Catalog No.
Product Name
Application
Product Information
Citations
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Sirtuin ligand
WAY-354574 is a potent ligand for sirtuin deacetylases, primarily utilized in research related to Huntington's disease (HD). This compound modulates sirtuin activity, impacting cellular processes associated with neurodegeneration. Researchers can apply WAY-354574 to investigate the therapeutic potential and molecular mechanisms underlying HD and related disorders. -
SIRT1 Inhibitor
CHIC35 is a selective inhibitor of SIRT1, exhibiting an IC50 of 0.124 μM. It demonstrates preferential inhibition of SIRT1 over SIRT2 (IC50=2.8 μM) and SIRT3 (IC50>100 μM). This compound is recognized for its anti-inflammatory properties and is applicable in research related to CHARGE syndrome. -
SIRT6 Activator
CL5D is a selective activator of the protein deacetylase SIRT6, enhancing its deacetylation activity and catalytic efficiency. By promoting conformational changes, specifically involving the Arg-65 residue, CL5D serves as a valuable tool for investigating the regulatory mechanisms of SIRT6. This compound is applicable in research areas related to metabolism, DNA repair, and aging, facilitating a deeper understanding of SIRT6’s biological functions. -
SIRT1 Activator
F0911-7667 is a potent activator of SIRT1, promoting autophagic cell death in U87MG and T98G glioblastoma cells through the activation of the AMPK-mTOR-ULK complex. Additionally, this compound has demonstrated its ability to reduce p53 acetylation in IMR32 neuroblastoma cells, providing protective effects against cell death induced by amyloid-beta (Aβ) fragments. Its unique mechanism and biological activities make it valuable for research in cancer and neurodegenerative disease models. -
SIRT Inhibitor
SIRT1/2/3-IN-2 is a potent inhibitor of SIRT1, SIRT2, and SIRT3, exhibiting inhibition rates of 27%, 72%, and 71% respectively at a concentration of 200 μM. This compound is instrumental in studying the roles of sirtuins in various biological processes, particularly their involvement in cancer biology. SIRT3, known as a potential tumor suppressor or promoter, has been linked to lymph node-positive breast cancer and oral squamous cell carcinoma, making SIRT1/2/3-IN-2 valuable for cancer research applications. -
SIRT2 Inhibtor
Sirt2-IN-5 is a selective inhibitor of SIRT2, a member of the sirtuin family involved in various cellular processes, including metabolism and stress response. This compound effectively reduces SIRT2 activity, thus influencing downstream signaling pathways associated with neuroprotection and cancer biology. It is useful in research applications focusing on the roles of SIRT2 in disease models and exploring therapeutic strategies targeting sirtuins. -
SIRT2 Inhibitor
SIRT2-IN-10 is a selective inhibitor of SIRT2, exhibiting an inhibitory concentration (IC50) of 1.3 μM. This compound is instrumental in studying its role in cancer pathology and neurodegenerative disorders, enabling research into potential therapeutic applications. Its ability to modulate SIRT2 activity makes it a valuable tool for investigating cellular mechanisms and disease progression. -
SIRT7 Inhibitor
Epigenetic factor-IN-1 is a selective SIRT7 inhibitor that plays a crucial role in modulating epigenetic regulation. It demonstrates a strong binding affinity for the SIRT7 protein, making it an important tool for exploring the mechanisms of epigenetic modifications. This compound is particularly relevant for liver cancer research, providing insights into the role of SIRT7 in cancer biology and therapeutic development. -
sirtuin SirT2 Inhibitor
Tenovin-D3 hydrochloride is a selective inhibitor of the sirtuin SirT2, which plays a crucial role in cellular regulation. This compound has been shown to enhance the expression of p21 (CDKN1A) independently of the p53 pathway. It is suitable for research applications focused on aging, cancer biology, and the modulation of cellular stress responses to explore the therapeutic potential of sirtuin inhibition. -
SIRT2 Inhibitor
Sirt2-IN-6 is a potent and selective inhibitor of SIRT2, exhibiting an IC50 of 0.815 μM. It demonstrates significant biological activity in modulating SIRT2-related pathways and is valuable for cancer research applications. This compound facilitates the exploration of SIRT2's role in oncogenesis and therapeutic development. -
