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Catalog No.
Product Name
Application
Product Information
Citations
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iNOS Inhibitor
iNOS inhibitor-10 is a selective inhibitor of inducible nitric oxide synthase (iNOS) with an IC50 of 65 nM. It exhibits antiproliferative effects against triple-negative breast cancer cells, making it a valuable tool for research on cancer biology and therapeutic approaches targeting the iNOS pathway. Its application in studying the role of nitric oxide in tumor progression highlights its potential relevance in cancer research. -
NO Synthase Inhibitor
Harzianol L is an inhibitor of nitric oxide (NO) synthase, derived from the Trichoderma species SCSIOW21. This compound has demonstrated the ability to inhibit NO production, contributing to its anti-inflammatory effects. Harzianol L is useful in research applications focused on studying inflammatory processes and the regulation of nitric oxide in various biological contexts. -
DDAH Inhibitor
Methyl-L-NIO hydrochloride is a selective inhibitor of dimethylarginine dimethylaminohydrolase (DDAH), exhibiting an IC50 value of 70 μM. This compound also demonstrates inhibitory effects on nitric oxide synthase (NOS) isoforms, with inhibition rates at 100 μM of 77% for neuronal NOS (nNOS), 20% for endothelial NOS (eNOS), and 72% for inducible NOS (iNOS). At a concentration of 1 mM, Methyl-L-NIO achieves 100% inhibition of both nNOS and iNOS, and 85% inhibition of eNOS. This reagent is valuable for research applications involving the modulation of nitric oxide signaling pathways and the study of DDAH activity. -
NO Synthase Inhibitor
Harzianol K is a harziane-type diterpene derivative that acts as an inhibitor of nitric oxide synthase (NO Synthase). This compound demonstrates significant inhibitory effects on nitric oxide production, making it a valuable tool for research in the anti-inflammatory field. Its unique origin from deep-sea sediment fungus Trichoderma sp. SCSIOW21 adds to its potential for exploring various biological pathways associated with inflammation. -
NO Synthase Inhibitor
Camstatin is a potent inhibitor of neuronal nitric oxide (NO) synthase, functioning through its interaction with calmodulin. This 25-residue fragment derived from the IQ motif of PEP-19 demonstrates significant activity in modulating NO production. Camstatin is valuable for research applications focusing on nitric oxide signaling pathways and their role in various neurological conditions. -
iNOS Inhibitor
GW274150 dihydrochloride is a selective and potent inhibitor of inducible nitric oxide synthase (iNOS), demonstrating an IC50 of 2.19 μM and a Kd of 40 nM, alongside an ED50 of 1.15 μM for rat iNOS. This compound exhibits reduced activity against endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS). Research applications include studying inflammatory responses and evaluating protective effects in models of acute lung injury. -
NOS Inhibitor
Iromycin A is a potent inhibitor of nitric oxide synthases (NOS), derived from Streptomyces sp. It effectively modulates nitric oxide production, making it valuable for research on vascular biology and inflammatory processes. This compound serves as a critical tool in studying the physiological and pathological roles of nitric oxide in various biological systems. -
NO Synthase Inhibitor
Trichaspside F is a sesquiterpene aminoglycoside that serves as a selective inhibitor of nitric oxide synthase. This compound effectively reduces nitric oxide production, exhibiting an IC50 value of 54.8 µM in RAW 264.7 macrophage cells. Its potential applications include studies related to anti-inflammatory mechanisms and the modulation of nitric oxide-related pathways in various biological contexts. -
NO Inhibitor
Staphylionoside D is a nitric oxide (NO) inhibitor derived from Annona squamosa L. It demonstrates significant anti-inflammatory activity by effectively reducing NO production. This compound is of interest for research applications focused on inflammation-related pathways and the modulation of nitric oxide signaling in various biological contexts. -
NO Synthase Inhibitor
Harzianol J is a harziane-type diterpene identified as a nitric oxide synthase inhibitor. Exhibiting significant anti-inflammatory properties, it achieves an 81.8% inhibition of nitric oxide production at a concentration of 100 µM, with an IC50 value of 66.7 µM. This compound is suitable for research applications focused on investigating anti-inflammatory mechanisms and potential therapeutic interventions. -
iNOS Inhibitor
