Catalog No.
Product Name
Application
Product Information
Citations
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5-LO/PGE2 Inhibitor
Canniprene is a potent inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase/microsomal prostaglandin E2 synthase (PGE2), with IC50 values of 0.4 μM and 10 μM, respectively. Derived from Cannabis sativa, Canniprene modifies the biosynthesis of inflammatory eicosanoids and prostaglandins, making it a valuable tool for researching inflammation and related pathways. Its unique mechanism of action positions Canniprene as a potential candidate for studying inflammatory diseases and therapeutic interventions targeting lipid mediators. -
PGE2 Inhibitor
Saikogenin D is an effective PGE2 inhibitor isolated from Bupleurum chinense. This compound exhibits significant anti-inflammatory properties by activating epoxygenases, leading to the conversion of arachidonic acid into epoxyeicosanoids and dihydroxyeicosatrienoic acids, which subsequently suppress PGE2 production. Saikogenin D also induces an increase in intracellular calcium levels ([Ca2+]i) through the release of Ca2+ from intracellular stores, making it a valuable tool for studying inflammatory pathways. -
COX-2 Inhibitor
Apricoxib is a selective inhibitor of cyclooxygenase-2 (COX-2), demonstrating a potent inhibitory effect on PGE2 production with an IC50 of 1.5 nM. This compound exhibits notable biological activities, including anticancer, analgesic, and anti-inflammatory properties. Apricoxib is a valuable tool for research applications focused on inflammation, pain management, and cancer therapeutics. -
PGE1 Analogue
SC 34301, an orally active PGE1 analogue, exhibits potent anti-inflammatory properties. It has been shown to significantly reduce bacterial translocation and enhance survival rates in burned mouse models. This compound is valuable for research applications focusing on inflammation, tissue repair, and the physiological effects of prostaglandin analogues. -
PGE2 Analog
Prostaglandin E2 Ethanolamide (PGE2-EA) is a biologically active analog of Prostaglandin E2, chiefly targeting the modulation of inflammatory responses. It is formed enzymatically through the COX-2-mediated oxygenation of endocannabinoids. PGE2-EA demonstrates the ability to influence the production of the pro-inflammatory cytokine TNF-α in human blood and monocytic cells, making it a valuable tool for research in inflammation and immunology. -
PGE2 Inhibitor
(+)-Oxypeucedanin methanolate is a potent inhibitor of prostaglandin E2 (PGE2) synthesis. This natural compound exhibits significant anti-inflammatory properties, making it a valuable reagent in studies focused on inflammation and pain modulation. Research applications include investigating the pathways of prostaglandin synthesis and exploring potential therapeutic interventions for inflammatory diseases. -
PGE2 Enantiomer
ent-Prostaglandin E2 (ent-PGE2) is an enantiomer of Prostaglandin E2 that serves as a poor substrate for 15-hydroxyprostaglandin dehydrogenase. This differential substrate activity can be leveraged in various biochemical studies to investigate the enzymatic pathways and regulatory mechanisms involving prostaglandins. Research applications include studying the physiological effects of PGE2 and the role of its enantiomers in inflammatory processes and cell signaling pathways. -
PGE1/PGE2 Metabolite
Tetranor-Prostaglandin E1 is a metabolite of Prostaglandin E1, resulting from β-oxidation processes. This compound serves as a crucial biomarker in studies related to prostaglandin metabolism and pathways. It is commonly utilized in research involving inflammatory responses and various physiological processes mediated by prostaglandins. -
PGE2 Precursor
Prostaglandin E2 isopropyl ester serves as a precursor for Prostaglandin E2 (PGE2). This compound is instrumental in various biological processes, including inflammation and modulation of immune responses. Researchers commonly utilize it in studies focused on prostaglandin synthesis and signaling pathways related to pain, edema, and cellular growth. Its role in mediating physiological functions makes it a valuable reagent for elucidating mechanisms in both basic and applied biomedical research. -
Nonsteroidal Anti-Inflammatory Agent
Amtolmetin guacil is a nonsteroidal anti-inflammatory agent that primarily targets cyclooxygenase (COX) to inhibit prostaglandin synthesis. It exhibits significant pain-relieving effects and has the added ability to stimulate capsaicin receptors in the gastrointestinal wall, promoting the release of gastroprotective nitric oxide (NO). This compound is particularly relevant for research focused on knee osteoarthritis and its associated inflammatory processes. -
