Catalog No.
Product Name
Application
Product Information
Citations
- Levothyroxine, also L-thyroxine or T4, is a synthetic form of the thyroid hormone thyroxine, which is normally secreted by the follicular cells of the thyroid gland.
- Human parathyroid hormone (hPTH) peptide fragment; contains the 34 N-terminal residues of hPTH. Agonist at parathyroid 1 (PTH1) and parathyroid 2 (PTH2) receptors.
- Parathyroid hormone (PTH) is the most important endocrine regulator of calcium and phosphorus concentration in extracellular fluid, which is secreted by the chief cell of the parathyroid glands as a polypeptide containing 84 amino acids.
- A Vieira-Neto, .et al. , J Dairy Sci, 2021, Jan;104(1):1018-1038 PMID: 33162070
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TRβ agonist
Sobetirome is a thyroid hormone receptor β (TRβ)-specific agonist, Sobetirome is designed to bind selectively to TRβ-1 with EC50 of 0.16 μM. - Protirelin is a thyrotropin-releasing hormone receptor used to treat hypothyroidism.
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TRH-R agonist
Taltirelin (TA0910) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release).- Tayler D Sheahan, .et al. , Sci Adv, 2024, Sep 27;10(39):eadp6038 PMID: 39321286
- 3,5-Diiodothyropropionic acid is a thyroid hormone analog, induces α-myosin heavy chain mRNA expression, binds to thyroid hormone receptor (TR), with Ka of 2.40 and 4.06 M-1 for TRα1 and TRβ1, respectively.
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TR antagonist
TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC50s of 36 and 22 nM for TRα and TRβ, respectively. - Liothyronine sodium is a thyroid hormone (T3) analog. It promotes adipogenic differentiation of MSCs.
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thyroid hormone receptor agonist
Eprotirome is a liver-selective thyroid hormone receptor agonist. - (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) is a potent and competitive antagonist of parathyroid hormone (PTH), with a Ki of 69 nM in bovine renal cortical membrane. (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) can be used for growth and development regulation.
- (Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS.
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THR-β agonist
ALG-055009 is a selective thyroid hormone receptor β (THR-β) agonist with an EC50 of 0.063 μM. It effectively reduces total cholesterol levels in high-fat diet-induced rat models and is a promising compound for research related to metabolic dysfunction-associated fatty liver disease (MAFLD). -
TIGIT/PVR Blocker
Liothyronine is an active form of thyroid hormone that primarily targets thyroid hormone receptors TRα and TRβ. It exhibits binding affinities of 2.33 nM and 2.29 nM for human TRα and TRβ, respectively. In addition, Liothyronine binds to PVR and effectively inhibits the interaction between TIGIT and PVR. This compound is useful in research applications related to thyroid hormone signaling and immune modulation studies. -
Thyroid Hormone Receptor Antagonist
DS08210767 is a potent antagonist of the thyroid hormone receptor, exhibiting an IC50 value of 90 nM. This compound effectively inhibits receptor activity, making it a valuable tool for investigating thyroid hormone signaling pathways. Its oral bioavailability enhances its utility in preclinical research focused on thyroid-related disorders and metabolic regulation. -
TRβ Receptor Agonist
Axitirome is a potent TRβ receptor agonist and thyromimetic agent. This compound exhibits significant liver-selective activity, primarily enhancing cholesterol-lowering effects. Axitirome is utilized in research related to metabolic disorders and thyroid hormone signaling, providing valuable insights into the modulation of cholesterol homeostasis. -
THR-β Modulator
THR-β modulator-3 is a selective THR-β modulator that demonstrates a significant reduction in total fat mass and body weight. Its primary biological activity indicates potential utility in the management of obesity-related conditions. This compound is useful in research focused on metabolic regulation, adipogenesis, and the broader implications of thyroid hormone signaling in metabolic disorders. -
Thyrotropin Releasing Hormone Analogue
JTP 2942 is a thyrotropin-releasing hormone analogue that targets neuroregulatory pathways. This compound enhances the release of acetylcholine in the hippocampus and frontal cortex, demonstrating neuroprotective effects and cognitive enhancement. JTP 2942 exhibits a dose-dependent improvement in motor and neurological deficits in rat models of chronic focal cerebral ischemia, making it a valuable tool for research focused on cerebral ischemia and motor neuron diseases. -
THR Antagonist
NH-3 is a reversible antagonist of the thyroid hormone receptor (THR) with an IC50 of 55 nM. It effectively inhibits the binding of thyroid hormones to their receptor, consequently preventing cofactor recruitment. Additionally, NH-3 serves as a click chemistry reagent due to its alkyne group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. This compound is useful in studies related to thyroid function and receptor signaling pathways. -
Thyroid Hormone
Reverse T3 is a thyroid hormone that results from the deiodination of thyroxine. It functions primarily by inhibiting the sodium current induced by other thyroid hormone analogs in neonatal rat myocytes. This unique action makes Reverse T3 a valuable tool for investigating thyroid hormone receptor signaling and its physiological effects in various biological contexts. -