ATV399 is an allosteric inhibitor of inducible nitric oxide synthase (iNOS) that effectively reduces nitric oxide (NO) production by preventing iNOS dimerization. This compound offers protective effects on rat pancreatic islet β-cells by mitigating cytokine-induced mitochondrial stress, endoplasmic reticulum stress, and apoptosis. ATV399 is suitable for research applications focused on type 1 diabetes and related metabolic disorders. -
nNOS Inhibitor
hnNOS-IN-3 is a selective inhibitor of neuronal nitric oxide synthase (nNOS) with a Ki value of 0.32 μM, demonstrating competitive binding with L-arginine. This compound exhibits remarkable selectivity, with 115-fold increased affinity for nNOS over inducible nitric oxide synthase (iNOS, Ki=37 μM) and 29-fold greater affinity over endothelial nitric oxide synthase (eNOS, Ki=9.4 μM). hnNOS-IN-3 serves as a valuable tool for studying nNOS-related biological processes and potential therapeutic interventions in neurological disorders. -
NO Synthase Inhibitor
Cycloneroside A is a sesquiterpene aminoglycoside that functions as an inhibitor of nitric oxide synthase. It exhibits significant activity in reducing nitric oxide production, with an IC50 value of approximately 100 µM observed in RAW 264.7 macrophage cells. This compound is valuable for investigating anti-inflammatory mechanisms and the modulation of nitric oxide in various biological contexts. -
NO Synthase Inhibitor
Oxyphyllenone A is a selective inhibitor of nitric oxide synthase (NOS), effectively reducing nitric oxide production in lipopolysaccharide-activated macrophages. With an IC50 value of 28 μM, it serves as a valuable tool in investigating the roles of nitric oxide in inflammatory responses and related biological processes. Oxyphyllenone A is useful for research applications focused on immunology and cellular signaling pathways. -
NOS Inhibitor
7-Nitroindazole sodium is a selective inhibitor of nitric oxide synthase (NOS) that effectively penetrates the blood-brain barrier. It demonstrates significant inhibitory activity towards central NOS, with an IC50 of 0.47 μM measured in murine cerebellar tissue. This compound exhibits neuroprotective and anti-injurious properties, making it a valuable tool for research into neurodegenerative diseases and neuropharmacology. -
NO Synthase Inhibitor
Inflexuside A is a potent inhibitor of nitric oxide synthase. Isolated from the aerial parts of Isodon inflexus, this abietane diterpenoid effectively suppresses lipopolysaccharide (LPS)-induced nitric oxide production in RAW264.7 macrophage cells. Its significant biological activity makes Inflexuside A a valuable reagent for research into inflammatory responses and nitric oxide signaling pathways. -
iNOS Inhibitor
MEG hemisulfate is a selective and potent inducible nitric oxide synthase (iNOS) inhibitor, exhibiting EC50 values of 11.5 μM for iNOS, alongside higher values for endothelial and brain nitric oxide synthases. In addition to its role as an iNOS inhibitor, MEG hemisulfate functions as a robust scavenger of peroxynitrite, mitigating peroxynitrite-induced oxidative damage. This compound demonstrates protective effects in various inflammation-related models, including ischemia/reperfusion injury, periodontitis, and inflammatory bowel disease, making it a valuable tool for research in inflammatory processes and oxidative stress responses. -
NO Synthase Inhibitor
Cycloneroside B is a novel sesquiterpene aminoglycoside that functions as an inhibitor of nitric oxide synthase, effectively reducing nitric oxide production with an IC50 value of 50.7 µM. This compound is significant for research in the anti-inflammatory domain, providing valuable insight into pathways and mechanisms associated with inflammation. Its unique structure and activity make it a relevant tool for investigators exploring nitric oxide's role in various biological processes. -
NO Production Inhibitor
Idesin is a nitric oxide production inhibitor derived from the fruits of Idesia polycarpa. It effectively inhibits lipopolysaccharide (LPS)-induced nitric oxide synthesis while exhibiting minimal cytotoxic effects. This compound is valuable in research applications focused on inflammation, immune response modulation, and studies exploring the roles of nitric oxide in various biological processes. -
NO Synthase Inhibitor
KLYP961 is a selective, orally active dual inhibitor of inducible and neuronal nitric oxide synthase (IC50 = 50-400 nM). This compound effectively reduces endotoxin-induced increases in plasma nitrates and alleviates pain behaviors in a mouse formalin model. KLYP961 is also shown to mitigate carrageenan-induced edema and inflammatory hyperalgesia, as well as the writhing response provoked by phenylbenzoquinone. It is suitable for research focused on neurological diseases and related inflammatory conditions. -
