Catalog No.
Product Name
Application
Product Information
Citations
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Fluorescent Lipophilic Tracer
4-Di-10-ASP is a fluorescent lipophilic tracer that primarily targets phospholipid membranes with its excitation wavelength at 485 nm and emission at 620 nm. This compound is utilized for specific staining of cellular membranes, aiding in studies of membrane dynamics and organization. Its application is particularly valuable in cellular biology and neuroscience research, where visualization of lipid membrane structures is essential. -
Fluorescent Dye
Rhodamine 6G hydrazide is a fluorescent dye known for its strong absorbance and emission characteristics. It exhibits robust colorimetric and fluorescent properties, making it suitable for a variety of sensing applications. This reagent is commonly utilized in biochemical assays and imaging studies, facilitating the detection of specific biomolecules. -
H2S Fluorescent Probe
CAY10731 is a highly selective fluorescent probe designed for the detection of hydrogen sulfide (H2S). This compound enables precise monitoring of both exogenous and endogenous H2S levels in various cell types, including cancerous and normal cells. CAY10731 is also effective for imaging H2S in living tissues at different depths and is applicable in studies involving nematodes, advancing research in cellular signaling and physiology. -
Azo Dye
Methyl Orange is an azo dye primarily utilized as an acid-base indicator. It exhibits a color change from red at pH 3.1 to bright yellow at pH 4.4, facilitating its application in various pH-related experiments. In addition to its use in acid-base titrations, Methyl Orange is employed for cellular staining and dyeing textiles. Notably, at concentrations of 500 mg/L, it has been shown to exhibit cytotoxic effects and can induce DNA damage, making it relevant for studies in cytotoxicity and genotoxicity. -
NO Fluorescent Probe
RB-OPD is a nitric oxide (NO) fluorescent probe that utilizes an o-phenylenediamine (OPD) lock mechanism to enhance sensitivity and selectivity. With excitation and emission wavelengths of 550 nm and 590 nm, respectively, this probe is designed for reliable detection of NO in various biological systems. It is ideal for applications in cellular imaging and research on NO signaling pathways, providing valuable insights into nitric oxide's role in physiological and pathological processes. -
Fluorescent Dye
SPQ (Sodium Coumarin-3-Carboxylic Acid) is a fluorescent dye primarily utilized for measuring chloride ion concentrations and transport dynamics. This compound exhibits high sensitivity and specificity, making it suitable for studying chloride ion transients in vesicles, cells, and intact epithelial tissues. SPQ is an essential tool for researchers investigating chloride ion signaling and transport mechanisms in various biological systems. -
Dye
Eosin B (Acid Red 91) is a multifunctional dye that primarily serves as a vital tool in biological research. Its primary mechanism involves staining biological samples, enabling the visualization and analysis of cell structures, tracking of biomolecules, and evaluation of cell functions. Eosin B is instrumental in distinguishing cell types, detecting biomolecules, studying tissue pathology, and monitoring microorganisms, making it suitable for diverse applications in both fundamental scientific research and clinical diagnostics. Additionally, it finds utility in traditional textile dyeing and emerging areas such as food pigments and dye-sensitized solar cells. -
DNA Fluorescent Label
JOE is a fluorescent dye designed for use as a fluorescent label in various nucleic acid amplification techniques, including DNA sequencing, polymerase chain reaction (PCR), and ligase chain reaction (LCR). With an absorbance maximum at 525 nm and an emission maximum at 550 nm, JOE provides enhanced sensitivity and specificity for detecting DNA. This compound is essential for applications requiring precise monitoring of nucleic acid interactions and concentrations. -
Sphingomyelin Fluorescent Analogue
C6 NBD Sphingomyelin is a fluorescent analogue of sphingomyelin, designed to study lipid dynamics within cellular membranes. This compound serves as a valuable tool for investigating the incorporation of sphingomyelin into the plasma membrane and its behavior under various biological conditions. C6 NBD Sphingomyelin is particularly useful in research involving Chlamydia trachomatis, as it can be synthesized from C6-NBD-ceramide and localized within the chlamydial inclusion. Its fluorescent properties enable visualization and analysis of sphingomyelin metabolism and distribution in cellular processes. -
Metallochromic dye