PGE2 Antagonist
SC-42867 is a potent PGE2 antagonist, specifically designed to inhibit prostaglandin E2 signaling pathways. This compound is metabolized in the liver through mechanisms such as oxidative N-dealkylation and aromatic hydroxylation. SC-42867 is highly relevant for studies focused on metabolic conditions, allowing researchers to explore the biochemical implications of PGE2 modulation in various physiological processes. -
PGE2 Analogue
FCE 20700 is an orally active analogue of prostaglandin E2 (PGE2) that primarily targets gastric mucosal integrity. It demonstrates the ability to prevent gastric mucosal damage and inhibit both gastric acid and pepsin secretion. This compound is valuable for research into gastrointestinal ulcers and related disorders, providing insights into therapeutic strategies for gastrointestinal protection. -
NO/PGE2 Inhibitor
Salviifoside A is a phenolic glycoside that acts as an inhibitor of nitric oxide (NO) and prostaglandin E2 (PGE2) production. Isolated from the leaves of Alangium salviifolium, Salviifoside A effectively suppresses LPS-induced nitric oxide and prostaglandin E2 production in macrophages while maintaining cell viability. This compound is valuable for research focused on inflammatory responses and the modulation of macrophage activation. -
PGE2 Metabolite
13,14-Dihydro-15-keto-tetranor prostaglandin E2 is a novel metabolite of Prostaglandin E2, functioning primarily as a bioactive mediator in various physiological processes. As a key derivative, it is involved in studies exploring the metabolic pathways of prostaglandins and their implications in inflammation and other biological responses. This compound has significant applications in research focused on prostaglandin signaling and its role in disease mechanisms. -
PGE2 Analog
8-Iso-16-cyclohexyl-tetranor prostaglandin E2 is a PGE2 analog that exhibits potent biological activity by modulating various physiological processes. It engages the prostaglandin receptors, influencing pathways related to inflammation, pain, and vascular regulation. This compound is valuable for research applications focused on the roles of prostaglandins in disease models, as well as studies investigating receptor-targeted therapies. -
Anti-Inflammatory Agent
Diftalone, an anti-inflammatory agent, primarily targets inflammatory pathways to modulate immune responses. This compound is utilized in research investigating inflammatory diseases, including rheumatoid arthritis, and offers valuable insights into potential therapeutic approaches for managing such conditions. Its efficacy in reducing inflammation makes it a pivotal tool in the study of chronic inflammatory disorders. -
PGE1 Analog
15-Methylprostaglandin E1 is an analog of prostaglandin E1 (PGE1) that primarily targets prostaglandin receptors to elicit cardiovascular effects. It demonstrates a positive chronotropic effect, leading to increased heart rate and enhanced levels of nicardipine. This compound is widely utilized in studies related to circulatory system regulation and pharmacological investigations into heart rate modulation. -
Antiinflammatory Agent
4-Oxoetodolac, a metabolite of Etodolac, acts as an orally bioavailable anti-inflammatory agent. It effectively inhibits prostaglandin production in cultured chondrocyte cells, contributing to its anti-inflammatory properties. Additionally, 4-Oxoetodolac demonstrates moderate anti-inflammatory activity in a rat adjuvant edema model. This compound is useful for research focused on inflammation and related biological processes. -
PGE2 Analog
(15S)-15-Methylprostaglandin E2 is a synthetic analog of prostaglandin E2 that primarily targets the PGE2 receptor. This compound exhibits significant biological activity by promoting cytoprotection in gastrointestinal cells and may inhibit gastrointestinal bleeding. Its applications in research include studies on inflammation, gastrointestinal health, and the pharmacological roles of prostaglandins in various biological processes. -
PGE2 Inducer
5S(6R)-EET is a metabolite derived from arachidonic acid that acts as a potent inducer of prostaglandin E2 (PGE2) synthesis. This compound enhances intracellular calcium levels and inhibits sodium absorption, contributing to membrane depolarization. Its biological activity makes it a valuable tool for research focused on the regulatory roles of prostaglandins in various physiological processes. -
PGE2 Analog