Anabolic Agent
pTH-Related Protein (1-34) is a fragment derived from parathyroid hormone-related protein and functions as an anabolic agent. This peptide is instrumental in stimulating bone formation and is primarily utilized in research focused on postmenopausal osteoporosis. Its application aids in exploring potential therapeutic interventions for bone density regulation and related metabolic disorders in human, mouse, and rat models. -
Thyroid Hormone Receptor
T3-ATA (S-isomer) is an active form of thyroid hormone that selectively targets thyroid hormone receptors. This compound is essential for studying thyroid hormone signaling pathways and their role in metabolic regulation. T3-ATA (S-isomer) can be utilized in research focused on thyroid-related disorders and cellular metabolism, providing insights into hormone-receptor interactions and downstream biological effects. -
PTH Fragment
pTH (1-37) (human) is a bioactive fragment of parathyroid hormone (PTH) that primarily targets the stimulation of cAMP production. This compound enhances alkaline phosphatase activity, promotes growth, and increases bone calcium content and mineral density in uremic animal models. pTH (1-37) (human) serves as a valuable tool for research into osteoporosis and associated bone health disorders. -
TSH Stimulator
Protirelin acetate is a potent thyrotropin-releasing hormone (TRH) analog that stimulates the release of thyroid-stimulating hormone (TSH) from the anterior pituitary gland. This neuropeptide plays a crucial role in the regulation of thyroid function and exhibits neuromodulatory properties. It is commonly used in research applications related to thyroid disorders, endocrine system studies, and neurophysiological investigations. -
Parathyroid Hormone
Glutaurine, an orally active hormone derived from parathyroid gland oxyphil cells, targets parathyroid hormone receptors. This compound exhibits significant biological activity, making it a valuable tool for research in antiepileptic and anti-amnesia studies. Its dual composition of glutamine and taurine residues contributes to its potential effectiveness in exploring therapeutic applications related to neuroprotection and neurological disorders. -
Parathyroid Hormone
Parathyroid hormone (1-34) (rat) is a peptide hormone that primarily targets bone metabolism through the activation of parathyroid hormone receptors. This compound is known to enhance both cortical and cancellous bone structure, making it a valuable tool in the study of osteogenesis and bone remodeling. It is particularly useful in research focused on osteoporosis and related bone disorders. -
TR-β Agonist
Elunetirom is a selective agonist of the thyroid hormone receptor beta (TR-β), designed as a prodrug with the capability to penetrate the central nervous system (CNS). This compound demonstrates potential in modulating pathways associated with major depressive disorder (MDD). Its targeted action on TR-β makes it a valuable reagent for researching neuropsychiatric conditions and exploring new therapeutic strategies. -
Thyroid Hormone Receptor
L-Thyroxine sodium xhydrate (Levothyroxine; T4) is a synthetic thyroid hormone targeting thyroid hormone receptors, primarily used in the treatment of hypothyroidism. It serves as a precursor for the biologically active hormone triiodothyronine (T3), which is generated through the action of deiodinase enzymes. This compound is essential for regulating metabolism, growth, and development, making it a valuable tool for research into thyroid function and related disorders. -
TR Antagonist
Thyroid hormone receptor antagonist (1-850) is a competitive and selective antagonist targeting thyroid hormone receptors (TR) with an IC50 of 1.5 μM. This compound effectively inhibits T3-mediated interactions between TRα and TRβ with nuclear receptor coactivators. Thyroid hormone receptor antagonist (1-850) is suitable for research focused on thyroid hormone signaling pathways and their implications in various biological processes, while exhibiting no effect on retinoic acid receptor alpha (RARα) activity. -
TRα Agonist
CO23 is a selective thyroid hormone receptor (TR) α agonist that plays a crucial role in the regulation of growth and development. This compound has significant biological activity in modulating metabolic processes and influencing gene expression related to thyroid hormone signaling. It is commonly employed in research applications aimed at understanding thyroid function and its implications in developmental biology and metabolic disorders. -
TRβ Agonist
VK-0214 is a selective agonist of the thyroid β receptor (TRβ), which modulates gene expression related to fatty acid metabolism. Its activation of ABCD2 leads to a reduction in very long-chain fatty acid (VLCFA) accumulation, providing a potential therapeutic approach for glioblastoma multiforme. VK-0214 is pertinent for research into X-linked adrenoleukodystrophy (X-ALD) and related metabolic disorders. -
TRα1 Inhibitor
Debutyldronedarone hydrochloride is a selective inhibitor of the thyroid hormone receptor α1 (TRα1), derived from the main metabolite of Dronedarone. This compound effectively inhibits T3 binding to TRα1 and TRβ1 by 77% and 25%, respectively. It is primarily utilized in research related to arrhythmic conditions, providing insights into the mechanisms of thyroid hormone signaling in cardiac physiology. -