Arsenazo III is a metallochromic dye that functions as a chelating agent and cation complexing agent. This compound forms stable 1:1 complexes with various cations, including Ca2+, Mg2+, Sr2+, Ba2+, K+, and Na+, with binding affinity influenced by pH and alkali metal cation concentration. Arsenazo III is widely utilized as a colorimetric indicator for the detection of micromolar levels of ionized calcium in cellular studies, making it a valuable tool in biochemical and physiological research. -
Fluorescent Probe
HKPerox-1 is a highly sensitive green fluorescent probe designed for the specific detection of hydrogen peroxide (H2O2) in living cells. It exhibits a maximum excitation wavelength of 520 nm and an emission wavelength of 543 nm, enabling effective visualization of oxidative stress and reactive oxygen species. This probe is ideal for research applications involving cellular metabolism, oxidative stress studies, and the assessment of redox biology in various experimental contexts. -
Selenol Fluorescent Probe
Sel-green is a selective selenol fluorescent probe designed to quantify selenium (Sec) content in selenoenzymes such as thioredoxin reductase. This reagent enables the imaging of endogenous Sec in live HepG2 cells, making it invaluable for studies focusing on selenium metabolism and its implications in cellular physiology. Researchers can utilize Sel-green to gain insights into the role of selenoenzymes in various biological processes and disease states. -
Fluorescent Mg2+ Probe
KMG-104 is a cell-impermeant fluorescent probe specifically designed for the selective detection of Mg2+ ions. This reagent enables real-time imaging of Mg2+ mobilization in the cytoplasm across various cell types, making it a valuable tool for studies involving cellular signaling and ion homeostasis. Its high specificity and sensitivity facilitate the exploration of magnesium's role in physiological and pathological processes. -
Fatty Acid Fluorescent Marker
C6-NBD Sphinganine is a fluorescent analog of sphinganine that serves as a potent fatty acid fluorescent marker. This compound enables the visualization and tracking of fatty acids in cellular and tissue studies, facilitating research in lipid metabolism and cellular signaling pathways. Its applications extend to studying lipid-related diseases and understanding the dynamics of sphingolipid metabolism. -
Cu2+ Fluorescent Dye
10-(4-(Bis(2-acetoxyethyl)amino)phenyl)-BODIPY 505/515 is a highly sensitive fluorescent dye specifically designed for the detection of Cu2+ ions. This compound exhibits enhanced fluorescence properties upon binding to copper ions, making it a valuable tool for studying metal ion distribution and dynamics in biological systems. Its application extends to fluorescence imaging and sensing in various research contexts, including environmental monitoring and biological assays. -
Fluorescent Dye
Alexa Fluor 647 maleimide is a far-red-emitting fluorescent dye designed for the selective labeling of protein thiol groups, particularly cysteine residues (Ex/Em = 656/670 nm). This reagent facilitates the attachment of the AF 647 fluorophore to various biomolecules, including proteins, peptides, and thiol-containing oligonucleotides. Its exceptional brightness makes it valuable for applications in cell biology, neuroscience, and disease diagnostics, enabling advanced fluorescence imaging and analysis. -
Mg2+ Fluorescent Probe
KMG-301AM TFA is an acetoxymethyl ester derivative of KMG-301, designed as a fluorescent probe targeting Mg2+ within mitochondria. Once inside the mitochondria, it is hydrolyzed to KMG-301, which selectively measures Mg2+ concentrations in live cells, as it remains confined within the mitochondria due to the impermeability of the mitochondrial membrane. This probe is suitable for assessing Mg2+ transport and monitoring changes in mitochondrial Mg2+ levels, providing valuable insights in cellular models of mitochondrial function and dysfunction. -
Fluorescent Dye
BHQ-1 NHS is a fluorescent dye designed for efficient labeling of nucleotide sequences. This compound serves as a quencher, offering enhanced fluorescence signaling for applications in nucleic acid research and diagnostics. BHQ-1 NHS is particularly valuable in the development of real-time PCR assays and other molecular biology techniques requiring precise fluorescence modulation. -
Fluorescent Dye
H-FluNox is a selective fluorescent probe designed to detect labile heme through biomimetic N-oxide deoxygenation, which activates its fluorescence. This compound demonstrates over 100-fold selectivity for labile heme compared to Fe(II), facilitating the differentiation of labile heme from intracellular Fe(II) pools. H-FluNox's high sensitivity enables the detection of labile heme at the subcellular level, making it an invaluable tool for studies of heme dynamics and related biological processes. -
Fluorescent Dye