SIRT1/2 Inhibitor
hsa62 is a dual inhibitor targeting SIRT1 and SIRT2, demonstrating IC50 values of 1.3 μM and 5.5 μM, respectively. This compound effectively modulates the activity of sirtuins, enzymes involved in various cellular processes, including metabolism and aging. hsa62 is suitable for research investigating the role of sirtuins in cellular regulation, disease models, and therapeutic applications. -
SIRT1 Activator
DCHC is a specific activator of SIRT1, enhancing its enzymatic activity without increasing SIRT1 expression levels. This compound is particularly useful in studies investigating mitochondrial damage and dysfunction, offering insights into metabolic regulation and cellular stress responses. DCHC's ability to activate SIRT1 makes it a valuable tool for exploring the roles of sirtuins in cellular health and disease. -
SIRT5 Inhibitor
SIRT5 Inhibitor 6 is a selective and potent inhibitor of SIRT5 that functions through a substrate-competitive mechanism, demonstrating an IC50 value of 3.0 μM. This compound shows promise in therapeutic applications for septic acute kidney injury (AKI) in vivo, making it a valuable tool for research in kidney health and related pathologies. -
SIRT1/SIRT2 Inhibitor
Guttiferone G is a selective inhibitor of the human SIRT1 and SIRT2 deacetylases, exhibiting IC50 values of 9 μM and 22 μM, respectively. This compound demonstrates weak cytotoxicity in the A2780 human ovarian cancer cell line, with an IC50 of 8.0 μg/mL. Guttiferone G is derived from Garcinia macrophylla and may serve as a valuable tool in research studies exploring SIRT1 and SIRT2 modulation in cellular processes. -
SIRT5 Inhibitor
SIRT5 inhibitor 5 is a potent inhibitor of the SIRT5 enzyme, exhibiting an IC50 value of 0.21 µM. This compound functions as a substrate-competitive inhibitor, specifically not occupying the NAD+-binding pocket, thereby modulating SIRT5 activity. SIRT5 inhibitor 5 is valuable in research focused on elucidating the role of SIRT5 in metabolic pathways and providing insights into its potential implications in various diseases. -
SIRT5 Inhibitor
SIRT5 Inhibitor 4 is a selective inhibitor of the SIRT5 enzyme, demonstrating an IC50 value of 26.4 μM. This compound exhibits minimal activity against other SIRT subtypes, with an IC50 greater than 400 μM, underscoring its specificity. It serves as a valuable tool for investigating the biological roles of SIRT5 in metabolic regulation and related pathways. Research applications include studying SIRT5's involvement in cellular processes and potential therapeutic targets in metabolic disorders. -
SIRT6 Activator
SIRT6 activator 2 is a specific activator of sirtuin 6, known for its anti-lipid accumulation properties. This compound effectively downregulates key transcription factors LXR and SREBP-1c, along with their downstream target genes involved in lipogenesis. SIRT6 activator 2 is valuable for research focused on lipid metabolism and associated diseases, enabling the exploration of therapeutic strategies targeting metabolic disorders. -
SIRT2 Inhibitor
AGK7 is a selective inhibitor of sirtuin 2 (SIRT2), demonstrating significant neuroprotective effects in the context of Parkinson's disease. This compound has been shown to alleviate alpha-synuclein toxicity and improve inclusion morphology in cellular models. In addition, AGK7 effectively protects against dopaminergic cell death in both in vitro studies and Drosophila models, making it a valuable tool for researching neurodegenerative disorders. -
SIRT3 Inhibitor
SIRT-IN-5 is a selective inhibitor of SIRT3, demonstrating an IC50 value of 2.88 μM. This compound has been shown to promote the differentiation of multiple myeloma cells, facilitating increased expression of differentiation antigens such as CD49e, as well as enhancement of human immunoglobulin light chains λ and κ. SIRT-IN-5 is a valuable tool in research focused on the modulation of cellular differentiation processes in hematological malignancies. -
SIRT1/2 Inhibitor
Sirtuin-IN-1 is a selective inhibitor of SIRT1 and SIRT2, with IC50 values of 6.2 μM and 4.2 μM, respectively. This compound has been shown to induce G1 phase cell cycle arrest, demonstrating its potential as an anti-cancer agent. Sirtuin-IN-1 is particularly effective against glioma, making it a valuable tool for research into cancer therapeutics and the exploration of sirtuin-related biological pathways. -
