THR-β agonist 11 is a selective agonist of the thyroid hormone receptor beta (THR-β) with oral bioavailability. This compound exhibits significant cholesterol-lowering effects, demonstrating the ability to reduce serum total triglycerides, LDL-cholesterol, and hepatic lipid accumulation in cholesterol-fed rat models. Additionally, THR-β agonist 11 alleviates hepatic steatosis, inflammation, and fibrosis in mice with metabolic dysfunction-associated steatohepatitis (MASH). It serves as a valuable reagent for investigating the mechanisms underlying MASH and related fibrotic diseases.
THR-β agonist 11 is a selective agonist of the thyroid hormone receptor beta (THR-β) with oral bioavailability. This compound exhibits significant cholesterol-lowering effects, demonstrating the ability to reduce serum total triglycerides, LDL-cholesterol, and hepatic lipid accumulation in cholesterol-fed rat models. Additionally, THR-β agonist 11 alleviates hepatic steatosis, inflammation, and fibrosis in mice with metabolic dysfunction-associated steatohepatitis (MASH). It serves as a valuable reagent for investigating the mechanisms underlying MASH and related fibrotic diseases.
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