16-Phenoxy tetranor Prostaglandin E2 is an analog of prostaglandin E2 (PGE2) that serves as a potent modulator of various biological processes. This compound exhibits significant biological activity by influencing the prostaglandin pathway, making it valuable for studying inflammatory responses and reproductive biology. Additionally, its role as a minor metabolite of sulprostone in human plasma provides insights into pharmacokinetics and metabolic pathways relevant to drug development and therapeutic applications. -
COX-2/PGE2 Inducer
Rebamipide-d4 is a deuterium-labeled derivative of Rebamipide, primarily targeting cyclooxygenase-2 (COX-2). This compound induces COX-2 expression and elevates prostaglandin E2 (PGE2) levels, thereby enhancing gastric mucosal defense mechanisms in a COX-2-dependent manner. Rebamipide-d4 is utilized in various research applications focused on gastric protection and the modulation of inflammatory responses. -
PGE2 Inducer
5R(6S)-EET is a metabolite derived from arachidonic acid that functions as a PGE2 inducer. It activates the synthesis of endogenous prostaglandin E2, leading to inhibition of sodium absorption, an increase in intracellular calcium levels, and enhanced depolarization of transmembrane voltage. This compound displays stereoselectivity, exhibiting differential activity compared to its stereoisomer, 5S(6R)-EET. Its biological effects make it a valuable tool for研究 applications focusing on prostaglandin signaling and related pathways. -
PGE1 Prodrug
Ecraprost is a prodrug of prostaglandin E1, designed to enhance the bioavailability of PGE1 in therapeutic applications. It effectively inhibits platelet adhesion and macrophage infiltration, as well as the expression of proliferating cell nuclear antigen in injured arterial walls. Ecraprost is utilized in research related to cardiovascular health and vascular injury repair. -
KRASG12C Inhibitor
KRASG12C IN-12 is a selective inhibitor of the KRASG12C mutant. This compound effectively forms a ternary complex with intracellular cyclophilin A (CYPA) and the activated KRASG12C, inhibiting its downstream signaling pathways. It has significant potential for research applications related to cancer biology, particularly in studies targeting KRAS-driven tumorigenesis. -
P2Y12 Receptor Activator
ADP-β-S trilithium is the trilithium salt form of ADP-β-S, serving as a potent activator of the P2Y12 receptor. It facilitates the upregulation of IL-1β and IL-6 production in microglial cells, promotes NF-κB phosphorylation and nuclear translocation, and enhances NLRP3 inflammasome activation. This reagent is valuable for research into inflammatory responses and signaling pathways involving P2Y12 receptor activation. -
GPR55 Agonist
O-1602 is a potent agonist of GPR55, a G protein-coupled receptor involved in various neuroinflammatory processes. It has been shown to reduce both the number and activation of hippocampal microglia triggered by methamphetamine exposure. Additionally, O-1602 decreases the expression of key proteins associated with the NLRP3 inflammasome, including NLRP3, ASC, and Caspase-1, making it a valuable tool for studies related to neuroinflammation and neurodegenerative disease research. -
NO Donor Agent
RIG 200 is an S-nitrosothiol nitric oxide (NO) donor that releases NO through decomposition, activating guanylate cyclase (sGCM) in vascular smooth muscle cells. This process increases cGMP levels, resulting in vasodilation. Additionally, RIG 200 significantly inhibits collagen-induced platelet aggregation in platelet-rich plasma (PRP), making it a valuable tool for research focused on thrombus prevention and cardiovascular studies. -
NO Donor
SE 175 is an organic nitrate compound that functions as a nitric oxide (NO) donor through the reductive conversion of its nitrate group. Its primary mechanism involves the stimulation of endothelial soluble guanylate cyclase, resulting in pronounced aortic vasorelaxation, with an EC50 value of 0.20 µM. This compound is valuable for research investigating vascular biology and cardiovascular function, particularly in studies related to NO-mediated signaling pathways. -
Anti-inflammatory Agent
11-Keto-beta-boswellic acid is a pentacyclic triterpenic acid derived from the oleogum resin of the Boswellia serrata tree, commonly known as Indian Frankincense. This compound exhibits significant anti-inflammatory activity through the inhibition of 5-lipoxygenase (5-LOX), which subsequently reduces leukotriene synthesis and attenuates nuclear factor-kappa B (NF-κB) activation, along with the production of tumor necrosis factor alpha. Due to its mechanism of action, 11-Keto-beta-boswellic acid is of interest in studies focused on inflammation-related conditions. -
