TEI-9647 is a potent and specific antagonist of the vitamin D receptor (VDR), functioning as a Vitamin D3 lactone analogue. It effectively inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3, thereby suppressing bone resorption and HL-60 cell differentiation triggered by this active form of vitamin D. TEI-9647 is a valuable tool for investigating pathological conditions such as Paget's disease, where it may help mitigate excessive bone resorption and osteoclast formation.
TEI-9647 is a potent and specific antagonist of the vitamin D receptor (VDR), functioning as a Vitamin D3 lactone analogue. It effectively inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3, thereby suppressing bone resorption and HL-60 cell differentiation triggered by this active form of vitamin D. TEI-9647 is a valuable tool for investigating pathological conditions such as Paget's disease, where it may help mitigate excessive bone resorption and osteoclast formation.
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