A 274

Catalog No.: A85498
Thyroid Hormone Receptor Inhibitor
A 274 is a thyroid hormone receptor inhibitor that functions as an analogue of amiodarone. It effectively inhibits the binding of triiodothyronine (T3) to both α1- and β1-thyroid hormone receptors in vitro, demonstrating significant potential for modulating thyroid hormone signaling. This compound can be utilized in research applications focused on thyroid function and its associated biochemical pathways.
Grouped product items
Size Price Stock Qty
25mg
$1,275.00
In stock
50mg
$1,625.00
In stock
100mg
$2,000.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionA 274 is a thyroid hormone receptor inhibitor that functions as an analogue of amiodarone. It effectively inhibits the binding of triiodothyronine (T3) to both α1- and β1-thyroid hormone receptors in vitro, demonstrating significant potential for modulating thyroid hormone signaling. This compound can be utilized in research applications focused on thyroid function and its associated biochemical pathways.
Product Information
Catalog NumA85498
FormulaC19H14O2
Molecular Weight274.31
CAS Number77273-75-7
SMILESOC1=CC=C(C2C3=C(OC4=C2C=CC=C4)C=CC=C3)C=C1
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