Catalog No.
Product Name
Application
Product Information
Citations
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THR-β Agonist
THR-β agonist 5 is a potent agonist of the thyroid hormone receptor beta (THR-β), exhibiting an EC50 of less than 50 nM. This compound plays a significant role in modulating metabolic processes and is valuable for research applications focused on metabolic diseases, thyroid hormone signaling, and related therapeutic developments. Its high potency and specificity make it an essential tool for investigating THR-β pathways in various biological systems. -
TRβ Agonist
TRβ agonist 1 is a selective agonist of the thyroid hormone receptor beta (TRβ), characterized by an EC50 of 21 nM. This compound demonstrates significant biological activity relevant to the study of dyslipidemia, nonalcoholic steatohepatitis (NASH), and resistance to thyroid hormone (RTH). Its mutation-sensitive properties make it an important tool for research into TRβ-related pathways and disorders. -
PTH Secretion Suppressor
1α-Hydroxy-3-epi-vitamin D3 is a natural metabolite of 1alpha,25-dihydroxyvitamin D3 that functions as a potent suppressor of parathyroid hormone (PTH) secretion. This compound plays a significant role in calcium metabolism and bone health by modulating endocrine responses. It serves as a valuable tool in research focused on understanding calcium homeostasis and related pathophysiological conditions. -
THR-β Agonist
THR-β Agonist 3 is a potent selective agonist of the thyroid hormone receptor beta (THR-β). This compound demonstrates significant biological activity in modulating metabolism and offers potential research applications in studying metabolic disorders, including obesity, hyperlipidemia, hypercholesterolemia, and diabetes. Additionally, THR-β Agonist 3 may provide insights into the mechanisms underlying conditions such as steatosis, non-alcoholic steatohepatitis (NASH), and atherosclerosis, making it a valuable tool for advancing research in metabolic disease therapies. -
pTH ((Human parathyroid hormone) fragment
pTH (1-44) (human) is a truncated form of human parathyroid hormone, encompassing amino acids 1 to 44. This fragment primarily targets the parathyroid hormone receptor, playing a crucial role in calcium homeostasis and bone metabolism. It is widely used in research applications focused on bone density studies, calcium signaling pathways, and the pathophysiology of metabolic bone diseases. -
TRH Analog
MK771 is a thyrotrophin-releasing hormone analog that modulates neuroendocrine functions. This compound is known to induce specific behaviors such as blinking and forepaw licking in experimental models. MK771 serves as a valuable research tool for investigating the mechanisms underlying morphine abstinence syndrome. -
THRβ Agonist
Simedeutirom is a potent agonist of the thyroid hormone beta receptor (THRβ). It plays a crucial role in regulating metabolic processes and has been identified as a valuable tool in researching metabolic diseases, including obesity and diabetes mellitus. Its ability to modulate THRβ activity makes Simedeutirom a significant compound for investigations into therapeutic approaches for metabolic disorders. -
TRβ Agonist
TRβ agonist 3 is a selective agonist of the thyroid hormone receptor beta (TRβ). It demonstrates significant biological activity by reducing lipid accumulation in HepG2 cells and promoting lipolysis, indicating its potential role in metabolic regulation. This compound is a promising candidate for further research into TRβ-selective thyromimetics and their applications in metabolic disorders. -
PTH Receptor Agonist
DPC-AJ1951 is a 14 amino acid peptide that functions as a potent agonist of the parathyroid hormone (PTH) and PTH-related peptide receptor (PPR). It is characterized by its significant activity in promoting bone resorption, making it a valuable tool for studies related to bone metabolism and disorders. DPC-AJ1951 can be utilized in both ex vivo and in vivo research applications to investigate the role of PTH signaling in skeletal physiology. -
THR-β Agonist
THR-β Agonist 6 is a selective agonist for the thyroid hormone receptor β (THR-β) with an EC50 of 0.03 μM. This compound demonstrates a favorable liver-to-serum ratio of 93:1 in murine models, indicating its potential for liver-targeted therapeutic applications. THR-β Agonist 6 is particularly relevant for research into nonalcoholic steatohepatitis (NASH), offering insights into metabolic regulation and liver health. -
pTH ((Human parathyroid hormone) fragment
pTH (13-34) (human) is a fragment of the human parathyroid hormone that primarily targets parathyroid hormone receptors. This peptide is known to regulate calcium and phosphate homeostasis by stimulating osteoclast activity and increasing renal tubular reabsorption of calcium. It is commonly used in research to study bone metabolism, calcium signaling, and related endocrine disorders. -
