Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC CRBN Degrader
CRBN-6-5-5-VHL is a potent and selective VHL-based PROTAC degrader targeting cereblon (CRBN), with a DC₅₀ of 1.5 nM. It selectively degrades CRBN without affecting neo-substrates IKZF1 and IKZF3. -
FKBP12F36V Degrader
dTAG-47 is a heterobifunctional degrader that selectively targets FKBP12^F36V-tagged proteins for degradation. By binding FKBP12^F36V, which acts as a degradation tag (dTAG), dTAG-47 enables conditional and selective protein degradation. It is a valuable tool for studying protein function in models such as basal-like breast cancer (BBC). -
PROTAC CDK4/6 Degrader
BSJ-03-204 triTFA is a potent and selective PROTAC degrader targeting CDK4/6, constructed using ligands for cereblon and CDK. Based on Palbociclib, it exhibits IC₅₀ values of 26.9 nM for CDK4/D1 and 10.4 nM for CDK6/D1. BSJ-03-204 triTFA does not induce IKZF1/3 degradation and shows anti-cancer activity, making it a valuable tool for cell cycle and oncology research. -
FKBP12F36V degrader
dTAGV-1 TFA is a potent and selective degrader of FKBP12^F36V-tagged fusion proteins. It enables efficient in vivo degradation of FKBP12^F36V-Nluc, making it a valuable tool for conditional protein degradation studies in live models. -
PROTAC CDK4 Degrader
BSJ-04-132 is a potent and selective Ribociclib-based PROTAC degrader targeting CDK4, constructed using ligands for cereblon and CDK. It exhibits IC₅₀ values of 50.6 nM for CDK4/D1 and 30 nM for CDK6/D1, while sparing CDK6 and IKZF1/3 from degradation. BSJ-04-132 demonstrates anti-cancer activity and is a valuable tool for cell cycle and oncology research. -
PROTAC CDK4/6 Degrader
BSJ-03-204 is a potent and selective PROTAC degrader targeting CDK4 and CDK6, constructed by linking Palbociclib to a cereblon ligand. It exhibits IC₅₀ values of 26.9 nM for CDK4/D1 and 10.4 nM for CDK6/D1, without inducing degradation of IKZF1 or IKZF3. BSJ-03-204 demonstrates strong anti-cancer activity and is a valuable tool for cell cycle and oncology research. -
FKBP12F36V degrader
dTAG-13 is a PROTAC-based heterobifunctional degrader that selectively targets FKBP12^F36V fused in-frame to a protein of interest. By engaging both FKBP12^F36V and the cereblon (CRBN) E3 ligase, dTAG-13 induces efficient and selective degradation of FKBP12^F36V-tagged proteins, making it a valuable tool for conditional protein knockdown studies. -
TLR-3 Agonist
Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic analog of double-stranded RNA that serves as an agonist for toll-like receptor 3 (TLR3) and RIG-I-like receptors, including RIG-I and MDA5. This compound enhances both innate and adaptive immune responses, making it valuable in vaccine development as an adjuvant. Additionally, Poly(I:C) influences the tumor microenvironment and can directly induce apoptosis in cancer cells, highlighting its potential applications in cancer immunotherapy and research. -
FAP Inhibitor
FAPI-4 is a potent inhibitor of fibroblast activation protein (FAP), targeting FAP with high specificity. This compound demonstrates significant potential in cancer research, particularly in improving diagnostic imaging. The use of 68Ga-FAPI-4 in PET/CT scans offers enhanced tumor-to-background contrast ratios, making it an effective tool for visualizing various types of tumors. -
IKAROS Protein Degrader
MGD-28 is a potent IKAROS protein degrader that functions through Cereblon (CRBN)-dependent mechanisms. It effectively degrades IKZF1 (DC50=3.8 nM), IKZF2 (DC50=56.3 nM), and IKZF3 (DC50=7.1 nM), along with CK1α (DC50=7.8 nM), in a dose-dependent manner. MGD-28 exhibits significant antiproliferative activity, making it a valuable tool for research in multiple myeloma and related hematological malignancies. -
PROTAC STING Degrader
PROTAC STING Degrader-1 is a PROTAC degrader designed to target the STING (Stimulator of Interferon Genes) pathway, demonstrating a DC50 value of 3.2 μM. It exhibits pronounced anti-inflammatory effects, making it a valuable tool for investigating conditions such as acute kidney injury and inflammatory bowel diseases (IBDs). This compound can facilitate research into STING-mediated signaling and its role in various inflammatory processes. -
BLC6 PROTAC Degrader
