Vitamin D Receptors

Calcifediol-D6 is the deuterated form of Calcifediol(25-hydroxy Vitamin D3), which is a prehormone that is produced in the liver by hydroxylation of vitamin D3 (cholecalciferol) by the enzyme cholecalciferol 25-hydroxylase.

Calcitriol D6 is the deuterated form of Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ), which is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

Metabolite of vitamin D2

Falecalcitriol(Fulstan; Hornel) is an analog of calcitriol; has a higher potency both in vivo and in vitro systems, and longer duration of action in vivo.

Seocalcitol is a vitamin D analog, binds vitamin D receptor protein from human osteosarcoma MG-63 cells with Kd of 0.27 nM.

Impurity of Doxercalciferol is an impurity of doxercalciferol, which is a synthetic analog of ergocalciferol (vitamin D2), used as a drug for secondary hyperparathyroidism and metabolic bone disease, and it suppresses parathyroid synthesis and secretion.

Vitamin D2 (Ergocalciferol) is a form of vitamin D, used as a vitamin D supplement.

Calcitriol Impurities A is the impurity of Calcitriol, Calcitriol is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

Calcipotriol Impurity C is the impurity of Calcipotriol, Calcipotriol is a ligand of VDR-like receptors.

Alfacalcidol-D6, a deuterated Alfacalcidol (1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3), is a non-selective VDR activator medication.

24R-Calcipotriol(PRI 2202) is an impurity of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors.

Impurity F of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors.

MC 1046(Impurity A of Calcipotriol) is an impurity of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors.

Cholecalciferol(Vitamin D3) is a naturally occuring form of vitamin D; Reported that upon metabolic activation, Cholecalciferol induces cell differentiation and prevents proliferation of cancer cells.

MeTC7 is a potent Vitamin D receptor (VDR) antagonist with an IC50 value of 2.9 μM. This compound exhibits significant VDR inhibition, contributing to its antitumor effects. MeTC7 is useful in research applications aiming to explore VDR signaling pathways and its implications in cancer biology.

ZK168281 is a potent VDR (Vitamin D Receptor) antagonist, functioning through its high affinity for the receptor with a Kd value of 0.1 nM. This compound effectively inhibits the interaction between the VDR and coactivators, thereby modulating pathways influenced by vitamin D signaling. ZK168281 is valuable for research applications focused on VDR-related signaling pathways and the study of vitamin D's role in various biological processes.

TEI-9647 is a potent and specific antagonist of the vitamin D receptor (VDR), functioning as a Vitamin D3 lactone analogue. It effectively inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3, thereby suppressing bone resorption and HL-60 cell differentiation triggered by this active form of vitamin D. TEI-9647 is a valuable tool for investigating pathological conditions such as Paget's disease, where it may help mitigate excessive bone resorption and osteoclast formation.

TEI-9648 is a potent and specific antagonist of the vitamin D receptor (VDR). It effectively inhibits the genomic actions mediated by 1α,25(OH)2D3, blocking associated biological pathways. Additionally, TEI-9648 impedes the differentiation of HL-60 cells induced by 1α,25(OH)2D3. This compound demonstrates potential applications in research related to bone metabolism and VDR signaling pathways.

5,6-trans-Vitamin D3, a photoproduct of Vitamin D3, plays a vital role in modulating cellular responses. This compound promotes cell differentiation while inhibiting the proliferation of cancer cells. Its biological activities make it relevant for research focused on cancer biology, cellular signaling, and vitamin D metabolism.

(1S)-Calcitriol is an active metabolite of 1α,25-dihydroxyvitamin D3, specifically targeting the vitamin D receptor (VDR). This compound exhibits significant biological activity, including the inhibition of keratinocyte proliferation and the suppression of parathyroid hormone secretion. Its VDR-mediated effects make (1S)-Calcitriol relevant for research in skin disorders, metabolic bone diseases, and the regulation of calcium homeostasis.

ZK159222 is a potent vitamin D receptor (VDR) antagonist, functioning as a 25-carboxylic ester derivative of 1α,25-(OH)2D3. Its mechanism of action involves preventing ligand-induced interactions between the vitamin D receptor and coactivators, thereby inhibiting the receptor's activity. ZK159222 also exhibits partial agonist characteristics, making it valuable for research into VDR signaling pathways and potential therapeutic applications in diseases related to vitamin D metabolism.

Dihydrotachysterol is a synthetic analog of vitamin D that primarily targets the vitamin D receptor. This compound exhibits key biological activity by enhancing intestinal calcium absorption and mobilizing calcium from bone, making it valuable in the study of conditions such as hypocalcemia and hypoparathyroidism. Dihydrotachysterol is widely used in research applications focusing on calcium homeostasis and related metabolic disorders.

Maxacalcitol-d6 is the deuterated form of Maxacalcitol (22-Oxacalcitriol), an analog of vitamin D3 that acts as a selective activator of the vitamin D receptor (VDR). This compound exhibits non-calcemic properties and is utilized in research to explore the roles of VDR in various biological processes. Maxacalcitol-d6 is particularly valuable for studies investigating calcium metabolism, bone health, and related signaling pathways.

