensitivity of leukemic blasts to Cytarabine by measuring intracellular levels. This compound plays a critical role in studies related to leukemia treatment and the evaluation of drug efficacy in cancer therapies. -
DNA Polymerases Sustrate
5-Propargylamino-dCTP is a substrate for DNA polymerases, enabling the synthesis of labeled nucleic acids. This reagent facilitates conjugation to molecular markers, enhancing applications in nucleic acid labeling and sequencing analysis. Featuring an alkyne group, 5-Propargylamino-dCTP is suitable for click chemistry, allowing for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. -
T7 RNA Polymerase
T7 RNA polymerase is a highly specific enzyme derived from the T7 bacteriophage, facilitating in vitro transcription (IVT) of mRNA in research applications. This enzyme utilizes single-stranded or double-stranded DNA templates containing the T7 promoter sequence in the presence of Mg2+, catalyzing the synthesis of RNA complementary to the DNA downstream of the promoter. Its precise activity makes T7 RNA polymerase an essential tool for RNA synthesis in molecular biology and genetic studies. -
MTH1 Inhibitor
BAY-707 is a potent and selective inhibitor of MTH1 (NUDT1) that functions through a substrate-competitive mechanism with an IC50 of 2.3 nM. This compound exhibits a favorable pharmacokinetic profile compared to other MTH1 inhibitors and demonstrates good tolerability in mouse models. Although BAY-707 has shown effective inhibition of MTH1, it does not exhibit significant anticancer activity in either in vitro or in vivo studies, making it suitable for research into MTH1 function and related pathways. -
RNA/DNA Synthesis Inhibitor
Sodium Camptothecin is a plant-derived alkaloid that functions primarily as an RNA and DNA synthesis inhibitor. It exhibits potent antitumor activity by effectively inhibiting the replication of adenoviruses, leading to significant disruption of viral DNA integrity. This compound is valuable for research applications focused on viral replication mechanisms and cancer therapy investigations. -
Topoisomerase II Inhibitor
F-14512 is a topoisomerase II inhibitor that selectively targets cancer cells via the polyamine transport system. By enhancing the interaction of polyamines with DNA, F-14512 effectively inhibits topoisomerase II, leading to significant DNA damage and subsequent cellular cytotoxicity, particularly in cells exhibiting high PTS activity. This compound has demonstrated potent antitumor efficacy in the MX1 breast tumor xenograft model, making it a valuable tool for researching breast cancer and exploring mechanisms of drug resistance in oncological studies. -
Viral DNA Polymerase Inhibitor
Foscarnet trisodium hexahydrate is a viral DNA polymerase inhibitor that reversibly suppresses viral replication. It is primarily utilized as an antiherpesvirus agent, demonstrating efficacy in the treatment of cytomegalovirus retinitis. This compound is valuable for researchers studying viral infections and developing antiviral therapies. -
Poly(A) polymerase Inhibitor
2'-Deoxyadenosine 5'-diphosphate disodium (dADP disodium) acts as an inhibitor of bacterial poly(A) polymerase. This compound is particularly useful in the synthesis of deoxyadenosine oligonucleotides when utilized with Escherichia coli polynucleotide phosphorylase and other related enzymes. Its role in inhibiting poly(A) polymerase makes it valuable for studies in RNA metabolism and gene regulation research. -
Pyrimidine Nucleoside Antimetabolite Drug
Sorivudine is a synthetic pyrimidine nucleoside antimetabolite that exerts its antiviral effects through selective phosphorylation by viral thymidine kinases. This process leads to the formation of nucleotides that disrupt viral DNA synthesis. Sorivudine is primarily used in research applications focusing on antiviral drug development and the mechanisms of viral replication. -
DNA Polymerase Inhibitor
ddATP trisodium solution (100 mM) serves as a chain-elongating inhibitor of DNA polymerase. As an active metabolite of 2',3'-dideoxyinosine, it is primarily utilized in the Sanger method for DNA sequencing. Additionally, this reagent is valuable for studying viral infections and other applications in molecular biology research. -
DENV Polymerase Inhibitor
