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Catalog No.
Product Name
Application
Product Information
Citations
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RNA polymerase II Inhibitor
Dideoxy-amanitin is an allosteric inhibitor of RNA polymerase II, demonstrating potent selectivity with an IC50 of 74.2 nM. This compound is particularly valuable for research applications focused on transcriptional regulation and RNA synthesis inhibition. Its ability to selectively hinder RNA polymerase II makes it a crucial tool for investigating gene expression and related pathways in various biological contexts. -
RNA Polymerase Inhibitor
2'-Deoxy-2'-fluoro-l-uridine is an L-nucleoside that serves as a selective inhibitor of viral RNA polymerase. It effectively inhibits the replication of RNA viruses, making it a valuable tool for research focused on viral replication mechanisms and the development of antiviral therapies. This compound is instrumental for studies investigating RNA virus pathogenesis and potential therapeutic interventions. -
RNA Polymerase II Inhibitor
ε-Amanitin is a cyclic peptide that specifically inhibits RNA polymerase II activity by binding to the enzyme's active site. This potent inhibitor disrupts transcription elongation, making it a valuable tool for investigating gene expression mechanisms. ε-Amanitin is commonly utilized in research focused on transcription regulation, RNA processing, and studying the effects of transcriptional inhibition in various biological systems. -
DNA Polymerase Inhibitor
ddhCTP is a nucleoside analog that acts as a selective inhibitor of DNA polymerase. It effectively disrupts DNA synthesis with Ki values of 1.32 μM for DNA polymerase beta and 0.034 μM for DNA polymerase gamma. This compound is valuable for research applications involving the study of DNA replication and polymerase-specific pathways, providing insights into cellular mechanisms and potential therapeutic targets. -
EV71 3D Polymerase Inhibitor
DTriP-22 is a potent inhibitor of the enterovirus 71 (EV71) 3D polymerase, characterized by low toxicity. It demonstrates broad-spectrum antiviral activity against RNA viruses, particularly within the picornavirus family, while exhibiting no effects on DNA viruses. By targeting and inhibiting viral RNA synthesis during the early stages of replication, DTriP-22 serves as a valuable reagent in anti-enterovirus research applications. -
DNA Polymerase λ Inhibitor
Procaspase-IN-5 is a selective inhibitor of human DNA polymerase λ, with significant implications for cancer research. It exhibits a potent inhibitory effect on DNA polymerization and terminal deoxynucleotidyl transferase (TdT) activities, with IC50 values of 5.9 μM and 4.5 μM, respectively. This compound serves as a valuable tool for studying the mechanisms of DNA replication and repair in cancer cells. -
NS5B Polymerase Inhibitor
A-837093 sodium is a potent inhibitor of the hepatitis C virus (HCV) nonstructural protein 5B (NS5B) polymerase, exhibiting high selectivity and oral bioavailability. It demonstrates strong inhibitory activity against HCV genotypes 1a (IC50 = 1.25 nM) and 1b (IC50 = 0.33 nM). A-837093 sodium has shown antiviral efficacy in in vivo studies involving HCV-infected chimpanzees, making it a valuable tool for research focused on HCV infection and therapeutic development. -
RNA Polymerase Inhibitor
Adafosbuvir is a uridine-based nucleotide analog that serves as a potent RNA polymerase inhibitor targeting the NS5B protein of Hepatitis C virus (HCV). It exhibits significant antiviral activity by effectively inhibiting HCV replication. This compound is primarily utilized in research applications aimed at understanding HCV biology and developing antiviral therapies. -
Polθ Polymerase Inhibitor
Polθ-IN-9 is a selective inhibitor of Pol θ polymerase, demonstrating an IC50 value of 9.6 nM and a Kd of 47.5 nM, with no significant inhibitory effects on other human DNA polymerases such as Pol α, Pol ε, Pol γ, Pol λ, and Pol μ. This compound exhibits potent antiproliferative activity in DLD1 BRCA2 knockout cells (IC50 = 2.9 μM) and MDA-MB-436 cells (IC50 = 4.9 μM), while also increasing DNA damage and γH2AX levels. In addition, Polθ-IN-9 has shown to inhibit tumor growth in conjunction with Olaparib in the MDA-MB-436 xenograft model, making it a valuable tool for studying homologous recombination-deficient cancers, including breast cancer. -
