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Catalog No.
Product Name
Application
Product Information
Citations
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DNA Polymerase α Inhibitor
NSC639828 is a potent inhibitor of DNA polymerase α, exhibiting an IC50 of 70 μM. This compound demonstrates significant antitumor activity, making it a valuable tool for cancer research. NSC639828 can be utilized to investigate the role of DNA polymerase α in tumorigenesis and to explore potential therapeutic strategies in cancer treatment. -
DNA Polymerase Inhibitor
Acyclovir triphosphate sodium is a potent inhibitor of viral DNA polymerase, functioning as a competitive analogue of deoxyguanosine triphosphate (dGTP). This compound also exhibits inhibitory activity against HIV-1 reverse transcriptase, leading to the termination of viral DNA synthesis. Acyclovir triphosphate sodium is valuable for research applications in virology and the study of antiviral mechanisms. -
RNA Polymerase I Transcription Inhibitor
BMH-22 is a selective inhibitor of RNA polymerase I transcription, functioning independently of p53 pathways. This benzonaphthyridin compound induces reorganization of nucleolar marker proteins, indicative of nucleolar segregation, and destabilizes RPA194 through a proteasome-dependent mechanism. Additionally, BMH-22 effectively inhibits the synthesis of nascent rRNA and the expression of the 45S rRNA precursor. Its potent anticancer properties make it a valuable tool for studying cancer biology and RNA transcription regulation in various tumor models. -
RNA Polymerase Inhibitor
MMV688845 is an RNA polymerase inhibitor targeting nontuberculous mycobacteria (NTM) with demonstrated bactericidal activity against Mycobacterium abscessus. This compound exhibits potential anti-tuberculosis efficacy, making it a valuable tool for research in tackling mycobacterial infections. Its selective mechanism positions MMV688845 as a promising candidate for further exploration in antimicrobial studies and drug development. -
NS5B Polymerase/RdRp Inhibitor
Lomibuvir is a selective non-nucleoside inhibitor of the NS5B RNA-dependent RNA polymerase (RdRp) associated with Hepatitis C Virus (HCV). It targets the thumb pocket 2 of the NS5B polymerase with a binding affinity (Kd) of 17 nM and effectively inhibits HCV replication, demonstrated by an EC50 value of 5.2 nM in the 1b/Con1 subgenomic replicon model. Lomibuvir primarily interferes with the elongation phase of RNA synthesis, making it a valuable tool for studying HCV replication mechanisms and developing antiviral therapies. -
RNA Polymerases Inhibitor
3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that serves as an inhibitor of DNA-dependent RNA polymerases I and II. It competitively inhibits the incorporation of UTP into RNA, demonstrating potent biological activity with a Ki value of 2.0 μM. This compound is valuable for research applications involving transcription regulation and the study of RNA synthesis mechanisms. -
RNA Polymerase Inhibitor
MRL-436 is an RNA polymerase inhibitor that exhibits significant antibacterial activity against Rifampicin-resistant strains. Its mechanism of action involves targeting residue 622 of the RNA polymerase β' subunit and the RNAP ω subunit. This compound is particularly valuable for research involving antibiotic resistance and the study of bacterial transcription mechanisms. -
Poly (ADP-ribose) Polymerase Inhibitor
8-NH2-ATP is an inhibitor of poly (ADP-ribose) polymerase (PARP), acting as a critical tool in research on cell apoptosis. This compound is derived from 8-NH2-Ado and exhibits potent effects by inducing apoptotic cleavage of PARP, making it useful for studying mechanisms of cell death, DNA repair, and cancer therapeutics. Its applications extend to exploring PARP's role in various biological pathways and assessing the therapeutic potential of PARP inhibition in disease models. -
T4 DNA Polymerase Inhibitor
3'-Fluorothymidine-5'-triphosphate tetrasodium is a competitive inhibitor of T4 DNA polymerase, functioning as an analog of dTTP. By inhibiting T4 DNA polymerases, including wild-type, L98, and CB121 variants, it effectively disrupts DNA synthesis processes. This compound is valuable for research applications involving DNA replication studies and exploration of polymerase inhibition mechanisms. -
DNA polymerase θ Inhibitor
RTx-303 is a selective inhibitor of DNA polymerase θ (Polθ), with an IC50 value of 5.1 nM. This compound demonstrates potent cellular activity and enhances the efficacy of PARP inhibitors in BRCA1/2 mutant cells and patient-derived xenograft models. RTx-303 is utilized in research focused on BRCA2-mutated breast cancer, providing valuable insights into therapeutic strategies targeting DNA repair mechanisms. -
