Catalog No.
Product Name
Application
Product Information
Citations
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PGE1 Metabolite
13,14-Dihydro PGE1 is a significant metabolite of Prostaglandin E1 (PGE1) that functions as a potent inhibitor of ADP-induced platelet aggregation, with an ID50 of 10.8 ng/mL in platelet-rich plasma. This compound is primarily utilized in research regarding cardiovascular health and platelet function. Its mechanism of action makes it valuable for studies focused on thrombotic disorders and the modulation of vascular responses. -
Non-Steroidal Antiinflammatory Agent
Diflumidone sodium is a non-steroidal anti-inflammatory agent that primarily targets the COX enzyme pathway. This compound exhibits potent anti-inflammatory activity and is utilized in various research applications aimed at understanding inflammatory processes and developing therapeutic strategies for inflammatory diseases. Its ability to modulate inflammation makes it a valuable tool in pharmacological studies and drug development. -
Anti-inflammatory Agent
Tixocortol pivalate is a corticosteroid that functions primarily as an anti-inflammatory agent. It exhibits significant anti-inflammatory properties, making it useful in the research of inflammatory conditions and disorders. This compound is typically employed in studies aimed at understanding the mechanisms of corticosteroids in therapeutic applications. -
Nrf2 Pathway Activator
Pyrraline is an Nrf2 pathway activator that enhances antioxidant defenses and mitigates inflammation. It promotes the upregulation of antioxidant enzymes, including NAD(P)H dehydrogenase (NQO1) and heme oxygenase-1 (HO-1), through the activation of the antioxidant response element (ARE), while also inhibiting NFκB-mediated inflammatory pathways. This compound holds significant potential for investigations into metabolic disorders, such as diabetic nephropathy, as well as various cancer research applications. -
Endogenous Metabolite
p60 (217–225) is a subdominant epitope derived from Listeria monocytogenes, recognized by H-2Kd MHC class I molecules. This peptide plays a crucial role in the immune response to Listeria infection, facilitating T cell recognition and activation. p60 (217–225) is essential for studying antigen presentation and T cell immunity in infectious disease research and vaccine development. -
Endogenous Metabolite
NC1153 is a Mannich base that targets and inhibits IL-2-induced JAK3 activation, subsequently preventing the activation of downstream substrates such as STAT5a/b. This compound has been shown to effectively extend the survival of kidney transplants in both MHC and non-MHC mismatched rat models. Additionally, NC1153 provides comprehensive protection against toxicity for recipients when used in conjunction with cyclosporine A (CsA), demonstrating a synergistic effect to enhance graft survival while avoiding nephrotoxicity, myelotoxicity, and lipotoxicity. -
Anti-Inflammatory Agent
Paranyline hydrochloride is an anti-inflammatory agent that exhibits topical antiallodynic activity. It is primarily utilized in research exploring pain modulation and inflammation pathways. This compound is valuable for studying the mechanisms underlying chronic pain and developing therapeutic strategies for inflammatory conditions. -
Anti-inflammatory Agent
3-Aminobenzoic acid (3-ABA) is an orally active anti-inflammatory agent that targets tight junction regulatory pathways in intestinal epithelial cells. This compound enhances intestinal barrier integrity and reduces epithelial permeability, thereby improving intestinal inflammation. 3-Aminobenzoic acid is valuable in research focused on gut health, and its analogs can serve as γ-aminobutyric acid transaminase (GABA-AT) inhibitors, demonstrating potential anticonvulsant effects. -
Anti-inflammatory Agent
α-Viniferin is an anti-inflammatory compound derived from the root of Caragana chamlagu. It demonstrates significant potential in modulating inflammatory pathways, making it valuable for research into inflammatory diseases. Its biological activity suggests applications in both pharmacological studies and the development of therapeutic agents targeting inflammation-related conditions. -
Arginase
Arginase, Microorganism (immobilized) is an enzyme that plays a crucial role in the urea cycle, catalyzing the hydrolysis of L-arginine to produce L-ornithine and urea. This enzyme is utilized in various biochemical applications, including studies of nitrogen metabolism and modulation of nitric oxide production. Its immobilized form enhances stability and facilitates its use in industrial processes and research settings. -
Antidiabetic/Anti-inflammatory Agent
