Catalog No.
Product Name
Application
Product Information
Citations
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Anti-inflammatory Agent
17(R)-Resolvin D1 methyl ester serves as a potent anti-inflammatory agent, derived from Aspirin-induced Resolvin D1. This compound is known to regulate the transendothelial migration of human polymorphonuclear leukocytes, displaying significant efficacy with an EC50 of approximately 30 nM for inhibiting neutrophil migration. Its stability as the 17R-trihydroxy-4Z form enhances its utility in inflammation research and therapeutic applications. -
PGE1 Metabolite
13,14-Dihydro PGE1 is a significant metabolite of Prostaglandin E1 (PGE1) that functions as a potent inhibitor of ADP-induced platelet aggregation, with an ID50 of 10.8 ng/mL in platelet-rich plasma. This compound is primarily utilized in research regarding cardiovascular health and platelet function. Its mechanism of action makes it valuable for studies focused on thrombotic disorders and the modulation of vascular responses. -
Non-Steroidal Antiinflammatory Agent
Diflumidone sodium is a non-steroidal anti-inflammatory agent that primarily targets the COX enzyme pathway. This compound exhibits potent anti-inflammatory activity and is utilized in various research applications aimed at understanding inflammatory processes and developing therapeutic strategies for inflammatory diseases. Its ability to modulate inflammation makes it a valuable tool in pharmacological studies and drug development. -
Anti-inflammatory Agent
Tixocortol pivalate is a corticosteroid that functions primarily as an anti-inflammatory agent. It exhibits significant anti-inflammatory properties, making it useful in the research of inflammatory conditions and disorders. This compound is typically employed in studies aimed at understanding the mechanisms of corticosteroids in therapeutic applications. -
Nrf2 Pathway Activator
Pyrraline is an Nrf2 pathway activator that enhances antioxidant defenses and mitigates inflammation. It promotes the upregulation of antioxidant enzymes, including NAD(P)H dehydrogenase (NQO1) and heme oxygenase-1 (HO-1), through the activation of the antioxidant response element (ARE), while also inhibiting NFκB-mediated inflammatory pathways. This compound holds significant potential for investigations into metabolic disorders, such as diabetic nephropathy, as well as various cancer research applications. -
Endogenous Metabolite
p60 (217–225) is a subdominant epitope derived from Listeria monocytogenes, recognized by H-2Kd MHC class I molecules. This peptide plays a crucial role in the immune response to Listeria infection, facilitating T cell recognition and activation. p60 (217–225) is essential for studying antigen presentation and T cell immunity in infectious disease research and vaccine development. -
PROTAC IKZF1/IKZF3 Degrader
(Rac)-Cemsidomide is a PROTAC degrader targeting IKZF1 and IKZF3, exhibiting potent antitumor activity through its molecular glue mechanism. This compound demonstrates a GI50 of 0.05 nM in NCIH929.1 cells, making it a valuable tool for research applications focused on the degradation of Ikaros and Aiolos proteins. Its unique properties facilitate investigations into mechanisms of action related to targeted protein degradation in cancer therapies. -
Molecular Glue
Acetyl-cyclosporin A aldehyde is a derivative of Cyclosporin A featuring an acetyl group and a reducing aldehyde moiety. This compound serves as a molecular glue by effectively inhibiting calmodulin and binding to cyclophilin, which can influence the nuclear translocation of NF-AT and may lead to mitochondrial damage. Its unique properties make it valuable for research applications aimed at understanding calcium signaling pathways and mitochondrial dynamics in various biological contexts. -
Covalent Ligand
EN171 is a covalent ligand that selectively modifies cysteine residues C38 and C96 on the 14-3-3 protein, thereby promoting its interactions with estrogen receptor α (ERα), YAP, and TAZ. This modulation leads to a reduction in transcriptional activity associated with both estrogen signaling and the Hippo pathway. EN171 serves as a molecular glue, enhancing native protein interactions, and acts as a covalent recruiter of 14-3-3 in heterobifunctional applications, facilitating the cytosolic sequestering of nuclear neo-substrates such as BRD4 and BCL6. -
PROTAC Linker