HCV Polymerase Inhibitor
Dasabuvir sodium is a non-nucleoside inhibitor of hepatitis C virus (HCV) polymerase, specifically targeting the RNA-dependent RNA polymerase encoded by the HCV NS5B gene. It demonstrates potent antiviral activity against HCV genotype 1a (strain H77) and 1b (strain Con1) replicons, with EC50 values of 7.7 nM and 1.8 nM, respectively. Dasabuvir sodium is primarily utilized in research focused on HCV replication and the development of antiviral therapies. -
RNA Polymerase Activities Inhibitor
Thio-ITP (6-Thioinosine 5'-triphosphate) is a competitive inhibitor of RNA polymerase activities. It exhibits a high apparent affinity for RNA polymerases, with inhibition constants of 40.9 μM for RNA polymerase I and 38.0 μM for RNA polymerase II. Thio-ITP is useful in research applications aimed at understanding transcriptional regulation and dissection of RNA polymerase mechanisms. -
RNA polymerase II Inhibitor
Dideoxy-amanitin is an allosteric inhibitor of RNA polymerase II, demonstrating potent selectivity with an IC50 of 74.2 nM. This compound is particularly valuable for research applications focused on transcriptional regulation and RNA synthesis inhibition. Its ability to selectively hinder RNA polymerase II makes it a crucial tool for investigating gene expression and related pathways in various biological contexts. -
RNA Polymerase Inhibitor
2'-Deoxy-2'-fluoro-l-uridine is an L-nucleoside that serves as a selective inhibitor of viral RNA polymerase. It effectively inhibits the replication of RNA viruses, making it a valuable tool for research focused on viral replication mechanisms and the development of antiviral therapies. This compound is instrumental for studies investigating RNA virus pathogenesis and potential therapeutic interventions. -
RNA Polymerase II Inhibitor
ε-Amanitin is a cyclic peptide that specifically inhibits RNA polymerase II activity by binding to the enzyme's active site. This potent inhibitor disrupts transcription elongation, making it a valuable tool for investigating gene expression mechanisms. ε-Amanitin is commonly utilized in research focused on transcription regulation, RNA processing, and studying the effects of transcriptional inhibition in various biological systems. -
DNA Polymerase Inhibitor
ddhCTP is a nucleoside analog that acts as a selective inhibitor of DNA polymerase. It effectively disrupts DNA synthesis with Ki values of 1.32 μM for DNA polymerase beta and 0.034 μM for DNA polymerase gamma. This compound is valuable for research applications involving the study of DNA replication and polymerase-specific pathways, providing insights into cellular mechanisms and potential therapeutic targets. -
EV71 3D Polymerase Inhibitor
DTriP-22 is a potent inhibitor of the enterovirus 71 (EV71) 3D polymerase, characterized by low toxicity. It demonstrates broad-spectrum antiviral activity against RNA viruses, particularly within the picornavirus family, while exhibiting no effects on DNA viruses. By targeting and inhibiting viral RNA synthesis during the early stages of replication, DTriP-22 serves as a valuable reagent in anti-enterovirus research applications. -
DNA Polymerase λ Inhibitor
Procaspase-IN-5 is a selective inhibitor of human DNA polymerase λ, with significant implications for cancer research. It exhibits a potent inhibitory effect on DNA polymerization and terminal deoxynucleotidyl transferase (TdT) activities, with IC50 values of 5.9 μM and 4.5 μM, respectively. This compound serves as a valuable tool for studying the mechanisms of DNA replication and repair in cancer cells. -
NS5B Polymerase Inhibitor
A-837093 sodium is a potent inhibitor of the hepatitis C virus (HCV) nonstructural protein 5B (NS5B) polymerase, exhibiting high selectivity and oral bioavailability. It demonstrates strong inhibitory activity against HCV genotypes 1a (IC50 = 1.25 nM) and 1b (IC50 = 0.33 nM). A-837093 sodium has shown antiviral efficacy in in vivo studies involving HCV-infected chimpanzees, making it a valuable tool for research focused on HCV infection and therapeutic development. -
RNA Polymerase Inhibitor
Adafosbuvir is a uridine-based nucleotide analog that serves as a potent RNA polymerase inhibitor targeting the NS5B protein of Hepatitis C virus (HCV). It exhibits significant antiviral activity by effectively inhibiting HCV replication. This compound is primarily utilized in research applications aimed at understanding HCV biology and developing antiviral therapies. -
Polθ Polymerase Inhibitor