9-PAHPA is a fatty acid ester of hydroxy fatty acids (FAHFA) that exhibits significant antidiabetic and anti-inflammatory properties. This compound modulates metabolic processes and inflammation pathways, making it a valuable tool for research in metabolic disorders and chronic inflammatory conditions. Its unique mechanism as an endogenous lipid positions it as a promising candidate for studies focused on therapeutic interventions in diabetes and related inflammatory diseases. -
Anti-Inflammatory reagent
9-OAHSA is a fatty acid ester of hydroxy fatty acids (FAHFAs) known for its anti-inflammatory properties. It exerts its effects by inhibiting cytokine production, notably reducing the expression of IL-1β and IL-6. Additionally, 9-OAHSA functions as a protective agent, preventing apoptotic cell death in colon carcinoma cells, making it a valuable tool for research in inflammation and cancer biology. -
Anti-Inflammatory Agent
9-POHSA is a fatty acid ester of hydroxy fatty acids (FAHFAs) that functions as an anti-inflammatory agent. It exhibits significant anti-inflammatory activity by inhibiting cytokine production, particularly reducing the expression of IL-1β and IL-6. This compound is relevant for research into inflammatory pathways and potential therapeutic applications in inflammatory diseases. -
Anti-inflammatory Agent
Lipoxin B4 (LXB4) is an anti-inflammatory agent derived from the metabolism of arachidonic acid. It effectively reduces leukocyte infiltration and mucus secretion in the nasal mucosa while inhibiting mast cell and eosinophil degranulation in the upper airway. Additionally, LXB4 mitigates airway inflammation, mucus metaplasia, and hyper-responsiveness in the lower airway, demonstrating significant mucosal protective actions. Its properties make it a valuable tool for research into allergic inflammation in the upper and lower respiratory tracts. -
Anti-Inflammatory Agent
Damascenone is a complex of E-isomer and Z-isomer variants, derived from Epipremnum pinnatum, known for its anti-inflammatory properties. This compound exhibits significant biological activity, making it a valuable candidate for research focused on inflammatory pathways and mechanisms. Its potential applications include investigations into new anti-inflammatory therapies and understanding the underlying biology of inflammation-related conditions. -
Anti-Inflammatory Agent
5-PAHSA is an anti-inflammatory agent that enhances insulin sensitivity and exhibits neuroprotective effects. In studies involving high-fat diet-induced diabetic mice, 5-PAHSA demonstrated significant oral activity in reducing inflammation and preserving neuronal function. This compound is suitable for research focused on neurological dysfunction associated with diabetes. -
PROTAC IKZF1/IKZF3 Degrader
(Rac)-Cemsidomide is a PROTAC degrader targeting IKZF1 and IKZF3, exhibiting potent antitumor activity through its molecular glue mechanism. This compound demonstrates a GI50 of 0.05 nM in NCIH929.1 cells, making it a valuable tool for research applications focused on the degradation of Ikaros and Aiolos proteins. Its unique properties facilitate investigations into mechanisms of action related to targeted protein degradation in cancer therapies. -
Molecular Glue
Acetyl-cyclosporin A aldehyde is a derivative of Cyclosporin A featuring an acetyl group and a reducing aldehyde moiety. This compound serves as a molecular glue by effectively inhibiting calmodulin and binding to cyclophilin, which can influence the nuclear translocation of NF-AT and may lead to mitochondrial damage. Its unique properties make it valuable for research applications aimed at understanding calcium signaling pathways and mitochondrial dynamics in various biological contexts. -
Covalent Ligand
EN171 is a covalent ligand that selectively modifies cysteine residues C38 and C96 on the 14-3-3 protein, thereby promoting its interactions with estrogen receptor α (ERα), YAP, and TAZ. This modulation leads to a reduction in transcriptional activity associated with both estrogen signaling and the Hippo pathway. EN171 serves as a molecular glue, enhancing native protein interactions, and acts as a covalent recruiter of 14-3-3 in heterobifunctional applications, facilitating the cytosolic sequestering of nuclear neo-substrates such as BRD4 and BCL6. -
PROTAC Linker
tert-Butyl 6-aminocaproate is a PROTAC linker that facilitates the development of targeted protein degraders. This compound plays a crucial role in the synthesis of PROTAC CARM1/IKZF3 degrader-1, enabling selective degradation of target proteins. Its utility in chemical research supports the exploration of innovative therapeutic strategies through targeted protein modulation. -
Immunomodulatory/Antineoplastic Agent
Lenalidomide hydrochloride is an oral immunomodulatory agent targeting cereblon (CRBN), acting as a molecular glue. It promotes the selective ubiquitination and degradation of transcription factors IKZF1 and IKZF3 via the CRBN-CRL4 ubiquitin ligase complex. This mechanism effectively inhibits the growth of mature B-cell lymphomas, including multiple myeloma, while also inducing the release of IL-2 from T cells, making it valuable in cancer research and therapeutic applications. -
