IL Receptor

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  1. Suplatast Tosilate is a novel capsular anti-asthmatic agent that suppresses both IgE production, IL-4 and IL-5 synthesis with IC50 above 100 μM.
  2. IRAK modulator

    IRAK inhibitor 3 is an interleukin-1 (IL-I) receptor-associated kinase (IRAK) kinase modulator extracted from patent WO2008030579 A2.
  3. IL-17 inhibitor

    Y320 is an orally active immunomodulator, and inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 nM.
  4. gp130 inhibitor

    SC-144 is an orally active small-molecule gp130 inhibitor.
  5. IL-12/IL-23 inhibitor

    Apilimod is a potent IL-12/IL-23 inhibitor, IL-12 production in cultures of IFN-r/LPS?Cstimulated human PBMCs is strongly inhibited by STA-5326 with an IC50 of 10 nM.
  6. T cell activator

    beta-Interleukin I (163-171), human, a peptide. Interleukins are a group of cytokines (secreted proteins/signaling molecules) that were first seen to be expressed by white blood cells (leukocytes).
  7. interleukin-5 receptor antagonist

    YM-90709 is an interleukin-5 receptor antagonist. YM-90709 inhibits the binding of IL-5 to its receptor on peripheral human eosinophils and butyric acid-treated eosinophilic HL-60 clone 15 cells, with IC50 values of 1.0 and 0.57 microM, respectively.
  8. IL-12/23 inhibitor

    APY0201 is a potent and selective IL-12/23 inhibitor.
  9. IL-1 inhibitor

    AS101, a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.
  10. IL-1 receptor antagonist

    AF 12198 is a potent and selective antagonist for the human type I interleukin-1 (IL-1) receptor.
  11. Neuroinflammation inhibitor

    GIBH-130 is an effective inhibitor of neuroinflammation. GIBH-130 significantly suppresses the IL-1β secretion by activated microglia (IC50=3.4 nM).
  12. IL-2 inhibitor

    SU5201 is an inhibitor of interleukin-2 (IL-2) production.

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