Simedeutirom

Catalog No.: A85468
THRβ Agonist
Simedeutirom is a potent agonist of the thyroid hormone beta receptor (THRβ). It plays a crucial role in regulating metabolic processes and has been identified as a valuable tool in researching metabolic diseases, including obesity and diabetes mellitus. Its ability to modulate THRβ activity makes Simedeutirom a significant compound for investigations into therapeutic approaches for metabolic disorders.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionSimedeutirom is a potent agonist of the thyroid hormone beta receptor (THRβ). It plays a crucial role in regulating metabolic processes and has been identified as a valuable tool in researching metabolic diseases, including obesity and diabetes mellitus. Its ability to modulate THRβ activity makes Simedeutirom a significant compound for investigations into therapeutic approaches for metabolic disorders.
Product Information
Catalog NumA85468
FormulaC18H9D3Cl2N6O4
Molecular Weight450.25
CAS Number2403721-24-2
SMILES[2H]C([2H])([2H])[C@H](CC1)C2=C1C(OC3=C(C=C(N4N=C(C(NC4=O)=O)C#N)C=C3Cl)Cl)=NNC2=O
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