Polθ-IN-9 is a selective inhibitor of Pol θ polymerase, demonstrating an IC50 value of 9.6 nM and a Kd of 47.5 nM, with no significant inhibitory effects on other human DNA polymerases such as Pol α, Pol ε, Pol γ, Pol λ, and Pol μ. This compound exhibits potent antiproliferative activity in DLD1 BRCA2 knockout cells (IC50 = 2.9 μM) and MDA-MB-436 cells (IC50 = 4.9 μM), while also increasing DNA damage and γH2AX levels. In addition, Polθ-IN-9 has shown to inhibit tumor growth in conjunction with Olaparib in the MDA-MB-436 xenograft model, making it a valuable tool for studying homologous recombination-deficient cancers, including breast cancer. -
Bacterial RNA Polymerase Inhibitor
Tirandamycin A is a potent bacterial RNA polymerase inhibitor. It exhibits significant antibacterial and antiamoebic activity, making it a valuable tool for research into bacterial inhibition mechanisms. This compound is useful for studies examining bacterial resistance and the development of new antibiotics. -
Topoisomerase II/DNA Polymerase Inhibitor
Epolactaene is a potent inhibitor of Topoisomerase II and DNA Polymerases, exhibiting IC50 values of 10 µM for Topoisomerase II, 25 µM for DNA Polymerase α, and 94 µM for DNA Polymerase β. Its ability to interfere with these key enzymes makes Epolactaene valuable for studying DNA replication and repair mechanisms. This compound is suitable for research applications involving cancer biology and the investigation of DNA-targeting therapies. -
Strand-displacement Activity Of DNA Polymerase Inhibitor
NSC666715 is a specific inhibitor of the strand-displacement activity of DNA polymerase. This compound enhances the effects of Temozolomide by inducing DNA damage, promoting cell senescence, and triggering apoptosis. NSC666715 serves as a valuable tool for research in colorectal cancer, aiding in the investigation of DNA repair mechanisms and therapeutic responses. -
DNA Polymerase-α Inhibitor
PHYLPA-8 is a selective inhibitor of DNA polymerase-α, targeting the enzyme's active site to restrict its function. This compound demonstrates unique structural features that influence its binding efficacy, allowing it to modulate DNA replication processes. PHYLPA-8 is suitable for research applications involving the study of DNA synthesis, repair mechanisms, and the evaluation of polymerase activity in various biological systems. -
DNA Polymerase Inhibitor
Lucidenic acid O acts as a potent inhibitor of DNA polymerases, targeting calf DNA polymerase-α, rat DNA polymerase-β, and HIV-1 reverse transcriptase. Its inhibitory activity is characterized by IC50 values of 42 μM, 99 μM, and 69 μM, respectively. This compound is valuable for research applications focusing on DNA replication and viral infections, offering insights into the mechanisms of polymerase inhibition. -
HCV NS5B Polymerase Inhibitor
RG7109 is a potent inhibitor of hepatitis C virus (HCV) NS5B polymerase, demonstrating EC50 values of 1.1 nM for HCV genotype 1a (H77) and 1.0 nM for genotype 1b (Con1). This compound exhibits favorable pharmacokinetic properties, making it a valuable tool for anti-HCV research. RG7109 is applicable in studies aimed at understanding HCV replication and developing antiviral strategies. -
RNA Polymerase Inhibitor
Favipiravir sodium is a potent inhibitor of viral RNA polymerase, effectively converted to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP demonstrates significant inhibition of influenza virus RNA-dependent RNA polymerase (RdRP) with an IC50 value of 341 nM. This compound is primarily utilized in research focused on antiviral mechanisms and the development of treatments against RNA virus infections. -
DNA Polymerase β Inhibitor
3′-Amino-2′,3′-dideoxy-CTP is a nucleoside triphosphate analogue that functions as a selective inhibitor of DNA polymerase β. This compound is particularly useful in studies related to DNA repair mechanisms and cellular responses to DNA damage. Its ability to inhibit polymerase activity makes it a valuable tool for researching the role of DNA polymerase β in various biological processes and cancer biology. -
RNA Polymerase Inhibitor
RNA polymerase-IN-4 is a potent inhibitor of RNA polymerase, exhibiting an EC50 of 22.81 nM. This compound demonstrates significant anti-influenza virus activity with an EC50 of 3.76 nM and displays relatively low cytotoxicity, with a CC50 of 29.91 μM. RNA polymerase-IN-4 is suitable for research applications focused on viral infections, particularly those related to influenza virus. -
RNA polymerase Inhibitor