Bacterial RNA Polymerase Inhibitor
Tirandamycin A is a potent bacterial RNA polymerase inhibitor. It exhibits significant antibacterial and antiamoebic activity, making it a valuable tool for research into bacterial inhibition mechanisms. This compound is useful for studies examining bacterial resistance and the development of new antibiotics. -
Topoisomerase II/DNA Polymerase Inhibitor
Epolactaene is a potent inhibitor of Topoisomerase II and DNA Polymerases, exhibiting IC50 values of 10 µM for Topoisomerase II, 25 µM for DNA Polymerase α, and 94 µM for DNA Polymerase β. Its ability to interfere with these key enzymes makes Epolactaene valuable for studying DNA replication and repair mechanisms. This compound is suitable for research applications involving cancer biology and the investigation of DNA-targeting therapies. -
Strand-displacement Activity Of DNA Polymerase Inhibitor
NSC666715 is a specific inhibitor of the strand-displacement activity of DNA polymerase. This compound enhances the effects of Temozolomide by inducing DNA damage, promoting cell senescence, and triggering apoptosis. NSC666715 serves as a valuable tool for research in colorectal cancer, aiding in the investigation of DNA repair mechanisms and therapeutic responses. -
DNA Polymerase-α Inhibitor
PHYLPA-8 is a selective inhibitor of DNA polymerase-α, targeting the enzyme's active site to restrict its function. This compound demonstrates unique structural features that influence its binding efficacy, allowing it to modulate DNA replication processes. PHYLPA-8 is suitable for research applications involving the study of DNA synthesis, repair mechanisms, and the evaluation of polymerase activity in various biological systems. -
DNA Polymerase Inhibitor
Lucidenic acid O acts as a potent inhibitor of DNA polymerases, targeting calf DNA polymerase-α, rat DNA polymerase-β, and HIV-1 reverse transcriptase. Its inhibitory activity is characterized by IC50 values of 42 μM, 99 μM, and 69 μM, respectively. This compound is valuable for research applications focusing on DNA replication and viral infections, offering insights into the mechanisms of polymerase inhibition. -
HCV NS5B Polymerase Inhibitor
RG7109 is a potent inhibitor of hepatitis C virus (HCV) NS5B polymerase, demonstrating EC50 values of 1.1 nM for HCV genotype 1a (H77) and 1.0 nM for genotype 1b (Con1). This compound exhibits favorable pharmacokinetic properties, making it a valuable tool for anti-HCV research. RG7109 is applicable in studies aimed at understanding HCV replication and developing antiviral strategies. -
RNA Polymerase Inhibitor
Favipiravir sodium is a potent inhibitor of viral RNA polymerase, effectively converted to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP demonstrates significant inhibition of influenza virus RNA-dependent RNA polymerase (RdRP) with an IC50 value of 341 nM. This compound is primarily utilized in research focused on antiviral mechanisms and the development of treatments against RNA virus infections. -
DNA Polymerase β Inhibitor
3′-Amino-2′,3′-dideoxy-CTP is a nucleoside triphosphate analogue that functions as a selective inhibitor of DNA polymerase β. This compound is particularly useful in studies related to DNA repair mechanisms and cellular responses to DNA damage. Its ability to inhibit polymerase activity makes it a valuable tool for researching the role of DNA polymerase β in various biological processes and cancer biology. -
RNA Polymerase Inhibitor
RNA polymerase-IN-4 is a potent inhibitor of RNA polymerase, exhibiting an EC50 of 22.81 nM. This compound demonstrates significant anti-influenza virus activity with an EC50 of 3.76 nM and displays relatively low cytotoxicity, with a CC50 of 29.91 μM. RNA polymerase-IN-4 is suitable for research applications focused on viral infections, particularly those related to influenza virus. -
RNA polymerase Inhibitor