FLAP Inhibitor
Fiboflapon sodium is a potent inhibitor of the 5-lipoxygenase-activating protein (FLAP) with a binding affinity of 2.9 nM. It has an IC50 value of 76 nM for the inhibition of leukotriene B4 (LTB4) in human blood. This compound is valuable in research applications focused on inflammation and related diseases by modulating leukotriene synthesis. Its oral bioavailability makes it suitable for in vivo studies investigating FLAP-related pathways. -
Selective FLAP Inhibitor
Veliflapon is a selective 5-lipoxygenase activating protein (FLAP) inhibitor. This compound effectively inhibits the synthesis of leukotrienes B4 and C4, thereby modulating inflammatory responses. Its primary application lies in research focused on asthma, allergies, and other inflammatory conditions, making it a valuable tool for studying leukotriene-mediated pathways. -
PA2/5-LOX/COX Inhibitor
LY256548 is a potent inhibitor of phospholipase A2, 5-lipoxygenase (5-LOX), and cyclooxygenase (COX), demonstrating significant anti-ischemic and anti-inflammatory properties. This compound effectively reduces leukotriene B4 production in response to A23187 stimulation. In preclinical models, LY256548 has shown efficacy in mitigating bone damage and paw swelling in rat models of Freund's complete adjuvant-induced arthritis (FCA), making it a valuable tool for research into inflammatory diseases and analgesic mechanisms. -
Leukotriene Receptor/FLAP Inhibitor
(S)-Veliflapon is a potent inhibitor of leukotriene biosynthesis targeting the 5-lipoxygenase activating protein (FLAP). It effectively inhibits the formation of leukotriene B4 (LTB4) in rat, mouse, and human leukocytes with IC50 values of 0.026 µM, 0.039 µM, and 0.22 µM, respectively. Additionally, (S)-Veliflapon demonstrates enantioselectivity in human whole blood, making it a valuable reagent for research in inflammation and related biological processes. -
Anti-inflammatory Agent
Mulberrofuran H is a 2-arylbenzofuran derived from the mulberry tree (Morus lhou (ser.) Koidz.), exhibiting significant anti-inflammatory properties. It effectively inhibits the enzymatic activity of L-tyrosine with an IC50 of 4.45 µM and L-DOPA with an IC50 of 19.70 µM. This compound is of interest in research applications focused on inflammation and oxidative stress, where it demonstrates potent antioxidative activity. -
Graft Protective Agent
N-Octanoyl dopamine is a graft protective agent that enhances contractile function in heart transplant recipients, particularly those from brain-dead donors. This compound functions by inhibiting cytokine production in activated T-cells, along with reducing MHC class II expression and adhesion molecules in interferon-gamma-stimulated endothelial cells. Its unique properties support research into transplant immunology and cardiac preservation. -
Anti-inflammatory agent
Pinolenic acid is a polyunsaturated fatty acid derived from the seed oils of Pinus orientalis and Pinus pinaster, primarily recognized for its anti-inflammatory properties. It has demonstrated significant lipid-lowering activities, making it valuable in research related to metabolic disorders and inflammation-related conditions. This compound serves as an important tool for exploring therapeutic interventions aimed at managing inflammatory responses and improving lipid profiles. -
TGR5 Agonist
Cholic acid 7-sulfate is a selective agonist for the TGR5 receptor with an EC50 of 0.17 μM. This compound enhances GLP-1 secretion in enteroendocrine L cells, leading to improved glucose tolerance through TGR5 activation. Additionally, as an endogenous ligand for MHC class I-related protein (MR1), it supports the survival of mucosal-associated invariant T (MAIT) cells and influences their development and function by modulating homeostatic gene expression. Cholic acid 7-sulfate is valuable in studies related to diabetes and MAIT cell-mediated immune regulation. -
Stable Isotope
Cholic acid 7-sulfate-d4 is a deuterium-labeled derivative of cholic acid 7-sulfate, a selective agonist for the TGR5 receptor with an EC50 of 0.17 μM. This compound plays a crucial role in stimulating GLP-1 secretion and enhancing glucose tolerance through its action on enteroendocrine L cells. Additionally, cholic acid 7-sulfate-d4 serves as an endogenous ligand for MHC class I-related protein (MR1), influencing the development and function of mucosal-associated invariant T cells (MAIT). It is primarily utilized in research focused on diabetes and immune regulation related to MAIT cells. -
Anti-inflammatory Agent