iNOS Inhibitor
iNOs-IN-3 is a selective inhibitor of inducible nitric oxide synthase (iNOS) with an IC50 of 3.342 µM. This compound exhibits significant anti-inflammatory effects and is applicable in research related to LPS-induced acute lung injury (ALI). Its ability to modulate nitric oxide production makes it a valuable tool for exploring inflammatory pathways and potential therapeutic interventions. -
NO Production Inhibitor
iNOS-IN-2 is a potent inhibitor of inducible nitric oxide synthase (iNOS), effectively reducing nitric oxide (NO) production with an IC50 of 6.4 μM. This compound demonstrates significant anti-inflammatory activity, making it a valuable tool for research into chronic inflammatory conditions. Its ability to modulate NO levels positions iNOS-IN-2 as an important reagent for studying the roles of iNOS in various biological processes and potential therapeutic interventions. -
NOS Inhibitor
L-ENIPO hydrochloride is a selective inhibitor of nitric oxide synthases (NOS), specifically targeting inducible NOS (iNOS), neuronal NOS (nNOS), and endothelial NOS (eNOS) with Ki values of 17, 10.3, and 58.2 μM, respectively. It demonstrates reversible, tight-binding inhibition with a preference for iNOS, particularly at extended incubation periods. This compound is valuable in research applications focused on inflammation, neurodegenerative diseases, and vascular biology, providing insight into the role of nitric oxide in various physiological and pathological processes. -
iNOS Inhibitor
Cindunistat (hydrochloride) maleate is a potent and selective inhibitor of inducible nitric oxide synthase (iNOS). This compound demonstrates significant anti-inflammatory activity, making it valuable for research into inflammatory diseases and associated pathways. Its oral bioavailability facilitates its use in in vivo studies, enabling deeper exploration of iNOS's role in various biological contexts. -
NO Synthase Inhibitor
Cycloneroside E is a sesquiterpene aminoglycoside that functions as a nitric oxide synthase inhibitor. It demonstrates significant inhibitory activity on nitric oxide production, with an IC50 value of 48.0 µM in RAW 264.7 macrophage cells. This compound is valuable for research in the field of anti-inflammatory therapeutics, providing insights into the modulation of nitric oxide levels in inflammatory responses. -
NO Synthase Inhibitor
(-)-10,11-Dihydroxyfarnesol is a potent nitric oxide synthase inhibitor derived from the endolichenic fungus Cryptomarasmius aucubae. This compound demonstrates significant inhibition of nitric oxide production, making it a valuable tool for studying NO-related biological pathways and mechanisms. Its applications include research into vascular biology, neurobiology, and inflammation where modulation of nitric oxide signaling is critical. -
iNOS Inhibitor
Juncutol is a potent inhibitor of inducible nitric oxide synthase (iNOS), effectively reducing iNOS protein expression stimulated by lipopolysaccharide (LPS). This compound plays a significant role in studies targeting inflammatory pathways, making it valuable for research in conditions characterized by excessive nitric oxide production, such as sepsis and neurodegenerative diseases. Its ability to modulate iNOS activity positions Juncutol as a crucial tool in understanding the regulation of nitric oxide in various biological contexts. -
NO Synthase Inhibitor
Isophysalin A is a potent inhibitor of inducible nitric oxide synthase (iNOS), targeting multiple cysteine residues on IKKβ and effectively diminishing nitric oxide (NO) production. Its mechanism involves binding to glutathione (GSH), which contributes to its anti-inflammatory properties. This compound is valuable for research applications focused on inflammation and related signaling pathways. -
NO Inhibitor
8A8 is a potent inhibitor of nitric oxide (NO) with an IC50 value of 4.7 μM. This compound effectively suppresses lipopolysaccharide (LPS)-induced proliferation of HaCat cells, demonstrating significant anti-inflammatory effects. 8A8 is useful for research applications focused on understanding NO's role in inflammatory processes and related cellular responses. -
NO Synthase Inhibitor
Harzianol M is a potent nitric oxide synthase inhibitor derived from Trichoderma sp. SCSIOW21. This compound effectively reduces nitric oxide production, demonstrating significant anti-inflammatory properties. Harzianol M is useful in research applications focused on inflammation-related pathways and nitric oxide modulation. -