tert-Butyl 6-aminocaproate is a PROTAC linker that facilitates the development of targeted protein degraders. This compound plays a crucial role in the synthesis of PROTAC CARM1/IKZF3 degrader-1, enabling selective degradation of target proteins. Its utility in chemical research supports the exploration of innovative therapeutic strategies through targeted protein modulation. -
Anti-inflammatory Agent
BI-L-45 XX is an orally active anti-inflammatory agent that targets and inhibits the release of neutrophil enzymes as well as chemotaxis. This compound is particularly useful for investigating mechanisms underlying adjuvant-induced arthritis and other inflammatory conditions. Its ability to modulate neutrophil activity makes it a valuable tool in the study of inflammatory pathways. -
TRP-2 Derived Peptide
Tyrosinase-related Protein 2 (TRP-2) (181-188) is a peptide derived from tyrosinase-related protein 2, corresponding to residues 181-188. This peptide contains the primary reactive epitope recognized by anti-B16 cytotoxic T lymphocytes (CTLs) and is designed to conform to the MHC class I H2-Kb binding motif. TRP-2 (181-188) is essential for studies in immunology and cancer research, particularly in the context of melanoma and anti-tumor immune responses. -
Anti-inflammatory agents
2-Hydroxy-4-methoxybenzoic acid potassium primarily functions as an anti-inflammatory agent. As a significant phytoconstituent derived from Decalepis arayalpathra, it exhibits a range of biological activities, including anti-inflammatory, antipyretic, antioxidant, and anti-diabetic effects. This compound is valuable for researchers investigating mechanisms of inflammation and related metabolic disorders. Its diverse pharmacological potential makes it a useful tool in therapeutic studies and drug development. -
Anti-inflammatory Compound
2′-Hydroxydaidzein is an anti-inflammatory compound that acts as a metabolite. It effectively inhibits the release of chemical mediators from inflammatory cells and significantly reduces the secretion of lysozyme and β-glucuronidase from rat neutrophils stimulated with fMLP/CB. This reagent is valuable for research applications related to inflammation and immune response modulation. -
Anti-inflammatory compound
β-Amyrin is a natural triterpenoid compound that exhibits anti-inflammatory properties. It effectively mitigates amyloid β (Aβ)-induced impairments in long-term potentiation (LTP), making it a promising candidate for Alzheimer's disease research. Additionally, β-Amyrin demonstrates protective activity against pulmonary fibrosis and possesses notable antibacterial capabilities, supporting its potential applications in various areas of biological and medicinal research. -
G6PD Inhibitor
6-Aminonicotinamide is a competitive inhibitor of glucose-6-phosphate dehydrogenase (G6PD) with a Ki value of 0.46 μM. This powerful antimetabolite of nicotinamide induces ATP depletion, enhancing the efficacy of DNA-crosslinking chemotherapy agents such as Cisplatin. Its ability to modulate metabolic pathways makes it a valuable tool in cancer research and therapeutic applications. -
Nox2 Inhibitor
CPP11G is a selective inhibitor of NADPH oxidase 2 (Nox2), exhibiting an IC50 of 20 μM. This compound is valuable for the investigation of inflammatory diseases, such as vasculitis and atherosclerosis, as well as conditions characterized by Nox2 overactivation, including ischemia-reperfusion injury. Its potential applications in research can aid in understanding the role of Nox2 in various pathological processes. -
Nox Inhibitor
VAS2870 is a selective inhibitor of NADPH oxidase (NOX), primarily targeting NOX1 and NOX2 isoforms. This compound exhibits strong antioxidant properties and effectively reduces reactive oxygen species (ROS) production. VAS2870 is widely utilized in research related to oxidative stress, inflammation, and various pathological conditions associated with NOX activity. -
NOX1/4 Inhibitor
GKT136901 is a selective and orally active inhibitor of NADPH oxidases NOX1 and NOX4, exhibiting inhibition constants (Kis) of 160 nM and 165 nM, respectively. This compound also serves as a direct scavenger of peroxynitrite, contributing to its anti-inflammatory properties. GKT136901 is particularly useful in research focused on diabetic nephropathy, stroke, and neurodegenerative diseases, providing valuable insights into oxidative stress-related pathologies. -
Nox1 Inhibitor
NoxA1ds is a selective inhibitor of NADPH oxidase 1 (NOX1), with an IC50 of 20 nM. It effectively inhibits NOX1-derived superoxide production in HT-29 human colon cancer cells. Additionally, NoxA1ds reduces VEGF-induced migration of human pulmonary artery endothelial cells under hypoxic conditions in vitro. This reagent is valuable for research into hypertension, atherosclerosis, and cancer biology. -
