Catalog No.
Product Name
Application
Product Information
Citations
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mtTrxR2 Probe
Mito-TRFS is an innovative off-on probe designed to selectively image mitochondrial thioredoxin reductase (TrxR2) in live cells. This reagent allows for the assessment of the redox status within mitochondria, facilitating the study of oxidative stress and mitochondrial function. Mito-TRFS is particularly valuable in research focusing on cellular responses to stress and the roles of TrxR2 in various disease models. -
Fluorescent Probe
DND-189 is a low-pH fluorescent probe that exhibits high sensitivity to neutral and acidic pH environments. This reagent is valuable for the quantification of pH levels within acidic organelles, enabling researchers to study intracellular pH dynamics in various biological contexts. Its unique properties make DND-189 an essential tool for applications in cellular imaging and pH monitoring. -
NO Fluorescent Detector
4,5-Diaminofluorescein is a sensitive fluorescent detector that specifically targets nitric oxide (NO). This reagent exhibits robust fluorescence upon reaction with NO, enabling the visualization and measurement of NO levels in cells and tissues. It is widely used in research applications related to nitric oxide signaling, endothelial function, and various physiological processes. -
Fluorescent Dye
ER Tracker Yellow is a temperature-sensitive fluorescent dye specifically designed to target the endoplasmic reticulum (ER). This probe exhibits exceptional temperature sensitivity of 3.9% per °C, with stable performance unaffected by pH or Ca2+ concentrations. It is ideal for real-time monitoring of local temperature changes in the ER, maintaining functionality in fixed cells. ER Tracker Yellow is compatible with a wide variety of cell lines and primary cells, including HeLa and MEF cells, making it a versatile tool for cellular research applications. -
Fluorescent Dye
Thiazole orange dimer YOYO 1 is a fluorescent dye that specifically targets DNA for staining applications. As a tetracationic homodimer of oxazole yellow, it exhibits minimal fluorescence in solution but significantly enhances its emission upon binding to double-stranded DNA via diintercalation, resulting in a fluorescence intensity increase of over 3200-fold. This remarkable amplification of fluorescence makes YOYO 1 an invaluable tool for various research applications, including nucleic acid quantification and visualization in molecular biology and genetic studies. -
Red Fluorophore
DFAME is a red fluorophore with excitation and emission wavelengths of 508 nm and 641 nm, respectively. It selectively binds to dimeric fluorescent RNA aptamers derived from Beetroot and Corn, yielding complexes with dissociation constants of 460 nM and 3600 nM, respectively. These Beetroot-DFAME and Corn-DFAME complexes facilitate the assembly of RNA structures within living cells, making them valuable tools for studying RNA nanostructures. The application of DNA/RNA nanostructures holds significant promise in advancing research in cell and gene therapy. -
Chemiluminescent Compound
Luminol sodium salt is a chemiluminescent compound that produces light at a maximum wavelength of 425 nm. This compound is widely utilized in forensic science as a sensitive indicator for the presence of blood stains, leveraging its unique ability to emit light in the presence of hemoglobin. Additionally, Luminol sodium salt has applications in environmental monitoring and biochemical assays, enhancing detection and analysis in various research fields. -
Fluorescent Dye
S0456 is a fluorescent dye precursor that facilitates the synthesis of the folate receptor-targeted near-infrared dye OTL 38. It enhances OTL 38 by imparting excellent optical properties along with high affinity and specificity for folate receptors. This compound is valuable in the research of tumor optical imaging agents, aiding in the development of advanced imaging techniques for cancer diagnostics. -
Quencher
Dabcyl acid is a nonfluorescent chromophore used primarily as a quencher in molecular fluorescent assays. It is effective in molecular beacon applications for the detection and reporting of specific nucleic acids in homogeneous solutions. Dabcyl acid enhances the sensitivity and specificity of nucleic acid probes, making it a valuable tool in genetic research and diagnostics. -
LDs/Mitochondria Dye
BETA-1 is a twisted intramolecular charge transfer (TICT) aggregation-induced emission (AIE) dye that targets lipid droplets (LDs) and mitochondria. It exhibits cyan fluorescence in LDs and red fluorescence in mitochondria, facilitating simultaneous dual-color imaging. BETA-1 is suitable for both in vivo and in vitro studies, making it an essential tool for researchers investigating cellular lipid metabolism and mitochondrial function. -