NOS Inhibitor
S-Isopropylisothiourea hydrobromide is a potent nitric oxide synthase (NOS) inhibitor that effectively penetrates the blood-brain barrier. With IC50 values of 0.66, 0.75, and 0.29 μM against mouse spinal cord, cerebellar, bovine aortic, and porcine endothelial cell NOS, it demonstrates a significant blood pressure-raising effect while preserving vital organ perfusion. This compound is utilized in research focused on hemorrhagic shock and the modulation of pain responses, particularly in models utilizing formalin-induced late-phase pain. -
NO Production Inhibitor
Lethedoside A is a natural flavonoid identified as an inhibitor of nitric oxide (NO) production, specifically targeting lipopolysaccharide (LPS)-induced pathways in RAW 264.7 cells. Its primary biological activity involves the modulation of inflammatory responses, making it a valuable tool for research into nitric oxide signaling and inflammatory diseases. This compound is applicable in studies exploring mechanisms of immune regulation and the development of anti-inflammatory strategies. -
Nitric Oxide Synthase Inhibitor
ONO-1714 is an orally active inhibitor of nitric oxide synthase, which plays a crucial role in nitric oxide production. This compound demonstrates significant biological activities, including the attenuation of endotoxin-induced acute lung injury, reduction of intestinal ischemia-reperfusion injury, and repression of biliary carcinogenesis. It is a valuable reagent for research applications focusing on inflammatory responses and tissue protection mechanisms. -
NO Synthase Inhibitor
S-MTC is a selective inhibitor of type I nitric oxide synthase (NOS), primarily targeting the enzymatic production of nitric oxide. This compound has been shown to effectively modulate nitric oxide levels in various biological systems and is valuable for studies investigating vascular function, neurobiology, and inflammation. S-MTC serves as a crucial tool in research aimed at understanding the role of nitric oxide in physiological and pathological processes. -
NO Inhibitor
(-)-Cryptamide C is a potent inhibitor of nitric oxide (NO) production. Derived from the Periostracum cicadae, this dopamine enantiomer trimer demonstrates significant anti-inflammatory activity. It serves as a valuable tool for studying inflammatory diseases and their underlying mechanisms. -
NO Synthase Inhibitor
nNOS-IN-5 is a potent inhibitor of human neuronal nitric oxide synthase (nNOS) with a Ki value of 22 nM. This compound demonstrates remarkable selectivity, exhibiting a 900-fold preference for nNOS over human endothelial nitric oxide synthase (eNOS). nNOS-IN-5 is suitable for research applications related to neurodegenerative diseases, including Alzheimer's and Parkinson's disease, providing valuable insights into nNOS's role in neurobiology and associated pathologies. -
iNOS Inhibitor
2-Iminopiperidine hydrochloride is a potent inhibitor of inducible nitric oxide synthase (iNOS). This compound is utilized in research to explore nitric oxide-mediated processes in various conditions, including arthritis, inflammatory bowel disease, diabetes, allodynia, and cerebral ischemia, as well as other central nervous system disorders. Its role in modulating nitric oxide production makes it a valuable tool for investigating the underlying mechanisms of inflammation and neuroprotection. -
NOS Inhibitor
L-NIO is a potent, non-selective nitric oxide synthase (NOS) inhibitor that acts by inhibiting the NADPH-dependent activity of the enzyme. It displays inhibition constants (Kis) of 1.7, 3.9, and 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS) isoforms, respectively. L-NIO has been shown to induce focal ischemic infarcts in rat models, making it a valuable tool for studying the role of nitric oxide in various physiological and pathological processes. Its ability to effectively modulate NOS activity positions it as a significant reagent in cardiovascular and neurobiological research applications. -
NO Production Inhibitor
Bisacurone is a natural terpenoid that acts as a nitric oxide production inhibitor. It demonstrates potent inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide production, with an IC50 value of 29.8 μM. Bisacurone is useful in research settings focused on inflammation and related pathways. -
SPSB2-iNOS Inhibitor