THR-β Agonist
THR-β agonist 11 is a selective agonist of the thyroid hormone receptor beta (THR-β) with oral bioavailability. This compound exhibits significant cholesterol-lowering effects, demonstrating the ability to reduce serum total triglycerides, LDL-cholesterol, and hepatic lipid accumulation in cholesterol-fed rat models. Additionally, THR-β agonist 11 alleviates hepatic steatosis, inflammation, and fibrosis in mice with metabolic dysfunction-associated steatohepatitis (MASH). It serves as a valuable reagent for investigating the mechanisms underlying MASH and related fibrotic diseases. -
PTH Analog
Human PTH-(1-31) amide is a parathyroid hormone (PTH) analog that primarily targets PTH receptor signaling pathways. This compound effectively stimulates phosphatidylcholine hydrolysis and promotes the release of adenylyl cyclase. Human PTH-(1-31) amide is essential for research applications focused on calcium homeostasis, bone metabolism, and endocrine signaling. -
Thyroid Hormone Analog
3,5-Diiodothyroacetic acid is a thyroid hormone analog that primarily targets thyroid hormone receptors. It has been shown to effectively lower blood cholesterol concentrations. This compound is utilized in research applications related to hypothyroidism and other thyroid-related disorders, providing insights into thyroid hormone function and its metabolic effects. -
TRα/TRβ Agonist
THR-β agonist 8 is an orally active agonist targeting thyroid hormone receptors TRα and TRβ. It demonstrates significant potential in modulating thyroid hormone signaling pathways, making it a valuable tool for investigating thyroid hormone-related diseases. This compound may aid in the understanding of metabolic regulation and therapeutic strategies for thyroid disorders. -
TRH Analog
Montirelin is a thyrotropin-releasing hormone (TRH) analog that demonstrates high affinity for TRH receptors. This compound exerts significant effects on the central nervous system (CNS), making it valuable for research into neuroendocrine regulation and related disorders. Its potent biological activity positions Montirelin as a useful reagent for studies focused on TRH signaling pathways and therapeutic developments in CNS-related conditions. -
PTH Antagonist
pTH-Related Protein (7-34) amide (human, mouse, rat) serves as a potent antagonist of parathyroid hormone (PTH). This peptide plays a crucial role in studies examining calcium homeostasis and bone metabolism. It is particularly useful in research focused on bone density regulation, osteoclast activity, and therapeutic strategies for managing metabolic bone diseases. -
Lipid Lowing Compound
Etiroxate is a lipid-lowering compound that targets hyperlipoproteinemia, providing insights into lipid metabolism. This reagent exhibits significant biological activity in modulating lipid profiles, making it suitable for cardiovascular and metabolic research applications. Its efficacy in reducing serum lipoprotein levels supports studies focused on dyslipidemia and associated therapeutic interventions. -
TRβ Agonist
TRβ agonist 2 is a potent thyroid hormone receptor beta (TRβ) agonist. It has demonstrated the ability to reduce lipid accumulation and promote lipolysis in HepG2 cells, indicating significant metabolic regulatory properties. This compound presents potential as a selective thyromimetic agent, offering valuable applications in research related to metabolic disorders and obesity. -
pTH ((Human parathyroid hormone) fragment
pTH (53-84) (human) is a fragment of human parathyroid hormone, primarily functioning to regulate calcium homeostasis and bone metabolism. This peptide plays a critical role in stimulating osteoclast activity and enhancing renal tubular reabsorption of calcium. It is widely utilized in research related to bone diseases, calcium signaling, and metabolic disorders associated with parathyroid function. -
THRβ Receptor Agonist
THRβ receptor agonist-1 selectively activates the thyroid hormone receptor beta (THRβ), promoting its downstream metabolic and transcriptional pathways. This compound demonstrates significant biological activity in enhancing insulin sensitivity and regulating lipid metabolism. It is a valuable tool for research applications focused on metabolic disorders, thyroid function, and related endocrine studies. -
TRβ Antagonist
MLS000389544 is a selective and potent antagonist of the thyroid hormone receptor beta (TRβ), effectively inhibiting its interaction with steroid receptor coactivator 2 (SRC2). This compound serves as a valuable tool in research related to thyroid hormone signaling, providing insights into the physiological and pathological roles of TRβ in various biological processes. Its application may extend to studies on metabolic disorders, cancer, and cardiovascular diseases, where TRβ signaling plays a crucial role. -
Thyroid Hormone Receptor Β Modulator