Hypochlorous Acid Detector
HKOCl-3 is a selective fluorescent probe designed for the detection of hypochlorous acid. This reagent exhibits high sensitivity with an excitation wavelength of 490 nm and an emission wavelength of 527 nm. HKOCl-3 is suitable for various biological research applications involving oxidative stress, inflammation studies, and the monitoring of hypochlorous acid levels in biological samples. -
Lipophilic Fluorescent Probe
5-Dodecanoylaminofluorescein is a lipophilic fluorescent probe that serves as a free fatty acid conjugate of fluorescein. This compound is instrumental in studies of membrane fluidity and the determination of critical micelle concentrations of detergents. Additionally, it can be utilized in the synthesis of hydrophobic nanospheres, enhancing applications in drug delivery systems. -
Fluorescent Calcium Indicator
Calcium Green 1AM is a cell-permeant fluorescent calcium indicator that targets calcium ions within cells. Upon cellular uptake, it is converted by intracellular esterases into its active form, facilitating precise measurement of calcium fluctuations. This reagent is widely utilized in cell physiology studies, calcium signaling research, and live-cell imaging applications. -
Fluorescent Dye
Acridine Orange base is a cell-permeable fluorescent dye primarily utilized for staining nucleic acids in various organisms, including bacteria, parasites, and viruses. This dye exhibits distinct fluorescence characteristics; it emits green light when bound to double-stranded DNA (Ex=488 nm, Em=520-524 nm) and red light when associated with single-stranded DNA or RNA (Ex=457 nm, Em=630-644 nm). Acridine Orange base is particularly valuable in fluorescence microscopy for distinguishing human cells under acidic conditions (pH=3.5) and is widely employed in cell cycle assays. -
Fluorescent Indicator
SBFI-AM is a sodium-selective fluorescent indicator designed for monitoring Na+ concentrations in biological systems. With a Kd of 6.7 mM for Na+ and 166 mM for K+, SBFI-AM demonstrates high selectivity for sodium ions. Its excitation and emission wavelengths are 340/380 nm and 500 nm, respectively. This reagent is widely used in cellular imaging and physiological studies to investigate sodium signaling and ion homeostasis. -
Lysosome-Specific Fluorescent Dye
Green DND-26 is a lysosome-specific fluorescent dye that exhibits a maximum excitation/emission wavelength of 504/511 nm. Comprising a fluorescein moiety linked to weak bases, this compound effectively penetrates cell membranes and accumulates in lysosomal structures. It is ideal for studying lysosomal biosynthesis and related pathological processes, facilitating the observation of cellular dynamics associated with lysosomal function. -
Neuronal Retrograde Tracer
True Blue is a fluorescent dye that serves as a neuronal retrograde tracer, excitable within the 395-425 nm wavelength range, with an emission barrier filter of 450 nm. It effectively labels neurons without compromising their survival, making it suitable for applications in neuronal tracing and mapping studies. This reagent is valuable for understanding neural connectivity and function in various research settings. -
DNA Dye
DAPI (4',6-Diamidino-2-phenylindole) is a fluorescent DNA dye that selectively binds to the AT base pairs in the minor groove of double-stranded DNA, enhancing fluorescence intensity approximately 20-fold upon binding. This property makes DAPI suitable for applications in fluorescence microscopy, allowing for quantification of DNA based on fluorescence intensity. Additionally, DAPI's ability to penetrate intact cell membranes enables its use in staining both live and fixed cells. DAPI also acts as an inhibitor of acid-sensing ion channel 3 (ASIC3), potentially contributing to research in chronic pain treatment (Ex/Em = 356/451 nm). -
Aluminum Ion Fluorescent Dyes
Lumogallion is a selective fluorescent reagent designed for the detection of aluminum ions, gallium, and other metal ions. Its high sensitivity allows for precise quantification and visualization in various biological and environmental samples. With an excitation wavelength of 490 nm and an emission spectrum ranging from 520 nm to 650 nm, Lumogallion exhibits a peak emission at approximately 580 nm, making it suitable for fluorescence-based applications in chemical research and analytical studies. -
Organic Anion Dye
Sulfobromophthalein disodium salt is an organic anion dye primarily utilized to investigate membrane carriers in animal tissues. This compound plays a critical role in understanding the transport mechanisms of various agents and metabolites across cell membranes. Its applications extend to studies related to pharmacokinetics and drug absorption, making it a valuable tool for researchers in the fields of biochemistry and pharmacology. -