SIRT1 Inhibitor
Sirtuin Modulator 4 is a selective SIRT1 inhibitor, demonstrating an EC50 value of 51-100 μM. This compound plays a critical role in modulating cellular pathways associated with lifespan extension and offers potential in researching a variety of conditions, including diabetes, obesity, neurodegenerative diseases, cardiovascular disorders, inflammation, and cancer. Its ability to inhibit SIRT1 makes it a valuable tool for studying the therapeutic implications of sirtuin regulation in metabolic and age-related diseases. -
SIRT1 Modulator
SIRT1-IN-5 is a selective modulator of the NAD-dependent protein deacetylase SIRT1. It demonstrates significant activity in regulating deacetylation processes, contributing to cellular metabolism and stress response. This compound can be utilized in research focused on aging, metabolic diseases, and neurodegenerative disorders, making it a valuable tool for exploring the therapeutic potential of SIRT1 modulation. -
SIRT2 Inhibitor
SIRT2-IN-14 is a selective inhibitor of SIRT2, demonstrating an IC50 value of 0.196 μM. This compound effectively modulates SIRT2 activity, making it a valuable tool for studying the role of SIRT2 in various biological pathways. Research applications may include investigations into neurodegenerative diseases, cancer biology, and cellular metabolism, providing insights into the therapeutic potential of targeting SIRT2. -
SIRT5 Inhibitor
SIRT5 inhibitor 2 is a selective inhibitor of the SIRT5 enzyme, exhibiting an IC50 value of 2.3 μM. It effectively inhibits SIRT5-dependent desuccinylation processes, making it a valuable tool for investigating the roles of SIRT5 in various biological contexts. This compound is suitable for research applications focusing on cancer biology and neurodegenerative diseases, aiding in the exploration of therapeutic strategies targeting SIRT5 activity. -
Sirtuin Modulator
Sirtuin Modulator 5 is a potent activator of SIRT1, demonstrating a DC50 value of less than 50 μM. This compound enhances cellular lifespan and facilitates research into various age-related and stress-related diseases, including diabetes, obesity, neurodegenerative disorders, cardiovascular diseases, blood clotting disorders, inflammation, and cancer. Additionally, Sirtuin Modulator 5 may promote increased mitochondrial activity, making it a valuable tool in the study of metabolic and age-related diseases. -
SIRT1 Inhibitor
ZINC08792355 is a selective SIRT1 inhibitor that plays a crucial role in the regulation of cellular processes associated with aging, metabolic disorders, and oncogenesis. This compound facilitates the exploration of SIRT1-related pathways in research on age-related diseases, diabetes, and cancer, making it a valuable tool for investigators studying these important biological phenomena. -
SIRT1 Activator
SRT3657 is a selective activator of SIRT1, exhibiting properties that enhance neuronal resilience. Its brain-permeable nature allows for effective modulation of SIRT1 activity, contributing to neuroprotection. This compound is valuable for research applications aimed at understanding neurodegenerative diseases and exploring potential therapeutic strategies. -
SIRT2 Inhibitor
SR94 is a selective SIRT2 inhibitor that features a unique six-membered ring structure with variable R2 substituents. This compound demonstrates potential in the investigation of cancer, ischemia-reperfusion injury, and neurodegenerative diseases. Its targeted inhibition of SIRT2 makes it a valuable tool for understanding the role of this enzyme in various biological processes and disease states. -
SIRT6 Modulator
IMU-856 is a small molecule modulator of SIRT6, exhibiting oral bioavailability and systemic action. It selectively inhibits the deacetylase activity of SIRT6 while simultaneously increasing its protein levels. This compound has demonstrated the ability to restore intestinal barrier function, making it a valuable tool for research on celiac disease and related gastrointestinal disorders. -
SIRT1 Activator