THR-β modulator-1 is a potent modulator of the thyroid hormone receptor β (THR-β). This compound selectively influences THR-β activity, making it valuable for investigating disorders related to thyroid hormone signaling. It has applications in understanding the physiological and pathological roles of THR-β in various biological contexts. -
pTH ((Human parathyroid hormone) fragment
pTH (3-34) (bovine) is a fragment of the human parathyroid hormone (PTH) that primarily targets the parathyroid hormone receptor. This peptide plays a crucial role in the regulation of calcium homeostasis and bone metabolism. It is commonly used in research applications related to bone health, osteoporosis studies, and the investigation of mineral ion balance. -
THR-β Agonist
THR-β agonist 7 is a selective THR-β receptor agonist, exhibiting an EC50 of 52 nM for THR-β and 1017 nM for THR-α. This compound is instrumental in investigating the role of THR-β in metabolic regulation and thyroid hormone signaling. Its specificity makes it valuable for research in metabolic disorders and thyroid-related conditions. -
Antitumor Agent
Iodothiouracil is an antitumor agent that selectively targets melanoma cells, demonstrating stability in melanin-rich environments. This compound aids in the imaging of melanoma when radiolabeled with iodine-123 and has applications in radiation therapy when conjugated with iodine-131. Its unique properties make it valuable for both diagnostic and therapeutic purposes in melanoma treatment. -
PTH Fragment
Human PTH-(1-31) is a fragment of parathyroid hormone (PTH) encompassing amino acids 1 to 31. This fragment primarily stimulates the production of cyclic adenosine monophosphate (cAMP) and exhibits a weaker activity in promoting the enzyme 25-hydroxyvitamin D-1α-hydroxylase. Human PTH-(1-31) is significant for inducing bone formation while minimizing bone resorption, making it a valuable tool for osteoporosis research and studies focused on bone metabolism. -
T3R Inhibitor
L-6424 is a selective inhibitor of triiodothyronine receptor (T3R) binding, specifically targeting alpha-1 (α1-T3R) and beta-1 (β1-T3R) receptors. Its primary mechanism interferes with T3 binding, making it a useful tool in research focused on thyroid hormone signaling pathways. This compound is applicable in studies investigating the role of T3R in metabolic regulation, cellular differentiation, and various endocrine disorders. -
Antilipidemic Drug
Acetiromate is a thyroxine analogue that functions as an antilipidemic agent. It primarily targets lipid metabolism to reduce elevated lipid levels, making it effective in the treatment of hyperlipidemia. This compound is utilized in research applications focusing on lipid regulation and metabolic disorders. -
Bone Formation Modulator
Osteostatin (human) is a bone formation modulator derived from the parathyroid hormone-related protein (PTHrP) 107-139 fragment. It has been shown to promote bone repair in animal models of bone defects and effectively prevent bone erosion associated with inflammatory arthritis. This compound is applicable in research focused on bone regeneration and the modulation of bone metabolism. -
THR-β Agonist
PF-00277343 is a selective agonist of thyroid hormone receptor beta (THR-β), exhibiting high affinity with a Ki value of 0.51 nM for THR-β and 8.0 nM for THR-α. This compound demonstrates significant biological activity in the treatment of androgenetic alopecia in animal models. Researchers can utilize PF-00277343 to explore the therapeutic potential of THR-β modulation in various biological contexts, particularly in hair growth and regeneration studies. -
Laevorotatory Isomer Of Thyroxine
D-Thyroxine sodium is the laevorotatory isomer of thyroxine, an essential thyroid hormone that primarily functions by inhibiting the secretion of thyroid-stimulating hormone (TSH). This compound demonstrates significant biological activities, including the inhibition of goiter formation, promotion of tadpole metamorphosis, and modulation of cholesterol metabolism. D-Thyroxine sodium is valuable for research applications focused on understanding hypercholesterolemia and thyroid function. -
Thyroid beta Agonist
Thyroid hormone receptor beta agonist-1 is a selective agonist of the thyroid hormone receptor beta (TRβ). This compound engages the TRβ pathway, eliciting biological activities associated with metabolism and developmental processes. It is primarily utilized in research related to thyroid hormone signaling, metabolic regulation, and related therapeutic developments. -
THR-β Agonist
THR-β Agonist 4 is a potent agonist of the thyroid hormone receptor beta (THR-β). It demonstrates significant biological activity in the modulation of metabolic pathways, making it valuable for research into metabolic disorders, including obesity, hyperlipidemia, hypercholesterolemia, and diabetes. Additionally, it may provide insights into conditions such as hepatic steatosis, non-alcoholic steatohepatitis (NASH), and atherosclerosis, furthering the understanding of relevant disease mechanisms. -