Fluorescent Dye
DCVJ (9-(2,2-Dicyanovinyl)julolidine) is a unique fluorescent dye known for its ability to act as a molecular rotor. It exhibits significantly enhanced fluorescence intensity upon the polymerization of tubulin and actin, making it a valuable tool for studying cytoskeletal dynamics. Additionally, DCVJ interacts with phospholipid bilayers, further amplifying fluorescence. This compound is applicable in research involving mast cell degranulation, with optimal absorption and emission spectra at 489 nm and 505 nm, respectively. -
Fluorescent Imaging Agent
Pafolacianine is a near-infrared fluorescent imaging agent utilized for the detection of tumor lesions during surgical interventions. This compound operates by exciting at wavelengths of 774 to 775 nm and emitting at 794 to 796 nm, allowing for enhanced visualization of tumor tissues. Its application in intraoperative imaging significantly aids in improving surgical outcomes by providing real-time feedback for tumor localization. -
H2O2 Fluorescent Probe
HKPerox-2 is a highly sensitive fluorescent probe specifically designed for the detection of hydrogen peroxide (H2O2) in live cells. It exhibits peak excitation and emission wavelengths at 520 nm and 543 nm, respectively, making it suitable for fluorescence microscopy applications. This reagent can be utilized to study oxidative stress and cellular signaling involving reactive oxygen species, enabling insights into various biological processes and disease mechanisms. -
Fluorescent Dye
CellTracker Blue CMF2HC Dye is a fluorescent dye primarily used for visualizing and tracking live cells. It emits a blue fluorescence when excited at wavelengths between 450-460 nm, making it suitable for applications such as two-channel nucleic acid sequencing. Additionally, this dye facilitates the rapid assessment of microbial antibiotic sensitivity, providing valuable insights for microbiological research. -
Phospholipid Fluorescent Probe
BODIPY FL-DHPE is a green-fluorescent phospholipid probe targeting lipid bilayers. It labels 1,2-dihexadecanoyl-sn-glycero-phosphoethanolamine (DHPE), facilitating the study of membrane dynamics through membrane fusion processes. This reagent is ideal for investigating membrane structure and function in various cellular contexts, as well as analyzing lipid interactions in live cell imaging applications. The excitation and emission wavelengths are λex=505 nm and λem=511 nm, respectively. -
Cationic Carbocyanine Dye
Stains-All is a cationic carbocyanine dye that serves as an effective probe for investigating the structural characteristics of individual calcium-binding sites within calmodulin (CaM) and other related calcium-binding proteins (CaBP). This dye facilitates the study of calcium-binding interactions, making it an invaluable tool in cellular and molecular biology research focused on calcium signaling pathways and protein interactions. -
Oxidized Fluorescent Product
2',7'-Dichlorofluorescein is a potent fluorescent probe primarily used for the detection of oxidative stress by quantifying reactive oxygen species (ROS) levels. It exhibits excitation and emission maxima at 503 nm and 523 nm, respectively. This compound is essential for applications in cellular biology and biochemistry, enabling researchers to study oxidative damage and its effects on biological systems. -
OH Indicator
HKOH-1r is a highly sensitive green fluorescent probe designed for the selective detection of hydroxyl radicals (·OH) in living cells. It exhibits excitation and emission maxima at 500 nm and 520 nm, respectively, facilitating real-time visualization of oxidative stress. This reagent is applicable in various research settings, including studies focused on cellular redox status and oxidative damage pathways. -
Fluorescent Probe
DASPEI is a cationic styrenyl dye that targets mitochondria, functioning as a fluorescent probe with a large Stokes shift. Exhibiting excitation and emission wavelengths of 550 nm and 573 nm respectively, DASPEI demonstrates excellent photostability and labeling capability. This reagent effectively stains mitochondria in living cells and can also label presynaptic nerve endings, providing insights into cellular and synaptic activity. Its applications are valuable in various fields including neurobiology and cellular imaging research. -
Microenvironment-sensitive Membrane Reporter
Prodan is a solvatochromic fluorophore that serves as a microenvironment-sensitive membrane reporter. Its unique properties allow for the detection of changes in the local environment of membranes by varying Stokes shift values in response to the orientational polarizability of solvents. This versatility makes Prodan an essential tool in the study of membrane dynamics and the characterization of fluorescent nucleosides. It is particularly useful in applications involving membrane biophysics and the assessment of lipid bilayer properties. -