DCAF1 Ligand
MY-11B is a ligand for DCAF1, specifically exhibiting reactivity with the DCAF1_C1113 domain. This compound effectively inhibits YT41R and YT47R-mediated degradation of HA-FKBP12, making it a valuable tool in studying protein degradation pathways. MY-11B is also applicable in the synthesis of PROTACs, contributing to the development of targeted protein degradation strategies in chemical research. -
FAP-PI3K Inhibitor
FAP-PI3KI1 is a fibroblast-activated protein (FAP) inhibitor that selectively targets the phosphoinositide 3-kinase (PI3K) pathway in FAP-expressing human cells. This compound effectively inhibits collagen synthesis and reduces collagen deposition, making it a valuable tool for research in idiopathic pulmonary fibrosis (IPF) and related fibrotic conditions. Its targeted action facilitates investigating the role of the PI3K signaling pathway in fibrosis and offers potential insights into therapeutic strategies for IPF. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-PEG3-amide-C2-COOH is an E3 ligase ligand-linker conjugate designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables the targeted degradation of proteins via the recruitment of E3 ligases, presenting significant potential for therapeutic applications in oncology and other areas of drug discovery. It serves as a building block for the creation of innovative PROTACs, such as BCL6 PROTAC 1, facilitating advancements in protein modulation research. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-NH-C4-Boc is a conjugate that targets the E3 ligase Cereblon through an innovative linker. This compound facilitates the synthesis of PROTAC CARM1/IKZF3 degrader-1, enabling targeted protein degradation studies. Its primary application lies in the development of novel therapeutics and novel molecular probes in cellular research. -
Anti-inflammatory Compound
Cuminaldehyde, a primary component of Cuminum cyminum, is recognized for its anti-inflammatory properties. This compound exhibits various biological activities, including inhibition of aldose reductase (IC50 = 0.00085 mg/mL), α-glucosidase (IC50 = 0.5 mg/mL), and lipoxygenase (IC50 = 1370 μM). Additionally, cuminaldehyde inhibits the fibrillation and aggregation of α-synuclein, indicating its potential application in the study of neurodegenerative diseases, cancer, diabetes, and neuropathic pain disorders. -
Antioxidant/Anti-Inflammatory Agent
PQM-164 is an antioxidant agent that targets oxidative stress by exhibiting potent radical scavenging activity (IC50: 0.93 μM for DPPH radical). It demonstrates anti-inflammatory effects by mitigating neuronal damage induced by 6-OHDA in activated microglial cells, and it reduces α-synuclein accumulation. Additionally, PQM-164 promotes the nuclear translocation and transcriptional activity of Nrf2. This compound serves as a valuable tool for research into neurodegenerative conditions such as Parkinson’s disease. -
NRF2 Glue Degrader
VVD-130037 is a covalent molecular glue and allosteric degrader of NRF2, targeting the KEAP1 protein. By binding to KEAP1, it enhances the formation of the KEAP1-CUL3 E3 ligase complex, leading to increased ubiquitination and subsequent degradation of NRF2. This compound demonstrates KEAP1 target-binding activity in both in vitro assays and mouse models, making it a useful tool in research involving NRF2-dependent cancers, solid tumors with KEAP1 mutations, and advanced solid tumors. -
PGK1 Inhibitor
CBR-470-1 is a selective inhibitor of phosphoglycerate kinase 1 (PGK1), a key enzyme in the glycolytic pathway. This compound also acts as a non-covalent activator of Nrf2, enhancing the cellular defense mechanisms against oxidative stress. In cellular models, CBR-470-1 has demonstrated protective effects against MPP+-induced cytotoxicity in SH-SY5Y neuronal cells by activating the Keap1-Nrf2 signaling pathway. This dual functionality makes CBR-470-1 a valuable tool for research in metabolic regulation and neuroprotection. -
Perfume Analogue
Safranal, the primary aromatic compound derived from Saffron (Crocus sativus), serves as a key target for research involving its neuroprotective and anti-inflammatory properties. Its potential applications in the study of neurodegenerative diseases, particularly Parkinson's disease, make it a valuable reagent for chemical research. Safranal's unique characteristics also support investigations into its effects on sensory perception and mood enhancement. -
Nrf2 Activator