Nox Inhibitor
NADPH oxidase-IN-1 is an orally active inhibitor of NADPH oxidase (Nox), specifically targeting Nox2 and Nox4 with IC50 values of 1.9 μM and 2.47 μM, respectively. This compound is notable for its ability to penetrate the blood-brain barrier, making it relevant for studies involving neuronal inflammation. NADPH oxidase-IN-1 effectively suppresses the production of pro-inflammatory cytokines and inhibits LPS-mediated microglial migration, demonstrating promising in vivo efficacy for potential therapeutic applications in neuroinflammatory conditions. -
Capsaicinoid Analog
Nordihydrocapsaicin is a capsacinoid analog known for its pungent properties and oral bioactivity. This compound exhibits potential anti-cancer activities and is derived from both fresh and processed peppers. It may induce a burning sensation upon consumption, making it relevant for research in pain mechanisms and anti-tumor effects. -
NOX1/4 Inhibitor
GKT136901 hydrochloride is a highly selective and orally active inhibitor of NADPH oxidase isozymes NOX1 and NOX4, exhibiting inhibition constants of 160 nM and 165 nM, respectively. This compound also functions as a direct scavenger of peroxynitrite, enhancing its therapeutic potential. GKT136901 hydrochloride is primarily utilized in research settings focusing on diabetic nephropathy, stroke, and neurodegenerative diseases, while also demonstrating notable anti-inflammatory properties. -
Nox2/4 Inhibitor
GLX481304 is a selective inhibitor of Nox2 and Nox4, exhibiting an IC50 of 1.25 μM. This compound effectively suppresses reactive oxygen species (ROS) production in isolated mouse cardiomyocytes and enhances cardiac contractility. GLX481304 is applicable in research focused on ischemic heart injury, providing valuable insights into oxidative stress-related pathophysiology. -
NOX1 Inhibitor/ROS Inhibitor
Fluoflavine is a selective inhibitor of NOX1 and reactive oxygen species (ROS) production. This compound effectively reduces ROS levels, NOX1-mediated signaling pathways, and prevents retinal ganglion cell death induced by oxygen-glucose deprivation. In preclinical studies, Fluoflavine has demonstrated the ability to inhibit NADPH oxidase activity and mitigate pathological retinal neovascularization in models of oxygen-induced retinopathy. It is a valuable tool for investigating retinal ischemia-reperfusion injury and proliferative retinopathy. -
NOX2 Inhibitor
NOX2-IN-2 diTFA is a potent inhibitor of NOX2, specifically targeting the p47phox-p22phox protein-protein interaction with a Ki of 0.24 μM. This compound effectively inhibits reactive oxygen species (ROS) production derived from NOX2 in cellular environments. It is valuable for research applications focused on oxidative stress and related signaling pathways. -
Intermediate
8-Hydroxycoumarin is an important intermediate in the microbial transformation of quinolones. It serves as a valuable building block in organic synthesis and is utilized in research focusing on metabolic pathways of various compounds. Its unique structural properties enable exploration in pharmacology and biochemistry, facilitating the study of enzymatic processes and potential therapeutic agents. -
NADPH Oxidase Inhibitor
NOX2-IN-3 is a selective inhibitor of NADPH Oxidase 2 (NOX2). This compound has been shown to enhance the sensitivity of tumor cells to MRTX1133, indicating its potential role in cancer research. NOX2-IN-3 may be valuable for studies focused on oxidative stress and its implications in tumor biology. -
CBR1 Inhibitor
YF-Mo1 is a selective inhibitor of the carbonyl reductase 1 (CBR1), exhibiting an IC50 value of 1.1 μM. This compound demonstrates potential in modulating CBR1 activity, which is significant in metabolic processes and drug metabolism. YF-Mo1 is valuable for research exploring the role of CBR1 in various physiological and pathological conditions, offering insights into metabolic therapies and drug interactions. -
NOX5 Dehydrogenase Domain Binder
Saikosaponin bk1 is a specific binder for the dehydrogenase domain of NADPH oxidase 5 (NOX5), exhibiting hepatoprotective properties. It forms stable interactions with the NOX5 enzyme derived from Cylindrospermum stagnale, making it a valuable tool in studies of oxidative stress. This compound is particularly relevant in research focused on COVID-19 and alcoholic liver injury, contributing to the understanding of these conditions at a molecular level. -
NQO1 Inhibitor
