DiSC3(5) is a fluorescent probe commonly used to assess mitochondrial membrane potential, with excitation/emission maxima at 622/670 nm. It can inhibit mitochondrial NAD-linked respiratory activity, with an IC₅₀ of 8 μM. In the presence of the Na⁺/K⁺-ATPase inhibitor ouabain, DiSC3(5) induces membrane hyperpolarization in Ehrlich ascites tumor cells.
DiSC3(5) is a fluorescent probe commonly used to assess mitochondrial membrane potential, with excitation/emission maxima at 622/670 nm. It can inhibit mitochondrial NAD-linked respiratory activity, with an IC₅₀ of 8 μM. In the presence of the Na⁺/K⁺-ATPase inhibitor ouabain, DiSC3(5) induces membrane hyperpolarization in Ehrlich ascites tumor cells.
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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