SRTCX1002 is a selective activator of the SIRT1 enzyme, functioning primarily through the promotion of p65 deacetylation, which subsequently inhibits NF-κB activity. This compound effectively suppresses inflammatory responses, demonstrated by its ability to inhibit stimuli-induced NF-κB transcriptional activation and reduce LPS-induced TNFα secretion, with IC50 values of 0.71 µM and 7.58 µM, respectively. SRTCX1002 serves as a valuable reagent for research focused on inflammation and related signaling pathways. -
SIRT5 Inhibitor
SIRT5 Inhibitor 7 is a selective substrate-competitive inhibitor targeting SIRT5, known for its anti-inflammatory properties. This compound effectively regulates protein succinylation and reduces the release of pro-inflammatory cytokines, offering potential renal protective effects. SIRT5 Inhibitor 7 demonstrates notable in vivo efficacy in mouse models of acute kidney injury induced by lipopolysaccharide (LPS) and cecal ligation/perforation (CLP), making it a valuable tool for researching sepsis-related kidney damage. -
Sirtuin Modulator
FLS-359 is an orally active allosteric modulator of sirtuin 2, demonstrating an IC50 of 3 μM. This compound exhibits significant antiviral activity, effectively inhibiting both RNA and DNA viral replication. FLS-359 is valuable for research applications focused on viral pathogenesis and therapeutic strategies targeting sirtuin signaling pathways. -
SIRT1 Activator
SRTCX1003 is an orally active SIRT1 activator that enhances SIRT1 activity, leading to the modulation of various biological processes. This compound has been shown to suppress inflammatory responses, making it a valuable tool for research related to inflammation and metabolic disorders. Its application in studies focused on SIRT1-mediated pathways provides insights into potential therapeutic approaches for a range of diseases. -
Sirtuin Modulator
Sirtuin Modulator 2 (Compound 132) is a selective modulator of sirtuin enzymes, exhibiting an effective dose (ED50) of 50 μM or lower. This compound plays a critical role in the regulation of cellular processes such as aging, metabolism, and stress response. Its ability to influence sirtuin activity makes it valuable for research in fields like cancer biology, neurodegenerative diseases, and metabolic disorders. -
Sirtuin Substrate
Ac-QPKK(Ac)-AMC is a fluorogenic substrate specifically designed for sirtuin enzymes, facilitating the study of sirtuin-mediated deacetylation processes. This reagent enables the quantitative analysis of sirtuin activity, making it a valuable tool for investigating the role of sirtuins in various biological processes and disease states, including aging and metabolic disorders. Researchers can leverage Ac-QPKK(Ac)-AMC to explore sirtuin function in high-throughput screening assays and in-depth mechanistic studies. -
SIRT1 Inhibitor
ZINC08792229 is a potent inhibitor of SIRT1, a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase playing a crucial role in cellular regulation. This compound exhibits significant biological activity that may contribute to research on SIRT1-related diseases, including aging, diabetes, and cancer. It serves as a valuable tool for exploring the therapeutic potential of targeting SIRT1 in various pathological conditions. -
SIRT1/SIRT2 Inhibitor
Aristoforin, a hypericin derivative, selectively inhibits SIRT1 and SIRT2, resulting in G1 phase cell cycle arrest. This compound also scavenges hydroxyl free radicals and demonstrates protective effects against Fe2+-induced DNA breakage. Aristoforin is valuable for research in the context of breast cancer and colon adenocarcinoma studies. -
SIRT6 Modulator
SIRT6 modulator-1 is a selective modulator of SIRT6, a key enzyme involved in regulating metabolic processes and DNA repair. This compound influences SIRT6 activity, enhancing its role in chromatin dynamics and cellular stress responses. SIRT6 modulator-1 has potential applications in research focused on aging, metabolic disorders, and cancer by elucidating the pathways regulated by SIRT6. -
SIRT3 Inhibitor
SIRT3-IN-2 is a selective inhibitor of the SIRT3 enzyme, demonstrating a reduction of SIRT3 activity by 39% at a concentration of 200 µM. This compound is valuable for investigations into metabolic homeostasis and its implications in tumor suppression. SIRT3-IN-2 can be utilized in research aimed at understanding the regulatory roles of sirtuins in cellular metabolism and cancer biology. -
SIRT2 Inhibitor