RNA polymerase-IN-1 is a selective inhibitor of DNA-dependent RNA polymerase, which is crucial for the transcription process in cells. This compound has demonstrated effective inhibition of CYP isozymes, highlighting its potential in studying the role of RNA polymerase in transcription regulation and drug metabolism. RNA polymerase-IN-1 is valuable for research applications focused on gene expression and the modulation of metabolic pathways. -
DNA Polymerase Inhibitor
Lucidenic lactone is a terpene compound that serves as an effective inhibitor of DNA polymerase. This compound demonstrates significant inhibitory activity against calf DNA polymerase-α (IC50 = 42 μM), rat DNA polymerase-β (IC50 = 99 μM), and HIV-1 reverse transcriptase (IC50 = 69 μM). Lucidenic lactone is valuable for research in molecular biology and virology, particularly in studies investigating DNA replication and reverse transcription processes. -
DNA Polymerase α inhibitor
Aphidicolin 17-acetate is a selective inhibitor of eukaryotic DNA polymerase α. This compound significantly impairs in vivo DNA synthesis in model systems such as sea urchin embryos and HeLa cells while demonstrating no effect on RNA and protein synthesis. Its specificity for DNA polymerase α, without inhibition of polymerases β and γ, makes Aphidicolin 17-acetate a valuable tool for studying DNA replication processes and cellular responses to DNA damage. -
RNA polymerase Inhibitor
RNA polymerase-IN-2 is a potent inhibitor of DNA-dependent RNA polymerase, targeting the transcription processes in cells. This compound has been shown to effectively inhibit CYP isozymes, making it a valuable tool for studies investigating RNA synthesis and related metabolic pathways. Its applications extend to research in gene regulation and the development of potential therapeutic strategies targeting RNA polymerase activity. -
HCMV DNA Polymerase Alpha Inhibitor
Naphthol AS-BS is a selective inhibitor of human cytomegalovirus (HCMV) DNA polymerase alpha, exhibiting an IC50 of 12 μM. This compound is significant for research into viral infections, particularly in understanding the mechanisms of HCMV replication and potential therapeutic interventions. Its inhibitory properties make it a valuable tool in virology studies and drug development efforts targeting HCMV. -
HCV NS5B RNA-dependent RNA Polymerase Inhibitor
HCV-IN-50 is a potent inhibitor of HCV NS5B RNA-dependent RNA polymerase, demonstrating a selective competitive mechanism with an IC50 of 0.3 μM for the NS5B △C21 enzyme compared to the △C55 variant. This compound exhibits significant antiviral activity, effectively inhibiting the replication of Hepatitis C virus subgenomic replicons, including mutant strains. HCV-IN-50 is valuable for research applications focused on HCV replication mechanisms and antiviral drug development. -
Antibacterial Agent, RNA Polymerase Inhibitor
2,5-Di-tert-butyl-1,4-benzoquinone serves as a potent antibacterial agent and an effective RNA polymerase inhibitor. Isolated from the marine species Streptomyces sp. VITVSK1, this compound exhibits significant antibacterial activity, providing critical insights into combating emerging antibacterial resistance. Its ability to inhibit RNA polymerase further supports its value in research applications focused on microbial gene expression and antibiotic mechanisms. -
DNA Polymerases α/δ/ε Inhibitor
PMEG is an inhibitor of nuclear DNA polymerases α, δ, and ε, leading to DNA chain termination and suppression of DNA synthesis, which induces cytotoxicity in rapidly dividing cells. As an acyclic nucleotide phosphonate, PMEG is converted within cells to its active form, PMEG diphosphate. This compound demonstrates efficacy against leukemia and melanoma in rodent models and exhibits antiviral activity against various DNA viruses, including murine and human cytomegalovirus. PMEG serves as a valuable reagent for research into non-Hodgkin's lymphoma and related areas of study. -
HIV reverse transcriptase inhibitor
Tenofovir is in a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). It works by decreasing the amount of HIV in the blood. -
HCV NS5B polymerase inhibitor
PSI-6206 13CD3 is the deuterium labeled PSI-6206. PSI-6206 is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. -