MitoMark Red I is a fluorescent dye specifically designed to target mitochondria in viable cells. This red fluorescent marker exhibits a peak excitation wavelength of 578 nm and an emission at 599 nm, enabling precise visualization of mitochondrial activity and dynamics. It is widely utilized in cellular and molecular biology research to study mitochondrial function, cell viability, and related physiological processes. -
HOCl Fluorescent Probe
EtS-DMAB is a fluorescent probe designed for the selective detection of hypochlorous acid (HOCl). Exhibiting fluorescence with excitation at 440 nm and emission at 610 nm, it is used to visualize both exogenous and endogenous levels of HOCl in live cells. This compound is valuable for studies involving oxidative stress and inflammation, providing insights into cellular responses under specific pathological conditions. -
Fluorescent Dye
DHPDS disodium salt is a pH-sensitive fluorescent dye that enables the measurement of intracellular pH (pHi). This compound is particularly useful in experimental setups involving isolated perfused rat liver, where it facilitates the assessment of pH variations through surface fluorescence. Its application extends to various biological studies requiring precise pH measurements in living cells. -
Fluorescent Substrate
Z-VEID-AFC is a fluorescent substrate specifically designed for the detection of caspase-6 activity. Upon cleavage by active caspase-6, it releases a fluorescent signal, making it useful for monitoring apoptotic processes in various biological systems. This reagent serves as a valuable tool in studies related to cell death, neurodegeneration, and tumor biology, facilitating the investigation of caspase-related pathways in research applications. -
Fluorescent Probe
Coumarin-SAHA is a fluorescent probe designed to investigate the binding affinities (kd) and dissociation off-rates (koff) of histone deacetylase 8 (HDAC8) inhibitor complexes. This compound is particularly valuable in research applications focused on epigenetic regulation and cancer biology. The fluorescent properties of Coumarin-SAHA enable real-time monitoring of molecular interactions, enhancing the understanding of HDAC functions and their role in disease mechanisms. -
Cationic Dye
Brilliant green is a cationic dye primarily utilized in the coloring of silk and wool. It exhibits antimicrobial activity by inhibiting the growth of Gram-positive bacteria, fungi, and certain intestinal parasites. This compound is also used in various biological research applications to study microbial resistance and the effects of dyes on cellular processes. -
Cetuximab-IRdye700DX Conjugate
Cetuximab sarotalocan is a conjugate of the anti-EGFR monoclonal antibody Cetuximab with the near-infrared photosensitizing dye IRdye700DX. This reagent is designed for applications in the research of head and neck cancers, specifically targeting epidermal growth factor receptors to facilitate imaging and therapeutic interventions. Its unique properties enable enhanced visualization in oncological studies, aiding in the exploration of tumor biology and treatment efficacy. -
Fluorescent Probe
ARHB is a selective and sensitive fluorescent probe targeting N-acetyltransferase 2 (NAT2), enabling real-time detection of NAT2 activity in various bacterial species. This probe effectively penetrates bacterial cells, with fluorescence intensity correlating positively with NAT2 expression levels. ARHB is particularly valuable for high-throughput screening of natural inhibitors aimed at combatting tuberculosis. -
Fluorescent Dye
WST-3 is a water-soluble tetrazolium dye that serves as a fluorescent probe for cellular activity. Upon reduction by NADH in the presence of an electron mediator, WST-3 is converted to WST-3 formazan, which exhibits a maximum absorption at 433 nm. This dye is widely utilized in cell viability assays and metabolic activity studies, making it a valuable tool for various biological and pharmaceutical research applications. -
Fluorescent Substrate APP+
IDT307 is a fluorescent substrate targeting the dopamine transporter (DAT). As an analog of the organic cation MPP+, it exhibits specific fluorescent properties that enable the visualization of DAT activity in various biological contexts. This compound is valuable for research applications focusing on dopamine signaling, drug interactions, and neurodegenerative disease models. -
Fluorescent Dye
R-Phycoerythrin (R-PE) is an orange-red fluorescent dye derived from the red algae Heterosiphonia japonica. This fluorescent probe consists of α, β, and γ subunits and is widely utilized in fluorescence microscopy, flow cytometry, and immunofluorescence analysis, with an excitation wavelength of 495 nm. Additionally, R-PE is employed in photodynamic therapy (PDT) for inducing apoptosis in tumor cells, making it a valuable tool in cancer research and diagnostics. -
Fluorescent Dye