Fluorescent Dye
6-CFDA is a fluorescent dye commonly used in biological research for cell tracking and viability assays. It undergoes free diffusion into cells, where it is hydrolyzed by intracellular non-specific lipases to produce carboxyfluorescein, a fluorescent compound that carries an additional negative charge. This enhanced charge improves retention within cells compared to traditional fluorescein dyes, facilitating more accurate analysis of cellular processes and functions. -
Fluorescent Marker
6-ROX is a selective fluorescent probe targeting cyclooxygenase-2 (COX-2). By binding to the active site of COX-2, it inhibits the conversion of arachidonic acid to prostaglandins, making it an essential tool for studying COX-2-related pathways. 6-ROX is widely utilized in optical imaging applications aimed at identifying tumors and inflamed tissues that exhibit elevated COX-2 expression. -
Fluorescent pH Indicator
OG 488, SE (Oregon Green 488 succinimidyl ester) is a fluorescent pH indicator that exhibits strong fluorescence properties. It is widely utilized in biochemistry and neurosciences for various applications, including cellular imaging and tracking pH changes in live cells. Its ability to provide real-time pH measurements makes it an invaluable tool for researchers studying cellular processes and physiological conditions. -
Fluorogenic Probe
HKYellow-AM (6/12-mixture) is a fluorogenic probe designed for the selective and sensitive detection of peroxynitrite (ONOO-) in living cells and tissues. This probe offers a non-cytotoxic option for real-time fluorescence imaging, enabling researchers to investigate oxidative stress and related pathophysiological processes. Its high selectivity allows for accurate assessment of ONOO- levels, making it a valuable tool for studies in cellular signaling and antioxidant defense mechanisms. -
Fluorescent Probe
5-CFDA-AM is a fluorescent probe designed to measure enzyme activity and assess cell membrane integrity. This cell-permeable esterase substrate enters cells efficiently and is hydrolyzed by intracellular esterases to form carboxyfluorescein, which exhibits enhanced retention due to its negative charge. Its quantitative fluorescence capacity makes it a valuable tool for various biological research applications, including studies on cellular processes and viability assessments. -
Histochemical Stain
X-34 is a lipophilic fluorescent derivative of Congo red, characterized by its bright yellow-green fluorescence. It selectively stains neuritic and diffuse plaques, neurofibrillary tangles, neuropil threads, and cerebrovascular amyloid in brain tissue. This reagent is widely utilized in research focused on Alzheimer's disease to facilitate the study of these key pathological features. -
Fluorophore
6-HEX is a fluorophore characterized by its excitation and emission wavelengths of 532 nm and 556 nm, respectively. It is particularly effective for recording nucleic acid sequences and is useful in the design of optical materials. Additionally, 6-HEX can be employed to visualize nucleic acids under 543 nm radiation, as well as to directly locate cell group bases using 550 nm and 650 nm wavelengths. -
Fluorescent Dye
ANTS is a fluorescent dye characterized by an excitation wavelength of 380 nm and an emission wavelength of 520 nm. This compound is utilized for assessing membrane integrity, particularly in studies involving liposomal formulations, where it effectively measures membrane leakage when encapsulated alongside DPX. ANTS is a valuable tool in biochemical and cellular research applications that require precise monitoring of membrane dynamics. -
Fluorescent Dye
Phenazine ethosulfate is a cationic fluorescent dye characterized by an excitation wavelength of 390 nm and an emission wavelength of 530 nm. This compound serves as an electron acceptor and is utilized in dye-linked enzyme assays. It is particularly effective in detecting nitric oxide reductase (Nors) activity in conjunction with ascorbic acid, making it valuable for biochemical research involving enzyme functions and redox reactions. -
Fluorescent Dye
6-NBDG is a fluorescent glucose analogue that selectively targets glucose transport mechanisms. It serves as an effective tool for fluorescence imaging, enabling the monitoring of glucose uptake in various biological contexts. Additionally, 6-NBDG can be utilized as a fluorescent probe to detect macrophage-rich atherosclerotic plaques, contributing to research in cardiovascular diseases and metabolic disorders. -
Dye