TRα/β Antagonist
TR Antagonist 2 is a competitive antagonist of thyroid hormone receptors TRα and TRβ with an IC50 of 47 nM. By competing with triiodothyronine (T3) for binding to the ligand-binding domain, it disrupts receptor-coactivator complex formation, thereby inhibiting target gene transcription and reducing the hypermetabolic effects associated with thyroid hormones. This compound is valuable for research into conditions such as hyperthyroidism and thyrotoxicosis, providing insights into therapeutic strategies for these disorders. -
Antihyperlipidaemic Agent
Omzotirome is a functional analog of iodothyronines that acts as an antihyperlipidaemic agent. It is primarily used in research focused on hyperlipidaemia, exploring its effects on lipid metabolism and regulation. This compound may provide insights into the therapeutic potential for managing dyslipidemia and related metabolic disorders. -
Thyroid Hormone Receptor
T4-ATA (S-isomer) selectively targets the thyroid hormone receptor, functioning as an active form of thyroid hormone. It exhibits significant biological activity in modulating gene expression related to metabolism, growth, and development. This compound is valuable for research applications focused on thyroid hormone signaling pathways and associated disorders. -
THR-β Agonist
ZTA-261 is a selective agonist of the thyroid hormone receptor β subtype (THR-β) with an IC50 value of 6.3 nM. This compound enhances lipid metabolism and promotes reductions in body weight and visceral fat through a liothyronine-mediated pathway. ZTA-261 is suitable for research into obesity and metabolic disorders, making it a valuable tool for studies on energy homeostasis and therapeutic interventions in related conditions. -
PTH Agonist
Canvuparatide is a prodrug that functions as a potent agonist of parathyroid hormone (PTH). By releasing the bioactive PTH[1-32] peptide with a fatty acylated lysine at the C-terminus, it significantly extends the compound's half-life. This unique mechanism makes Canvuparatide a valuable tool for addressing the symptoms of hypoparathyroidism, including hypocalcemia and hyperphosphatemia, facilitating research into therapeutic interventions for these conditions. -
Thyroxine Derivative
Thyroxine methyl ester is a derivative of thyroxine, primarily targeting thyroid hormone receptors. This compound exhibits biological activity that influences metabolic processes and cellular growth. It is used in research applications related to thyroid function, metabolic regulation, and the study of thyroid-related disorders. -
THR-β Agonist
THR-β Agonist 2 is a selective agonist of the thyroid hormone receptor beta (THR-β), facilitating metabolic regulation. This compound exhibits significant biological activity relevant to the study of various metabolic disorders, including obesity, hyperlipidemia, hypercholesterolemia, diabetes, and conditions such as steatosis and non-alcoholic steatohepatitis (NASH). THR-β Agonist 2 is a valuable reagent for research aimed at understanding the mechanisms underlying metabolic diseases and potential therapeutic interventions. -
Thyroid Hormone
3,5,3'-Triiodo-D-thyronine, a thyroid hormone, primarily targets thyroid hormone receptors to regulate metabolic processes. This compound demonstrates biological activity by modulating gene expression involved in energy metabolism and growth regulation. Research applications include studies on thyroid function, metabolic disorders, and conditions associated with abnormal plasma creatine phosphokinase (CPK) levels. Its effectiveness as a therapeutic agent can be assessed in various experimental models related to thyroid hormone signaling. -
TRH-DE Inhibitor
Glp-Asn-Pro-AMC is a selective inhibitor of thyrotropin-releasing hormone degrading enzyme (TRH-DE), exhibiting a Ki value of 0.97 μM. This compound is valuable for studying the role of TRH-DE in metabolic and neuroendocrine regulation. Its inhibitory action on TRH-DE makes it a useful tool in research related to thyroid hormone regulation and potential therapeutic interventions in conditions impacted by TRH signaling. -
THR-β Agonist
THR-β Agonist 1 is a potent and selective agonist of the thyroid hormone receptor beta (THR-β). This compound facilitates the physiological effects mediated by thyroid hormones, which are crucial for normal growth, development, and metabolic homeostasis. THR-β Agonist 1 is useful for investigating thyroid hormone receptor-related diseases and understanding the role of thyroid hormones in various biological processes. -
pTH ((Human parathyroid hormone) fragment
pTH (44-68) (human) is a fragment of the human parathyroid hormone. This peptide plays a crucial role in regulating calcium homeostasis and bone metabolism by acting on the parathyroid hormone receptors. pTH (44-68) is primarily used in research applications focused on osteoporosis, metabolic bone disease, and calcium signaling pathways. Its specific activity allows for the investigation of parathyroid hormone signaling mechanisms and potential therapeutic interventions. -
Anti-thyroid Agent
Metamizole is an anti-thyroid agent that inhibits the synthesis of thyroid hormones in the thyroid gland. It is primarily used in research focused on thyroid dysfunction and disorders. Additionally, caution is advised due to its potential hepatotoxicity, which may be relevant in studies investigating liver metabolism and drug safety.
