IMU-856

Catalog No.: A57025
SIRT6 Modulator
IMU-856 is a small molecule modulator of SIRT6, exhibiting oral bioavailability and systemic action. It selectively inhibits the deacetylase activity of SIRT6 while simultaneously increasing its protein levels. This compound has demonstrated the ability to restore intestinal barrier function, making it a valuable tool for research on celiac disease and related gastrointestinal disorders.
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Size Stock
5mg
10mg
50mg
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Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionIMU-856 is a small molecule modulator of SIRT6, exhibiting oral bioavailability and systemic action. It selectively inhibits the deacetylase activity of SIRT6 while simultaneously increasing its protein levels. This compound has demonstrated the ability to restore intestinal barrier function, making it a valuable tool for research on celiac disease and related gastrointestinal disorders.
Product Information
Catalog NumA57025
FormulaC30H38F3N7O2
Molecular Weight585.66
CAS Number2303528-97-2
SMILESCN1C([C@@H]2CC[C@H](CC2)C3=CN(N=C3)[C@@H]4CC[C@H](CC4)N5CC6(CCO6)C5)=NN=C1COC7=CC(C(F)(F)F)=CC=N7
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