N-Benzyl-N-demethylpronqodine A is an inhibitor of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), exhibiting an IC50 value of 83.3 nM. This compound plays a significant role in the study of redox biology and the mechanisms of cellular response to oxidative stress. Its application includes investigating the implications of NQO1 inhibition in various disease models, facilitating research in cancer biology and drug metabolism. -
NOX2 Inhibitor
NOX2-IN-2 is a potent inhibitor of NOX2, specifically targeting the p47phox-p22phox protein-protein interaction with a Ki of 0.24 μM. This compound effectively reduces reactive oxygen species (ROS) production mediated by NOX2 in cellular contexts. NOX2-IN-2 is ideal for research applications focused on oxidative stress, inflammation, and related signaling pathways. -
ALK Inhibitor
TSR-011-isomer is a potent anaplastic lymphoma kinase (ALK) inhibitor with an IC50 of 6 nM. This compound demonstrates significant biological activity by undergoing metabolic hydrolysis and NADPH-dependent metabolism, facilitating its clearance in biological systems. TSR-011-isomer is suitable for research focused on ALK-driven cancers, making it a valuable tool for studies in cancer biology and targeted therapy development. -
CBR1 Inhibitor
CBR1-IN-3 is a potent inhibitor of carbonyl reductase 1 (CBR1), exhibiting an IC50 value of 0.034 μM. This compound serves as a valuable research tool for studies focusing on the modulation of carbonyl metabolites in various biological systems. Its ability to effectively inhibit CBR1 makes it suitable for investigating the enzyme's role in drug metabolism and potential therapeutic applications. -
NADPH Oxidase Inhibitor
Diapocynin, a dimeric derivative of Apocynin, functions as a potent NADPH oxidase inhibitor. This compound exhibits significant anti-inflammatory, neuroprotective, and antioxidant activities, making it valuable for research into oxidative stress, neurodegenerative diseases, and inflammation-related conditions. Its oral bioavailability enhances its utility in various experimental settings aimed at understanding the role of reactive oxygen species in cellular processes. -
NOX2 Inhibitor
NOX2-IN-1 is a selective inhibitor of nicotinamide adenine dinucleotide phosphate oxidase isoform 2 (NOX2). It effectively disrupts the protein-protein interaction between p47phox and p22phox, demonstrating favorable binding affinities and significant cellular activity. This compound is valuable for research applications focusing on oxidative stress-related diseases and inflammation pathways. -
NOX1 Inhibitor
ML171 analog 1 is a selective inhibitor of NOX1, a member of the NADPH oxidase family implicated in various cellular processes. This compound exhibits significant biological activity in the modulation of reactive oxygen species, making it a valuable tool in cancer research. Its role in inhibiting NOX1 provides insights into oxidative stress related pathways in tumor biology. -
Thrombin Inhibitor
PPACK dihydrochloride is a potent and selective irreversible inhibitor of thrombin. It serves as an alternative anticoagulant to lithium heparin for blood gas and electrolyte analyses in whole blood. Additionally, PPACK dihydrochloride inhibits plasminogen activator (rt-PA), preventing its binding to plasma protease inhibitors. This compound also reduces plasmin-induced endothelial permeability and morphological changes in bovine aortic endothelial cell monolayers, making it suitable for investigations in thrombosis-related research. -
Anti-inflammatory Agent
Fendosal is a potent, orally active non-steroidal anti-inflammatory agent that primarily targets and inhibits Plasminogen activator inhibitor-1 (PAI-1). It demonstrates significant anti-inflammatory activity, making it a valuable tool for research in inflammatory disease models and therapeutic applications. Its dual action offers insights into conditions mediated by PAI-1, enhancing the understanding of inflammatory pathways and potential treatments. -
PPT1 Inhibitor
Ezurpimtrostat (hydrochloride) is a potent and selective PPT1 inhibitor with multiple biological activities. It disrupts lysosomal function, modulates autophagy, and induces apoptosis, making it a valuable tool in cancer research and immunology. This compound has demonstrated efficacy in reducing inflammatory markers such as IFN-α and CRP, as well as in lowering viral loads of SARS-CoV-2. Ezurpimtrostat is suitable for investigating conditions such as systemic lupus erythematosus, hepatocellular carcinoma, fibrosis, and other related disorders. -