Complex 3 is a fluorescent dithiocarbazate-copper complex targeting mitochondrial function, demonstrating significant anticancer properties. It exhibits excitation and emission maxima of 455-495 nm and 535 nm, respectively. Complex 3 effectively inhibits the proliferation of several pancreatic cancer cell lines, including BxPC-3, AsPC-1, PANC-1, and WI38, with IC50 values of 0.74, 0.41, 0.62, and 2.06 µM, respectively. Additionally, it induces lipid peroxidation, mitochondrial rupture, and apoptosis, while also disrupting cytokine-cytokine receptor interactions in AsPC-1 cells. In vivo, Complex 3 has demonstrated efficacy by reducing tumor volume in an AsPC-1 mouse xenograft model, making it a valuable tool for cancer research. -
Magenta Dye
Fuchsine base monohydrochloride is a triaminotriphenylmethane dye known for its application as a magenta dye. It exhibits notable bactericidal, fungicidal, and anesthetic properties, making it valuable in various biological studies. This reagent can effectively stain collagen, muscle tissue, mitochondria, and is particularly useful in highlighting tuberculosis during microscopy. Additionally, Fuchsine base monohydrochloride serves as a reliable counterstain in Gram staining procedures, enhancing the differentiation of microbial cell walls. -
Photosensitive Dye
Rose Bengal is a water-soluble photosensitive dye exhibiting significant antibacterial activity through both dark-state and light-activated mechanisms. It demonstrates lethal photodynamic effects against S. carlsbergensis under aerobic light conditions while also inhibiting the growth of S. aureus in the dark. Furthermore, Rose Bengal restricts colony size in filamentous fungi and suppresses the growth of diffusive fungi. This compound is valuable for research related to infections and photodynamic therapy applications. -
Geldanamycin Fluorescent Probe
Geldanamycin-FITC is a fluorescent probe that specifically targets HSP90. This compound enables the evaluation of HSP90 inhibitors through fluorescence polarization assays and can effectively detect cell surface HSP90 with an excitation/emission wavelength of 488/515 nm. It serves as a valuable tool in understanding HSP90-related biological processes and evaluating therapeutic interventions in diseases associated with this chaperone protein. -
Fluorescently-tethered Hsp90 Inhibitor
HS-27 is a fluorescently-tethered inhibitor targeting Heat Shock Protein 90 (Hsp90), facilitating the assessment of surface Hsp90 expression on intact tissue specimens. Comprising core elements of SNX-5422 linked through a PEG spacer to a fluorescein derivative, HS-27 selectively binds to ectopically expressed Hsp90. This reagent is particularly valuable in breast cancer research, providing a tool for applications involving visualization and treatment strategies. -
Dye Tethered Hsp90 Inhibitor
HS-131 is a dye-tethered inhibitor that targets heat shock protein 90 (Hsp90). This compound exhibits the ability to selectively bind to and inhibit Hsp90, facilitating the detection of oncogene-driven breast cancers across various molecular subtypes. HS-131 is a valuable research tool for studying the role of Hsp90 in cancer biology and for developing novel therapeutic strategies targeting breast cancer. -
Diazo Dye
Fast Blue B Salt is a diazo dye that serves as a chromogenic substrate in biochemical analysis. It acts as a coupling agent for histochemical demonstration of proteases, facilitating the detection of acid phosphatase in Clostridium perfringens and the determination of lipase activity. Additionally, Fast Blue B Salt directly reacts with active hydroxyl groups in phenolic compounds, allowing for the quantification of phenolic substances. -
Fluorescent Fatty Acid
12-NBD Stearate is a fluorescent fatty acid analogue that targets fatty acid binding proteins (FABPs) and sterol carrier protein-2 (SCP-2). Its ability to bind to these proteins enhances the transport of long-chain fatty acids, particularly in systems overexpressing SCP-2 isoforms. This reagent serves as a valuable tool for studying the uptake and internalization of long-chain fatty acids through microscopic techniques, facilitating insights into lipid metabolism and transport mechanisms. -
ALP Fluorescent Probe
ALP Green is an amphiphilic fluorescent probe designed for detecting alkaline phosphatase (ALP) activity, with an emission wavelength of 550 nm. This probe is particularly useful in studying liver injury induced by acetaminophen (APAP) through its specific interaction with ALP. Researchers can utilize ALP Green to gain insights into liver function and enzyme activity in various biological assays. -
Fluorescent Peptide Substrate
Z-Val-Val-Arg-AMC is a fluorescent peptide substrate specifically designed for the assessment of cathepsin enzyme activity. This compound exhibits a high degree of specificity, facilitating the study of cathepsin-mediated biological processes. It is valuable in research applications involving proteolytic activity and enzyme kinetics, enabling researchers to investigate the roles of cathepsins in various physiological and pathological conditions. -