Nrf2 activator-2 (compound O15) is a potent Nrf2 agonist that functions by disrupting the interaction between Keap1 and Nrf2, thereby promoting Nrf2 activation. With an EC50 of 2.9 μM in 293 T cells, this compound significantly reduces the levels of ubiquitinated Nrf2, enhancing its stability and nuclear translocation. Nrf2 activator-2 is valuable in studies exploring oxidative stress response, cellular defense mechanisms, and potential therapeutic applications in diseases associated with Nrf2 dysregulation. -
Keap1-Nrf2 Activator
Dibenzoylmethane is a potent activator of the Keap1-Nrf2 pathway. By promoting the dissociation of Nrf2 from Keap1, it facilitates the nuclear translocation of Nrf2, leading to enhanced expression of antioxidant and cytoprotective genes. This compound has potential applications in cancer prevention research and studies focused on mitigating oxidative stress. -
NRF2/ATF4 Activator
I-152 is a bifunctional conjugate designed as an NRF2 and ATF4 activator. This compound enhances cellular antioxidant responses and promotes cytoprotective signaling pathways. Additionally, I-152 exhibits anti-proliferative properties, making it a valuable tool for research in cancer biology and oxidative stress studies. -
Nrf2 Activator
DDO-7263 is a potent activator of Nrf2, functioning primarily through its binding to Rpn6, which inhibits the assembly of the 26S proteasome and prevents the degradation of ubiquitinated Nrf2. This results in the translocation of Nrf2 into the nucleus, thereby enhancing its transcriptional activity. Additionally, DDO-7263 has been shown to inhibit the activation of the NLRP3 inflammasome, demonstrating significant anti-inflammatory properties. It holds promise for research applications in neurodegenerative diseases, such as Parkinson's disease. -
Nrf2 Activator
Eriodictyol-7-O-glucoside is a flavonoid that functions as an Nrf2 activator. It demonstrates potent scavenging activity against hydroxyl radicals and superoxide anions, with IC50 values of 0.28 mM and 0.30 mM, respectively. This compound enhances the nuclear localization of Nrf2, leading to the induction of Nrf2/ARE-dependent gene expression. Eriodictyol-7-O-glucoside offers protective effects against oxidative stress induced by oxygen and glucose deprivation, and exhibits neuroprotective properties in models of focal cerebral ischemia. It is valuable for research in stroke and neuroprotection studies. -
NRF2 Activator
Monoethyl fumarate is the monoethyl ester of fumaric acid and serves as an activator of the Nrf2 pathway. This compound exhibits significant potential for antioxidant activity and may play a crucial role in cellular defense mechanisms. Its applications extend to research involving neuroprotection and inflammation modulation, as well as in the exploration of therapeutic strategies for various diseases. Additionally, monoethyl fumarate is utilized as a preservative and polymerization agent for macromolecular materials. -
Keap1-Nrf2 PPI Inhibitor
NXPZ-2 is an orally active inhibitor of the Keap1-Nrf2 protein-protein interaction with a Ki value of 95 nM and EC50 values of 120 and 170 nM. It has demonstrated the ability to dose-dependently mitigate Aβ[1-42]-induced cognitive dysfunction and improve brain tissue pathology in Alzheimer's disease models by enhancing neuronal quantity and function. NXPZ-2 functions by inhibiting oxidative stress through increased expression of Nrf2 and promoting its translocation from the cytoplasm to the nucleus, supporting research into Keap1-Nrf2 interactions and Alzheimer’s disease. -
Anticancer/Anti-inflammatory Agent
Antroquinonol, a ubiquinone derivative derived from the mushroom Antrodia camphorata, demonstrates notable anticancer and anti-inflammatory properties. This compound is primarily studied for its potential in colon cancer research due to its ability to reduce oxidative stress by activating the Nrf2 signaling pathway. Additionally, Antroquinonol has shown efficacy in inhibiting inflammation and sclerosis in models of focal segmental glomerulosclerosis. -
Nrf2 Activator
Nrf2 activator-3 is a potent activator of the NF-E2-related factor 2 (Nrf2) pathway. This compound enhances antioxidant response element (ARE) transcriptional activity, promoting the expression of various cytoprotective genes. Nrf2 activator-3 is primarily utilized in research focusing on cerebral ischemic injury, where it may help elucidate mechanisms of neuroprotection and potential therapeutic strategies. -
NRF2 Activator
CBR-470-2 is a glycine-substituted analog that functions as an NRF2 activator. This compound significantly enhances NRF2 signaling pathways, making it a valuable tool for research into metabolic modulation, particularly glycolysis. Its ability to influence key cellular processes positions CBR-470-2 as an important reagent for exploring the roles of oxidative stress and inflammation in various biological systems. -
Keap1-Nrf2 PPI Inhibitor