L-Galactose is a crucial intermediate in the biosynthesis of vitamin C (L-ascorbic acid) in plants. Through the VTC2 cycle, it undergoes enzymatic conversions that contribute to antioxidant activities, cellular integrity, and the regulation of carbon flow in photosynthesis. This compound is valuable for investigating the synthesis pathways of vitamin C and exploring its physiological roles in plant biology.

Windaus ketone is a vitamin D (VD) antagonist that inhibits the activity of the vitamin D receptor (VDR). This compound is valuable in research focused on understanding vitamin D signaling pathways and their implications in various biological processes, including bone metabolism and immune function. Its antagonistic properties make it an important tool for studying the effects of disrupting VD/VDR interactions in cellular and molecular research.

Calcitriol Derivatives are analogs of Vitamin D3 that primarily target vitamin D receptors. These compounds exhibit potent biological activity, influencing calcium homeostasis and bone metabolism. They are widely utilized in research to explore pathways related to bone health, immune response modulation, and cellular differentiation.

Chlorindione is a potent anticoagulant that functions as a vitamin K1 antagonist. By inhibiting the synthesis of vitamin K-dependent clotting factors, it effectively reduces thrombus formation. This reagent is primarily utilized in research to study coagulation pathways and the mechanisms of anticoagulation therapy.

Previtamin D3 is a key intermediate in the biosynthesis of cholecalciferol, commonly known as vitamin D3. It plays a crucial role in the metabolic pathway leading to the synthesis of this essential nutrient, which is vital for calcium homeostasis and bone health. Previtamin D3 is utilized in research applications focused on vitamin D metabolism and its implications in various physiological processes.

Coumetarol is a vitamin K antagonist that acts primarily as a vascular endothelial growth factor (VEGF) and vitamin D receptor (VDR) antagonist. It is utilized in research to study mechanisms related to coagulation, as well as potential implications in cancer biology and cardiovascular diseases. This compound is valuable for investigating the role of vitamin K in various biological processes and evaluating its effects on cell signaling pathways.

CB1151 is a 20-epi analogue of 1,25-dihydroxyvitamin D3 (VD) that targets the vitamin D receptor (VDR). This compound demonstrates significant anti-tumor activity, effectively inhibiting the growth of MCF-7 breast cancer cells with an IC50 value of 0.82 nM. CB1151 is primarily utilized in research focusing on cancer biology and the mechanisms of vitamin D in therapeutic applications.

trans-Doxercalciferol is an isomer of Doxercalciferol, which is a Vitamin D2 analog that functions as an activator of the Vitamin D receptor. This compound plays a critical role in calcium homeostasis and bone metabolism, making it important for research into renal disease prevention and the modulation of immune responses. Its ability to influence cellular differentiation and proliferation makes trans-Doxercalciferol valuable for studies in various areas of biomedical research.

Atocalcitol is a vitamin D3 analogue that primarily targets the vitamin D receptor. It exhibits significant biological activity in modulating keratinocyte proliferation and differentiation, making it a valuable tool for psoriasis research. Its effects on immune response regulation also provide insights into potential therapeutic applications for autoimmune conditions related to skin health.

Butyrate-Vitamin D3 (Butyrate-Cholecalciferol) is a novel derivative of Vitamin D3, where a hydroxyl group is substituted with a butyric acid moiety. This compound modulates gene expression and enhances cellular functions while exhibiting anti-inflammatory properties. Butyrate-Vitamin D3 is valuable for research on immune regulation, metabolic disorders, and cancer biology, providing insights into the interplay between these critical processes.

(1R,5Z)-Calcitriol is an isomer of calcitriol, the most biologically active metabolite of vitamin D. This compound functions as a vitamin D receptor (VDR) agonist, influencing calcium metabolism and bone health. Its biological activity makes it valuable in research focused on bone disorders, immunomodulation, and calcium signaling pathways.

VDR Agonist 2 is a potent compound that acts as an agonist for the vitamin D receptor (VDR). This reagent effectively inhibits the TGF-β1-induced activation of hepatic stellate cells (HSC), demonstrating significant anti-hepatic fibrosis effects in both in vitro and in vivo studies. It is suitable for research applications focused on liver fibrosis and the mechanistic understanding of VDR-mediated pathways.

22-Hydroxyvitamin D3 is a novel vitamin D analog that lacks agonist activity in both intestinal and bone tissues. Its unique profile makes it a valuable tool for research into vitamin D metabolism and signaling pathways. This compound can be utilized in studies investigating the modulation of calcium homeostasis and potential therapeutic applications in vitamin D-related disorders.

Tioclomarol is a coumarin anticoagulant that acts as a vitamin K antagonist. By inhibiting vitamin K-dependent clotting factors, it effectively reduces the risk of thromboembolic events. Tioclomarol is utilized in various research applications related to coagulation processes and the study of anticoagulant therapies.

