ER-Tracker dye is a BODIPY-based fluorescent probe conjugated with Glibenclamide, exhibiting high selectivity for the endoplasmic reticulum (ER). It is cell-permeable, non-toxic at low concentrations, and retains partial fluorescence after formaldehyde fixation. As an environment-sensitive dye, R-Tracker offers a long fluorescence lifetime and a high extinction coefficient. Glibenclamide, an ATP-sensitive K⁺ channel (Kir6.x, KATP) and CFTR Cl⁻ channel blocker, mediates ER targeting. R-Tracker is not suitable for post-fixation staining.
ER-Tracker dye is a BODIPY-based fluorescent probe conjugated with Glibenclamide, exhibiting high selectivity for the endoplasmic reticulum (ER). It is cell-permeable, non-toxic at low concentrations, and retains partial fluorescence after formaldehyde fixation. As an environment-sensitive dye, R-Tracker offers a long fluorescence lifetime and a high extinction coefficient. Glibenclamide, an ATP-sensitive K⁺ channel (Kir6.x, KATP) and CFTR Cl⁻ channel blocker, mediates ER targeting. R-Tracker is not suitable for post-fixation staining.
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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