NITD-2 is a selective inhibitor of dengue virus (DENV) polymerase, specifically targeting the RNA-dependent RNA polymerase (RdRp) to impede RNA elongation. This compound exhibits potent antiviral activity against DENV, making it a valuable tool for research focused on understanding dengue virus replication and developing therapeutic strategies. Its limited ability to penetrate cell membranes can be an important consideration for in vitro experimental design. -
DNA/RNA Synthesis Inhibitor
DHPS-IN-1 is a potent inhibitor of dihydropteroate synthase (DHPS), exhibiting a remarkable inhibitory potency with an IC50 of 0.014 μM. This compound effectively impedes DNA and RNA synthesis, demonstrating significant anti-melanoma activity. DHPS-IN-1 is relevant for research applications focused on understanding metabolic pathways in cancer and developing targeted therapies against melanoma. -
DNA/RNA Synthesis Inhibitor
3-Isomangostin is a potent inhibitor of the MutT homologue 1 (MTH1) with an IC50 value of 52 nM, impacting DNA and RNA synthesis. Derived from the shell of Garcinia mangostana L., it presents a valuable chemical tool for investigating anticancer mechanisms and developing novel therapeutic strategies against cancer. Its ability to inhibit MTH1 highlights its potential for applications in cancer research and drug discovery. -
DNA Polymerase α Inhibitor
NSC639828 is a potent inhibitor of DNA polymerase α, exhibiting an IC50 of 70 μM. This compound demonstrates significant antitumor activity, making it a valuable tool for cancer research. NSC639828 can be utilized to investigate the role of DNA polymerase α in tumorigenesis and to explore potential therapeutic strategies in cancer treatment. -
DNA/RNA Synthesis Chemical
2-O-Methylcytosine is an O-alkylated analogue of cytosine, functioning as a DNA and RNA synthesis chemical. This modified nucleobase plays a critical role in the study of DNA alterations and epigenetic modifications. It is widely utilized in molecular biology research, particularly in the synthesis of modified nucleic acids and the investigation of nucleobase interactions. -
DNA Polymerase Inhibtior
3′-Deoxythymidine, also known as 2′,3′-dideoxythymidine, serves as a potent inhibitor of eukaryotic cellular and viral DNA polymerases. This nucleoside analog demonstrates significant antiviral activity, particularly against retroviruses, making it a valuable tool in the study of viral replication and infection mechanisms. Its application extends to research targeting antiviral therapies and understanding the biochemical pathways of DNA synthesis. -
DNA Polymerase Substrate
7-Deaza-2'-deoxyadenosine is a structural analog of 2'-deoxyadenosine that serves as a substrate for various DNA polymerases. Its unique chemical properties facilitate incorporation into DNA strands, enabling site-specific labeling through a bioorthogonal inverse electron demand Diels-Alder reaction with tetrazine-modified molecules. This reagent has shown to influence DNA curvature and reduce the stability of DNA/RNA double helices, with implications for decreasing antisense activity against SV40 T Antigen. 7-Deaza-2'-deoxyadenosine is particularly useful in the study of cancers related to SV40 T Antigen. -
Adenosine Analog
2'-O,4'-C-Methyleneadenosine is a locked nucleic acid (LNA) and an adenosine analog that exhibits increased stability and binding affinity for complementary RNA sequences. This compound serves as a valuable tool in nucleic acid research, enabling precise modulation of gene expression and investigation of RNA structures. Its application extends to antisense oligonucleotide design and RNA interference studies, making it essential for researchers exploring RNA-related therapies and molecular diagnostics. -
RNA Synthesis Inhibitor
Nitracrine is an RNA synthesis inhibitor that covalently and reversibly binds to DNA, forming covalent adducts in vivo. As a 1-nitroacridine derivative, it exhibits potent hypoxia-selective cytotoxicity in vitro and serves as an effective antitumor agent. Nitracrine demonstrates cytotoxic effects against a wide range of cell types, making it a valuable tool for cancer research and therapeutic investigations. -
DNA Synthesis Substrate