eukaryotic DNA polymerase α inhibitor
Dehydroaltenusin is a small molecule selective inhibitor of eukaryotic DNA polymerase α, a type of antibiotic produced by a fungus with an IC50 value of 0.68 μM. -
RSV polymerase inhibitor
Lumicitabine (ALS-008176) is an inhibitor of the respiratory syncytial virus (RSV) polymerase. -
polymerase inhibitor
ERDRP-0519 is an orally available inhibitor of polymerase that shows efficacy against a lethal morbillivirus infection in a large animal model. -
DNA polymerase theta (Polθ) inhibitor
RP-6685 is a potent, selective, and orally active inhibitor of DNA polymerase theta (Polθ), with an IC50 of 5.8 nM as measured by the PicoGreen assay. It exhibits significant antitumor efficacy in mouse xenograft models. Additionally, RP-6685 contains an alkyne functional group, making it a useful click chemistry reagent capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing molecules, enabling its application in chemical biology and drug discovery research. -
Polθ DNA polymerase inhibitor
ART899 is a highly specific allosteric inhibitor of the DNA polymerase domain of polymerase theta (Polθ). It effectively enhances the radiosensitivity of tumor cells and demonstrates good tolerability when combined with fractionated radiation therapy. ART899 significantly reduces tumor growth compared to radiation alone, making it a promising candidate for combination cancer radiotherapy strategies. -
DNA polymerase inhibitor
Aphidicolin is a tetracyclic diterpenoid antibiotic produced by the mold Cephalosporium aphidicola, known for its potent and selective inhibition of DNA polymerase α and δ. By interfering with these polymerases, Aphidicolin blocks DNA synthesis and prevents mitotic cell division, making it a valuable tool for studying cell cycle regulation and DNA replication. In addition to its antiproliferative properties, Aphidicolin inhibits viral DNA synthesis and demonstrates antiviral activity against herpes simplex virus and orthopoxviruses. It also enhances apoptosis induced by arabinosyl nucleosides in human promyelocytic leukemia cells, suggesting potential in combination therapies for cancer and viral infections. Aphidicolin is widely used in research involving DNA replication stress, antiviral mechanisms, and cell cycle synchronization. -
Viral DNA Polymerase Inhibitor
Foscarnet sodium, a viral DNA polymerase inhibitor, effectively suppresses viral replication through the reversible inhibition of polymerase activity. This compound is primarily utilized as an antiviral agent against herpesviruses, particularly in the treatment of cytomegalovirus retinitis. Its mechanism of action makes it a valuable tool for studying viral replication and evaluating therapeutic strategies against herpesvirus infections. -
Poly(ADP-ribose) Polymerase Inhibitor
PD128763 is a selective inhibitor of poly(ADP-ribose) polymerase (PARP). This compound enhances the cytotoxic effects of Streptozotocin, making it a valuable tool for studying cellular mechanisms in leukemia. PD128763 is suitable for research applications focused on PARP-related pathways and therapeutic strategies in cancer treatment. -
HSV Polymerases Inhibitor
PNU-183792 is a potent inhibitor of herpes simplex virus (HSV) polymerases, classified as a 4-oxo-dihydroquinoline. It demonstrates broad-spectrum antiviral activity, exhibiting IC50 values of 0.69 μM for human cytomegalovirus (HCM), 0.37 μM for varicella zoster virus, and 0.58 μM for HSV polymerases. Importantly, PNU-183792 operates selectively, showing no activity against human α, γ, or δ polymerases. Additionally, it exhibits inhibitory effects on simian varicella virus (SVV), murine cytomegalovirus (MCMV), and rat cytomegalovirus (RCMV), making it a valuable tool for antiviral research. -
Ns5b Polymerase Inhibitor
Anti-infective agent 10 is an NS5B polymerase inhibitor designed for research into hepatitis C virus (HCV) infections. This compound effectively disrupts the viral replication process, making it a valuable tool for studying HCV biology and developing antiviral therapies. Its applications extend to evaluating drug resistance mechanisms and supporting drug discovery efforts in combating HCV. -