RNA polymerase-IN-1 is a selective inhibitor of DNA-dependent RNA polymerase, which is crucial for the transcription process in cells. This compound has demonstrated effective inhibition of CYP isozymes, highlighting its potential in studying the role of RNA polymerase in transcription regulation and drug metabolism. RNA polymerase-IN-1 is valuable for research applications focused on gene expression and the modulation of metabolic pathways. -
DNA Polymerase Inhibitor
Lucidenic lactone is a terpene compound that serves as an effective inhibitor of DNA polymerase. This compound demonstrates significant inhibitory activity against calf DNA polymerase-α (IC50 = 42 μM), rat DNA polymerase-β (IC50 = 99 μM), and HIV-1 reverse transcriptase (IC50 = 69 μM). Lucidenic lactone is valuable for research in molecular biology and virology, particularly in studies investigating DNA replication and reverse transcription processes. -
DNA Polymerase α inhibitor
Aphidicolin 17-acetate is a selective inhibitor of eukaryotic DNA polymerase α. This compound significantly impairs in vivo DNA synthesis in model systems such as sea urchin embryos and HeLa cells while demonstrating no effect on RNA and protein synthesis. Its specificity for DNA polymerase α, without inhibition of polymerases β and γ, makes Aphidicolin 17-acetate a valuable tool for studying DNA replication processes and cellular responses to DNA damage. -
RNA polymerase Inhibitor
RNA polymerase-IN-2 is a potent inhibitor of DNA-dependent RNA polymerase, targeting the transcription processes in cells. This compound has been shown to effectively inhibit CYP isozymes, making it a valuable tool for studies investigating RNA synthesis and related metabolic pathways. Its applications extend to research in gene regulation and the development of potential therapeutic strategies targeting RNA polymerase activity. -
HCMV DNA Polymerase Alpha Inhibitor
Naphthol AS-BS is a selective inhibitor of human cytomegalovirus (HCMV) DNA polymerase alpha, exhibiting an IC50 of 12 μM. This compound is significant for research into viral infections, particularly in understanding the mechanisms of HCMV replication and potential therapeutic interventions. Its inhibitory properties make it a valuable tool in virology studies and drug development efforts targeting HCMV. -
HCV NS5B RNA-dependent RNA Polymerase Inhibitor
HCV-IN-50 is a potent inhibitor of HCV NS5B RNA-dependent RNA polymerase, demonstrating a selective competitive mechanism with an IC50 of 0.3 μM for the NS5B △C21 enzyme compared to the △C55 variant. This compound exhibits significant antiviral activity, effectively inhibiting the replication of Hepatitis C virus subgenomic replicons, including mutant strains. HCV-IN-50 is valuable for research applications focused on HCV replication mechanisms and antiviral drug development. -
Antibacterial Agent, RNA Polymerase Inhibitor
2,5-Di-tert-butyl-1,4-benzoquinone serves as a potent antibacterial agent and an effective RNA polymerase inhibitor. Isolated from the marine species Streptomyces sp. VITVSK1, this compound exhibits significant antibacterial activity, providing critical insights into combating emerging antibacterial resistance. Its ability to inhibit RNA polymerase further supports its value in research applications focused on microbial gene expression and antibiotic mechanisms. -
DNA Polymerases α/δ/ε Inhibitor
PMEG is an inhibitor of nuclear DNA polymerases α, δ, and ε, leading to DNA chain termination and suppression of DNA synthesis, which induces cytotoxicity in rapidly dividing cells. As an acyclic nucleotide phosphonate, PMEG is converted within cells to its active form, PMEG diphosphate. This compound demonstrates efficacy against leukemia and melanoma in rodent models and exhibits antiviral activity against various DNA viruses, including murine and human cytomegalovirus. PMEG serves as a valuable reagent for research into non-Hodgkin's lymphoma and related areas of study. -
RSV Polymerase inhibitor
RSV L-protein-IN-3 is an inhibitor of respiratory syncytial virus (RSV) polymerase, displaying an IC50 value of 10.4 μM and an EC50 value of 2.1 μM against RSV. It demonstrates reduced cytotoxicity compared to the clinical agent Ribavirin, making it a suitable candidate for further research into treating RSV infections. This compound is valuable for studies focusing on antiviral mechanisms and drug development targeting RSV. -
RSV Polymerase Inhibitor
RSV L-protein-IN-4 is a noncompetitive inhibitor of the respiratory syncytial virus (RSV) polymerase, exhibiting an IC50 value of 0.88 μM. This compound demonstrates significant antiviral activity against various RSV strains, with an EC50 of 0.25 μM. RSV L-protein-IN-4 is essential for research into antiviral therapies targeting RSV infections. -
RSV Polymerase Inhibitor