5-Fluoro-2′-deoxy-UTP is a nucleotide analog primarily utilized as a substrate in DNA synthesis. This compound incorporates into DNA strands, allowing researchers to study nucleotide incorporation and the effects of fluorinated nucleotides on replication and genetic stability. It is widely used in molecular biology applications, including the synthesis of modified oligonucleotides and in various labeling techniques for DNA analysis. -
DNA Polymerase Inhibitor
Acyclovir triphosphate sodium is a potent inhibitor of viral DNA polymerase, functioning as a competitive analogue of deoxyguanosine triphosphate (dGTP). This compound also exhibits inhibitory activity against HIV-1 reverse transcriptase, leading to the termination of viral DNA synthesis. Acyclovir triphosphate sodium is valuable for research applications in virology and the study of antiviral mechanisms. -
DNA Polymerase Substrate
2'-Deoxyadenosine-5'-triphosphate (dATP) serves as a critical substrate for DNA polymerase during DNA synthesis and replication. This nucleotide plays a vital role in the formation of DNA molecules by providing the necessary building blocks for polymerization. dATP is essential for various molecular biology applications, including DNA amplification, sequencing, and cloning, making it a valuable reagent for biochemical and genetic research. -
DNA Synthesis Activator
Isorhamnetin 3-gentiobioside is a flavonoid known for its role as a DNA synthesis activator, particularly in MCF-7 human breast cancer cells, exhibiting an EC50 of 3.1 μg/mL. This compound demonstrates significant biological activity, promoting cell proliferation and exhibiting ABTS radical scavenging activity with an IC50 of 33.43 μg/mL. It serves as a valuable reagent for investigating the regulatory mechanisms underlying cancer biology. -
DNA/RNA Synthesis Inhibitor
Methotrexate α-tert-butyl ester is an antimetabolite and antifolate compound that acts as a potent inhibitor of DNA and RNA synthesis. It demonstrates significant anti-tumor activity by effectively reducing tumor growth in HT1080 tumor-bearing mouse models. This compound is also utilized for its immunosuppressive and antineoplastic properties in various research applications. -
RNA Polymerase I Transcription Inhibitor
BMH-22 is a selective inhibitor of RNA polymerase I transcription, functioning independently of p53 pathways. This benzonaphthyridin compound induces reorganization of nucleolar marker proteins, indicative of nucleolar segregation, and destabilizes RPA194 through a proteasome-dependent mechanism. Additionally, BMH-22 effectively inhibits the synthesis of nascent rRNA and the expression of the 45S rRNA precursor. Its potent anticancer properties make it a valuable tool for studying cancer biology and RNA transcription regulation in various tumor models. -
RNA Polymerase Inhibitor
MMV688845 is an RNA polymerase inhibitor targeting nontuberculous mycobacteria (NTM) with demonstrated bactericidal activity against Mycobacterium abscessus. This compound exhibits potential anti-tuberculosis efficacy, making it a valuable tool for research in tackling mycobacterial infections. Its selective mechanism positions MMV688845 as a promising candidate for further exploration in antimicrobial studies and drug development. -
MTH1 Activator
MTH1 activator-1 is a potent activator of MTH1, a critical enzyme involved in the repair of oxidative damage to nucleotide pools. This compound significantly enhances endogenous MTH1 activity, leading to reduced levels of 8-oxo-dG in cellular DNA. MTH1 activator-1 serves as a valuable tool for investigating the cellular and biological implications of enhanced oxidative damage repair, and it may provide insights into strategies for delaying or preventing tumorigenesis. -
NS5B Polymerase/RdRp Inhibitor
Lomibuvir is a selective non-nucleoside inhibitor of the NS5B RNA-dependent RNA polymerase (RdRp) associated with Hepatitis C Virus (HCV). It targets the thumb pocket 2 of the NS5B polymerase with a binding affinity (Kd) of 17 nM and effectively inhibits HCV replication, demonstrated by an EC50 value of 5.2 nM in the 1b/Con1 subgenomic replicon model. Lomibuvir primarily interferes with the elongation phase of RNA synthesis, making it a valuable tool for studying HCV replication mechanisms and developing antiviral therapies.