ARV-393 is a potent BCL6 PROTAC degrader that facilitates the ubiquitination and subsequent proteasomal degradation of BCL6. This compound exhibits significant biological activity and is particularly relevant for research focused on advanced non-Hodgkin lymphoma. Its ability to modulate protein levels through targeted degradation makes it a valuable tool for elucidating BCL6-related pathways in cancer biology. -
PROTAC PD-1/PD-L1 Degrader
PROTAC PD-1/PD-L1 degrader-1 is a bifunctional degrader that targets the PD-1/PD-L1 immune checkpoint interaction by utilizing a Cereblon E3 ligase ligand. It demonstrates potent inhibitory activity with an IC50 of 39.2 nM, effectively restoring immune function in co-culture models involving liver cancer cells and CD3 T cells. Additionally, this compound reduces PD-L1 protein levels through a lysosome-dependent degradation pathway, making it a valuable tool for research in cancer immunotherapy and immune modulation. -
PROTAC FKBP12 Degrader
FKBP12 PROTAC RC32 is a targeted protein degrader utilizing PROTAC technology to selectively degrade FKBP12. This compound combines Rapamycin, a well-characterized immunosuppressant, with a Cereblon E3 ubiquitin ligase ligand derived from Pomalidomide, facilitating the ubiquitination and subsequent proteasomal degradation of FKBP12. It serves as an important tool in research applications aimed at investigating the modulation of protein levels and the functional consequences of targeted degradation in various biological contexts. -
FKBP12F36V PROTAC Degrader
dTAGV-1 hydrochloride is a highly selective degrader targeting FKBP12F36V-tagged proteins through the PROTAC mechanism. This compound effectively induces the degradation of FKBP12F36V-Nluc in vivo, making it a valuable tool for studies involving targeted protein degradation. Its application in research facilitates the investigation of protein function, dynamics, and the development of therapies that exploit the proteolysis pathway. -
Nrf2 Degrader
Nrf2 Degrader 1 is a potent PROTAC that targets and degrades Nrf2, a key regulator of antioxidant response and cell survival. This compound demonstrates significant anticancer activity, effectively inhibiting the growth of A549 and LK-2 cancer cell lines with IC50 values of 100 nM and 40 nM, respectively. It is a valuable tool for studying the role of Nrf2 in cancer biology and has potential applications in therapeutic development. -
PROTAC FKBP12 Degrader
KB02-SLF is a PROTAC-based nuclear FKBP12 degrader designed to facilitate targeted protein degradation. It achieves this by covalently modifying DCAF16, an E3 ligase, thereby enhancing the stability of FKBP12 degradation within biological systems. The compound consists of a molecular glue linking the ubiquitin E3 ligase ligand KB02 with SLF, enabling efficient degradation of FKBP12 for various research applications in protein regulation and degradation pathways. -
Endogenous Metabolite
Ergothioneine is an endogenous metabolite that acts as a potent antioxidant. It functions primarily as a specific inhibitor of p38 MAPK and Akt, which are critical signaling pathways involved in cellular stress responses. Ergothioneine is utilized in research focused on neuroprotection, cell apoptosis, and oxidative stress, making it a valuable compound for investigations into cellular resilience and health. -
Rab27a-JFC1 Inhibitor
Nexinhib20 is a selective inhibitor of the Rab27a-JFC1 interaction (IC50: 2.6 μM) and Rac-1-GTP signaling. This compound effectively inhibits neutrophil exocytosis, adhesion, and β2 integrin activation, demonstrating significant anti-inflammatory properties. Nexinhib20 is suitable for research applications focused on systemic inflammation and myocardial ischemia-reperfusion injury. -
FKBP12(F36V) Inhibitor
dTAGV-1-NEG is a diastereomer that acts as a heterobifunctional negative control for dTAGV-1, specifically targeted at FKBP12(F36V). This compound is utilized in research to study the selectivity and efficacy of FKBP12(F36V) degraders, helping to elucidate cellular mechanisms and pathways influenced by FKBP12 modulation. Its role as a control reagent makes it essential for validating experimental results in protein degradation studies. -
PROTAC CSK Degrader
DB-3-291 is a potent and selective PROTAC degrader targeting the protein CSK, exhibiting a Kd of 1 nM. This compound facilitates the degradation of CSK through its specific interaction with the E3 ligase, enabling in-depth studies of CSK-related biological pathways and providing insights into potential therapeutic strategies. It is valuable for researchers investigating targeted protein degradation and cancer biology. -
