NOD-like Receptor (NLR)

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  1. NLRP3 inflammasome inhibitor

    Isoliquiritigenin is a licorice chalconoid, a type of natural phenols that is currently under experimentation phase testing for use as a cancer treatment as well as an aide for cocaine addiction.
  2. Mifamurtide is a liposomal formulation containing a muramyl dipeptide (MDP) analogue with potential immunomodulatory and antineoplastic activities
  3. NOD-like receptors inhibitor

    NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors, NOD1 and NOD2, with IC50 of 5.74 μM and 6.45 μM, respectively.
  4. NLRP3 inhibitor

    MCC950 sodium is a potent NLRP3 inflammasome inhibitor that inhibits IL-1beta production with IC50 value of 7.5 nm.
  5. NOD1 inhibitor

    Nodinitib-1 (ML130;CID-1088438) is a NOD1 inhibitor with an IC50 of 0.56 μM.
  6. NLRP3 inhibitor

    CY-09 is a NLRP3 inhibitor with Kd value of 500 nM. It directly binds to ATP-binding motif of NLRP3 NACHT domain.
  7. NLRP3 inhibitor

    INF39 is an irreversible and noncytotoxic NLRP3 inhibitor.
  8. NLRP3 activator

    Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore, a NLRP3 activator.
  9. Arglabin is a sesquiterpene gamma-lactone is isolated from Artemisia glabella; anticancer natural compound.
  10. NLRP3 inhibitor

    MCC950 (CP-456773, CRID3) is a potent and selective inhibitor of NLRP3 (NOD-like receptor (NLR) family, pyrin domain-containing protein 3) with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively.

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