SYBR Green I Chloride is a versatile nucleic acid stain that primarily interacts with double-stranded DNA. It exhibits high fluorescence upon binding, making it an essential tool in quantitative PCR, gel electrophoresis, and various molecular biology applications. This dye is useful for visualizing and quantifying nucleic acids in research studies, enabling the analysis of gene expression, pathogen detection, and other genomic investigations. Additionally, its properties facilitate studies in cell biology and diagnostics, supporting a broad spectrum of scientific research and clinical applications. -
Fluorescent Membrane Probe
Merocyanin 540 is a fluorescent membrane probe that selectively labels the membranes of electrically excitable cells while excluding non-excitable cells (Ex/Em: 540/580 nm). This compound is particularly useful in studies involving neuronal activity and can aid in the visualization of membrane dynamics in various cell types. Its selective staining capabilities make it a valuable tool for researchers investigating membrane properties and excitability in cellular systems. -
DNA Fluorescent Dye
Methyl Green is a non-intercalating fluorescent dye that targets DNA by selectively binding to the major groove. It exhibits high affinity, resistance to photobleaching, and stable fluorescence emission, making it suitable for various applications. Methyl Green can be utilized for fluorescent labeling of nuclei in embryonic tissues or cells, as well as for DNA staining and assessing cell activity in gel electrophoresis. Its fluorescence peaks are observed at 633 nm and 677 nm, enabling direct measurement through microscopy and flow cytometry. -
NO Fluorescent Probe
1,2-Diaminoanthraquinone is a selective and nontoxic fluorescent probe for the detection of nitric oxide (NO). It demonstrates high sensitivity with a detection limit of 5 μM, making it suitable for measuring NO production in live cells and animal models. This compound absorbs maximally at approximately 540 nm, facilitating accurate imaging and analysis in various biological research applications. -
Fluorescent Probe
LysoTracker Yellow HCK 123 is a membrane-permeable fluorescent probe that selectively targets acidic cellular compartments. This compound is a weakly basic amine that accumulates in environments with low luminal pH, enabling researchers to visualize and study lysosomal dynamics and function. It is widely utilized in cellular imaging applications to investigate cellular processes such as autophagy, metabolism, and organelle dynamics. -
Fluorochrome
YO-PRO-1 is a green fluorescent dye designed for detecting apoptotic and necrotic cells through its inability to penetrate intact cell membranes. It exhibits a strong affinity for DNA; when bound, it emits a bright green fluorescence (Ex/Em: 488/530±30 nM), facilitating the identification of cellular states. YO-PRO-1 is commonly utilized in conjunction with other reagents, such as Propidium Iodide, enhancing the analysis of cell viability and apoptosis in various biological research applications. -
Potential-sensitive Fluorescence Dye
DiBAC4(5) is a voltage-sensitive fluorescent dye that targets changes in membrane potential. It is widely used to monitor transmembrane potentials in various cell types, including Papain-dissociated retinal cells from adult zebrafish in the presence of GABAergic ligands. This reagent facilitates the study of excitability and membrane dynamics, contributing to research on neuronal signaling and cell physiology. -
Mitochondrial Marker
4-Di-2-ASP is a styryl pyridinium fluorescent dye primarily used as a mitochondrial marker. This compound demonstrates reliable and specific labeling of neuroepithelial bodies (NEBs) in pulmonary tissues, facilitating the investigation of mitochondrial dynamics and cellular respiration. Its application is critical in studies aimed at understanding respiratory physiology and neuroepithelial signaling. -
Peroxynitrite Indicator
HKGreen-4I is a selective fluorescent probe for the detection of peroxynitrite (ONOO-) in living cells. With a maximum excitation wavelength of 520 nm and emission wavelength of 543 nm, this highly sensitive indicator enables real-time monitoring of oxidative stress. It is useful for research applications involving nitric oxide signaling, reactive oxygen species, and related cellular processes. -
Cationic Dye
Pyronin Y, a cationic dye, primarily targets RNA by intercalating with nucleic acids. This compound forms fluorescent complexes with double-stranded RNA, facilitating semi-quantitative analysis of cellular RNA levels. Pyronin Y is suitable for identifying specific RNA subspecies within ribonucleoprotein complexes in living cells, making it a valuable tool for studies in molecular biology and cellular research.