Kinases PROTAC
DB1113 is a bifunctional compound designed for targeted protein degradation of various kinases. It effectively induces degradation of ABL1, ABL2, BLK, CDK4, CDK11B, EPHA3, MAPK7, RIPK1, and others, facilitating the investigation of kinase-related signaling pathways. DB1113 is suitable for research focusing on diseases or disorders associated with dysregulated kinase activity, providing a valuable tool for exploring therapeutic interventions in cancer and other conditions. -
dTAG-13 Negative Control
dTAG-13-NEG serves as a negative control for dTAG-13, a PROTAC-based bifunctional degrader that selectively targets FKBP12F36V in the presence of a protein of interest. While dTAG-13 promotes the degradation of FKBP12F36V, dTAG-13-NEG allows for the assessment of specificity and background in experimental setups involving this pathway. This compound is essential for validating experimental results when studying protein degradation mechanisms and their implications in cellular biology. -
PROTAC FKBP Degrader
PROTAC FKBP Degrader-3 is a proteolysis-targeting chimera that utilizes a FKBP ligand binding group and a von Hippel-Lindau (VHL) E3 ligase recruiting moiety linked by a flexible linker. This compound effectively induces the degradation of FKBP12, demonstrating potent biological activity in targeted protein degradation. It is primarily used in research applications related to protein homeostasis, cellular signaling mechanisms, and therapeutic development strategies for modulating protein levels. -
ROS Probe
Lucigenin is a chemiluminescence probe primarily utilized for the detection of the endogenous superoxide anion radical (O2-). This compound exhibits high sensitivity and can also function as a chloride indicator, as its fluorescence is quenched in the presence of chloride ions. With excitation and emission wavelengths of 455 nm and 505 nm, respectively, Lucigenin serves as a valuable tool in studies involving reactive oxygen species and chloride ion interactions. -
Fluorescent Probe
2′,7′-Dichlorofluorescein diacetate (DCFH2-DA) is a cell-permeable fluorescent probe utilized for the detection of reactive oxygen species (ROS). It becomes fluorescent upon cleavage by intracellular esterases and subsequent oxidation, allowing for the assessment of oxidative stress levels in biological systems. This reagent is essential for studies in toxicology and cellular signaling, enabling researchers to monitor and evaluate oxidative phenomena in various experimental contexts. -
Alkaloid
Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine (Natural Yellow 18) has antineoplastic properties.
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NO Synthase Inhibitor
L-NAME hydrochloride inhibits NOS with an IC50 of 70 μM. L-NAME is a precursor to NOS inhibitor L-NOARG which has an IC50 value of 1.4 μM. -
NLRP3 Activator
Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes. Nigericin is a NLRP3 activator. Nigericin shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin induces pyroptosis through caspase 1/GSDMD in TNBC. -
Iron Chelator
Deferoxamine (Deferoxamine B) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine upregulates HIF-1α levels with good antioxidant activity. Deferoxamine also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19. -
Endogenous Metabolite
ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. ATP can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP has anti-bacterial infection effects and can protect mice against bacterial infection in mice. -
Anticancer Agent
(+)-Erinacin A (Erinacine A) is a cyanoditerpenoid isolated from Hericium erinaceus with anticancer, anti-inflammatory and neuroprotective activities. (+)-Erinacin A can induce cancer cell death by activating extrinsic and intrinsic apoptosis pathways. (+)-Erinacin A can also inhibit the expression of NO synthase (iNOS) and the production of nitrotyrosine to exert inflammatory and neuroprotective effects, thereby reducing ischemic brain damage. -
Mitochondrial ROS Indicator