Ns5b Polymerase Inhibitor
HCV NS5B polymerase-IN-2 is an inhibitor targeting the NS5B polymerase of the hepatitis C virus (HCV). This compound demonstrates significant antiviral activity against HCV replication, making it a valuable tool for the investigation of hepatitis C viral infections and the development of therapeutic strategies. Its efficacy in inhibiting NS5B polymerase highlights its potential role in studying HCV dynamics and drug resistance. -
HCV NS5B Polymerase Inhibitor
BI 207524 is a selective non-nucleoside inhibitor of HCV NS5B polymerase, specifically targeting thumb pocket 1. This compound demonstrates antiviral activity against hepatitis C virus (HCV). BI 207524 is applicable in research focused on HCV infection and the mechanisms of antiviral response. -
HCV Polymerase Inhibitor
HCVP-IN-1 is a potent inhibitor of hepatitis C viral polymerase (HCVP). This compound effectively disrupts viral replication, making it a valuable tool for studying the dynamics of hepatitis C virus infection. HCVP-IN-1 is particularly relevant in research focused on developing antiviral therapies and understanding the mechanisms of HCV-related diseases. -
RSV Polymerase inhibitor
RSV L-protein-IN-3 is an inhibitor of respiratory syncytial virus (RSV) polymerase, displaying an IC50 value of 10.4 μM and an EC50 value of 2.1 μM against RSV. It demonstrates reduced cytotoxicity compared to the clinical agent Ribavirin, making it a suitable candidate for further research into treating RSV infections. This compound is valuable for studies focusing on antiviral mechanisms and drug development targeting RSV. -
RSV Polymerase Inhibitor
RSV L-protein-IN-4 is a noncompetitive inhibitor of the respiratory syncytial virus (RSV) polymerase, exhibiting an IC50 value of 0.88 μM. This compound demonstrates significant antiviral activity against various RSV strains, with an EC50 of 0.25 μM. RSV L-protein-IN-4 is essential for research into antiviral therapies targeting RSV infections. -
RSV Polymerase Inhibitor
RSV L-protein-IN-2 is a noncompetitive inhibitor of the Respiratory Syncytial Virus (RSV) polymerase, exhibiting an IC50 value of 4.5 μM. This compound demonstrates significant antiviral activity against long strains of RSV, with an EC50 of 1.3 μM. It is applicable in research focused on developing therapeutic strategies against RSV infections and understanding viral replication mechanisms. -
RNA-dependent RNA Polymerase Inhibitor
BPR3P0128 is a non-nucleoside inhibitor of RNA-dependent RNA polymerase (RdRp), demonstrating potent antiviral activity against various SARS-CoV-2 variants. It exhibits EC50 values of 0.62 μM for SARS-CoV-2 and 0.14 μM for HCoV-229E, effectively inhibiting virus replication within the submicromolar range. Additionally, BPR3P0128 shows synergistic effects when used in combination with Remdesivir, making it a promising candidate for further antiviral research against coronaviruses. -
HCV NS5B Polymerase Inhibitor
MB-11362 is a potent, orally active inhibitor of the hepatitis C virus (HCV) NS5B polymerase, functioning as a 4′-azidouridine triphosphate prodrug. Upon oral administration, MB-11362 is converted to its active form, 4′-azidouridine triphosphate, which effectively disrupts viral RNA synthesis. This compound is valuable for research focusing on HCV infection and understanding the mechanisms of antiviral therapies targeting RNA polymerases. -
HCV RNA Polymerase Inhibitor
BILB 1941 is a potent nonnucleoside inhibitor targeting the hepatitis C virus (HCV) RNA polymerase. It demonstrates significant antiviral activity in vitro, making it a valuable tool for research applications related to HCV replication and drug development strategies against hepatitis C. -
NS5B Polymerase Inhibitor
ABT-072 potassium trihydrate is a potent non-nucleoside inhibitor of the hepatitis C virus (HCV) NS5B polymerase. It demonstrates significant antiviral activity, exhibiting EC50 values of 1 nM against HCV genotype 1a and 0.3 nM against genotype 1b. This compound is primarily utilized in research focused on HCV replication and the development of antiviral therapies.