Pyrocholecalciferol is a vitamin D analogue that arises from the photochemical transformation of 7-dehydrocholesterol (7-DHC). This compound exhibits significant biological activity in regulating calcium and phosphate homeostasis, playing a crucial role in bone health and metabolic processes. Its applications extend to studies involving vitamin D signaling pathways and the exploration of related metabolic disorders.

5,6-trans-Vitamin D2 is an isomer of Vitamin D2, primarily known for its role in regulating calcium and phosphate metabolism. This compound demonstrates significant biological activity related to bone health and immune function, making it valuable in various research applications. It is often utilized in studies focused on vitamin D receptor activation and its effects on cellular processes in health and disease.

2MD is an orally active vitamin D analog that primarily targets bone metabolism. It stimulates periosteal bone formation while decreasing trabecular bone resorption, effectively restoring both trabecular and cortical bone mass and strength. Additionally, 2MD regulates genes associated with intraocular pressure (IOP) and has been shown to reduce IOP in non-human primates, making it a valuable tool for research in bone health and ocular physiology.

(R)-Acenocoumarol is a vitamin K epoxide reductase inhibitor, serving as a potent orally active anticoagulant. It exhibits superior in vivo anticoagulant potency compared to Warfarin, attributed to its longer plasma elimination half-life and slower plasma clearance rate. This compound is particularly valuable in research applications focused on coagulation studies and the pharmacodynamics of anticoagulants. Its unique chiral center allows for exploration into the distinct biological activities of its enantiomeric forms.

Tisocalcitate is a Vitamin D analogue that primarily targets the vitamin D receptor. It exhibits anti-proliferative and immunomodulatory effects, making it valuable for research on plaque-type psoriasis. Its use in scientific studies contributes to understanding the therapeutic potential of vitamin D derivatives in skin disorders.

Pefcalcitol, a phosphodiesterase inhibitor, exhibits potential as a therapeutic agent for psoriasis management. Its unique 16-en-22-oxa-vitamin D3 structure contributes to its biological activity, influencing cellular signaling pathways associated with skin inflammation and proliferation. This reagent is instrumental in pharmacological research aimed at understanding psoriasis pathophysiology and developing innovative treatment strategies.

Ro-65-2299 is an orally active vitamin D analogue that functions as a potential agonist of the vitamin D receptor (VDR), with an effective dose (ED50) of 180 nM. It promotes thickening of the epidermis and demonstrates antipsoriatic activity in hairless mice, with an ED50 of 7.5 mg/kg. This compound is suitable for research into inflammation and immunology, particularly in the context of psoriasis and related skin disorders.

19-Nor-22-oxa-1a,25(OH)2-VD3 is a vitamin D₃ analogue that exhibits low affinity for the vitamin D receptor (VDR) and minimal binding to the vitamin D binding protein (DBP). This compound effectively induces the differentiation of HL-60 cells and promotes G₀-G₁ phase cell cycle arrest. It serves as a valuable tool for investigating conditions such as excessive hyperparathyroidism in biological research.

Pre-vitamin D3 decanoate is a vitamin D3 derivative involved in the metabolic conversion to active vitamin D forms. Upon administration, it is first converted to 25-hydroxyvitamin D3 in the liver and subsequently transformed into 1,25-dihydroxyvitamin D3 in the kidneys. This compound is particularly relevant for research into diseases related to vitamin D deficiency, including osteoporosis, autoimmune disorders, and particular cancers, due to its role in modulating calcium metabolism and immune function. Its unique formulation enhances the stability and bioavailability of vitamin D3, making it a valuable tool in biomedical research.

Coumachlor is an orally active anticoagulant agent and a vitamin K antagonist. It interferes with the synthesis of vitamin K-dependent clotting factors, thereby inhibiting the coagulation cascade. Coumachlor is primarily used in research related to thrombosis and hemostasis, providing insight into the mechanisms of blood coagulation and potential therapeutic interventions.

Chol-5-en-24-al-3β-ol is a steroid compound that serves as a derivative of Vitamin D3, targeting the Vitamin D receptor (VDR). This compound is known for its biological activity in modulating calcium homeostasis and influencing gene expression related to bone and immune health. Research applications include studies on vitamin D metabolism, signaling pathways, and potential therapeutic effects in various diseases.

Vitamin D-C22 acid is an analog of vitamin D that targets the vitamin D receptor (VDR). Its [125I]-labeled form is utilized in the development of detection methods for vitamin D metabolites. Additionally, [125I]Vitamin D-C22 acid serves as a tracer in radioimmunoassays, facilitating the quantification of vitamin D levels in research applications.

Tecarfarin is an orally active, non-competitive antagonist of vitamin K epoxide reductase (VKOR), which plays a critical role in the activation of vitamin K-dependent clotting factors II, VII, IX, and X. By inhibiting VKOR, Tecarfarin exhibits significant antithrombotic activity, making it valuable for research in coagulation disorders and anticoagulation therapies. This compound is useful in studying the mechanisms of thromboembolism and the development of novel anticoagulant agents.