Non-steroidal Antiinflammatory Agent
Protizinic acid is a non-steroidal anti-inflammatory agent that exerts its effects primarily through the inhibition of phospholipase A2 (PLA2) activity, with an IC50 value of 210 μM. This compound exhibits notable anti-inflammatory and antipyretic properties, making it a valuable tool in research focused on inflammatory processes and pain relief mechanisms. It is suitable for studies involving the modulation of inflammatory pathways. -
Anti-inflammatory Agent
BMS-188184 is a type II secretory phospholipase A2 (s-PLA2) inhibitor with an IC50 value of 17 µM. This compound exhibits significant anti-inflammatory activity, making it a valuable tool for studying various inflammatory conditions. It is particularly useful in research aimed at understanding the role of s-PLA2 in mediating inflammatory processes and potential therapeutic interventions. -
FAP Inhibitor
BR102910 is a selective inhibitor of fibroblast activation protein (FAP) with an IC50 of 2 nM. Additionally, BR102910 exhibits inhibition of prolyl oligopeptidase (PREP) with an IC50 of 49.00 μM. This compound is primarily used in research focusing on type 2 diabetes and related metabolic disorders, making it a valuable tool for exploring FAP's role in these conditions. -
Nrf2 Peptide
Nrf2 (69-84) is a peptide derived from the Nrf2 protein, featuring the essential ETGE motif critical for binding to the Kelch domain of the Keap1 protein. This peptide serves as a valuable tool for investigating the regulatory functions of Nrf2 in various biological processes, particularly in the context of cancer, neurodegenerative disorders, and inflammatory diseases. Its application aids in elucidating the mechanisms by which Nrf2 modulates cellular responses to oxidative stress and inflammation. -
Nrf2 Activator
Nrf2-Activator-12G is a potent activator of Nrf2, a critical transcription factor involved in cellular antioxidant defense mechanisms. This compound effectively induces the expression of Nrf2-dependent antioxidant enzymes at the mRNA and protein levels in dopaminergic neuronal cells. Nrf2-Activator-12G is applicable in research related to Parkinson's Disease, facilitating studies on oxidative stress and neuroprotection. -
Nrf2/ARE Pathway Activator
(R)-5-Hydroxy-1,7-diphenyl-3-heptanone is a diarylheptanoid that serves as an activator of the Nrf2/ARE signaling pathway. This compound demonstrates significant antioxidant properties, alleviating oxidative stress and improving insulin resistance. Its role in enhancing cellular defense mechanisms makes it valuable for research in metabolic disorders and oxidative stress-related conditions. -
Keap1-Nrf2 Activator
Dimethyl fumarate-d6 is a deuterium-labeled derivative of Dimethyl fumarate, functioning as a Keap1-Nrf2 pathway activator. This compound enhances the expression of antioxidant genes by stimulating the Nrf2 signaling pathway, thereby providing potential protective effects against oxidative stress. It is useful in research focused on oxidative stress, inflammation, and cellular response mechanisms. -
Anti-inflammatory Drug
Sanggenon A is an anti-inflammatory compound that modulates the NF-κB and HO-1/Nrf2 signaling pathways, demonstrating significant effects in BV2 and RAW264.7 cells. This reagent effectively inhibits the lipopolysaccharide (LPS)-induced production of nitric oxide, making it a valuable tool for research into inflammatory processes and potential therapeutic applications in inflammation-related diseases. -
Anticancer Agent
Tigloylgomisin H is a lignan that targets the induction of quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. This compound functions as a monofunctional inducer, specifically enhancing the expression of the phase II detoxification enzyme NQO1 via the NF-E2-related factor 2 (Nrf2)-ARE pathway. As a result, Tigloylgomisin H demonstrates potential as a preventive agent against liver cancer, making it valuable for cancer research applications. -
Keap1-Nrf2 Activator
LMDP10 is an orally active 3-amino quinazoline derivative that functions as a Keap1-Nrf2 activator. By binding to Keap1, LMDP10 disrupts the Keap1-Nrf2 interaction, leading to the activation of the Nrf2 pathway. This compound enhances the levels of Nrf2, superoxide dismutase (SOD), and glutathione (GSH), while decreasing malondialdehyde (MDA) and tumor necrosis factor-alpha (TNF-α) levels. LMDP10 exhibits potential in mitigating neurodegeneration and improving cognitive function in models of Alzheimer's disease, making it a valuable tool for research in neurodegenerative disorders.