RSV L-protein-IN-2 is a noncompetitive inhibitor of the Respiratory Syncytial Virus (RSV) polymerase, exhibiting an IC50 value of 4.5 μM. This compound demonstrates significant antiviral activity against long strains of RSV, with an EC50 of 1.3 μM. It is applicable in research focused on developing therapeutic strategies against RSV infections and understanding viral replication mechanisms. -
RNA-dependent RNA Polymerase Inhibitor
BPR3P0128 is a non-nucleoside inhibitor of RNA-dependent RNA polymerase (RdRp), demonstrating potent antiviral activity against various SARS-CoV-2 variants. It exhibits EC50 values of 0.62 μM for SARS-CoV-2 and 0.14 μM for HCoV-229E, effectively inhibiting virus replication within the submicromolar range. Additionally, BPR3P0128 shows synergistic effects when used in combination with Remdesivir, making it a promising candidate for further antiviral research against coronaviruses. -
HSV Polymerases Inhibitor
PNU-183792 is a potent inhibitor of herpes simplex virus (HSV) polymerases, classified as a 4-oxo-dihydroquinoline. It demonstrates broad-spectrum antiviral activity, exhibiting IC50 values of 0.69 μM for human cytomegalovirus (HCM), 0.37 μM for varicella zoster virus, and 0.58 μM for HSV polymerases. Importantly, PNU-183792 operates selectively, showing no activity against human α, γ, or δ polymerases. Additionally, it exhibits inhibitory effects on simian varicella virus (SVV), murine cytomegalovirus (MCMV), and rat cytomegalovirus (RCMV), making it a valuable tool for antiviral research. -
Ns5b Polymerase Inhibitor
Anti-infective agent 10 is an NS5B polymerase inhibitor designed for research into hepatitis C virus (HCV) infections. This compound effectively disrupts the viral replication process, making it a valuable tool for studying HCV biology and developing antiviral therapies. Its applications extend to evaluating drug resistance mechanisms and supporting drug discovery efforts in combating HCV. -
Ns5b Polymerase Inhibitor
HCV NS5B polymerase-IN-2 is an inhibitor targeting the NS5B polymerase of the hepatitis C virus (HCV). This compound demonstrates significant antiviral activity against HCV replication, making it a valuable tool for the investigation of hepatitis C viral infections and the development of therapeutic strategies. Its efficacy in inhibiting NS5B polymerase highlights its potential role in studying HCV dynamics and drug resistance. -
HCV NS5B Polymerase Inhibitor
BI 207524 is a selective non-nucleoside inhibitor of HCV NS5B polymerase, specifically targeting thumb pocket 1. This compound demonstrates antiviral activity against hepatitis C virus (HCV). BI 207524 is applicable in research focused on HCV infection and the mechanisms of antiviral response. -
HCV Polymerase Inhibitor
HCVP-IN-1 is a potent inhibitor of hepatitis C viral polymerase (HCVP). This compound effectively disrupts viral replication, making it a valuable tool for studying the dynamics of hepatitis C virus infection. HCVP-IN-1 is particularly relevant in research focused on developing antiviral therapies and understanding the mechanisms of HCV-related diseases. -
Chikungunya Virus Polymerase Inhibitor
GAP-1173149 is a selective inhibitor of the Chikungunya virus (CHIKV) polymerase, specifically targeting the nsP4 RNA-dependent RNA polymerase. This compound demonstrates potent antiviral activity by hindering viral RNA replication, making it a valuable tool for studying CHIKV biology and developing antiviral strategies. Its application is particularly relevant in research focused on emerging viral threats and potential therapeutic interventions for Chikungunya virus infections. -
Viral DNA Polymerases Inhibitor
Cidofovir diphosphate is a potent inhibitor of viral DNA polymerases, primarily targeting human cytomegalovirus (HCMV), herpes simplex virus type 1 (HSV-1), and herpes simplex virus type 2 (HSV-2). With Ki values of 6.6 μM, 0.86 μM, and 1.4 μM for these polymers, respectively, it demonstrates selective antiviral activity. This compound is instrumental in research focusing on antiviral drug development and elucidating the mechanisms underlying viral DNA replication. -
Polymerase Inhibitor
T-1105 is a novel broad-spectrum viral polymerase inhibitor that acts by being converted into a ribonucleoside triphosphate (RTP) metabolite. This compound demonstrates antiviral activity against multiple RNA viruses by inhibiting their polymerases. T-1105 is particularly significant in studies aimed at understanding viral replication and developing antiviral strategies. Its mechanism of action highlights its potential applications in viral pathogenesis research and therapeutic interventions.
