KB-141 is a potent and selective thyroid hormone receptor beta (TRβ) agonist. It demonstrates strong binding affinities, with IC50 values of 23.9 nM for the human thyroid receptor alpha (hTRα1) and 3.3 nM for the human thyroid receptor beta (hTRβ1). This compound exhibits significant biological activities, including anti-obesity, anti-diabetic, and lipid-lowering effects, making it valuable for research in metabolic disorders and cholesterol regulation.
KB-141 is a potent and selective thyroid hormone receptor beta (TRβ) agonist. It demonstrates strong binding affinities, with IC50 values of 23.9 nM for the human thyroid receptor alpha (hTRα1) and 3.3 nM for the human thyroid receptor beta (hTRβ1). This compound exhibits significant biological activities, including anti-obesity, anti-diabetic, and lipid-lowering effects, making it valuable for research in metabolic disorders and cholesterol regulation.
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