MitoSOX Red is a live cell fluorescent probe that specifically targets mitochondria and is cell membrane permeable. MitoSOX Red enters mitochondria and is oxidized by superoxide but not by other ROS or RNS generating systems. The oxidized MitoSOX Red then binds to nucleic acids in mitochondria/nucleus, producing strong red fluorescence. MitoSOX Red can be used as a fluorescent indicator to specifically detect superoxide. In addition, superoxide dismutase (SOD) can prevent the oxidation of MitoSOX Red. Excitation/emission wavelength: 510/580 nm. -
Cyanotoxin
Cylindrospermopsin, a cyanotoxin, is a polycyclic uracil derivative containing guanidine and sulfate groups, which can inhibit protein synthesis and covalently modify DNA or RNA. Cylindrospermopsin induces hepatocellular hypertrophy, renal cellular hypertrophy, intracellular reactive oxygen species (ROS), DNA strand breaks, mitochondrial hyperpolarisation, ultrastructural damage, and altered gene expression in liver, kidney, and intestinal cells. Cylindrospermopsin can be used in research including hepatocellular carcinoma and water quality testing. -
PDE Inhibitor
Theophylline, a potent phosphodiesterase (PDE) inhibitor, primarily targets PDE3, leading to relaxation of airway smooth muscle and enhanced bronchodilation. This compound also functions as an adenosine receptor antagonist and exhibits anti-inflammatory properties by elevating IL-10 levels and inhibiting NF-κB translocation into the nucleus. Additionally, Theophylline has been shown to induce apoptosis in certain cell types. Its applications are particularly relevant in the research of asthma and chronic obstructive pulmonary disease (COPD). -
Topoisomerase IV Inhibitor
Ciprofloxacin is a potent topoisomerase IV inhibitor that demonstrates significant antibacterial activity as a fluoroquinolone antibiotic. It induces both mitochondrial and nuclear DNA damage, leading to mitochondrial dysfunction and increased reactive oxygen species (ROS) production. Ciprofloxacin exhibits anti-proliferative properties and triggers apoptotic pathways, making it a valuable tool for research applications focused on bacterial infections, oxidative stress, and cancer biology. -
Antiviral Agent
Dendrobine is an alkaloid derived from Dendrobium nobile, primarily targeting viral infections as an antiviral agent. It demonstrates significant antiviral activity against influenza A viruses, exhibiting IC50 values of 3.39 μM, 2.16 μM, and 5.32 μM for strains A/FM-1/1/47 (H1N1), A/Puerto Rico/8/34 H274Y (H1N1), and A/Aichi/2/68 (H3N2), respectively. Additionally, Dendrobine activates the JNK/p38/Nrf2 signaling pathway and possesses various biological properties, including antitumor, anti-inflammatory, and neuroprotective effects, making it valuable in diverse research applications. -
AMPK Agonist
10-Gingerol is an AMPK agonist derived from ginger oleoresin, exhibiting notable anti-inflammatory, antioxidant, and anti-proliferative properties. It effectively suppresses neointimal hyperplasia and inhibits the proliferation of vascular smooth muscle cells. Demonstrating significant radical scavenging activities, 10-Gingerol has IC50 values of 10.47 μM against DPPH, 1.68 μM against superoxide, and 1.35 μM against hydroxyl radicals. This compound also inhibits MDA-MB-231 tumor cell line proliferation with an IC50 of 12.1 μM, while targeting the PI3K/Akt signaling pathway to suppress proliferation, migration, invasion, and promote apoptosis. It holds potential for research applications in ulcerative colitis. -
TNF Receptor Inhibitor
Muscone, a TNF receptor inhibitor, is derived from the traditional Chinese medicine musk. It effectively inhibits NF-κB signaling and NLRP3 inflammasome activation, resulting in a significant reduction of inflammatory cytokines such as IL-1β, TNF-α, and IL-6. This compound is valuable in research focused on inflammation, cardiac function restoration, and improving survival rates in various pathological conditions. -
Anti-Inflammatory/Antibacterial Agent
(20R)-Protopanaxadiol acts as an anti-inflammatory and antibacterial agent, derived from ginsenosides. It effectively exhibits anti-inflammatory properties while maintaining a lack of significant cytotoxicity against tumor cell lines. Additionally, (20R)-Protopanaxadiol has been shown to inhibit the uptake of 2-deoxy-D-glucose (2-DG), making it relevant for research applications focusing on metabolic pathways and the modulation of inflammatory processes. -
IL-1 Inhibitor
