ZK159222 is a potent vitamin D receptor (VDR) antagonist, functioning as a 25-carboxylic ester derivative of 1α,25-(OH)2D3. Its mechanism of action involves preventing ligand-induced interactions between the vitamin D receptor and coactivators, thereby inhibiting the receptor's activity. ZK159222 also exhibits partial agonist characteristics, making it valuable for research into VDR signaling pathways and potential therapeutic applications in diseases related to vitamin D metabolism.
ZK159222 is a potent vitamin D receptor (VDR) antagonist, functioning as a 25-carboxylic ester derivative of 1α,25-(OH)2D3. Its mechanism of action involves preventing ligand-induced interactions between the vitamin D receptor and coactivators, thereby inhibiting the receptor's activity. ZK159222 also exhibits partial agonist characteristics, making it valuable for research into VDR signaling pathways and potential therapeutic applications in diseases related to vitamin D metabolism.
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