SIRT2-IN-15 is a selective inhibitor of the SIRT2 deacetylase and deamyloacylase enzymes, demonstrating IC50 values of 7 μM and 37 μM, respectively. This compound modulates cellular acetylation states, making it a valuable tool for investigating the roles of SIRT2 in various biological processes, including neurodegenerative diseases, cancer metabolism, and aging. SIRT2-IN-15 can be utilized in research applications focusing on the molecular mechanisms of SIRT2-related pathways and potential therapeutic targets. -
SIRT1 Activator
3β,6α,12β-Dammar-E-20(22)-ene-3,6,12,25-tetraol is a potent SIRT1 activator that enhances SIRT1 activity significantly. This compound has demonstrated anti-tumor activity, making it a valuable tool for research in cancer biology and therapeutic interventions targeting SIRT1 modulation. Its role in promoting cellular metabolism and longevity pathways further supports its use in studies related to aging and metabolic disorders. -
SIRT2 Inhibitor
A2B57 is a selective inhibitor of SIRT2, exhibiting an IC50 value of 6.3 µM. This compound effectively modulates the activity of SIRT2, making it a valuable tool for exploring the role of this enzyme in various biological processes. Its application extends to studies in neurodegeneration, metabolism, and cellular stress responses, providing insights into SIRT2-related pathways. -
SIRT1/2/3 Inhibitor
SIRT-IN-6 is a pan-inhibitor targeting SIRT1, SIRT2, and SIRT3, with IC50 values exceeding 50 μM. This compound is valuable for studying its effects in metabolic, inflammatory, oncologic, and neurodegenerative disorders. Its broad inhibition profile makes it a suitable tool for elucidating the roles of sirtuins in various biological processes and disease states. -
SIRT2 Inhibitor
A1B11 is a selective inhibitor of Sirtuin 2 (SIRT2) with an IC50 value of 5.3 μM. This compound is primarily utilized in research focused on neurodegenerative diseases, where SIRT2 modulation plays a critical role in the underlying mechanisms of pathology. A1B11 provides a valuable tool for investigating the therapeutic potential of SIRT2 inhibition in various neurodegenerative conditions. -
SIRT1/3 Activator
Nicotinamide riboside (triflate) is a potent activator of the SIRT1 and SIRT3 pathways, functioning as an orally active precursor to NAD+. This compound significantly elevates NAD+ levels, thereby enhancing oxidative metabolism and providing protective effects against metabolic disturbances triggered by high-fat diets. Additionally, it has demonstrated neuroprotective properties, as evidenced by its ability to mitigate cognitive decline in transgenic mouse models of Alzheimer’s disease, making it valuable for research in metabolic health and neurodegenerative disorders. -
SIRT1/2 Inhibitor
Sirt1/2-IN-1 is a selective inhibitor of SIRT1 and SIRT2, exhibiting IC50 values of 1.81 and 2.10 µg/mL, respectively, while also inhibiting SIRT3 with an IC50 of 20.5 µg/mL. This compound induces hyperacetylation of α-tubulin, with an IC50 of 32.05 µg/mL, demonstrating its potential for modulating protein acetylation. Sirt1/2-IN-1 is particularly relevant in cancer research, showcasing significant anticancer activity that supports its use in investigating therapeutic strategies targeting sirtuin pathways. -
Sirtuin-modulating Compound
Sirtuin Modulator 9 is a sirtuin-modulating compound that enhances cellular lifespan and promotes mitochondrial activity. This compound has potential applications in research related to aging, inflammation, and cancer. Investigators may utilize Sirtuin Modulator 9 to explore its therapeutic effects in age-related disorders and diseases associated with compromised mitochondrial function. -
AMPK/SIRT3/PGC-1α Modulator
MitoPBN is an AMPK/SIRT3/PGC-1α modulator that enhances mitochondrial function by acting as a reactive oxygen species scavenger. This compound promotes mitochondrial biogenesis through increased AMPK phosphorylation, restoration of SIRT3 expression, and upregulation of PGC-1α. MitoPBN is effective in regulating glucose metabolism, as it decreases blood glucose levels by inhibiting hepatic gluconeogenesis and enhancing glucose uptake, while also improving ATP production and maintaining mitochondrial membrane potential. Additionally, it can reduce apoptosis and enhance sperm motility and membrane integrity, making it a valuable reagent for research related to diabetes and metabolic disorders.