Diacerein is a potent IL-1 inhibitor that functions by reducing the production of IL-1 converting enzyme, thereby inhibiting the activation of IL-1β and its downstream signaling pathways. This compound exhibits significant anti-inflammatory and anti-rheumatic properties, making it useful for various research applications, including studies on osteoarthritis and the management of bronchospasm and airway inflammation in asthmatic models. Diacerein is recognized as a slow-acting drug for symptomatic relief of osteoarthritis, facilitating insights into long-term therapeutic strategies. -
Bacterial Inhibitor
Lactobionic acid is a bionic acid that functions as a bacterial inhibitor, comprising gluconic acid and galactose. It exhibits potent antimicrobial and antioxidant properties, making it valuable in research related to food safety and microbiology. Lactobionic acid is effective against food-borne pathogens and has been shown to inhibit DNA repair, protein synthesis, and key metabolic pathways in methicillin-resistant Staphylococcus aureus (MRSA). Its applications extend to developing new functional products and enhancing food preservation. -
Histamine H1 Receptor Antagonist
Epinastine is a selective histamine H1 receptor antagonist, known for its effectiveness as a mast cell stabilizer. It exhibits high affinity for neuronal octopamine receptors in various insects, demonstrating potential roles in modulating immune responses. Epinastine also inhibits pro-inflammatory cytokines such as TARC, IL-8, and IL-4, making it valuable for research into allergic diseases and anti-cancer immunity mechanisms. Its ability to reduce scratching behavior and vascular permeability further underscores its relevance in studying allergic and inflammatory conditions. -
ROS Probe
HKOH-1 is a sensitive green fluorescent probe designed for the selective detection of hydroxyl radicals (·OH) in living cells, utilizing a maximum excitation wavelength of 500 nm and an emission wavelength of 520 nm. This reagent enables researchers to monitor oxidative stress and assess cellular responses to reactive oxygen species. Its application is critical in studies related to redox biology, neurodegenerative diseases, and cancer research. -
Cell Permeant Tracer
5(6)-Carboxy-2',7'-dichlorofluorescein diacetate is a cell-permeant fluorescent indicator that targets reactive oxygen species (ROS) within cells. This reagent is particularly useful for monitoring ROS generation in human neuronal-glial (HNG) cells during primary co-culture experiments. Its ability to penetrate cellular membranes makes it a valuable tool for evaluating oxidative stress and related biological processes. -
H2O2 Fluorescent Probe
HKPerox-2 is a highly sensitive fluorescent probe specifically designed for the detection of hydrogen peroxide (H2O2) in live cells. It exhibits peak excitation and emission wavelengths at 520 nm and 543 nm, respectively, making it suitable for fluorescence microscopy applications. This reagent can be utilized to study oxidative stress and cellular signaling involving reactive oxygen species, enabling insights into various biological processes and disease mechanisms. -
Oxidized Fluorescent Product
2',7'-Dichlorofluorescein is a potent fluorescent probe primarily used for the detection of oxidative stress by quantifying reactive oxygen species (ROS) levels. It exhibits excitation and emission maxima at 503 nm and 523 nm, respectively. This compound is essential for applications in cellular biology and biochemistry, enabling researchers to study oxidative damage and its effects on biological systems. -
OH Indicator
HKOH-1r is a highly sensitive green fluorescent probe designed for the selective detection of hydroxyl radicals (·OH) in living cells. It exhibits excitation and emission maxima at 500 nm and 520 nm, respectively, facilitating real-time visualization of oxidative stress. This reagent is applicable in various research settings, including studies focused on cellular redox status and oxidative damage pathways. -
Fluoregenic Peroxide Reactive Probe
Diphenyl-1-pyrenylphosphine (DPPP) serves as a fluoregenic peroxide-reactive probe, facilitating the detection of reactive oxygen species. This compound exhibits a distinctive phototriggered aggregation-induced emission (AIE) and aggregation-induced quenching (ACQ) transition, showcasing significant alterations in its third-order nonlinear optical signals. DPPP is ideal for research applications involving oxidative stress and the study of ROS-related biological processes.