Thyroid Hormone Receptor Inhibitor
A 274 is a thyroid hormone receptor inhibitor that functions as an analogue of amiodarone. It effectively inhibits the binding of triiodothyronine (T3) to both α1- and β1-thyroid hormone receptors in vitro, demonstrating significant potential for modulating thyroid hormone signaling. This compound can be utilized in research applications focused on thyroid function and its associated biochemical pathways. -
Thyroid Hormone Receptor Agonist
KB-141 is a potent and selective thyroid hormone receptor beta (TRβ) agonist. It demonstrates strong binding affinities, with IC50 values of 23.9 nM for the human thyroid receptor alpha (hTRα1) and 3.3 nM for the human thyroid receptor beta (hTRβ1). This compound exhibits significant biological activities, including anti-obesity, anti-diabetic, and lipid-lowering effects, making it valuable for research in metabolic disorders and cholesterol regulation. -
Thyrotropin-Releasing Hormone Analog
Rovatirelin is an orally active analog of thyrotropin-releasing hormone (TRH) that targets the human TRH receptor, exhibiting a Ki value of 702 nM. This compound is primarily utilized in research focused on spinocerebellar degeneration (SCD), providing insights into its underlying mechanisms and potential therapeutic approaches. Researchers can leverage Rovatirelin to further understand the role of TRH in neurodegenerative disorders. -
TRH Precursor
Trh-gly (TRH-glycine) serves as a precursor for thyrotropin-releasing hormone (TRH), facilitating the release of thyrotropin (TSH) and prolactin. This compound is valuable for research into endocrine signaling and hormonal regulation, providing insights into the mechanisms underlying pituitary gland function. Its role in the synthesis and modulation of TRH makes it an important reagent for studies focused on thyroid function and reproductive biology. -
Thyrotropin Releasing Hormone Analogue
[Phe2]-TRH is an analogue of thyrotropin-releasing hormone (TRH) that exhibits conformational similarities to Leu5-enkephalin. This compound acts primarily on TRH receptors, modulating the release of thyroid-stimulating hormone (TSH) and prolactin. It serves as a valuable tool in research applications focused on neuroendocrine regulation, hormone signaling, and thyroid function. -
Thyroid Hormone Analogue
N-Acetylthyroxine is a thyroid hormone analogue that exhibits weak binding affinity for thyroxine-binding globulin (TBG) in isolated human serum. This compound is utilized in research to investigate thyroid hormone signaling pathways and their physiological implications. Its ability to modulate thyroid hormone activity makes it a valuable tool for studying thyroid function and related disorders. -
TRH Analog
Posatirelin is a thyrotropin-releasing hormone (TRH) analog that enhances the levels of monoamine metabolites in the cerebral cortex, nucleus accumbens, and striatum. This compound is believed to activate central nervous system pathways by modulating various neurotransmitter systems. It is valuable for research exploring the neurochemical basis of mood regulation and potential therapeutic approaches for neurological disorders. -
TRH Analogue
Orotirelin is a thyrotrophin-releasing hormone (TRH) analogue that functions by modulating the release of thyroid-stimulating hormone (TSH) from the anterior pituitary. This compound exhibits potential therapeutic effects in neurological disorders by influencing neuroendocrine pathways. Orotirelin is primarily utilized in the research of neurological diseases, contributing to the understanding of TRH’s role in neurobiology and its implications for treatment strategies. -
THRβ Receptor Agonist
THRβ receptor agonist-2 is a selective agonist of the THRβ receptor, primarily involved in metabolic regulation. This compound exhibits potent biological activity in modulating lipogenesis and glucose metabolism, making it valuable for research into liver disorders and cardiometabolic diseases. Its role in enhancing insulin sensitivity and improving lipid profiles provides a basis for investigating therapeutic strategies in metabolic syndrome. -
THR-β Modulator
THR-β modulator-2 is a selective modulator of the thyroid hormone receptor β (THR-β). This compound demonstrates biological activity by enhancing the metabolic effects associated with THR-β activation. Its applications in research include studying thyroid hormone signaling pathways and investigating metabolic disorders, making it a valuable tool in endocrine research and drug development. -
Thyroid Hormone Receptor
KAT681 is a selective agonist of the thyroid hormone receptor, primarily affecting liver tissue. It exhibits thyromimetic activity, promoting metabolic processes associated with thyroid hormone signaling. This compound is useful in research applications exploring metabolic disorders, thyroid function, and related therapeutic targets.