Fluorescent Substrate Analog
Guanosine 5'-triphosphate-5'-adenosine (GpppA) serves as a fluorescent substrate analog targeting RNA synthesis in vitro. As a 5′ cap analog, it plays a pivotal role in facilitating the incorporation of nucleotides during RNA transcription and can be utilized in various research applications, including studies of mRNA capping and translation initiation. -
Fluorescent Probe
Dihydrorhodamine 6G (DHR 6G) serves as a fluorescent probe targeting mitochondrial membranes. This nonfluorescent compound easily penetrates cells and is oxidized by reactive oxidative species or cellular redox systems, converting into the fluorescent rhodamine 6G. DHR 6G is valuable for the detection of reactive oxygen species (ROS), including superoxide, making it a crucial tool for research involving oxidative stress and mitochondrial function. -
Fluorescent Probe
PCL-2 is a reactive oxygen species-responsive fluorescent probe targeting hydrogen peroxide. It selectively reacts with hydrogen peroxide to produce 6-hydroxy-2-cyanobenzothiazole, exhibiting minimal response to other biologically relevant reactive oxygen species. PCL-2 is suitable for chemoselective imaging of hydrogen peroxide in in vitro models and can be applied in acute inflammation research using mouse models. This probe allows for the investigation of hydrogen peroxide's role in acute inflammatory processes. -
Fluorescent Probe
7-Hydroxy-4-methyl-2(1H)-quinolone is a fluorescent probe that effectively targets hydroxyl radicals. It plays a critical role in detecting DNA damage induced by oxidative stress, providing valuable insights into cellular damage mechanisms. This compound is utilized in various research applications, including studies focused on oxidative stress and DNA repair processes. -
Fluorescent Substrate
Nicotinamide 1,N6-ethenoadenine dinucleotide (ε-NAD) acts as a fluorescent substrate with significant utility in biochemical research. This analog of NAD can be cleaved by phosphodiesterase I, sourced from C. adamanteus venom, and demonstrates binding affinity to bovine liver glutamate dehydrogenase. It serves as a substrate for G-ADP ribosylation of G proteins, a process facilitated by bacterial toxins, making it valuable for investigating ADP ribosylation reactions. Its fluorescent properties enhance detection and analysis in experimental applications. -
CD206 Targeted Fluorescent Dye
MR2-cy5 is a fluorescent dye specifically designed to target CD206, a receptor expressed on macrophages. This reagent enables precise tracking of CD206+ macrophages in various biological samples, facilitating studies in immunology and cellular biology. MR2-cy5 is ideal for applications such as flow cytometry and imaging, contributing to the understanding of macrophage function and behavior in health and disease. -
Fluorescent Dye
Cy5-DBCO is a near-infrared fluorescent dye that features an absorption maximum at 646 nm and emission maximum at 670 nm. This compound functions as a click chemistry reagent, containing a DBCO group that readily participates in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. It is particularly useful in bioconjugation applications, facilitating the labeling of proteins and other biomolecules for imaging and tracking studies, although it is not recommended for staining intracellular components in permeabilized cells due to potential high background. -
Orange Fluorescent Dye
DBCO-Cy3 is an orange fluorescent dye derived from the Cyanine3 fluorophore, exhibiting stable fluorescence across a pH range of 4-10. It has an excitation maximum at 555 nm and an emission maximum at 580 nm, making it suitable for various fluorescence applications. DBCO-Cy3 features rapid reaction kinetics and is compatible with standard fluorescence instruments. As a click chemistry reagent, it contains a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling targeted labeling and imaging in biochemical research. -
Fluorescent Dye
CPM is a maleimide derivative that functions as a blue fluorescent thiol-reactive dye, with excitation and emission maxima at 387 and 463 nm, respectively. This compound is primarily utilized for the selective labeling of sulfhydryl groups in proteins and peptides, enabling the study of protein interactions, dynamics, and functions in various biological contexts. Its applications are valuable in biochemistry, cell biology, and proteomics research. -
Nonfluorescent Reagent
NBD-Cl is a nonfluorescent reagent that undergoes a transformation to become highly fluorescent upon reacting with thiols or amino groups. This unique property makes it an invaluable tool for labeling and detecting biomolecules in various biochemical assays. NBD-Cl is widely used in the characterization of proteins and peptides, facilitating studies in areas such as biochemistry, molecular biology, and pharmacology.