EA-230 is a synthetic oligopeptide derived from beta-human chorionic gonadotropin (beta-hCG) lysates, serving as an anti-inflammatory agent. It exhibits significant anti-inflammatory properties, making it valuable for research focused on sepsis and related inflammatory conditions. EA-230 is useful in elucidating the mechanisms of inflammation and developing potential therapeutic strategies. -
Antiinflammatory Agent
Ibuprofen alcohol is a nonsteroidal anti-inflammatory agent (NSAID) that primarily functions by inhibiting cyclooxygenase enzymes, leading to a decrease in the synthesis of prostaglandins. It exhibits potent anti-inflammatory activity, making it useful in studies related to pain management and inflammation. This compound serves as a valuable tool in understanding the biochemical pathways involved in inflammatory responses. -
Anti-inflammatory Agent
Salnacedin is an anti-inflammatory agent that exhibits keratolytic activity. It has demonstrated efficacy in reducing inflammation, making it suitable for the study of conditions such as seborrhoeic dermatitis and acne. Researchers can utilize Salnacedin to investigate its therapeutic potential and underlying mechanisms in dermatological disorders. -
PGE1 Metabolite
13,14-Dihydro-15-keto-PGE1 is a metabolite of prostaglandin E1 (PGE1) that exhibits inhibitory effects on platelet aggregation. It has been shown to inhibit ADP-induced aggregation in human isolated platelet-rich plasma with an IC50 value of 14.8 μg/mL. This compound is useful in research applications focusing on thrombotic disorders and the role of prostaglandins in platelet function. -
Etoricoxib Metabolite
Etoricoxib N1'-oxide is a metabolite of Etoricoxib that serves as an important biochemical marker in pharmacological studies. This compound is notable for its lack of inhibition on both COX-1 and COX-2 enzymes, making it a valuable tool for researchers investigating the metabolic pathways and safety profiles of COX inhibitors. Its characterization can aid in understanding the pharmacodynamics and pharmacokinetics of Etoricoxib in clinical settings. -
Anti-inflammatory/Antioxidant
1-(4-Methoxyphenyl)-1-propanol is an orally active derivative of anethole, primarily exhibiting anti-inflammatory and antioxidant properties. It demonstrates significant antioxidant activity and has been shown to possess anti-inflammatory effects alongside moderate gastric protective activity in mouse models. This compound is useful for studying gastric ulcers and related gastrointestinal conditions in research applications. -
Anti-inflammatory Agent
Phochinenin K is a 9,10-dihydrophenanthrene derivative that demonstrates significant anti-inflammatory activity. Isolated from the rhizomes of Bletilla formosana, this compound is suitable for research applications focused on understanding the mechanisms of inflammatory diseases and developing therapeutic strategies. Its unique properties make it a valuable reagent for studying inflammation-related pathways. -
Antiinflammatory Agent
Aristololactam IIIa functions as an anti-inflammatory agent by effectively inhibiting superoxide anion generation and elastase release, demonstrating IC50 values of 0.12 and 0.20 μg/mL, respectively. This compound is valuable in research applications focused on oxidative stress and inflammatory responses, making it suitable for studying various inflammatory diseases. -
Endogenous Antiinflammatory Mediator
Resolvin E1 (RvE1) is an endogenous anti-inflammatory mediator derived from eicosapentaenoic acid (EPA). It plays a critical role in the resolution of inflammation by inhibiting polymorphonuclear leukocyte (PMN) transendothelial migration and reducing leukocyte infiltration. Additionally, RvE1 suppresses dendritic cell migration and interleukin-12 (IL-12) production, making it a valuable tool for studying inflammatory processes and potential therapeutic interventions in chronic inflammatory diseases. -
Anti-inflammatory Agent
Oxycinchophen functions as an anti-inflammatory agent, demonstrating significant uricosuric activity. It effectively displaces urate from albumin and displays a high affinity for the DNSA-binding site on the albumin molecule. This compound is suitable for research applications focused on inflammation and gout treatment mechanisms. -
Anti-inflammatory Agent
5-Hydroxy-8-methoxypsoralen, a metabolite of Xanthotoxin, functions as a potent anti-inflammatory agent through its inhibition of cytochrome P-450 enzymes. This compound is primarily utilized in the treatment of dermatological conditions such as psoriasis, eczema, and vitiligo, often in conjunction with phototherapy. Its biological activity supports ongoing research in skin inflammation and dermatological therapies.