SPSB2-iNOS inhibitory cyclic peptide-2 is a selective inhibitor of the interaction between SPSB2 and inducible nitric oxide synthase (iNOS), exhibiting a binding affinity with a KD of 21 nM. This cyclic peptide is both reduction-resistant and oxidatively stable, making it suitable for various biological assays. Its ability to inhibit SPSB2-iNOS interactions positions it as a valuable tool in research focused on nitric oxide signaling and related pathophysiological processes. -
NO Production Inhibitor
Nitric oxide production-IN-1 is a potent inhibitor of nitric oxide (NO) synthesis, isolated from Tupistra chinensis. It effectively reduces NO production in rat abdominal macrophages stimulated by lipopolysaccharide (LPS). This compound is valuable for research applications investigating inflammatory processes and the regulation of nitric oxide in various biological contexts. -
iNOs Inhibitor
iNOs-IN-7 is a potent inhibitor of inducible nitric oxide synthase (iNOS), a critical enzyme involved in the production of nitric oxide during inflammatory responses. This compound has demonstrated efficacy in modulating inflammatory pathways and is valuable for research applications related to inflammatory diseases and pain management. Its use may facilitate the exploration of therapeutic strategies targeting iNOS in various pathological conditions. -
NO Production Inhibitor
19-[(β-D-Glucopyranosyl)oxy]-19-oxo-ent-labda-8(17),13-dien-16,15-olide is a potent nitric oxide (NO) production inhibitor, primarily targeting lipopolysaccharide-activated macrophages. As a metabolite of Neoandrographolide, it exhibits significant anti-inflammatory properties, making it a valuable tool for research into inflammatory responses and related pathways. Its ability to modulate NO levels in immune cells supports investigations into various conditions involving excessive inflammation and immune dysregulation. -
iNOS Inhibitor
Hirundigoside E is an iNOS inhibitor that exhibits significant anti-inflammatory activity. It effectively suppresses lipopolysaccharide (LPS)-induced iNOS protein expression in macrophages. This compound is suitable for research focused on understanding and mitigating inflammatory diseases. -
NO Synthase Inhibitor
Inflexuside B is an abietane diterpenoid that functions as a potent inhibitor of nitric oxide (NO) synthase. Isolated from the aerial parts of Isodon inflexus, Inflexuside B demonstrates significant inhibitory activity against LPS-activated NO synthase in RAW264.7 macrophages. This compound serves as a valuable tool in research focused on inflammatory pathways and nitric oxide-related signaling mechanisms. -
NOS Inhibitor
hnNOS-IN-2 is a selective inhibitor of human neuronal nitric oxide synthase (hnNOS), demonstrating excellent metabolic stability. This compound is primarily utilized in research focusing on neurodegenerative diseases, offering insights into the role of nitric oxide in neuronal function and pathology. Its inhibition capability provides a valuable tool for studying the therapeutic potential in various neurological disorders. -
nNOS Inhibitor
NOS-IN-4 is a selective inhibitor of neuronal nitric oxide synthase (nNOS) with an IC50 value of 4.00 μM, effectively reducing nNOS enzyme activity. It has been shown to offer neuroprotective effects, particularly in the context of MPTP-induced dopamine depletion in murine models. This compound is valuable for studying neurodegenerative disorders and the associated pathophysiological mechanisms. -
NO Inhibitor
Physalin O is a natural compound derived from Physalis angulata, functioning primarily as a nitric oxide (NO) inhibitor. It exhibits notable cytotoxicity against Hep G2 and MCF-7 cancer cell lines, with IC50 values of 31.1 µM and 11.4 µM, respectively. In addition to its anti-cancer properties, Physalin O demonstrates significant anti-inflammatory activities through the inhibition of NO production, making it a valuable tool in related research applications. -
NO Production Inhibitor
Pratialin B is a C14-polyacetylenol glycoside analog that acts as an inhibitor of nitric oxide (NO) production. Isolated from the roots of Codonopsis pilosula, Pratialin B demonstrates weak inhibitory effects on LPS-induced NO production. This compound serves as a valuable tool for investigations into inflammatory processes and the modulation of nitric oxide signaling pathways in biological research. -
NO/mPGES-1 Inhibitor
Shanciol B is a selective inhibitor of nitric oxide (NO) production and microsomal prostaglandin E synthase-1 (mPGES-1). Isolated from the ethyl acetate extract of Pholidota imbricate, Shanciol B exhibits notable anti-inflammatory properties and demonstrates effective 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity. This compound is valuable for research applications focused on inflammation and oxidative stress.