Keap1-Nrf2-IN-13 is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction (PPI), exhibiting an IC50 of 0.15 μM. This compound effectively disrupts the binding of Keap1 to Nrf2 by establishing hydrogen bonds with critical polar residues such as Asn414, Arg415, Arg483, and Gln530. Keap1-Nrf2-IN-13 is valuable for research focused on oxidative stress-related conditions and inflammatory diseases, including pulmonary fibrosis, chronic obstructive pulmonary disease (COPD), and various cancers. -
Keap1-Nrf2 Inhibitor
Toralactone is a selective inhibitor of the Keap1-Nrf2 pathway, which plays a crucial role in cellular antioxidant defense mechanisms. Originating from Cassia obtusifolia, Toralactone exhibits significant hepatoprotective effects mediated through Nrf2 activation. This compound is suitable for research applications focused on oxidative stress, hepatotoxicity, and the modulation of antioxidant responses in various biological systems. -
Keap1-Nrf2 Inhibitor
Nrf2 activator-12 is a potent activator of the Keap1-Nrf2 pathway, with an EC50 value of 83.5 nM. This compound demonstrates significant pharmacological effects, including the ability to reverse disease progression and mitigate demyelination in an experimental autoimmune encephalomyelitis mouse model. Nrf2 activator-12 is valuable for studies exploring oxidative stress responses and potential neuroprotective strategies in various neurological disorders. -
Keap1-Nrf2 PPI Inhibitor
Keap1-Nrf2-IN-9 is a selective inhibitor of the Keap1-Nrf2 protein-protein interaction (PPI) with a reported IC50 of 0.575 μM. This compound enhances the expression of Nrf2 target genes, including heme oxygenase 1 (Hmox1), glutathione S-transferase P (GstP), and the modulatory and catalytic subunits of glutamate-cysteine ligase (Gclc and Gclm). Keap1-Nrf2-IN-9 exhibits low cytotoxicity in ARPE19 cells, making it a valuable tool for studies focused on oxidative stress and cellular defense mechanisms. -
Nrf2 Activator
Nrf2 activator-1 is a potent activator of the NF-E2 related factor 2 (Nrf2), a key regulator of cellular antioxidant response. It demonstrates significant biological activity in modulating oxidative stress and inflammation. This compound is valuable for research applications related to chronic obstructive pulmonary disease (COPD), asthma, acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and pulmonary fibrosis, facilitating the exploration of therapeutic interventions in these conditions. -
NRF2 Activator
MIND4-17 is a selective NRF2 activator that covalently modifies the C151 residue of Keap1. By disrupting the association between Keap1 and Nrf2, MIND4-17 promotes Nrf2 protein stabilization and subsequent nuclear translocation, enhancing the cellular antioxidant response. This compound demonstrates strong antioxidant activity and is valuable for research applications focused on oxidative stress and related pathways. -
Keap1-Cul3 E3 ligase Complex Allosteric Molecular Glues
VVD 065 is an allosteric modulator of the Keap1-Cul3 E3 ligase complex that functions as a molecular glue. By activating KEAP1, VVD 065 promotes the degradation of NRF2, an essential regulator of antioxidant defenses. This compound has demonstrated the ability to inhibit tumor growth in non-small cell lung cancer and esophageal squamous cell carcinoma xenograft models. VVD 065 serves as a valuable tool for research on cancer biology and therapeutic strategies targeting oxidative stress responses. -
NR0B1-protein Interactions Destructive Agent
BPK-29 hydrochloride is a selective agent that disrupts interactions between the atypical orphan nuclear receptor NR0B1 and its protein partners, such as RBM45 and SNW1, through covalent modification of cysteine residue C274. This compound has been shown to inhibit anchorage-independent growth in KEAP1-mutant cancer cell lines, making it a valuable tool for studying the biological functions of NR0B1 and its role in cancer development. BPK-29 hydrochloride is essential for research on targeted therapies in oncology and the mechanisms underlying cancer cell proliferation. -
Keap1-Nrf2 PPI Inhibitor
Keap1-Nrf2-IN-7 is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction (PPI), exhibiting an IC50 value of 0.45 µM. This compound plays a crucial role in modulating the Nrf2 signaling pathway, which is essential for cellular responses to oxidative stress. Its application is significant in studies focused on neuroprotection, cancer therapy, and various diseases associated with oxidative damage. -
Nrf2 Peptide
Nrf2 (69-84) is a peptide derived from the Nrf2 protein, featuring the essential ETGE motif critical for binding to the Kelch domain of the Keap1 protein. This peptide serves as a valuable tool for investigating the regulatory functions of Nrf2 in various biological processes, particularly in the context of cancer, neurodegenerative disorders, and inflammatory diseases. Its application aids in elucidating the mechanisms by which Nrf2 modulates cellular responses to oxidative stress and inflammation.
